AU713582B2 - 4-oxa and 4-thia steroids - Google Patents

4-oxa and 4-thia steroids Download PDF

Info

Publication number
AU713582B2
AU713582B2 AU74644/96A AU7464496A AU713582B2 AU 713582 B2 AU713582 B2 AU 713582B2 AU 74644/96 A AU74644/96 A AU 74644/96A AU 7464496 A AU7464496 A AU 7464496A AU 713582 B2 AU713582 B2 AU 713582B2
Authority
AU
Australia
Prior art keywords
androst
oxa
carboxamide
thia
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU74644/96A
Other languages
English (en)
Other versions
AU7464496A (en
Inventor
Raman K. Bakshi
Gool F. Patel
Gary H. Rasmusson
Richard L. Tolman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602905.3A external-priority patent/GB9602905D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU7464496A publication Critical patent/AU7464496A/en
Application granted granted Critical
Publication of AU713582B2 publication Critical patent/AU713582B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/006—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by sulfur as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU74644/96A 1995-10-26 1996-10-22 4-oxa and 4-thia steroids Ceased AU713582B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US600195P 1995-10-26 1995-10-26
US60/006001 1995-10-26
GB9602905 1996-02-13
GBGB9602905.3A GB9602905D0 (en) 1996-02-13 1996-02-13 4-oxa and 4-thia steroids
PCT/US1996/016883 WO1997015564A1 (en) 1995-10-26 1996-10-22 4-oxa and 4-thia steroids

Publications (2)

Publication Number Publication Date
AU7464496A AU7464496A (en) 1997-05-15
AU713582B2 true AU713582B2 (en) 1999-12-02

Family

ID=26308677

Family Applications (1)

Application Number Title Priority Date Filing Date
AU74644/96A Ceased AU713582B2 (en) 1995-10-26 1996-10-22 4-oxa and 4-thia steroids

Country Status (5)

Country Link
EP (1) EP0858455A4 (de)
JP (1) JPH11513981A (de)
AU (1) AU713582B2 (de)
CA (1) CA2233966A1 (de)
WO (1) WO1997015564A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402577B2 (en) * 2001-10-03 2008-07-22 Merck & Co., Inc. Androstane 17-beta-carboxamides as androgen receptor modulators
US7351698B2 (en) * 2003-05-07 2008-04-01 Merck & Co., Inc. Androgen receptor modulators and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3644421A (en) * 1968-12-02 1972-02-22 Syntex Corp 4-oxa-3-keto-delta**1-pregnene derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ225100A (en) * 1987-06-29 1991-09-25 Merck & Co Inc Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3644421A (en) * 1968-12-02 1972-02-22 Syntex Corp 4-oxa-3-keto-delta**1-pregnene derivatives

Also Published As

Publication number Publication date
WO1997015564A1 (en) 1997-05-01
CA2233966A1 (en) 1997-05-01
EP0858455A4 (de) 2000-04-12
AU7464496A (en) 1997-05-15
JPH11513981A (ja) 1999-11-30
EP0858455A1 (de) 1998-08-19

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired