JPH1157014A - Guide wire - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a guide wire wherein, even when a first wire and a bonding member are formed of different materials, both parts can be bonded by a sufficient strength, and which can be safely used. SOLUTION: This guide wire is equipped with a first wire 11 having flexibility, which is arranged at the tip end side, a second wire 12 which is arranged on the base end side compared with the first wire 11 and the rigidity of which is larger than that of the first wire 11, and a bonding member 13 in order to connect the first wire 11 and the second wire 12. The bonding member 13 is formed of a material which is different from the first wire 11. At the connected part between the first wire 11 and the bonding member 13, a metal thin film 15 for bonding supplement is provided, and the first wire 11 is bonded with and fixed to the bonding member 13 with a wax 14 at the metal thin film formed part.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a guidewire, and more particularly, to a guidewire having a function of guiding a catheter or the like to a target site in a living body.

[0002]

2. Description of the Related Art A guide wire is used for a treatment for a site that is difficult to perform a surgical operation or for a minimally invasive treatment of a human body.
PTCA (Percutaneous Transl)
uminal Coronary Angioplas
ty: percutaneous coronary angioplasty), used for guiding a catheter used for examinations such as cardioangiography. P
The guidewire used for TCA operation is inserted into the vicinity of the target vascular stenosis with the catheter with the distal end of the guidewire protruding from the distal end of the catheter, and guides the distal end of the catheter to the vicinity of the vascular stenosis. I do.

A blood vessel is complicatedly curved, and a guide wire used for inserting a catheter into the blood vessel has appropriate flexibility, pushability and torque for transmitting an operation at a proximal end to a distal end. Transmission properties (collectively referred to as “operability”), kink resistance (bending resistance), and the like are required. Among these characteristics, as a structure for obtaining a suitable flexibility, a structure provided with a flexible metal coil around a thin tip core material of a guide wire, Ni-Ti or the like as a core material of the guide wire. Using a super-elastic wire.

In a conventional guide wire, the core material is substantially one.
It is made of various materials, and a relatively rigid material is used in order to enhance the operability of the guidewire, and as a result, the flexibility of the distal end portion of the guidewire is lost. In addition, if a material having relatively low rigidity is used to obtain the flexibility of the distal end portion of the guide wire, the operability at the proximal end portion of the guide wire is lost. Thus, it has been difficult to satisfy the required flexibility and operability with one kind of core material.

[0005] In order to improve such a defect, for example, a Ni-Ti alloy wire is used as a core material, and a heat treatment is performed under different conditions on a tip end portion and a base end portion thereof to enhance the flexibility of the tip end portion.
There has been proposed a guide wire having an increased rigidity at the base end.
However, there is a limit in controlling the flexibility by such heat treatment, and even if sufficient flexibility is obtained at the distal end, satisfactory rigidity may not always be obtained at the proximal end.
Further, in order to satisfy the flexibility at the distal end and the high rigidity at the proximal end, using a tubular joining member of Ni-Ti alloy,
A guide wire in which a Ni-Ti alloy wire and a stainless steel wire are connected is disclosed in Japanese Patent Application Laid-Open No. Hei 4-9162.

[0006]

Although the guide wire disclosed in Japanese Patent Application Laid-Open No. Hei 4-9162 has a sufficient effect, the present inventors have found that the guide wire is made of a superelastic metal from the viewpoint of safety. It has been considered that the bonding strength between the first wire and the bonding member, which has been performed, should be increased. An object of the present invention is to provide a guidewire that can be used with a sufficient strength and can be used safely even if the first wire and the joining member are formed of different materials. is there.

[0007]

The above object can be achieved by a first flexible wire disposed on the distal end side and a first flexible wire disposed on the proximal end side of the first wire.
And a joining member for connecting the first wire and the second wire, the joining member being formed of a different material from the first wire. Further, a metal thin film for assisting bonding is provided at a connecting portion between the first wire and the bonding member, and the first wire is provided at the metal thin film forming portion. The guide wire is joined to the joining member by the solder.

