JPH11513981A - ４−オキサ及び４−チアステロイド - Google Patents

４−オキサ及び４−チアステロイド

Info

Publication number
JPH11513981A
JPH11513981A JP9516711A JP51671197A JPH11513981A JP H11513981 A JPH11513981 A JP H11513981A JP 9516711 A JP9516711 A JP 9516711A JP 51671197 A JP51671197 A JP 51671197A JP H11513981 A JPH11513981 A JP H11513981A
Authority
JP
Japan
Prior art keywords
androst
methyl
oxa
thia
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9516711A
Other languages
English (en)
Japanese (ja)
Inventor
バクシ，ラマン・ケイ
パテル，グール・エフ
ラースムセン，ゲーリー・エイチ
トルマン，リチヤード・エル
Original Assignee
メルク エンド カンパニー インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602905.3A external-priority patent/GB9602905D0/en
Application filed by メルク エンド カンパニー インコーポレーテッド filed Critical メルク エンド カンパニー インコーポレーテッド
Publication of JPH11513981A publication Critical patent/JPH11513981A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/006—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by sulfur as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP9516711A 1995-10-26 1996-10-22 ４−オキサ及び４−チアステロイド Pending JPH11513981A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US600195P 1995-10-26 1995-10-26
GB60/006,001 1996-02-13
GBGB9602905.3A GB9602905D0 (en) 1996-02-13 1996-02-13 4-oxa and 4-thia steroids
GB9602905.3 1996-02-13
PCT/US1996/016883 WO1997015564A1 (en) 1995-10-26 1996-10-22 4-oxa and 4-thia steroids

Publications (1)

Publication Number Publication Date
JPH11513981A true JPH11513981A (ja) 1999-11-30

Family

ID=26308677

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9516711A Pending JPH11513981A (ja) 1995-10-26 1996-10-22 ４−オキサ及び４−チアステロイド

Country Status (5)

Country Link
EP (1) EP0858455A4 (de)
JP (1) JPH11513981A (de)
AU (1) AU713582B2 (de)
CA (1) CA2233966A1 (de)
WO (1) WO1997015564A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005508934A (ja) * 2001-10-03 2005-04-07 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体調節剤としてのアンドロスタン１７β−カルボキサミド類

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1622567B1 (de) * 2003-05-07 2013-07-24 Merck Sharp & Dohme Corp. Androgen-rezeptor-modulatoren und verfahren zu ihrer verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3644421A (en) * 1968-12-02 1972-02-22 Syntex Corp 4-oxa-3-keto-delta**1-pregnene derivatives
NZ225100A (en) * 1987-06-29 1991-09-25 Merck & Co Inc Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005508934A (ja) * 2001-10-03 2005-04-07 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体調節剤としてのアンドロスタン１７β−カルボキサミド類

Also Published As

Publication number Publication date
AU7464496A (en) 1997-05-15
EP0858455A1 (de) 1998-08-19
CA2233966A1 (en) 1997-05-01
AU713582B2 (en) 1999-12-02
WO1997015564A1 (en) 1997-05-01
EP0858455A4 (de) 2000-04-12

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