JPH03181402A - Method and agent for repelling mouse - Google Patents

Abstract

PURPOSE:To provide a mouse repellent having improved safety and handling property by containing a monoterpene such as l-menthol, dl-camphor, n-borneol or alpha-pinene as an active ingredient. CONSTITUTION:A mouse repellent contains as an active ingredient l-menthol, l-menthone, dl-camphor, n-borneol, 1,8-cineole, eugenol, 1-perillyl aldehyde, d-limonene, alpha-pinene, citronella, etc., or an essential oil (e.g. peppermint oil, pennyroyal oil or camphor oil) containing the monoterpenes. The active amount of the monoterpene is 0.03g/l when the vapor of the monoterpene is directly applied to a target space, 10g/m<2> when employed as a coating agent, and 0.03g/g based on the weight of a molded product when kneaded in the molded product. The microcapsule of the agent is preferable from a point of the sustained release property thereof.

Description

[Detailed description of the invention]

(a) Industrial Application Field The present invention relates to a rat repellent method and a rat repellent which contain monoterbenes as an active ingredient and have improved safety and workability. (b) Conventional techniques and issues Mice taxonomically belong to the class Holactidae, the order Porites, and the family Rodentidae.
20ml/liter is known in Japan. Among these, the rats that cause damage in the living environment are called house rats, and specifically there are three types: brown rats, house rats, and black rats. The damage caused by these house mice can be broadly classified into economic and sanitary damages. First, in terms of economic damage, damage to crops and food has traditionally been the focus of attention, but now that Japan is living in a time when there is a surplus of food, less attention has been paid to it. However, damage caused by rats on ships when importing grain from overseas, or damage caused while grain is stored in warehouses in developing countries, is still a major problem. In addition, damage to electrical equipment has been attracting attention recently. Today, the advanced use of iiE energy and the transformation of its structure, as well as combinations. - The spread of centralized control and management systems is remarkable, and the damage caused by rats eating them is enormous. On the other hand, from a hygiene perspective, because house mice lie in filthy areas, they carry a variety of harmful bacteria such as bubonic plague, typhus fever, rat bite, and many other pathogens that can be transferred to humans outside their bodies. There are many cases. Therefore, even if house mice do not eat, they can spread these harmful pathogens to the surrounding area just by running around, which can cause serious sanitary damage. To deal with the damage caused by rats, drugs such as rat poison or rat repellent (repellent) are used, and rat traps are used. Among these methods, in the method using rodenticides, many of the poisonous baits in which the rodenticides are introduced are repellent, and the eating rate of these poisonous baits is low, so there is a problem of how to feed the rats. In addition, if rats that eat this poisonous bait develop severe symptoms, it causes stress in the rat population, and they tend not to approach the poisoned bait in the future. However, the repellent effect of the poisoned bait is not sufficient to eliminate rats from a given space. Additionally, if a rat dies from poison bait, its carcass decomposes and becomes a breeding ground for flies, causing further sanitary problems. On the other hand, as a repellent, cycloheximide (naramycin), which is a type of antibiotic produced by several types of actinomycetes, is known. This naramycin is microencapsulated and kneaded into soft polyvinyl chloride (PVC) and the like. This taste is unpleasant to rats (astringent bitterness), and when rats eat it, they instantly perceive this unpleasant taste and take advantage of the fact that they exhibit an aversion reaction. However, this repellent has the disadvantage that it cannot be effective unless it is consumed once. In the case of this naramycin, methods such as kneading can be used to deal with damage to electrical equipment, etc., but cannot sufficiently deal with damage to agricultural products and food. The present invention has been made in view of the above situation, and it is an object of the present invention to provide a method for repelling prowling rats and a repellent thereof, which safely and effectively exclude rats from a certain space. (c) Means for solving am Thus, according to the present invention, there is provided a method for repelling rats, characterized in that rats selected from brown rats, mice, and black rats are repelled with monoterbenes, and monoterbenes are used as an active ingredient. A rat repellent will be provided. In this invention, brown rats, mice, and black rats that are to be repelled are rats called so-called house rats, and the inventors have discovered that monoterbenes alone have a remarkable repellent effect on the above-mentioned house rats. This finding was first discovered by et al. Monoterbenes are generally used in cosmetics, flavors, etc., and their safety in terms of skin irritation and toxicity has been confirmed, making them extremely safe repellent methods and repellents for humans and animals. can be provided. The monoterbenes used in this invention include Q