The first wire is formed of a superelastic metal, and the metal thin film is formed of nickel, silver, gold,
It is preferably one of tin, palladium, and an alloy composed of two or more metals selected from these. Preferably, the joining member is made of stainless steel. Furthermore, it is preferable that the joining member and the second wire are made of stainless steel, and both are fixed by welding. In addition, the first
It is preferable that the connection end face between the second wire and the second wire is inclined at a predetermined angle with respect to a plane whose normal line is the axis of both wires. Further, it is preferable that a slit is provided at a distal end portion of the joining member. Further, it is preferable that at least the distal end side of the slit forming portion of the joining member is not joined to the first wire. Preferably, the slit is a spiral slit.

[0009]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS A guide wire according to the present invention will be described below in detail with reference to an embodiment shown in the drawings. FIG. 1 is a plan view of the guidewire of the present invention. FIG. 2 is a sectional view of a distal end portion of the guide wire shown in FIG. FIG. 3 is a partially-peeled external view in which the vicinity of the guide wire joining member shown in FIG. 1 is enlarged. FIG. 4 is an enlarged sectional view of the vicinity of the guide wire joining member shown in FIG.

[0010] The catheter guide wire 1 of the present invention comprises:
Flexible first wire 11 disposed on the distal end side
A joining member for connecting the first wire 11 and the second wire 12 to a second wire 12 disposed closer to the base end than the first wire 11 and having a higher rigidity than the first wire 11 (Connection member) 13. The joining member 13 is a first member.
Is formed of a material different from that of the wire 11. First
A metal thin film 15 for assisting bonding is provided at a connection portion of the wire 11 with the bonding member 13.
Are joined and fixed by the joining member 13 and the solder 14 at the metal thin film forming portion.

The guide wire 1 of the present invention has a wire main body (core wire) that mainly constitutes the guide wire 1. This wire main body is composed of a first wire 11 arranged on the distal end side and a second wire 1 arranged on the proximal end side of the wire main body.
The rear end portion 11b of the first wire 11 and the front end portion 12a of the second wire 12 are connected by being covered with a tubular joining member 13.

The first wire 11 is a flexible wire, and its material is not particularly limited. For example, various plastics and various metals can be used. preferable. Thereby, the first
Without increasing the diameter of the wire 11, a tip end portion of the wire main body having excellent operability and kink resistance can be obtained. Here, the superelastic alloy is generally called a shape memory alloy,
An alloy that exhibits superelasticity at the operating temperature. Superelasticity means that at the operating temperature, that is, at least the living body temperature (around 37 ° C.), deformation (bending,
Even if it is pulled or compressed), it is a property that almost recovers its original shape. The preferred composition of the superelastic alloy is 49 to 5
8 atomic% Ni Ti-Ni alloy, 38.5-41.5 wt% Zn Cu-Zn alloy, 1-10 wt% X Cu-
Zn-X alloy (X is at least one of Be, Si, Sn, Al and Ga), 36 to 38 atomic% Al Ni
A superelastic body such as an Al alloy; Of these, particularly preferred are the above-mentioned Ti-Ni alloys.

On the outer surface of the rear end 11b of the first wire 11, a metal thin film 15 is formed. First wire 11
And the joining member 13 are made of different materials, for example, the first wire 1.
When 1 is made of a superelastic metal and the joining member 13 is made of stainless steel, it is difficult to join them by welding, and the outer surface of the rear end portion 11b of the first wire 11 (connection portion with the joining member 13) Include metals such as nickel, silver, gold, tin, and palladium or 2 arbitrarily selected from these.
Metal film 15 for assisting bonding made of an alloy of at least one kind of metal
Is provided. Then, the inner surface of the joining member 13 and the first
Both are fixed by the brazing filler 14 filled between the outer surfaces (the brazing filler space) of the wire 11. As the solder 14, an alloy of silver and tin, an alloy of tin and lead, an alloy of gold and nickel, and an alloy of tin, lead and nickel are preferable. By using the metal thin film 15 applied to the outer surface of the rear end portion 11b of the first wire 11 as described above, even if the first wire and the joining member are formed of different metal materials, both are joined by the metal brazing. It can be joined firmly, and becomes a safe guide wire with high joining strength.

