JPH1149653A - Dentifrice - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a dentifrice excellent in re-calcification of teeth and polishing property of teeth and capable of exhibiting excellent palatability by including a fluorine ion feeding compound, polishing silica, sugar alcohol and a calcium ion feeding compound. SOLUTION: This dentifrice contains (A) polishing silica (preferably having 80-200 ml/100 g oil absorption amount of silicic anhydride, water-containing silicic acid, etc., and 2-20 μm average particle diameter, (B) fluorine ion feeding compound (preferably sodium fluoride), (C) a calcium ion feeding compound (preferably calcium lactate) and (D) sugar alcohol (preferably containing xylitol in a weight ratio of >=1/2), and does not substantially contain calcium-based abrasive. Furthermore, it is preferable that the content of the component A is 5-30 wt.% and the content of the component is 0.002-0.5 wt.% expressed in terms of fluorine and the content of the component C is 0.005-0.5 wt.% expressed in terms of calcium as compounding amount of each component contained in the dentifrice. Thereby, dentifrice capable of exhibiting excellent characteristic is obtained.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a dentifrice, and more particularly, to a dentifrice without reducing its palatability.
Toothpaste that promotes remineralization of teeth.

[0002]

2. Description of the Related Art Fluoride ion-supplying compounds such as sodium monofluorophosphate and sodium fluoride have an effect of preventing cavities. That is, when the fluorine ion supplying compound acts on the tooth surface, the hydroxyl group of hydroxyapatite, which is the main component of enamel, is replaced with fluorine to change to fluoroapatite, and the acid resistance of the enamel is improved, thereby preventing tooth enamel. The effect is improved. Based on this finding, a technique is known in which, for example, a fluorine ion-supplying compound and xylitol are blended at a specific ratio to promote remineralization of teeth and to repair initial caries (Japanese Patent Laid-Open No. 3-48613).
No.).

[0003] On the other hand, an abrasive removes extraneous matter on the tooth surface without damaging the tooth surface and gives the teeth a natural luster, and is generally used as one of the main components of a toothpaste. Such abrasives include calcium carbonate,
Dibasic calcium phosphate, silica, aluminum hydroxide and the like, but in a dentifrice composition containing the fluorine ion-supplying compound, in order to avoid generation of an insoluble salt by reacting with fluorine, silica, especially Abrasive silica is generally used.

[0004]

However, when brushing the teeth with a dentifrice containing abrasive silica and a fluorine ion supplying compound, the teeth have a feeling that the teeth are jagged,
There is a problem that the palatability as a dentifrice decreases.

Accordingly, an object of the present invention is to provide a dentifrice which is excellent in remineralization of teeth and abrasiveness of teeth, and which is excellent in palatability as a dentifrice.

[0006]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to achieve the above object, and as a result, the present invention contains a fluorine ion-supplying compound, abrasive silica, a sugar alcohol, and a calcium ion-supplying compound. Found that if it does not contain a calcium-based abrasive, it does not generate insoluble calcium fluoride, is excellent in remineralization of teeth, and is a toothpaste with excellent abrasiveness and palatability. The present invention has been completed.

That is, the present invention provides a dentifrice containing abrasive silica, a fluorine ion-supplying compound, a calcium ion-supplying compound, and a sugar alcohol, and substantially containing no calcium-based abrasive.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The fluorine ion supplying compound used in the present invention may be either an inorganic compound or an organic compound. Specifically, for example, sodium fluoride, potassium fluoride, sodium fluoride silicate, tin fluoride, sodium monofluorophosphate, aluminum fluoride, silver fluoride, hexylamine hydrofluorate, deca hydrofluoride Examples thereof include nolamine and octadecenylamine hydrofluoride. Of these, sodium fluoride is particularly preferred in terms of safety, solubility, flavor and the like. The compounding amount of the fluorine ion supplying compound in the dentifrice is 0.002 to 0.002 in terms of fluorine.
It is preferably 1% by weight, particularly preferably 0.01 to 0.2% by weight. 0.002 to 1
If it is% by weight, the remineralization effect can be improved without adversely affecting the flavor and physical properties of the dentifrice.