-Menthol, Q-menthone, dl-camphor, n-borneol, 1.8-cineole, eugenol, l-
Suitable examples include perillaldehyde, d-limonene, α-pinene, citronellal, and the like. The monoterbenes mentioned above may be used as essential oils substantially containing these monoterbenes. Here, "substantially containing" means that the target monoterbenes are at least about 10% by weight or more, preferably about 50% by weight.
% by weight or more. Examples of this include, for example, peppermint oil (Menthaar oil), which substantially contains e-menthone and a-menthol.
vensis L, var, Piperascens
Holmes) and Mentha (lAentha)
Piperita L.),
Examples include beniroyal oil and dementholized oil obtained by removing menthol from heart oil (also known as menthone oil (contains about 70% l-menthon) or heart white oil (contains about 30% 12-menthon)). The above-mentioned monoterbenes are used singly or in a blend of two or more, from the viewpoint of the rat repellent effect and the taste preference of humans who come into contact with the environment in which the monoterbenes are used. In this invention, using the monoterbenes to repel rats means that the monoterbenes are used so as to stimulate the five senses of rats, such as smell and taste. Therefore, monoterbenes are used so that the vapor of monoterbenes can exist in the space to be repelled, materials containing monoterbenes are left standing, monoterbenes are applied to objects to be eaten by rats, and monoterbenes are used when molding objects to be eaten. knead the kind,
etc. The method of using the vapor of the monoterbenes mentioned above not only keeps rats away from a certain space where the vapor may exist, but also has the effect of expelling rats from this space, making it possible to effectively eliminate rats from a certain space. It has the advantage of being able to Many of the monoterbenes themselves are volatile, but even liquids with poor volatility or solids with no sublimation properties may be used in a manner that allows the monoterbenes to be volatilized. In this case, a suitable heat treatment may be used to generate steam. When using the vapor of monoterbenes as described above, the vapor of monoterbenes is used so as to be effectively supplied to a predetermined space to be avoided. Example t. For example, using monoterbenes directly or formulating them into sustained-release preparations containing monoterbenes as described below and leaving them directly in the space to be avoided, or impregnating and containing them in interior materials such as sheet materials and wall materials. For example, it can be used as In addition, when directly using the volatilized vapor of monoterbenes,
It is preferable to configure the gas flow so that this vapor flows into the space to be avoided. In this invention, the effective amount of the monoterbenes used cannot be limited, but the following amounts are generally used as a guide. For example, when using monoterbenes vapor directly in a space to be avoided, it may vary slightly depending on the temperature of the target system, but 0.
．． 03g/+2 is mentioned. In addition, when monoterbenes are used in a coating agent to be applied to objects to be avoided, the ratio of log/m' to the applied area is determined, and when the monoterbenes are used after being kneaded into a molded article, For example, it may be used at a rate of 0.03 g/g based on the weight of the molded piece. In this invention, when the above monoterbenes are actually applied, they can be used alone as they are without adding other ingredients, but they can be mixed with a suitable carrier as described below to contain the monoterbenes as an active ingredient. It can be used as a preparation. Examples of the above-mentioned formulations include arbitrary net forms such as sprays, oils, heated fumigants, sheets, powders, granules, fine granules, microcapsules, and wettable powders. Its preparation method is
Techniques known in the art may be used in consideration of the properties of monoterbenes as active ingredients. As an example,
A propellant can be prepared by diluting the above monoterbenes with a small amount of an organic solvent, if necessary, and using an oxidizing gas propellant such as dichlorofluoromethane. Further, in order to form microcapsules, the above-mentioned monoterbenes as active ingredients may be added to a solution of the cyclodextrin clathrate compound forming agent, and the solvent may be removed. In particular, microcapsules can be provided as a suitable sustained-release preparation for preparation of coating agents applied to the interior materials and objects to be eaten by rats, and when kneaded during the molding of objects to be eaten. This is a preferable formulation from the viewpoint of sustaining the effect. An example of formulation into the above-mentioned microcapsules includes a method using cyclodextrin. In this case, cyclodextrin includes α-1β-9γ-isomers and branched dextrins with methyl and ethyl group side chains as modified dextrins. It can also be done, and is selected as appropriate depending on the purpose. Specifically, water and cyclodextrin from 99.L to 70