The metal thin film 15 is formed on the outer surface of the rear end portion 11b of the first wire 11 by vapor deposition of a metal to be coated (for example, vacuum vapor deposition), ion plating, sputtering, plasma CVD, A chemical vapor deposition method (CVD method) such as an electrolytic plating method, a hydrolysis reaction, and a thermal decomposition reaction, a dipping method, and the like can be used. In particular, a vapor deposition method (for example, a vacuum vapor deposition method) that can be processed at a temperature that does not affect the physical properties of the superelastic metal (specifically, a method that can be performed at about 400 ° C. or less), and ion plating Method, sputtering method, plasma CVD method,
Electroplating is preferred. The thickness of the metal thin film 15 is preferably about 1 to 10 μm.

The outer diameter of the first wire 11 is gradually reduced toward the distal end, and the first wire 11 becomes flexible toward the distal end. An X-ray contrast member 16 is fixed to the distal end 11a of the first wire 11. As the X-ray contrast member 16, for example, a line of an X-ray opaque material (for example,
It is preferable to wind a metal wire such as gold or platinum) in a coil shape. A synthetic resin film 17 is provided on the outer surface of the first wire 11 excluding the rear end portion, at least the outer surface from the intermediate portion to the front end, and the outer diameter is substantially uniform. The tip 17a of the synthetic resin film 17 has a rounded shape and a substantially hemispherical shape.

The polymer material used for the synthetic resin covering the first wire 11 includes polyethylene, polyvinyl chloride, polyester, polypropylene, polyamide,
Polyurethane, fluorinated resin (PTFE, ETFE
Etc.), silicone rubber, other various elastomers, or composite materials thereof are preferably used. In particular, a wire having flexibility or flexibility equal to or higher than that of the first wire 11 is preferable.

Further, the outer surface of the synthetic resin film 17 is preferably coated with a hydrophilic polymer substance having lubricity in a wet state. A so-called chemical fixation is suitable as the coating form. By performing such a coating with a hydrophilic polymer substance, when the guide wire 1 is inserted,
Friction is reduced, insertion can be performed smoothly, and operability is improved.

Examples of the hydrophilic polymer substance include natural polymer substances (eg, starch, cellulose, tannin / lignin, polysaccharide, and protein) and synthetic polymer substances (PVA-based). , Polyethylene oxide,
Acrylic acid, maleic anhydride, phthalic acid, water-soluble polyester, ketone aldehyde resin, (meth) acrylamide, vinyl heterocyclic, polyamine, polyelectrolyte, water-soluble nylon, glycidyl acrylate) and so on. Among these, in particular, cellulose-based polymer substances (eg, hydroxypropyl cellulose), polyethylene oxide-based polymer substances (polyethylene glycol), and maleic anhydride-based polymer substances (eg, methyl vinyl ether-maleic anhydride copolymer) Such as maleic anhydride copolymer), acrylamide polymer (for example, polydimethylacrylamide), and water-soluble nylon (for example, AQ-nylon P manufactured by Toray Industries, Inc.)
-70) or a derivative thereof is preferable since a low coefficient of friction can be stably obtained in blood. Details of these are described in JP-A-9-84871.

The second wire 12 is a wire having flexibility, and its constituent material is not particularly limited. Various plastics and various metals can be used, but the rigidity of the second wire 12 is larger than that of the first wire 11. It is made of a rigid material, particularly a metal material. Thereby, a wire main body excellent in operability and kink resistance can be obtained without increasing the diameter of the second wire 12. Further, in order to enhance the operability and the kink resistance, the outer diameter of the second wire 12 is larger than the outer diameter of the first wire 11, as shown in FIG. In this case, the outer diameter of the portion of the second wire 12 that is covered by the joining member 13 is set to facilitate connection.
It is preferable that the outer diameter of the portion of the first wire 11 covered by the joining member 13 be equal to the outer diameter of the first wire 11.

Examples of the material used for the second wire 12 include metal materials such as stainless steel and piano wire. Among them, particularly preferred is stainless steel having excellent rigidity. Specifically, it is preferable that the first wire 11 is made of a superelastic metal and the second wire 12 is made of stainless steel. A guide wire having an abundant base end and gentle change in rigidity can be configured.