The abrasive silica used in the present invention includes, for example, an oil absorption such as silicic anhydride and hydrous silicic acid (JIS K5).
80-200 ml by the method according to 101)
/ 100 g preferably has an average particle size of 2 to 20 μm. The amount of the abrasive silica in the dentifrice is 5 to 5.
It is preferably 30% by weight, particularly preferably 10 to 20% by weight. When the amount is 5 to 30% by weight, the polishing effect can be sufficiently exhibited. In the present invention, it is preferable to use 2 to 15% by weight of a thickening silica having an oil absorption of 200 to 400 ml / 100 g because the shape retention of the paste is improved.

[0010] Sugar alcohol has an effect of suppressing the production of calcium fluoride, promoting remineralization, and further reducing the jaggedness of teeth. Examples of sugar alcohols include lactitol, erythritol,
Arabitol, ribitol, xylitol, sorbitol, mannitol, maltitol and the like. Such sugar alcohol may be any of D-form and L-form,
Further, a mixture thereof may be used. Among them, xylitol suppresses the growth of bacteria causing causal teeth in plaque and reduces the pH of plaque.
It has the effect of suppressing the decrease and is particularly excellent as a flavoring agent among sugar alcohols. Therefore, in the present invention, the blending amount (weight ratio) of xylitol in the sugar alcohol is preferably 1/2 or more, particularly preferably 2/3 or more.

The calcium ion supplying compound used in the present invention may be either an inorganic compound or an organic compound. Specific examples include calcium chloride, calcium bromide, calcium nitrate, calcium lactate, calcium gluconate, calcium acetate, calcium glycerophosphate and the like. Among them, calcium lactate is particularly preferred from the viewpoint of alleviating the jaggedness of teeth. The amount of the calcium ion-supplying compound in the dentifrice is preferably 0.005 to 0.5% by weight, particularly preferably 0.01 to 0.1% by weight in terms of calcium. When the compounding amount is 0.005 to 0.5% by weight, it is possible to alleviate the jaggedness of the teeth and to prevent the generation of calcium fluoride.

The amount of calcium ion-supplying compound (calcium equivalent) (weight ratio) to the amount of fluorine ion-supplying compound (calculated as fluorine) is preferably 以下 or less, more preferably １ ／ or less. Is particularly preferred. If it is 以下 or less, generation of calcium fluoride is further suppressed, remineralization is further promoted, and the feeling of tooth bruise can be further alleviated.

[0013] In the present invention, further having 10 to 10 carbon atoms.
When 20 or preferably 12 to 16 phosphoric acid monoester or a salt thereof is blended, remineralization of teeth is further promoted and teeth can be given a slick feel. Here, the phosphoric acid monoester is represented by the following general formula (1)

[0014]

Embedded image

(Wherein, R ¹ represents a linear or branched alkyl or alkenyl group having 6 to 20 carbon atoms, and 1 represents a number of 0 to 4). Examples of the salt include a sodium salt, a potassium salt, a calcium salt, a magnesium salt and the like. The calcium salt and the magnesium salt may be either calcium or the like forming a salt with one molecule of the phosphoric acid monoester, or two cases of forming a salt by crosslinking two molecules of the phosphoric acid monoester.
Phosphoric acid monoester salts include, for example, sodium hydroxide,
It is easily produced by mixing potassium hydroxide or the like with a phosphoric acid monoester. Therefore, when a salt of a phosphoric acid monoester is blended, the phosphoric acid monoester and sodium hydroxide may be blended to form a phosphoric acid monoester salt in a dentifrice.

