JP2002212051A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To develop a combination of a protective membrane ingredient having high protectability and excellent usability and to provide a skin care preparation containing the ingredients. SOLUTION: This skin care preparation is obtained by including a polyhydric alcohol and cocamidopropyl PG-dimonium chloride phosphate and/or sodium coco PG-dimonium chloride phosphate.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin, and more particularly, to an external preparation for skin suitable for cosmetics.

[0002]

2. Description of the Related Art In the field of skin external preparations such as cosmetics and skin external medicines, one of the important factors is to form a protective film on the skin to prevent the dissipation of moisture from the skin, To prevent the entry of irritants from the skin into the skin. Mucopolysaccharides such as sodium hyaluronate and heparin-like substances are known as substances for forming such a film, but these are not used in pharmaceuticals or physical properties until such protective film effect is sufficiently exerted. It is difficult to incorporate the amount into the external preparation for skin. That is, if the content of such components is too large, the viscosity becomes extremely high, and the usability is impaired, and unacceptable stickiness is felt in the feel during use. For this reason, development of a protective coating component having high protection and excellent usability has been desired.

On the other hand, cocamidopropyl PG-dimonium chloride phosphate or sodium coco PG-dimonium chloride phosphate is a pseudophospholipid mixture containing a phosphoric diester or triester having a plurality of long-chain hydrophobic groups as components. It is known as a raw material for cosmetics, but it cannot be combined with a polyhydric alcohol such as glycerin, 1,3-butanediol, isoprene glycol, dipropylene glycol, diglycerin or 1,2-pentanediol. It was not known, and it was not known at all that including such a combination in an external preparation for skin could provide an external preparation for skin that would form an excellent protective film.

[0004]

DISCLOSURE OF THE INVENTION The present invention has been made under such circumstances, and has been developed in combination with a protective coating component having high protection and excellent usability, and provides an external preparation for skin containing the same. That is the task.

[0005]

In view of such circumstances, the present inventors have developed a combination of protective film components having high protective properties and excellent usability, and have made intensive research efforts to provide an external preparation for skin containing the same. As a result, the inventors have found such properties in a skin external preparation such as a cosmetic containing a polyhydric alcohol and cocamidopropyl PG-dimonium chloride phosphate, and completed the invention. That is, the present invention relates to the following technology. (1) Polyhydric alcohol and cocamidopropyl PG-dimonium chloride phosphate and / or sodium coco PG
-An external preparation for skin, characterized by containing dimonium chloride phosphate. (2) The polyhydric alcohol includes one selected from 1,3-butanediol, isoprene glycol, dipropylene glycol, diglycerin and 1,2-pentanediol, as described in (1). External preparation for skin. (3) The polyhydric alcohol is one or more selected from glycerin, 1,3-butanediol, isoprene glycol, dipropylene glycol, diglycerin and 1,2-pentanediol. The external preparation for skin according to (1) or (2). (4) The skin according to any one of (1) to (3), further comprising a salt of a carboxyvinyl polymer and / or a salt of acrylic acid / methacrylic acid (C10-30) alkyl. External preparation. (5) The external preparation for skin according to any one of (1) to (4), which is for protecting the skin from irritants. (6) (1) to (5) characterized in that it is a cosmetic.
The external preparation for skin according to any one of claims 1 to 7. (7) The cosmetic according to (6), which is for sensitive skin. Hereinafter, the present invention will be described in more detail focusing on embodiments.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS (1) Polyhydric alcohol which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing a polyhydric alcohol as an essential component. In the present invention, the polyhydric alcohol is used together with cocamidopropyl PG-dimonium chloride phosphate and / or sodium coco PG-dimonium chloride phosphate, which is another essential component, to form an adhesive film that does not allow stimulants to pass through. Has the effect of forming. In the skin external preparation of the present invention, polyhydric alcohols usually used in skin external preparations can be used. For example, propylene glycol, 1,3-butanediol, glycerin, polyethylene glycol, isoprene glycol, dipropylene glycol, Preferred examples include diglycerin, maltitol, sorbitol, xylitol and 1,2-pentanediol. Among these, 1,3-butanediol, isoprene glycol, dipropylene glycol, diglycerin and 1,2-pentanediol are preferred. Preferred forms include those selected, more preferably glycerin, 1,3-butanediol, isoprene glycol,
One or more forms selected from dipropylene glycol, diglycerin and 1,2-pentanediol can be exemplified. The content of these polyhydric alcohols is 4 to 15% by weight based on the total amount of the external preparation for skin.
And more preferably 5 to 10% by weight.
It is. Further, among such constitutions, a form containing 3 to 6% by weight of 1,3-butanediol, 1,2-pentanediol or isoprene glycol with respect to the total amount of the external preparation for skin is particularly preferable.