Further, it is preferable that the second wire 12 is subjected to a treatment for suppressing friction generated by contact with the inner wall of the catheter used simultaneously with the guide wire 1. Specifically, a material having a low coefficient of friction with respect to the material of the catheter inner wall (for example, a fluororesin such as polytetrafluoroethylene, silicone, or the like) is provided at a proximal portion (base) 12b where the second wire 12 contacts the inner wall of the catheter. etc)
Should be coated. By suppressing the friction, the operability of the second wire 12 in the catheter is improved.

The joining member 13 is flexible, has an opening through which the first wire 11 is inserted, and an opening through which the second wire 12 is inserted. It is tubular as a whole. By making the joining member 13 into a tubular shape, the connection process between the first wire 11 and the second wire 12 is facilitated, and the rigidity in the circumferential direction is uniform. The material of the joining member 13 is not particularly limited.
As with the first and second wires 12, various plastics and various metals can be used. In particular, the joining member 13 is formed of a material different from the first wire 11 in consideration of the purpose. In particular, in consideration of joining with the second wire 12, it is more preferable that the second wire 12 is made of the same or similar material. As the joining member 13, stainless steel is preferably used.

The diameter of each of the first wire 11, the joining member 13, and the second wire 12 is not particularly limited. However, when the first wire 11, the joining member 13, and the second wire 12 are used for inserting a PTCA catheter, each diameter (average) is 0.25 to 0.25. 0.65 mm (0.010-0.0
25 inches), preferably 0.36-0.
More preferably, it is about 45 mm (0.014 to 0.018 inch). Further, between the outer surface of the first wire 11 and the joining member 13, a solder filling space for fixing is formed. In order to form this space, the first wire 1
1 is smaller than the inner diameter of the joining member 13 by 0.01 to 0.1.
It is as small as about 07 mm. It should be noted that the present invention is not limited to this, and the rear end portion 11b of the first wire 11 may have an elliptical or polygonal cross section so that the first wire 11 has a first shape.
A solder filling space may be formed between the outer surface of the rear end portion 11b of the wire 11 and the outer surface of the joining member 13.

The thickness of the tubular joining member 13 is 0.02 to 0.02.
0.06 mm, preferably 0.03 to 0.0
Those having a diameter of 5 mm are more preferable. As shown in FIGS. 2 and 3, the rear end of the wire 11 and the front end of the wire 12 are cut at a predetermined angle (θ) with respect to a plane normal to the axes of the wires 11 and 12. I have. Then, it is preferable that the end face of the first wire 11 and the end face of the second wire 12 are connected in a state of being brought into contact in the joining member 13. Here, the angle θ may be θ ≦ 90 degrees, preferably 0 <θ ≦ 45 degrees, and 0.5 ≦ θ
It is more preferred that ≦ 20 degrees. The reason is the first
This is because the change in rigidity at the contact end surface between the wire 11 and the second wire 12 can be further reduced, and excellent kink resistance can be obtained.

Further, in order to increase the joining strength between the first wire 11 and the joining member 13, a groove may be formed on the outer surface of the first wire 11 or the inner surface of the joining member 13. As the groove, a groove extending in parallel to the axis of the wire, a spiral extending, a ring-shaped groove, or the like can be considered. In addition, a rib 41 is provided at the rear end of the first wire 11 like a guide wire 40 shown in FIGS. 7 and 8 in order to increase the joining strength of the first wire 11 and the joining member 13 by the solder 14. You may. FIG. 7 is a cross-sectional view of a distal end portion of a guide wire according to another embodiment of the present invention. FIG. Note that, as the rib 41, it is preferable to form an annular and oblique rib as shown in FIG. 7 at the rear end of the first wire 11. However, the present invention is not limited to this, and a plurality of hemispherical ribs are provided on the outer surface of the rear end portion 11b of the first wire 11 in addition to the annular rib perpendicular to the axis of the first wire 11. It may be made to be.

