JPH11511654A - 比較的非分化の細胞の連続的選択的クローン原性増大 - Google Patents

比較的非分化の細胞の連続的選択的クローン原性増大

Info

Publication number
JPH11511654A
JPH11511654A JP8535103A JP53510396A JPH11511654A JP H11511654 A JPH11511654 A JP H11511654A JP 8535103 A JP8535103 A JP 8535103A JP 53510396 A JP53510396 A JP 53510396A JP H11511654 A JPH11511654 A JP H11511654A
Authority
JP
Japan
Prior art keywords
cells
population
chamber
cell
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP8535103A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11511654A5 (enExample
Inventor
クラウス,モレイ
フライバー,ジイ.ジル
Original Assignee
ティー.ブリーダーズ,インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ティー.ブリーダーズ,インコーポレイテッド filed Critical ティー.ブリーダーズ,インコーポレイテッド
Publication of JPH11511654A publication Critical patent/JPH11511654A/ja
Publication of JPH11511654A5 publication Critical patent/JPH11511654A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0647Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16Particles; Beads; Granular material; Encapsulation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/95Protein-free medium and culture conditions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Sustainable Development (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP8535103A 1995-05-19 1996-05-17 比較的非分化の細胞の連続的選択的クローン原性増大 Ceased JPH11511654A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/446,165 US5674750A (en) 1995-05-19 1995-05-19 Continuous selective clonogenic expansion of relatively undifferentiated cells
US08/446,165 1995-05-19
PCT/US1996/007195 WO1996036696A1 (en) 1995-05-19 1996-05-17 Continuous selective clonogenic expansion of relatively undifferentiated cells

Publications (2)

Publication Number Publication Date
JPH11511654A true JPH11511654A (ja) 1999-10-12
JPH11511654A5 JPH11511654A5 (enExample) 2004-07-08

Family

ID=23771556

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8535103A Ceased JPH11511654A (ja) 1995-05-19 1996-05-17 比較的非分化の細胞の連続的選択的クローン原性増大

Country Status (6)

Country Link
US (1) US5674750A (enExample)
EP (1) EP0830448A4 (enExample)
JP (1) JPH11511654A (enExample)
AU (1) AU5797496A (enExample)
CA (1) CA2221623A1 (enExample)
WO (1) WO1996036696A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925567A (en) * 1995-05-19 1999-07-20 T. Breeders, Inc. Selective expansion of target cell populations
US6100043A (en) * 1995-08-04 2000-08-08 The Perkin-Elmer Corporation Recombinant clone selection system
US5843656A (en) * 1995-08-07 1998-12-01 The Perkin-Elmer Corporation Recombinant clone selection system
AU6844696A (en) * 1995-08-07 1997-03-05 Perkin-Elmer Corporation, The Recombinant clone selection system
WO1998025634A1 (en) * 1996-12-10 1998-06-18 Hadasit Medical Research Services & Development Company Ltd. Serum-derived factor inducing cell differentiation and medical uses thereof
US20020034819A1 (en) * 1998-02-23 2002-03-21 Alan K. Smith Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses
BR9914465A (pt) 1998-09-29 2001-10-09 Gamida Cell Ltd Métodos para controlar a proliferação e a diferenciação de células-tronco e células progenitoras e uma composição farmacêutica para induzir a diferenciação em uma população de células
US7585323B2 (en) 2000-05-05 2009-09-08 Medlden, Llc In vitro mechanical loading of musculoskeletal tissues
US7811557B1 (en) 2000-10-27 2010-10-12 Viacell, Inc. Methods for improving central nervous system functioning
IL160030A0 (en) * 2001-07-23 2004-06-20 Viacell Inc Treatment of muscular dystrophy with cord blood cells
AU2002363322A1 (en) * 2001-10-26 2003-05-19 Large Scale Biology Corporation Endothelial cell derived hemotopoietic growth factor
JP2005536179A (ja) * 2001-11-09 2005-12-02 バイアセル インコーポレーティッド 細胞懸濁液の製造方法
US7169278B2 (en) * 2002-01-21 2007-01-30 Tecan Trading Ag Apparatus and separation media for separating particles in free-flow electrophoresis
US7169275B2 (en) * 2002-01-21 2007-01-30 Tecan Trading Ag Method for separating particles in free flow electrophoresis
IL152904A0 (en) * 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
WO2003062404A1 (en) 2002-01-25 2003-07-31 Gamida-Cell Ltd. Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
WO2003078567A2 (en) * 2002-03-18 2003-09-25 Gamida-Cell Ltd. Methods of inducing differentiation in ex vivo expanded stem cells
US20040028661A1 (en) * 2002-08-07 2004-02-12 Bartelmez Stephen H. Expansion of cells using thrombopoietin and anti-transforming growth factor-beta
US20050054097A1 (en) * 2002-11-17 2005-03-10 Tony Peled EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
CA2517959A1 (en) * 2003-03-07 2004-09-16 Gamida-Cell Ltd. Expansion of renewable stem cell populations using modulators of pi 3-kinase
IL161903A0 (en) * 2003-07-17 2005-11-20 Gamida Cell Ltd Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs
EP1708757A4 (en) * 2003-12-19 2007-01-17 Viacell Inc USE OF PLURIPOTENTIAL CELLS TAKEN FROM HUMAN CORDIAL BLOOD BLOOD FOR THE TREATMENT OF DISEASE
US20070298015A1 (en) * 2004-04-28 2007-12-27 Viacell, Inc. Treatment of Muscular Dystrophy with Mobilized Peripheral Blood Pluripotent Cells
WO2006030442A2 (en) 2004-09-16 2006-03-23 Gamida-Cell Ltd. Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells
WO2006116793A1 (en) 2005-05-04 2006-11-09 Australian Stem Cell Centre Limited Selecting, culturing and creating lineage committed hematopoietic stem cells
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
JP2012533519A (ja) 2009-06-18 2012-12-27 エムシーツー セル エイピーエス 骨髄細胞外マトリックス抽出物およびその治療上の使用
WO2012048298A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
JP6348848B2 (ja) 2012-02-13 2018-06-27 ガミダ セル リミテッド 間葉系幹細胞の増殖
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
WO2015073918A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
GB2619893A (en) 2021-03-23 2023-12-20 Terumo Bct Inc Cell capture and expansion
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
CN115011556B (zh) * 2022-08-10 2022-10-25 山东省齐鲁干细胞工程有限公司 一种脐带血造血干细胞的分离方法
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514499A (en) * 1983-02-04 1985-04-30 Corning Glass Works Cell culture using a monolithic support
US5004681B1 (en) * 1987-11-12 2000-04-11 Biocyte Corp Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
US5399493A (en) * 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
WO1991016116A1 (en) * 1990-04-23 1991-10-31 Cellpro Incorporated Immunoselection device and method
JPH07503127A (ja) * 1991-10-23 1995-04-06 セルプロ インコーポレイテッド 幹細胞を選択的に増加する方法
US5460964A (en) * 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
DE4240635C2 (de) * 1992-12-03 1997-07-10 Lothar Prof Dr Kanz Vermehrung hämatopoetischer Vorläuferzellen ex vivo sowieZusammensetzungen hämatopoetischer Wachstumsfaktoren