(2) Cocamidopropyl PG-dimonium chloride phosphate and / or sodium coco PG-dimonium chloride phosphate, which are essential components of the present invention, The external preparation for skin of the present invention comprises cocamidopropyl PG-dimonium chloride phosphate and / Or Sodium Coco PG
-Containing dimonium chloride phosphate is another essential component. Here, both cocamidopropyl PG-dimonium chloride phosphate and sodium coco PG-dimonium chloride phosphate are pseudophospholipid mixtures containing a phosphoric diester or triester having a plurality of long-chain hydrophobic groups, Showa 5
It can be produced by the method described in JP-A-9-4478. Some of these compounds are already commercially available, and such compounds can also be used. Examples of such commercially available products include, for example, phospholipid PTC as cocamidopropyl PG-dimonium chloride phosphate, which is commercially available from Uniquema.
Preferred examples of sodium coco PG-dimonium chloride phosphate include phospholipid CDM. As the skin external preparation of the present invention, it is particularly preferable to use such a commercially available product as cocamidopropyl PG-dimonium chloride phosphate and / or sodium coco PG-dimonium chloride phosphate from the viewpoint of maintaining quality stability. These cocamidopropyl PG-dimonium chloride phosphates and / or sodium coco PG-dimonium chloride phosphates can contain either one or both. The preferred content of cocamidopropyl PG-dimonium chloride phosphate and / or sodium coco PG-dimonium chloride phosphate in the skin external preparation of the present invention is 0.01 to 0.01% based on the total amount of the skin external preparation. 1
0% by weight is preferable, and 0.1 to 1% by weight is more preferable. This is because if the amount is too small, the film properties may become unfavorable, and if the amount is too large, the effect may reach a plateau.

