JPH11513249A - プロテアーゼにより開裂可能なタンパク質を組込んだ組換えウイルス - Google Patents
プロテアーゼにより開裂可能なタンパク質を組込んだ組換えウイルスInfo
- Publication number
- JPH11513249A JPH11513249A JP9513224A JP51322497A JPH11513249A JP H11513249 A JPH11513249 A JP H11513249A JP 9513224 A JP9513224 A JP 9513224A JP 51322497 A JP51322497 A JP 51322497A JP H11513249 A JPH11513249 A JP H11513249A
- Authority
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- Prior art keywords
- cells
- protease
- nucleic acid
- envelope
- heterologous polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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- C07K—PEPTIDES
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- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
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- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/00—Fusion polypeptide
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- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
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- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
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- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Microbiology (AREA)
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- Public Health (AREA)
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- Hematology (AREA)
- Analytical Chemistry (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9519691.1A GB9519691D0 (en) | 1995-09-27 | 1995-09-27 | Improvements in or relating to viral targeting |
| GB9519691.1 | 1995-09-27 | ||
| GBGB9523225.2A GB9523225D0 (en) | 1995-11-14 | 1995-11-14 | Recombinant viruses incorporating a protease cleavage site |
| GB9523225.2 | 1995-11-14 | ||
| GBGB9604562.0A GB9604562D0 (en) | 1996-03-04 | 1996-03-04 | Recombinant viruses incorporating a protease cleavable protein |
| GB9604562.0 | 1996-03-04 | ||
| PCT/GB1996/002381 WO1997012048A1 (fr) | 1995-09-27 | 1996-09-27 | Virus recombines comprenant une proteine pouvant etre clivee par une protease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH11513249A true JPH11513249A (ja) | 1999-11-16 |
Family
ID=27267926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9513224A Pending JPH11513249A (ja) | 1995-09-27 | 1996-09-27 | プロテアーゼにより開裂可能なタンパク質を組込んだ組換えウイルス |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0854929A1 (fr) |
| JP (1) | JPH11513249A (fr) |
| AU (1) | AU716466B2 (fr) |
| CA (1) | CA2232669A1 (fr) |
| WO (1) | WO1997012048A1 (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014504868A (ja) * | 2011-01-05 | 2014-02-27 | アダムド エスピー．ゼット オー．オー． | 抗がん性融合タンパク質 |
| JP2015508648A (ja) * | 2012-02-16 | 2015-03-23 | ブイエルピー・セラピューティクス・リミテッド・ライアビリティ・カンパニーＶＬＰ Ｔｈｅｒａｐｅｕｔｉｃｓ， ＬＬＣ | ウイルス様粒子組成物 |
| JP2017513921A (ja) * | 2014-03-03 | 2017-06-01 | アーチャルジー、スジャータ | ジストロフィン異常症を治療するためのキメラジストロフィン−ｖｓｖ−ｇタンパク質 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19737442C2 (de) * | 1997-08-22 | 1999-06-24 | Olfert Landt Tib Molbiol Synth | Proteinumhüllte Polyribonukleinsäuren, ein Verfahren zu ihrer Herstellung und ihre Verwendung |
| GB9810999D0 (en) * | 1998-05-21 | 1998-07-22 | Goken Joop | Materials and methods relating to the expression of genes |
| WO2000006717A2 (fr) | 1998-07-27 | 2000-02-10 | Genentech, Inc. | Efficacite de transformation amelioree de l'expression a la surface des phages par modification d'une proteine de coque |
| US6586411B1 (en) | 2000-08-16 | 2003-07-01 | Mayo Foundation For Medical Education And Research | System for monitoring the location of transgenes |
| AU7546600A (en) * | 1999-10-08 | 2001-04-23 | Biofocus Discovery Limited | Methods and compositions for targeting a cell |
| CA2370803A1 (fr) * | 2000-02-25 | 2001-08-30 | Cambridge Drug Discovery, Ltd. | Methodes d'identification d'un inhibiteur de protease |
| EP1266036A4 (fr) * | 2000-02-25 | 2003-05-21 | Biofocus Discovery Ltd | Procedes et compositions permettant d'identifier une protease |
| US6942853B2 (en) * | 2001-01-09 | 2005-09-13 | Queen Mary And Westfield College | Latent fusion protein |
| US20060068421A1 (en) * | 2004-08-05 | 2006-03-30 | Biosite, Inc. | Compositions and methods for phage display of polypeptides |
| CA2847413C (fr) | 2010-09-02 | 2018-05-22 | Mayo Foundation For Medical Education And Research | Virus de la stomatite vesiculaire |
| US9951117B2 (en) | 2010-09-02 | 2018-04-24 | Mayo Foundation For Medical Education And Research | Vesicular stomatitis viruses |
| TWI676636B (zh) | 2013-07-12 | 2019-11-11 | Ｖｌｐ醫療股份有限公司 | 包含ｐｄ－１抗原或ｐｄ－１配體抗原的類病毒粒子 |
| US10385101B2 (en) | 2014-08-08 | 2019-08-20 | Vlp Therapeutics, Llc | Virus like particle comprising modified envelope protein E3 |
| EP3177720B1 (fr) | 2014-08-08 | 2021-09-22 | VLP Therapeutics, Inc. | Particule analogue à un virus comprenant une protéine d'enveloppe e3 modifiée |
| SG11201701669PA (en) | 2014-09-11 | 2017-04-27 | Vlp Therapeutics Llc | Flavivirus virus like particle |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5179007A (en) * | 1989-07-07 | 1993-01-12 | The Texas A & M University System | Method and vector for the purification of foreign proteins |
| US5723286A (en) * | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| MX9206981A (es) * | 1991-12-06 | 1994-08-31 | Whitehead Biomedical Inst | Vacunas de recombinantes y metodo para producirlas. |
| JPH08504091A (ja) * | 1992-09-22 | 1996-05-07 | メディカル・リサーチ・カウンシル | 外部表面に非ウィルス性ポリペプチドを提示する組換えウィルス |
| DE9307847U1 (de) * | 1993-05-26 | 1993-08-19 | Lenarcic, Davorin, 86825 Bad Wörishofen | Behälter für Kosmetikartikel |
| AU7097494A (en) * | 1993-06-01 | 1994-12-20 | Targeted Genetics Corporation | Envelope fusion vectors for use in gene delivery |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
-
1996
- 1996-09-27 CA CA002232669A patent/CA2232669A1/fr not_active Abandoned
- 1996-09-27 WO PCT/GB1996/002381 patent/WO1997012048A1/fr not_active Application Discontinuation
- 1996-09-27 JP JP9513224A patent/JPH11513249A/ja active Pending
- 1996-09-27 AU AU70911/96A patent/AU716466B2/en not_active Ceased
- 1996-09-27 EP EP96931908A patent/EP0854929A1/fr not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014504868A (ja) * | 2011-01-05 | 2014-02-27 | アダムド エスピー．ゼット オー．オー． | 抗がん性融合タンパク質 |
| JP2015508648A (ja) * | 2012-02-16 | 2015-03-23 | ブイエルピー・セラピューティクス・リミテッド・ライアビリティ・カンパニーＶＬＰ Ｔｈｅｒａｐｅｕｔｉｃｓ， ＬＬＣ | ウイルス様粒子組成物 |
| JP2017513921A (ja) * | 2014-03-03 | 2017-06-01 | アーチャルジー、スジャータ | ジストロフィン異常症を治療するためのキメラジストロフィン−ｖｓｖ−ｇタンパク質 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU716466B2 (en) | 2000-02-24 |
| AU7091196A (en) | 1997-04-17 |
| WO1997012048A1 (fr) | 1997-04-03 |
| CA2232669A1 (fr) | 1997-04-03 |
| EP0854929A1 (fr) | 1998-07-29 |
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