JPH11302155A - Skin external preparation for atopic dermatitis - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin external preparation for atopic dermatitis capable of alleviating symptoms such as itch, inflammation, etc., of atopic dermatitis, not causing side effects. SOLUTION: This external preparation is obtained by formulating ceramide with a gel base containing a component capable of forming a liposome.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a skin external preparation for atopic dermatitis, and more particularly to a skin external preparation for atopic dermatitis used as cosmetics, pharmaceuticals and the like.

[0002]

2. Description of the Related Art As is well known, atopic dermatitis is an allergic or endogenous skin disease that presents symptoms such as itching, inflammation, keratinization and dry skin, and the number of patients is increasing year by year. It is in.

[0003]

However, there are many unclear points in the cause and the mechanism of occurrence, and it is recognized that it is difficult to heal in the short term.

[0004] As a coping therapy for relieving itching, administration of steroids or the like has been performed, but there is a problem that side effects are involved.

The present invention has been made in order to solve such problems, and can alleviate various symptoms such as itching and inflammation of atopic dermatitis, and also have no side effects. It is an object to provide a skin external preparation for skin care.

[0006]

Means for Solving the Problems The present invention is intended to solve such problems, and a means for solving the problems is a gel base containing ceramide and a component capable of forming liposomes. And that it is blended.

[0007]

Atopic dermatitis is caused by a decrease in the moisturizing function of the skin. More specifically, it is thought that the cause is a decrease in lipid components such as ceramide present on the skin surface. By administering to the skin an external preparation containing, a decrease in lipid components such as ceramide present on the skin surface is prevented.

[0008]

Embodiments of the present invention will be described below.

The composition of an external preparation for skin as one embodiment is as follows.

Type Ingredients Weight% Base Glycerol 8% 1,3-butylene glycol 7% Diglycerin 7% Triglyceride 8% Cetyl 2-ethylhexate 5% Squalane (natural seed-derived squalane) 8% Soybean lysophospholipid liquid 7% Hydrogenated soybean phospholipid 6% Shea butter 5% Moisturizing ingredient Eldow (cholesteryl ester) 4% Ceramide 5% Bisabolol 3% Betaine 3% Chamomile extract 2% Rose water 3% Allantoin 2% Natural vitamin E 2% β-glycyrrhetinic acid 3 % Stearyl glycyrrhetinate 1% Asparasas linealis 1% Preservatives Paraben 5% Phenoxyethanol 5%

In the above ingredients, Bioceramide LS (trade name: manufactured by Yamakawa Trading Co., Ltd.) was used as ceramide.

The composition of this bioceramide LS is as follows.

Ingredients% by weight galactosylceramide (glycosphingolipid) 70% sphingomyelin (sphingolipid) 10% phosphatidylethanolamine (glycerophospholipid) 9% lecithin (glycerophospholipid) 9% cholesterol 2%

[0014] Further, in the base in the above external preparation for skin,
Glycerol, 1,3-butylene glycol, triglyceride and cetyl 2-ethylhexate were formulated for moisturizing, and diglycerin was formulated for moisturizing and reducing stickiness. The lysophospholipid liquid and the hydrogenated soybean phospholipid are blended to have a function of forming liposomes in addition to moisturizing, and the shea butter is blended for UV protection in addition to moisturizing. It is blended as a sebum-like component.

On the other hand, among the moisturizing components in the above-mentioned external preparation for skin, ceramide and betaine are used for the purpose of moisturizing themselves, while Eldew is added to have a function of forming liposomes in addition to moisturizing. Yes, chamomile extract is formulated for the purpose of masking in addition to moisturizing, and Asparasas linealis is S
It is formulated for the purpose of making it OD-like,
Rose water is formulated for masking,
Bisabolol is formulated for antimicrobial and anti-inflammatory, allantoin is formulated for anti-inflammatory, β-glycyrrhetinic acid and stearyl glycyrrhetinate are formulated for anti-inflammatory and anti-allergic. Natural vitamin E is used for antioxidation.

Furthermore, paraben and phenoxyethanol are blended for preservation.

Since the external preparation for skin of the above embodiment contains ceramide, which is a main component for moisturizing, it can supplement lipid components such as ceramide present on the skin surface. And the moisture retention effect can be maintained.

In addition, various moisturizing components other than ceramide are compounded, and the component for moisturizing is also compounded in the base, so that the moisturizing effect as a whole is very excellent. It has the effect of becoming something.

Further, since the soybean lysophospholipid solution capable of forming liposomes and the hydrogenated soybean phospholipid are blended in the base, the liposomes function as a surfactant, and a humectant such as ceramide is used as the base. Will be suitably mixed.

A clinical test was conducted on 90 externally monitored patients using the skin external preparations of the above examples.

The results are shown in Tables 1 to 3.

[0022]

[Table 1]

[0023]

[Table 2]

[0024]

[Table 3]

As is clear from Tables 1 to 3, the degree of improvement was good for many monitor patients.

[0026] In addition, the ingredients and the weight%
Is not limited to the above embodiment.

For example, the following components are also used. Type Ingredients Weight% Base Triglyceride 18% Soybean lysophospholipid liquid 16% Hydrogenated soybean phospholipid 16% Shea butter 15% Moisturizing ingredient Eldeu (cholesteryl ester) 8% Ceramide 7% Betaine 7% β-Glycyrrhetinic acid 7% Glycyrrhetinic acid Stearyl 6%

In short, it is only necessary that the gel base and the ceramide are blended, and it is sufficient that the gel base contains a component capable of forming liposomes.

Therefore, it is not a condition to mix other components, and the components can be arbitrarily changed.

Further, in the above-mentioned embodiment, bioceramide LS composed of the above-mentioned components was used as ceramide. However, the type of ceramide is not limited to this, and for example, ceramide III (trade name) [generic name is N- Stearoyl phytosphingosin], and glycoceramide or the like can also be used.

Further, the use of the external preparation for skin of the present invention can be used not only for cosmetics but also for pharmaceuticals, and its use is not limited.

[0032]

As described above, according to the present invention, a ceramide and a liposome-containing gel base are blended in an external preparation for skin. Ceramide, which is a compounding component, is supplemented to the skin surface.

Therefore, when atopic dermatitis develops,
In general, ceramide and the like present on the skin surface are reduced, but the reduction of lipid components present on the skin surface is prevented by supplementing the ceramide which is a compounding component as described above, whereby atopic skin is reduced. It has the effect of alleviating the symptoms of flame.

In addition, since ceramide itself is generally a substance that can be metabolized in a living body, there is an advantage that there is little possibility of causing side effects unlike steroids.

Further, since the base is a gel base,
In addition to being able to be suitably applied to the affected area, there is an advantage that no irritation is given even if a scratch or the like due to itch is present in the affected area.

Further, since a component capable of forming a liposome is blended in the base, the liposome functions as a surfactant, and has an effect that a moisturizing component such as ceramide is suitably mixed with the base. is there.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 31/16 ADA A61K 31/16 ADA

Claims (1)

[Claims] 1. A skin external preparation for atopic dermatitis, comprising a mixture of ceramide and a gel base containing a component capable of forming liposomes.