Also Published As

Publication number Publication date
CA2221623A1 (en) 1996-11-21
WO1996036696A1 (en) 1996-11-21
EP0830448A4 (en) 2001-12-05
US5674750A (en) 1997-10-07
EP0830448A1 (en) 1998-03-25
AU5797496A (en) 1996-11-29

Similar Documents

Publication Publication Date Title
JPH11511654A (ja) 比較的非分化の細胞の連続的選択的クローン原性増大
US6338942B2 (en) Selective expansion of target cell populations
EP0730639B1 (en) Cell separation device
JP6661544B2 (ja) 遺伝子改変したt細胞の自動生成法
US5759793A (en) Method for mammalian cell separation from a mixture of cell populations
AU720285B2 (en) Process for preparing macrophages, and kits and compositions therefore
Hoover et al. T cells with Fc receptors for IgA: induction of T alpha cells in vivo and in vitro by purified IgA.
JP2656988B2 (ja) 細胞捕獲及び回収のための装置及び方法
JPH078274A (ja) 膜バイオリアクター中の物質移動を改良する方法及び装置
JP2002535981A (ja) 造血幹細胞および/または前駆細胞を維持および増加するための方法および装置
DE69232682T2 (de) Verfahren zur selektiven vermehrung von cd34 positiven zellen
JP2004500095A (ja) 細胞の同時の刺激および濃縮
JP2006516197A (ja) 細胞の活性化および拡大の方法
EP4314244B1 (en) Cell capture and expansion
JP2003510068A (ja) 細胞を培養するための方法および装置
JPH0825888B2 (ja) 免疫選択法
EP1453949B1 (en) Production of cell suspensions
WO2018075940A1 (en) Methods and systems for t cell expansion
Mandrusov et al. Membrane-based cell affinity chromatography to retrieve viable cells
WO2000011139A9 (en) Cell population containing non-fetal hemangioblasts and method for producing same
AU752573B2 (en) Selective expansion of target cell populations
AU711528B2 (en) Continuous selective clonogenic expansion of relatively undifferentiated cells
JP4288352B2 (ja) 細胞の分離回収装置および分離回収方法
CA2221433A1 (en) Selective expansion of target cell populations
US20050202514A1 (en) Competitively Stable Target Cell Populations Isolated from Selectively Expanded Target Cell Populations

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20060912

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20061206

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070129

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20070427

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20070605