(3) External preparation for skin of the present invention The external preparation for skin of the present invention comprises polyhydric alcohol and cocamidopropyl PG-dimonium chloride phosphate and / or sodium coco PG-dimonium chloride phosphate as described above. It is characterized by containing. Here, in the present invention, the external preparation for skin means a generic name of those used for external application such as cosmetics, external preparation medicines, external use disinfectants and disinfectants. Although the skin external preparation of the present invention can be applied to any of these, it is preferably applied to cosmetics due to its mild properties, and particularly preferably applied to cosmetics for sensitive skin. The external preparation for skin of the present invention may contain, in addition to the above essential components, any components that are usually used in external preparations for skin. Such optional components include, for example, hydrocarbons such as squalane, liquid paraffin, and solid paraffin; silicones that are not essential components such as dimethicone and femethicone; esters such as jojoba oil and gay wax; stearic acid and olein. Fatty acids such as acids, higher alcohols such as behenyl alcohol, cetanol, and oleyl alcohol; triglycerides such as tallow and olive oil;
Nonionic surfactants such as stearic acid monoglyceride, sorbitan sesquiolate, polyoxyethylene sorbitan monooleate, polyoxyethylene stearate,
Anionic surfactants such as sodium lauryl stearate, cationic surfactants such as quaternary alkylammonium salts, powders such as crystalline cellulose, salts of carboxyvinyl polymer, acrylic acid / methacrylic acid (C10-3
0) Salts of alkyl copolymers, salts of polyacrylic acid, bentonite, thickeners such as xanthan gum and hydroxypropylcellulose, and active ingredients such as vitamins and glycyrrhizin are preferred. Of these, particularly preferred components for the external preparation for skin of the present invention include salts of carboxyvinyl polymers and / or salts of alkyl (meth) acrylate and methacrylate (C10-30). This is because they exhibit an effect of strengthening the protective film. These salts of the carboxyvinyl copolymer and the salts of the acrylic acid / alkyl methacrylate (C10-30) copolymer are obtained by neutralizing the carboxyvinyl copolymer and the acrylic acid / alkyl methacrylate (C10-30) copolymer. It can be formed in the system. As such a salt, any salt that is physiologically acceptable and forms a gel can be used without any particular limitation. Examples thereof include alkali metal salts such as sodium salt and potassium salt, ammonium salt, triethanolamine and triethylamine salt. And the like, and organic amino acid salts such as lysine salts and arginine salts. Several of these are commercially available due to their viscosity characteristics, but they can be used alone or in combination of two or more. Preferred is a form containing both of these two types. In the case of containing the salt of such a carboxyvinyl copolymer and the salt of an acrylic acid / alkyl methacrylate (C10-30) copolymer, a preferable combination is a carboxyvinyl polymer: acrylic acid in terms of a free form. -Alkyl methacrylate (C10-30) copolymer = 99: 1 to 9: 1. The content is 0.05 to 1% by weight, more preferably 0.1% by weight, based on the total amount of the external preparation for skin in terms of the free form.
1 to 0.5% by weight. This is because if the amount is too large, the durability of the protective film may be impaired and the duration of the protective film may be shortened. If the amount is too small, the protective film strengthening effect may not be exhibited. In addition, cocamidopropyl PG-dimonium chloride phosphate and / or sodium coco PG-dimonium chloride phosphate, which are essential components of the skin external preparation of the present invention, also have an antibacterial effect. In addition, it is preferable not to contain parabens such as methylparaben and butylparaben which may cause irritation on sensitive skin. The external preparation for skin of the present invention has a sufficient preservative action even if such a preservative is not contained or its content is reduced. For those with hypersensitivity caused by such ingredients, such ingredients are reduced to 1/5 of the usual usage.
It is more preferable that the content is not contained in an amount of 0.05% by weight or less. The external preparation for skin of the present invention can be produced by treating these essential components and optional components according to a conventional method.

[0009]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples, but it goes without saying that the present invention is not limited to only these Examples.

<Examples 1 to 3> A lotion, which is an external preparation for skin of the present invention, was prepared according to the following formulation. That is, the components (a) and (b) were heated at 80 ° C., and (a) was gradually added to (b) for neutralization, followed by stirring and cooling to obtain a lotion. At the same time, as Comparative Example 1, cocamidopropyl PG-dimonium chloride phosphate and sodium coco PG-
One in which dimonium chloride phosphate was substituted by sodium hyaluronate, and one in which phosphatidylethanolamine was substituted as Comparative Example 2 were produced. Using these lotions, Hartley white guinea pigs 1 group 6
The back of each animal was shaved, and 0.01 ml of a 2 cm × 2 cm portion stripped twice with a piece of adhesive tape was applied thereto, and a patch adhesive bandage impregnated with 0.01 ml of a 1% aqueous solution of sodium lauryl sulfate was applied thereto, and applied for 24 hours. Closed patch. One hour after the removal of the patch, the skin reaction was evaluated based on Draise's criteria (++; reaction with edema, +; reaction with obvious erythema, ±; reaction with indistinct erythema,-; no reaction). As a control, one obtained by substituting component 1 in the following formulas with water was used. Table 1 shows the results. From this, it is clear that the lotion, which is the external preparation for skin of the present invention, suppresses the intrusion of the stimulant sodium lauryl sulfate into the skin by the protective film. A 1% aqueous solution of carboxyvinyl polymer 6 parts by weight 1% aqueous solution of Carbopol 1382 5 parts by weight (acrylic acid / alkyl methacrylate (C10-30) alkyl) quince extract 0.1 part by weight Component 1 * 0.1 part by weight 1, 3-butanediol 3 parts by weight 1,2-pentanediol 3 parts by weight Water 77.3 parts by weight b 10% aqueous solution of potassium hydroxide 5.5 parts by weight * Details are shown in Table 1.