The connection between the joining member 13 and the second wire 12 is not particularly limited, but in this embodiment, both are fixed by welding. As the welding, for example, welding using a laser or the like is used. The weld 19 is located at the boundary 1
It is sufficient if it is closer to the base end than 8. The welding 19 may be spot welding at several points, but is preferably performed annularly as shown in FIG. The size of the welded portion 19 may have a predetermined width as shown in FIG. Note that the entire inner surface of the joining member 13 that contacts the inner peripheral surface of the second wire 12 in an annular shape may be welded. Further, welding may be performed on the rear end surface of the joining member 13.

When the joining member 13 is made of stainless steel, which is a highly rigid material, its thickness can be reduced. Further, if both the second wire 12 and the joining member 13 are made of stainless steel, excellent weldability can be obtained due to the identity or similarity of the compositions of the two.

Next, the guide wire 30 of the embodiment shown in FIGS. 5 and 6 will be described. FIG. 5 is a sectional view of a distal end portion of a guide wire 30 according to another embodiment of the present invention, and FIG. 6 is an enlarged view of the vicinity of a joining member of the guide wire 30 shown in FIG. FIG. The basic configuration of the guide wire 30 is the same as that of the above-described guide wire 1, and the same portions are denoted by the same reference numerals and description thereof will be omitted.

In the guide wire 30, the joining between the second wire 12 and the joining member 13 is also performed by the solder 14. Therefore, the outer surface of the second wire 12 and the joining member 13
Between them, a wax filling space for fixing is formed,
In order to form this space, the outer diameter of the second wire 12 is 0.01 to 0.07 mm larger than the inner diameter of the joining member 13.
It is about small. For this reason, the front end 12a of the second wire 12 and the rear end 11b of the first wire 11
Have almost the same outer diameter. The second wire 12
Is formed of a material different from that of the joining member 13, the first wire 12a is attached to the tip 12a of the second wire 12.
A metal thin film may be formed like the rear end portion 11b of the wire 11. Further, in order to increase the bonding strength between the first wire 11 and the bonding member 13, a groove may be formed on the outer surface of the first wire 11 or the inner surface of the bonding member 13. FIG.
1, a V-shaped groove 33 extending in the axial direction is provided on the outer surface of the first wire 11. As the groove 33, a groove extending in a direction parallel to the axis of the wire as shown in FIG. 5, a groove extending in a spiral shape, an annular groove, or the like can be considered. Also, at the tip 12a of the second wire 12,
A similar groove may be provided.

Further, at the tip of the first wire 11,
A coil member 31 having the same outer diameter as the maximum outer diameter portion of the first wire 11 is fixed by a headpiece (tip member) 32 having a hemispherical shape. Coil member 3
1 and the head piece 32 are formed of an X-ray opaque material, for example, gold, platinum or the like. The base end of the coil member 31 is fixed to the first wire 11.
Since the inner diameter of the coil member 31 is larger than the outer diameter of the first wire 11, except for the base end of the coil body, the first wire 11
A space is formed between the coil member 31 and the coil member 31. Note that the first wire 11 and the coil member 31 may be fixed at the center of the coil member 31. Further, a thin synthetic resin film may be provided on the outer surface of the coil member 31.
The same synthetic resin film as that used for the above-described guide wire can be used, and it is preferable that the above-mentioned hydrophilic polymer substance is coated on the synthetic resin film.

Note that the first part which is to be joined to the headpiece is
The outer surface of the distal end 11c of the wire 11 and the outer surface of the distal side tapered portion 11d of the first wire 11 at the portion to be joined to the coil member are similar to the rear end 11b of the first wire 11 described above. A metal thin film may be formed, and these may be joined and fixed with a braze. In addition, the above-mentioned guide wire 1
In this case, the distal end structure of the guide wire (the outer structure of the first wire) may be the same as the above-described guide wire 30.

Next, the guide wire 50 shown in FIGS. 9 to 12 will be described. FIG. 9 is a plan view of the guide wire 50 of the present invention. FIG. 10 is a sectional view of the distal end portion of the guide wire shown in FIG. FIG. 11 is a partially peeled external view in which the vicinity of the joining member of the guide wire shown in FIG. 9 is enlarged. FIG. 12 is an enlarged cross-sectional view near the joining member of the guide wire shown in FIG. The basic configuration of the guide wire 50 is the same as that of the above-described guide wire 1, and the same portions are denoted by the same reference numerals and description thereof will be omitted. The difference between the guide wire 50 and the above-described guide wire 1 is the shape of the joining member 53 and the first wire 1.
1 and the joining member 53 only.