: 30 (weight ratio) A slurry liquid is prepared by adding the above-mentioned active ingredient monoterbenes or a substance substantially containing the monoterbenes to the mixture, and then spray-drying this, for example, to obtain a powder-like dry product. It can be obtained by As the above-mentioned cyclodextrin, a compound obtained from the decomposition of starch may be used as it is, or the decomposition product may be purified to isolate a desired cyclodextrin for use. Further, dextrin can be used in accordance with the substance to be included in the above-mentioned cyclodextrin. In the above formulation, it is preferable that the active ingredient monoterbenes, which are clathrate substances, be contained in the resulting dry powder in an amount of usually about 3 to 30% by weight. For example, in the case of a liniment, the microcapsule prepared as a sustained-release formulation containing monoterbenes obtained as described above is applied to the base resin composition to form a coating film of the +#i finger joint. It is used in an amount sufficient to release an effective amount of repellent component without impeding performance. Specifically, about 1 to 401 i based on the solid content of the resin composition.
! It can be used in a wide range of %. The resin composition for coating containing the monoterbenes-containing microcapsules in the proportions described above has, for example,
(d) Effect: According to the present invention, the monoterbenes are selected from brown rats, myna rats, and black rats, and stimulate the sense of smell, taste, etc. of the rats. By doing so, rats are repelled.The present invention will be described in detail with reference to practical rows below, but the present invention is not limited thereby.(The following is a blank space) (e) Practical row repellent test l The following chemicals were mixed into solid feed for animal breeding, and the amount of feed consumed after 24 hours was measured to observe the repellency. 4 mice (No. 1 to 4) were placed individually in a box, Two of them (No. 1.2) were given untreated feed, and two of them in the pond were fed untreated feed.
The animal (No. 3.4) was given drug-treated feed. The results are shown in Table 1 below. Test drug: Pharmacopoeia oil repellent Target animal: Rhabdo Wista 16-week-old drug,
Kneading ratio: 9.2% From the above results, it can be seen that rats hardly eat the feed mixed with peppermint oil. Repellent test 2 Drug-treated feed and untreated feed were prepared in the same manner as above, and 3 rats (same species as in test 1 above) (No. 1,
~3) were placed one by one in a box, and each was given treated feed and untreated feed. The results are shown in [Table 2]. Note) In the above results, the reason why rats No. 2 did not eat 100% of the untreated feed is thought to be due to the hunger level of the rats at this time. Repellency Test 3 Using the apparatus shown in Figure 1, a test was conducted to determine whether feed could be eaten in the presence of various drug vapors. Test equipment: Synthetic (12 mm thick) rectangular parallelepiped box (inside dimensions: length 240 mm x +Ii 240 mm x height 26
0 mm) was produced. Line up 3 of these boxes directly on y11,
Vinyl chloride pipes (inner diameter 62 mm, length 500 mm) (a) were connected to each other with (a), and one set of these was used as a test device for one drug. Test Method: Two sets of the above test apparatus were used for each drug test, and each was distinguished as "A" rBJ. - Among the three boxes in one test device, the boxes at both ends were numbered "■" and "■", and a feeder and water were installed. In addition, only water was placed in the central box.・We investigated in advance the amount of food consumed without the test drug. After confirming the selectivity of the test animals to the test device itself, the test drug was placed in the box on the side that had been eaten the most. -Two rats were used as the test animals, and they were always introduced through the sealable immersion opening (c) in the central box. - The test drugs used were Ig (solid) and IsuQ (liquid). - 24 hours after introducing the test animal, "■". The feeder was taken out from the box labeled "■", and the eating rate was determined from the amount of food lost and evaluated.・As a reference when considering the behavior of the test animals, the feces collected at the bottom of the box were counted and recorded as defecation losses. Test drugs: 12-menthol, Q-menthone, ti, (
1-camphor, n-borneol, 1.8-cineole, eugenol, l-periraldehyde, d-limonene, α-pinene, citronellal (margin below)