[0011]

[Table 1]

<Examples 4 to 8> Similar examinations were performed as in Examples 1 to 3 except that the polyhydric alcohol was changed. Table 2 shows the results
Shown in From the above, as the polyhydric alcohol of the present invention,
It can be seen that a form containing one selected from 1,3-butanediol, isoprene glycol, dipropylene glycol, diglycerin and 1,2-pentanediol is preferable. A 1% aqueous solution of carboxyvinyl polymer 6 parts by weight 1% aqueous solution of carbopol 1382 5 parts by weight (acrylic acid / methacrylic acid (C10-30) alkyl) quince extract 0.1 part by weight Phospholipid PTC 0.1 part by weight Multivalent Alcohol ** 6 parts by weight Water 77.3 parts by weight b Potassium hydroxide 10% aqueous solution 5.5 parts by weight ** Details are shown in Table 2.

[0013]

[Table 2]

Example 9 A lotion was prepared according to the following formulation in the same manner as in the above example. The results of the protective film evaluation of these were ± 3 cases and −3 cases, and it is understood that the presence of a salt of acrylic acid / alkyl methacrylate is preferred. B Carboxyvinyl polymer 1% aqueous solution 11 parts by weight Quince extract 0.1 parts by weight Phospholipid PTC 0.1 parts by weight Isoprene glycol 6 parts by weight Water 77.3 parts by weight b 10% aqueous solution of potassium hydroxide 5.5 parts by weight

Example 10 A lotion was prepared according to the following formulation in the same manner as in the above example. The results of the protective film evaluation of these were ± 3 examples and −3 examples, and it is understood that the presence of a carboxyvinyl copolymer salt is more preferable. I Acrylic acid / alkyl methacrylate 11 parts by weight Quince extract 0.1 parts by weight Phospholipid PTC 0.1 parts by weight Isoprene glycol 6 parts by weight Water 77.3 parts by weight 5.5% by weight potassium hydroxide 10% aqueous solution

Example 11 According to the following formula,
An under makeup cosmetic, which is a skin external preparation of the present invention, was prepared. That is, the components (a), (b) and (c) are heated at 80 ° C., and (b) is gradually added to (a) to emulsify the mixture, and (c) is added to neutralize the mixture. Then, an under makeup cosmetic was obtained. Using this make-up cosmetic, the right half face is treated with this under makeup for 14 people who are likely to feel irritation with the foundation, then the foundation is applied, and the left half face is foundation without under makeup. Was applied. After having used such a use for one week,
We asked the respondents to answer the following three questions regarding the degree of the stimulating feeling of the foundation: the right side is less likely to feel stimulation, the left and right is the same, and the left side is less likely to feel stimulation. The result was that all 14 persons answered that the right side was less likely to feel irritation (the use of under make-up was less likely to cause irritation), and that the skin external preparation of the present invention, the protective film for under-make-up cosmetics The effect as was confirmed. I Cetanol 0.1 parts by weight Jojoba oil 0.5 parts by weight Hazelnut oil 0.1 parts by weight Olive oil 0.1 parts by weight Cetyl 2-ethylhexanoate 4 parts by weight Squalane 5 parts by weight Tocopherol 0.1 parts by weight Paraben 0.1 Parts by weight Phenoxyethanol 0.1 parts by weight Polyoxyethylene stearate 0.6 parts by weight Glyceryl monostearate 3 parts by weight Diglyceryl monooleate 0.5 parts by weight Iris foil (red) 1 part by weight Spherical acrylic resin powder 4 parts by weight Part 2 parts by weight of methylsiloxane network polymer 12 parts by weight of "silicone 9028J" (highly polymerized dimethylpolysiloxane; manufactured by Shin-Etsu Chemical) 0.5 parts by weight of phospholipid PTC 0.5 parts by weight of phospholipid CDM 0.5 parts by weight carboxyvinyl polymer 1% aqueous solution 10 parts by weight "Pemlen TR-1 "1% aqueous solution 1 part by weight (acrylic acid / methacrylic acid (C10-30) alkyl copolymer) quince extract 0.1 part by weight 1,3-butanediol 6 parts by weight isoprene glycol 2 parts by weight water 51. 2 parts by weight c 10% aqueous sodium hydroxide solution 5.5 parts by weight