Guide wire 5 for catheter of this embodiment
Reference numeral 0 denotes a first wire 11 having flexibility disposed on the distal end side, and a first wire 11 disposed on the proximal end side with respect to the first wire 11.
A second wire 12 having a greater rigidity than the first wire 11 and the first wire 11 and the second wire 12; and
The first wire 11 has a tubular joining member 53 formed of a different material. The first wire 11 is provided with a metal thin film 15 for bonding with the bonding member 53 at a connection portion with the bonding member 53. The first wire 11 and the joining member 53 are joined and fixed by the solder 14 using a metal thin film. The metal thin film 15 is formed on the outer surface of the rear end 11 b of the first wire 11, similarly to the guide wire 1. As the metal thin film 15, nickel, silver, gold,
Metals such as copper and tin or alloys of two or more metals arbitrarily selected from these are used.

The joining member 53 has an opening through which the first wire 11 is inserted and an opening through which the second wire 12 is inserted. . Further, the joining member 53 has a first slit 54 at a tip end thereof. Specifically, the joining member 53 is
A first slit 54 extending from the tip to the vicinity of the center is provided. The first slit 54 is a spiral slit. In this embodiment, a second slit 57 that is not continuous with the first slit 54 is formed on the rear end side of the first slit 54, in other words, near the center of the joining member 53. This slit 57 is also spiral. The width of the second slit 57 is wider than that of the first slit 54, and forms a filling port of the soldering joint 14. The second slit 5
7 may not be spiral and may be provided with a plurality of discontinuous short slits. The second slit 57
Is a boundary 1 between the first wire 11 and the second wire 12.
Preferably, it does not extend to the rear end side beyond 8.

The rear end 11b of the first wire 11 has a first rear end 55 having an outer diameter substantially equal to the inner diameter of the joining member 53, and the first rear end 55 A second rear end portion 56 extends further to the rear end side and forms a solder filling space between the joint member 53 and the inner surface thereof. In this embodiment, the outer diameter of the second rear end portion 56 is
3 is smaller than the inner diameter. The cross section of the second rear end portion 56 is not limited to such an elliptical shape.
By using a polygonal shape, a wax filling space may be formed between the outer surface of the second rear end portion 56 and the outer surface of the joining member 53.

The filling opening of the brazing filler metal 14 formed by the second slit 57 is located above the brazing filler space, and communicates the brazing filler space with the outside. Also, the first wire 11
A rib 41 is provided at the rear end. Further, in order to increase the bonding strength between the first wire 11 and the bonding member 53,
A groove may be formed on the outer surface of the second rear end portion 56 of the first wire 11 or the inner surface of the brazing filler space forming portion of the joining member 53. The groove extends parallel to the axis of the wire,
Spirally extending ones and annular ones are also conceivable.

The rigidity of the first slit 54 may be changed as appropriate by changing the interval or pitch. Specifically, the pitch of the slits 54 may be shortened toward the distal end of the joining member 53. Further, the width of the slit 54 may be increased toward the distal end of the joining member 53. By doing so, the rigidity of the joining member 53 becomes smaller toward the distal end side,
The deformation of the tip becomes smoother. Note that one or more spiral slits may be provided. Further, the first slit 54 may not be helical but may have a plurality of slits extending linearly in parallel with the axial direction. In this case, it is preferable to make the width of the rear end of the slit wide. Further, the first slit 54 and the second slit 57 may be continuous, and in this case, the second slit 5
It is preferable that the width of 7 is wider than the width of the first slit 54.

Then, as shown in FIGS. 11 and 12, the brazing filler 14 is filled into the brazing filler space formed between the joining member 53 and the second rear end portion 56 by the second slit 57. Are also filled in the slit 57.
As a result, the first wire 11 is fixedly joined to the joining member 53. In addition, the wax 14 has a first slit 54.
Therefore, the space formed by the first slit 54 is maintained as it is, and the first slit forming portion of the joining member 53 is not joined to the first wire 11. Since the guide wire of this embodiment has a flexible portion formed by having the first slit 54 on the distal end side of the joining member 53, the guide wire at the boundary between the joining member 53 and the first wire 11 is provided. Since kink is prevented and the bending at the distal end portion of the joining member 53 is facilitated, high operability is achieved. In particular, the first slit forming portion of the joining member 53 is the first wire 1
By not being joined to 1, it will have higher kink resistance and operability.

