JPH1129474A - Method for dissolving biotin, and liquid internal medicine - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a liquid internal medicine which is dissolved quickly and easily without supplementing unnecessary ingredients for preparation, and contains biotin, by dissolving biotin in an aqueous solution of a benzoate. SOLUTION: This medicine is prepared by dissolving a benzoate, if necessary after mixing the benzoate with caffeine and/or an aspartate in water, followed by the dissolution of biotin in the obtained solution. The obtained solution and a solution in which various ingredients were dissolved are mixed, if necessary followed by the adjustment of pH to 2-5, to give liquid internal medicine containing biotin. The benzoate aqueous solution for dissolving biotin is a 50-100 ml solution prepared by dissolving 5-200 mg of the benzoate in 100 ml of water, 0.1-10 parts wt. of caffeine and 0.1-10 parts wt. of the aspartate are added to 1 part wt. of the benzoate. This procedure gives liquid internal medicine containing biotin, which is stable at acidic pH for a time and allows supplementation of various ingredients.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a method for dissolving biotin and an oral solution containing biotin.

[0002]

2. Description of the Related Art Biotin, also called vitamin H, is a vitamin necessary for maintaining normal skin and hair. Acidic range (2 to 2)
In 5), biotin is hardly soluble in water, and a solution was required for its dissolution. As a method of dissolving biotin,
Conventionally, a method using polyvinylpyrrolidone (Japanese Unexamined Patent Publication No.
No. -76520), a method of adjusting the pH to neutral to alkaline using an alkali hydroxide or the like, and then dissolving biotin. However, polyvinylpyrrolidone may react with coexisting components to form a precipitate or react with other components such as vitamins and amino acids to lower the components. Further, in the method using alkali hydroxide or the like, even if biotin is dissolved in a neutral to alkaline state, biotin may be precipitated with time when the pH is returned to an acidic range which is the pH of an oral solution ( JP-A-7-76520
issue). Even if it does not precipitate, it is not necessarily a preferred method, for example, it is necessary to add a component unnecessary for its medicinal effect and the preparation becomes complicated.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide a method for rapidly and easily dissolving biotin in water without adding unnecessary components in a pharmaceutical preparation, and to provide an oral solution containing biotin. .

[0004]

Means for Solving the Problems The inventors of the present invention have made intensive studies on the above-mentioned objects, and as a result, have found that when biotin is dissolved in an aqueous solution of benzoate, caffeine, aspartate, etc., the intended object can be achieved. And completed the present invention. Thus, the present invention provides (1) a method for dissolving biotin, which comprises dissolving biotin in an aqueous solution of benzoate, and (2) dissolving biotin in an aqueous solution in which benzoate and caffeine are dissolved. A biotin dissolving method characterized by dissolving biotin in an aqueous solution in which benzoate, caffeine and aspartate are dissolved, and (4) an aqueous solution of benzoate. Biotin is dissolved and the pH is in the range of 2 to 5; (5) that the biotin is dissolved in an aqueous solution of benzoate and caffeine and the pH is in the range of 2 to 5; (6) Biotin is dissolved in an aqueous solution of benzoate, caffeine and aspartate, and the pH is in the range of 2 to 5; (7) Biotin and biotin Dissolution (8) Biotin and a benzoate for dissolving biotin and an oral solution containing caffeine, (9) Biotin and a benzoate for dissolving biotin, It is an oral solution containing caffeine and aspartate.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The benzoate in the present invention is
Examples thereof include sodium benzoate, potassium benzoate, calcium benzoate, and the like, with preference given to sodium benzoate. The aspartate is one or a combination of magnesium potassium aspartate, magnesium aspartate, and potassium aspartate, and magnesium potassium potassium aspartate is particularly preferred.

In the present invention, the dissolution of biotin is achieved by first dissolving benzoate (and caffeine and aspartate) in water, and then dissolving biotin in this solution. In addition, the biotin-containing oral solution of the present invention is prepared by first dissolving biotin in an aqueous solution of benzoate (and caffeine and aspartate) as described above, and separately preparing solutions in which various components are dissolved. Is manufactured by adjusting pH as needed after mixing.

The aqueous solution of benzoate for dissolving biotin is usually, for example, 5 to 200 mg, preferably 10 to 80 mg of benzoate for dissolving 0.2 mg of biotin.
50 to 100 ml of an aqueous solution prepared by dissolving mg in 100 ml of water
Is used. Hereinafter, the amount of the aqueous solution of benzoate is determined by the amount of biotin to be dissolved.