Example 12 According to the following formula,
A steroid (external skin medicine), which is a skin external preparation of the present invention, was prepared. That is, the prescription components A, B, and C were each heated to 70 ° C., and gradually added to B and emulsified, and the mixture was gradually added and neutralized to obtain a steroid. A Light liquid isoparaffin 5 parts by weight Cetanol 2 parts by weight Polyoxyethylene (20) cetyl ether 1 part by weight Phospholipid PTC 0.2 part by weight Phospholipid CDM 0.3 part by weight Beclomethasone 1 part by weight b Isoprene glycol 3 parts by weight 1,2-pentanediol 4 parts by weight 1,3-butanediol 1 part by weight 1% aqueous solution of carboxyvinyl polymer 5 parts by weight 1% aqueous solution of pemulene TR-2 20 parts by weight Water 35 parts by weight c 10% aqueous solution of potassium hydroxide 2. 5 parts by weight Water 20 parts by weight

[0018]

According to the present invention, it is possible to develop a combination of protective coating components having high protection and excellent usability, and to provide an external preparation for skin containing the same.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (reference) A61K 47/24 A61K 47/24 47/32 47/32 F term (reference) 4C076 AA06 BB31 CC04 DD09 DD30 DD34 DD37 DD38 DD63 EE09 EE53 FF29 4C083 AA112 AA122 AB032 AC022 AC072 AC111 AC112 AC121 AC122 AC172 AC182 AC352 AC402 AC422 AC482 AC901 AC902 AD041 AD042 AD091 AD092 AD152 AD172 AD492 AD531 AD532 AD572 AD662 CC01 CC11 EE12

Claims (7)

[Claims] 1. A polyhydric alcohol and cocamidopropyl PG
-An external preparation for skin, comprising: dimonium chloride phosphate and / or sodium coco PG-dimonium chloride phosphate. 2. The method according to claim 1, wherein the polyhydric alcohol contains one selected from 1,3-butanediol, isoprene glycol, dipropylene glycol, diglycerin and 1,2-pentanediol. 2. The external preparation for skin according to item 1. 3. The polyhydric alcohol is glycerin, 1,3
The external preparation for skin according to claim 1 or 2, wherein the external preparation is at least one selected from butanediol, isoprene glycol, dipropylene glycol, diglycerin, and 1,2-pentanediol. . 4. The composition according to claim 1, further comprising a salt of a carboxyvinyl polymer and / or a salt of an alkyl (C10-30) acrylate / methacrylate.
The external preparation for skin according to any one of claims 1 to 7. 5. The external preparation for skin according to claim 1, which is for protecting the skin from irritants. 6. The external preparation for skin according to any one of claims 1 to 5, which is a cosmetic. 7. The cosmetic according to claim 6, which is for sensitive skin.