JPH1135407A - Control of ectoparasite - Google Patents

Abstract

PROBLEM TO BE SOLVED: To extremely effectively control ectoparasites by applying a foamable aersol agent containing 4-phenoxy 2-(2-pyridyloxy)propyl ether (hereinafter abbreviated as pyriproxyfen) and a pyrethroid compound to the surface of an animal body. SOLUTION: A foamable aerosol agent containing (A) 0.01-l wt.% of pyriproxyfen, (B) 0.05-10 wt.% of 3-phenoxybenzyl chrysanthemate, (C) 0.1-10 wt.% of a nonionic surfactant such as a polyoxyethylene hardened castor oil, (D) 0.1-20.0 wt. % of a water-soluble silicone resin, (E) 1.0-50.0 wt.% of a lower alcohol, (F) 35.0-95.0 wt.% of water and (G) 5-30 wt.% of a propellant based on the foamable aerosol to effectively control animal ectoparasites such as ectoparasites of the order Siphonaptera, e.g. cat flea or dog flea, ectoparasites of the order Siphunculata, the family Ixodidae, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a method for controlling ectoparasites of animals such as dogs, cats, cattle, pigs and the like.

2. Description of the Related Art It has been known to use foamed aerosols as a method for controlling ectoparasites in animals (Japanese Patent Publication No. 6-61193).
Foamed aerosols containing a pyrethroid compound are commercially available.

[0002]

However, when animals are treated with a foamed aerosol containing a pyrethroid compound, most of the adult ectoparasites are usually exterminated, but some of them are not exterminated but remain. In addition, since the eggs of the ectoparasites are not exterminated, there is a problem that spawning by the surviving ectoparasite adults and growth from the remaining eggs to adults are repeated, and a sufficient control effect cannot be obtained. There has been a demand for a method capable of exterminating eggs simultaneously with adult parasites.

[0003]

Under such circumstances, the inventors of the present invention have proposed a method for producing 4-phenoxyphenyl 2- (2-pyridyloxy) propyl ether (hereinafter referred to as pyriproxyfen) and a pyrethroid compound. The present inventors have found that by applying a foaming aerosol agent contained as an active ingredient to the surface of an animal body, external pests of an animal can be controlled extremely effectively, and have reached the present invention.

[0004]

DETAILED DESCRIPTION OF THE INVENTION Examples of the pyrethroid compound used in the method of the present invention include 3-phenoxybenzylchrysanthemate (hereinafter referred to as phenothrin), 5-benzyl-3-furylmethylchrysanthemate.
3,4,5,6-tetrahydrophthalimidomethyl chrysanthemate, 3-phenoxybenzyl 3-
(2,2-dichlorovinyl) -2,2-dimethylcyclopropanecarboxylate, 2-methyl-4-oxo-
3- (2-propynyl) cyclopent-2-enyl chrysanthemate, 2-methyl-4-oxo-3- (2-
Propenyl) cyclopent-2-enyl chrysanthemate, α-cyano-3-phenoxybenzyl chrysanthemate, 2-methyl-4-oxo-3- (2-propenyl) cyclopent-2-enyl 2,2,3,3 -Tetramethylcyclopropanecarboxylate, 3,5
6-tetrafluoro-4-methylbenzyl 3- (2,
2-dichlorovinyl) -2,2-dimethylcyclopropanecarboxylate, 2,3,5,6-tetrafluorobenzyl 3- (2,2-dichlorovinyl) -2,2-
Dimethylcyclopropanecarboxylate, α-cyano-3-phenoxybenzyl 2,2-dimethyl-3-
(1,2,2,2-tetrabromoethyl) cyclopropanecarboxylate, α-cyano-3-phenoxybenzyl 2- (4-chlorophenyl) -3-methylbutyrate, α-cyano-3-phenoxybenzyl 2,2
3,3-tetramethylcyclopropanecarboxyla-
G, α-cyano-3-phenoxybenzyl 3- (2,
2-dichlorovinyl) -2-dimethylcyclopropanecarboxylate, α-cyano-3-phenoxybenzyl 2- (2-chloro-4-trifluoromethylanilino)
-3-Methylbutyrate, 2- (4-ethoxyphenyl) -2-methylpropyl 3-phenoxybenzyl
Ethers and the like are mentioned, and the use of phenothrin is more preferred.