[0039]

The guide wire according to the present invention has a flexible first wire disposed on the distal end side and a proximal end side disposed on the proximal side of the first wire, and has a higher rigidity than the first wire. A large second wire, and a joining member for connecting the first wire and the second wire, wherein the joining member is formed of a different material from the first wire; A metal thin film for assisting bonding is provided at a connecting portion of the first wire with the bonding member, and the first wire is connected to the bonding member at the metal thin film forming portion by soldering. Are joined. Therefore, even if the first wire and the joining member are formed of different materials, the first wire and the joining member can be joined with sufficient strength, and the guide wire can be used safely. In particular, the first
By using the metal thin film applied to the outer surface of the rear end of the wire, even if the first wire and the joining member are formed of different metal materials, both are firmly joined by the metal brazing, This guidewire is highly secure.

[Brief description of the drawings]

FIG. 1 is a plan view of a guide wire according to the present invention.

FIG. 2 is a cross-sectional view of a distal end portion of the guide wire shown in FIG.

FIG. 3 is an enlarged partial peeling appearance view in the vicinity of a guide wire joining member shown in FIG. 1;

FIG. 4 is an enlarged sectional view of the vicinity of a guide wire joining member shown in FIG. 1;

FIG. 5 is a sectional view of a distal end portion of a guide wire according to another embodiment of the present invention.

FIG. 6 is an enlarged partial peeling appearance view of the vicinity of a guide wire joining member shown in FIG. 5;

FIG. 7 is a sectional view of a distal end portion of a guide wire according to another embodiment of the present invention.

FIG. 8 is a partially-peeled external view in which the vicinity of a guide wire joining member shown in FIG. 7 is enlarged.

FIG. 9 is a plan view of a guide wire according to the present invention.

FIG. 10 is a sectional view of the distal end portion of the guide wire shown in FIG. 9;

FIG. 11 is an enlarged partial peeling external view of the vicinity of a guide wire joining member shown in FIG. 9;

FIG. 12 is an enlarged sectional view of the vicinity of a joining member of the guide wire shown in FIG. 9;

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Guide wire 11 1st wire 12 2nd wire 13 Joining member 14 Brazing 15 Metal thin film 16 X-ray contrast member 17 Synthetic resin coating 11a First wire end 11b First wire rear end 12a Second 12b Base end of second wire 19 Welded part 30 Guide wire 40 Guide wire 50 Guide wire 53 Joining member 54 First slit 57 Second slit

Claims (8)

[Claims] 1. A flexible first member disposed on a distal end side.
And a wire disposed closer to the proximal end than the first wire,
A second wire having a greater rigidity than the first wire; and a joining member for connecting the first wire and the second wire, wherein the joining member is different from the first wire. A metal thin film for assisting bonding is provided at a connecting portion of the first wire with the bonding member, and the first wire is formed of a material,
A guide wire, which is joined to the joining member by a solder at the metal thin film forming portion. 2. The first wire is formed of a superelastic metal, and the metal thin film is made of any one of nickel, silver, gold, tin, palladium, and two or more alloys selected from these. 2. The guidewire according to 1. 3. The guide wire according to claim 1, wherein the joining member is made of stainless steel. 4. The guide wire according to claim 1, wherein the joining member and the second wire are made of stainless steel, and both are fixed by welding. 5. A connection end face between the first wire and the second wire is inclined at a predetermined angle with respect to a plane whose normal line is the axis of both wires. The guidewire according to any one of the above. 6. The guide wire according to claim 1, wherein a slit is provided at a distal end portion of the joining member. 7. The guidewire according to claim 6, wherein the slit is a spiral slit. 8. The guide wire according to claim 6, wherein at least a distal end side of the slit forming portion of the joining member is not joined to the first wire.