In the present invention, further, the carbon number is 10 to 10.
By blending 20 or preferably 12 to 16 linear or branched carboxylic acids or salts thereof, it is possible to further reduce the jagged feeling after brushing the teeth. Examples of such carboxylic acids include lauric acid, palmitic acid, stearic acid, oleic acid, linoleic acid and the like.
Examples of such carboxylic acid salts include sodium salts, potassium salts, calcium salts, and magnesium salts. The salt of a carboxylic acid is easily formed, for example, by mixing sodium hydroxide, potassium hydroxide or the like with a carboxylic acid. Therefore, when a salt of a carboxylic acid is compounded, the salt of the carboxylic acid may be formed in a dentifrice by mixing the carboxylic acid with sodium hydroxide or the like.

In the present invention, a foaming agent such as sodium lauryl sulfate generally used as a dentifrice, a wetting agent such as glycerin and polyethylene glycol, a caking agent such as sodium carboxymethylcellulose and carrageenan are used as long as the effects of the present invention are not impaired. Agents, sweeteners such as saccharin sodium, coloring agents, preservatives such as methyl parahydroxybenzoate and benzoic acid, disinfectants such as benzethonium chloride and isopropylmethylphenol, anti-inflammatory agents, flavors and the like can be added. However, calcium-based abrasives such as calcium carbonate and calcium phosphates such as calcium hydrogen phosphate and calcium pyrophosphate are not preferable because they inactivate fluorine ions and hinder the effect of promoting remineralization.

The dentifrice of the present invention can be obtained by adding abrasive silica, a sugar alcohol, a fluorine ion supplying compound, a calcium ion supplying compound, and other additives to water and stirring or kneading them. The dentifrice of the present invention can be used as a moisturizing dentifrice, a toothpaste, a liquid dentifrice and the like.

[0019]

EXAMPLES Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples.

Examples 1 to 4, Comparative Example 1 Raw materials having the composition shown in Table 1 were added to purified water and stirred to prepare a dentifrice.

[0021]

[Table 1]

Test Example 1 Using each of the dentifrices obtained above, ten panelists brushed the teeth twice a day for 5 minutes each in the morning and at night, and then touched the teeth after brushing. They were evaluated according to the following evaluation criteria. Table 1 shows the average of the evaluations of 10 persons. ◎ Evaluation criteria of tooth feel: 2: Slippery 1: Slightly slippery 0: Neither can be said -1: Slightly jagged -2: Slightly jagged

From Table 1, it can be seen that the dentifrices of Examples 1 to 4 have a better tooth feel than the dentifrices of Comparative Example 1, and particularly contain a monoester phosphate, carboxylic acid or a salt thereof having a specific chain length. It was confirmed that the effect was remarkable.
Further, the toothpaste of Example 1 was used for one month by five subjects having vitiligo on the front teeth of the upper jaw. As a result, there was a tendency for the white spots to shrink due to remineralization.

[0024]

The dentifrice of the present invention is excellent in remineralization of teeth and abrasion of teeth, and also has excellent palatability as a dentifrice.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Miyuki Okajima 2606 Kabane-cho, Akaba, Kaga-cho, Haga-gun, Tochigi Prefecture (72) Inventor Koji Maeda 2606 Akabane-Akabane, Kaiga-cho, Haga-gun, Tochigi Pref.

Claims (5)

[Claims] 1. A dentifrice comprising abrasive silica, a fluorine ion supplying compound, a calcium ion supplying compound, and a sugar alcohol, and substantially free of a calcium-based abrasive. 2. The dentifrice according to claim 1, wherein at least 1/2 (by weight) of the sugar alcohol is xylitol. 3. The dentifrice according to claim 1, further comprising a phosphate monoester having 10 to 20 carbon atoms or a salt thereof. 4. The dentifrice according to claim 1, further comprising a carboxylic acid having 10 to 20 carbon atoms or a salt thereof. 5. The dentifrice according to claim 1, wherein the fluoride ion supplying compound is sodium fluoride, and the calcium ion supplying compound is calcium lactate.