[0005] The composition of the foamed aerosol preparation used in the method of the present invention is such that the content (weight / weight%) of each component with respect to the foamed aerosol is high in view of its control efficiency and irritation to animals. Proxyfen 0.01-1
%, A pyrethroid compound 0.05 to 10%, a nonionic surfactant 0.1 to 10%, a water-soluble polymer 0.1
20.0%, lower alcohol 1.0-50.0%, water 35.0-95.0% and propellant 5-30%.

In the present invention, examples of the nonionic surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, and polyoxyethylene glycerin fatty acid. Ester, polyoxyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene lanolin, polyoxyethylene lanolin alcohol Polyoxyethylene beeswax derivative, polyoxyethylene alkylamine, polyoxyethylene fatty acid amide, polyoxyethylene alkylphenylformaldehyde condensate, single chain Polyoxyethylene alkyl Est -
Terbitol, sorbitan fatty acid ester, glycerin fatty acid ester, decaglycerin fatty acid ester, propylene glycol, pentaerythritol fatty acid ester and the like. These can be used as one kind or a mixture of two or more kinds, and the use of polyoxyethylene hydrogenated castor oil or polyoxyethylene castor oil is preferred.
Higher alcohols such as stearyl alcohol and cetyl alcohol can also be added as foaming agents. Examples of the water-soluble polymer include water-soluble silicone resin, gum arabic, carrageenan, xanthan gum, C
Examples thereof include MC, tragacanth gum, polyvinyl alcohol, rabonite, and the like, and these can be used as one kind or a mixture of two or more kinds. Examples of the lower alcohol include ethyl alcohol and n-propyl alcohol.
Isopropyl alcohol, n-butyl alcohol and the like. As water, it is desirable to use purified water that has been subjected to treatment such as deionization in order to stably maintain the properties of the preparation. Propellants include propane, butane, dimethyl ether
Tellurium, chlorofluorocarbon gas, carbon dioxide gas, nitrogen gas and the like.

[0007] The foaming aerosol agent thus obtained is directly applied to a surface of an animal body and then spread by a comb, a brush or a hand, or placed on a comb, a brush or a hand. After the quantitation has been applied, it is applied to the animal body surface. It is also possible to use an aerosol agent in which a comb or a brush is attached to a can body in advance. In this case, it is sufficient to spread a predetermined amount on the surface of the animal body with a comb or a brush while spraying. The animals to be treated in the method of the present invention include, in addition to pet animals such as dogs and cats, livestock animals such as cows, pigs, chickens, sheep, goats, and horses. 0.1 per
g to 10 g. Of course, the amount of treatment may vary depending on the length of the hair of the target animal. By the method of the present invention, effective control of animal ectoparasites, for example, insects of the order Lepidoptera such as cat fleas and dog fleas, lice of the order Lice, ticks and the like can be achieved.

[0008]

Next, the present invention will be described in more detail with reference to Test Examples and Examples, but it should not be construed that the invention is limited thereto. Formulation Example 1 Phenothrin 0.5 part by weight, pyriproxyfen 0.0
5 parts by weight, 0.4 parts by weight of polyoxyethylene hydrogenated castor oil, 0.6 parts by weight of dimethylsiloxane / methylpolyoxyethylenesiloxane copolymer, isopropyl alcohol
24.0 parts by weight of 1,3-butylene glycol 3.0
To a solution consisting of 0.3 parts by weight of cetyl alcohol and 0.7 parts by weight of stearyl alcohol, 47.5 g of an insect repellent composition obtained by adding purified water to 95.0 parts by weight was added to 100 parts by weight.
After filling into a ml pressure-resistant aerosol container and loading a spray valve, 2.5 g of LPG was press-fitted to obtain a foamed aerosol. Formulation Example 2 In Formulation Example 1, instead of isopropyl alcohol,
A foamed aerosol was obtained in the same manner except that 24.0 parts by weight of ethyl alcohol was used.