[Q-menthol repellent effect]

seems to have absorbed water. In rats, no eating or defecating was observed in the e-menthol treated box (■), indicating a repellent effect. [12-Repellent effect of menthone] It is thought that (the following margin) has absorbed moisture. In rats, no eating or defecating was observed in the Q-menthon-treated box (■), indicating a repellent effect. [d12-Camphor repellent effect] It is thought that the d12-camphor repellent effect absorbed moisture. In rats, no eating or defecating was observed in the dl-camphor-treated box (■), indicating a repellent effect.

[N-borneol repellent effect]

In rats, Box treated with n-borneol (■) No eating or defecating was observed inside the cage, indicating a repellent effect.

[1.8-Repellent effect of cineole] In rats, 1.8-Cineol treated box (■) No eating or defecating was observed inside the cage, indicating a repellent effect.

[Eugenol repellent effect]

In rats, although a repellent effect was observed in the eugenol-treated box (■), a small amount of eating and defecation were observed. In rats, although a repellent effect was observed in the box treated with perilaldehyde (■), a small amount of eating and defecation were observed. In rats, although a repellent effect was observed in the d-limonene-treated box (■), a small amount of eating and defecation were observed. In rats, a repellent effect was observed in the α-pinene-treated box (■), or a small amount of eating and defecation were observed.

[/Repellent effect of Tronellal]

*) The reason why the weight of the bait increased after 24 hours is probably because the bait absorbed water due to the high humidity inside the device. In rats, no eating or defecating was observed in the citronellal-treated box (■), and a repellent effect was observed. [Results] From the above results, Q-menthol, Q-menthone,
- camphor, n-borneol, 1.8-neol,
Regarding the six citronellal drugs, no rats ingested the food in the boxes in which they were placed, indicating that they had a repellent effect on rats. On the other hand, four drugs, eugenol, 1-periraldehyde, d-limonene, and α-pinene, were also found to have repellent effects, but a small amount of them were consumed. (f) Effects of the Invention According to the present invention, house mice can be effectively repelled using monoterbenes. - Be able to exclude it from the window space.

[Brief explanation of drawings]

FIG. 1 is an explanatory diagram of the configuration of a test device for testing the rat repellent effect of monoterbenes.

Claims (1)

[Scope of Claims] 1. A method for repelling rats, which comprises repelling rats selected from brown rats, house rats, and black rats using monoterbenes. 2. One monoterbene selected from l-menthol, l-menthone, dl-camphor, n-borneol, 1,8-cineole, eugenol, l-periraldehyde, d-limonene, α-pinene, and citronellal. or 2 or more types. 3. A rat repellent containing monoterbenes as an active ingredient. 4. One type of monoterbenes selected from l-menthol, l-menthone, dl-camphor, n-borneol, 1,8-cineole, eugenol, l-periraldehyde, d-limonene, α-pinene, and citronellal or 2 or more types of rat repellents according to claim 3.