Formulation Example 3 According to Formulation Example 1, phenothrin 1.0% by weight, pyriproxyfen 0.02% by weight, polyoxyethylene hydrogenated castor oil 0.4% by weight, dimethylsiloxane / methylpolyoxyethylenesiloxane copolymer 0.6% by weight of coalescence, 24% by weight of ethanol, 1,3-butylene glycol 3.0
Weight%, cetyl alcohol 0.7 weight%, distilled water 65.
Foamed aerosol comprising 28% by weight and 5.0% by weight of LPG
I got

Formulation Example 4 Phenothrin 0.5 parts by weight, pyriproxyfen 0.0
5 parts by weight, 0.2 parts by weight of polyoxyethylene hydrogenated castor oil, 0.2 parts by weight of dimethylsiloxane / methylpolyoxyethylenesiloxane copolymer, isopropyl alcohol
47.5 g of an insect repellent composition prepared by adding purified water to 95.0 parts by weight of a solution consisting of 0.6 parts by weight of a water-containing solution was charged into a 100-ml pressure-resistant aerosol container, and the injection valve was charged.
G2.5 g was press-fitted to obtain a foaming aerosol agent. Formulation Example 5 phenothrin 0.5 part by weight, pyriproxyfen 0.0
An insect repellent composition comprising 9 parts by weight of purified water added to a solution consisting of 5 parts by weight, 0.4 parts by weight of polyoxyethylene hydrogenated castor oil, and 0.6 parts by weight of a dimethylsiloxane / methylpolyoxyethylenesiloxane copolymer. 47.5 g to 1
After filling into a 00 ml pressure-resistant aerosol container and loading an injection valve, 2.5 g of LPG was injected as injection gas,
A foamed aerosol was obtained.

Comparative Formulation Example 1 According to Formulation Example 1, phenothrin 1.0% by weight, polyoxyethylene hydrogenated castor oil 0.4% by weight, dimethylsiloxane / methylpolyoxyethylenesiloxane copolymer 0.6% by weight, ethanol Comparative foaming aerosol consisting of 24% by weight of alcohol, 3.0% by weight of 1,3-butylene glycol, 0.7% by weight of cetyl alcohol, 65.3% by weight of distilled water and 5.0% by weight of LPG. Obtained.

Test Example 1 The foamed aerosols prepared in Formulation Examples 1, 2, 4 and 5 were sprayed onto a polyethylene terephthalate plate from a distance of about 10 cm, and the properties of the foams were observed. Table 1 shows the results.
Shown in The evaluation was ◎: extremely good, ：: good, Δ:
Slightly poor, ×: Bad.

[Table 1]

Test Example 2 Approximately 2 g each of the foaming aerosols prepared in Formulation Examples 1 and 2.
After spraying and attaching the foam to the brush, the brush was used to brush cat hair. Thereafter, the hair loss, skin inflammation, health condition, and presence or absence of abnormal behavior were observed for one week of the treatment. As a result, no abnormality was observed.

Test Example 3 A predetermined amount (body weight of 1) of the foamed azole prepared in Formulation Example 3 and Comparative Formulation Example 1 was added to a cat in which 30 cat fleas were infested in advance.
(4 g per kg) was applied using a brush. One week later, the number of cat flea parasitoids was observed, and at the same time, the produced cat flea eggs were collected (the number of eggs collected was set to 50).
The hatching inhibition effect was evaluated. The results are shown in Table 2 (the number of parasitism of the cat flea) and Table 3 (hatch inhibition rate (%) in each sample).
Shown in

[Table 2]

[0015]

[Table 3]

According to the method of the present invention, not only the adult ectoparasites but also the eggs of the animals can be exterminated, so that these ectoparasites can be effectively controlled.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI A01N 53:00)

Claims (4)

[Claims] An ectoparasite characterized in that a foaming aerosol containing 4-phenoxyphenyl 2- (2-pyridyloxy) propyl ether and a pyrethroid compound is applied to the surface of an animal body as an active ingredient. Control method 2. The composition of the foaming aerosol agent is 4-phenoxyphenyl 2- (2-pyridyloxy) propyl ether.
Tell content 0.01-1% (weight / weight), pyrethroid compound content 0.05-10% (weight / weight), nonionic surfactant 1-10% (weight / weight), water-soluble polymer 0 0.1 to 20.0% (weight / weight), lower alcohol 1.0 to 50.0% (weight / weight), water 35.0 to 9
5.0% (weight / weight) and 5-30% propellant (weight / weight)
2. The control method according to claim 1, wherein 3. The control method according to claim 1, wherein the pyrethroid compound is 3-phenoxybenzyl chrysanthemate. 4. The control method according to claim 1, wherein the ectoparasite is a flea.