The amount of caffeine added is 0.1 to 10 parts by weight, preferably 0.5 to 5 parts by weight per 1 part by weight of benzoate.
Parts by weight. The amount of aspartate added is 0.1 to 10 parts by weight, preferably 0.5 to 5 parts by weight, per 1 part by weight of benzoate.

In the present invention, as the pH adjuster,
For example, lactic acid, citric acid, malic acid, succinic acid, fumaric acid, tartaric acid, phosphoric acid, and salts thereof can be used.

[0010] In addition to the above components, the oral liquid preparation of the present invention may contain other components which can be used in the oral liquid preparation, such as various vitamins, amino acids, crude drugs, royal jelly, etc.
Polyhydric alcohols, organic acids, mineral components, fragrances, preservatives, and the like can be blended within a range that does not impair the effects of the present invention.

[0011]

According to the present invention, a quick and easy dissolving method can be provided without adding unnecessary components for the medicinal effect for dissolving biotin. A replenishable biotin-containing oral solution was provided.

[0012]

The present invention will be described below in more detail with reference to examples and test examples. Example 1 Taurine 2000 mg Biotin 200 μg Maltitol 1500 mg Vitamin B6 5 mg Citric acid (pH adjuster) Appropriate amount Sodium benzoate 70 mg Stevia extract 30 mg Fragrance Trace amount Purified water 100 ml (pH 3.5) Sodium benzoate is added to purified water 60 ml and dissolved. Thereafter, biotin was added and dissolved while stirring. Thereafter, taurine, maltitol, vitamin B6, stevia extract, and flavor are added in this order, and after confirming dissolution, citric acid is added and pH 3.5.
Then, purified water was added to make the total amount 100 ml to obtain an oral liquid preparation.

Example 2 Taurine 1000 mg Biotin 200 μg Vitamin B2 5 mg Caffeine 50 mg Sorbitol 2000 mg Maltitol 9000 mg Citric acid (pH adjuster) Suitable amount Malic acid 100 mg Sodium benzoate 60 mg Stevia extract 25 mg Fragrance Trace amount Purified water Total 100 ml (pH 2.8) After dissolving sodium benzoate and caffeine in 60 ml of purified water, biotin was added and dissolved while stirring. Then, after adding taurine, vitamin B2, sorbitol, maltitol, malic acid, stevia extract, and flavor, confirming dissolution, adjusting the pH to 2.8 by adding citric acid, adding purified water to make the total volume 100 ml, Obtained.

Example 3 Taurine 1000 mg Biotin 300 μg Magnesium / potassium aspartate 200 mg Vitamin B1 nitrate 2 mg Caffeine 50 mg Erythritol 5000 mg Citric acid (pH adjuster) Appropriate amount Malic acid 100 mg Nipapuchi 4 mg Sodium benzoate 60 mg Stevia extract Total water 15 mg Purified water (PH 4.0) Sodium benzoate, caffeine, and magnesium / potassium aspartate were dissolved in 60 ml of purified water, and then biotin was added with stirring to dissolve. Then taurine,
After adding vitamin B1 nitrate, erythritol, malic acid, nipabuti and stevia extract and confirming dissolution, adjust the pH to 4.0 by adding citric acid, and add purified water to a total volume of 100 m.
As l, an oral solution was obtained.

Test Example [Solubility test] In Example 1, sodium benzoate was added and dissolved in 60 ml of purified water, and then biotin was added at room temperature with stirring.
When 0 μg was added, the dissolution was confirmed 9 minutes after the addition of biotin. The other ingredients were added to the solution and the pH was adjusted to make the total volume 100 ml. 5 ℃
And at 40 ° C., but no biotin was deposited even after 6 months.

In Example 2, 60 mg of sodium benzoate and 50 mg of caffeine were added to and dissolved in 60 ml of purified water, and 200 μg of biotin was added with stirring at room temperature. The dissolution was confirmed 7 minutes after the addition of biotin. The other ingredients were added to the solution and the pH was adjusted to make the total volume 100 ml. This is 5 ℃ and 40 ℃
However, no biotin was deposited even after 6 months.

In Example 3, 60 mg of sodium benzoate, 50 mg of caffeine and 200 mg of magnesium / potassium aspartate were added to 60 ml of purified water and dissolved, and then 300 μg of biotin was added with stirring at room temperature. Dissolution was confirmed. The other ingredients were added to the solution and the pH was adjusted to make the total volume 100 ml. This was stored at 5 ° C. and 40 ° C., but no deposition of biotin was observed even after 6 months.

At room temperature, 200 μg of biotin was added to 60 ml of purified water while stirring to try to dissolve, but after 60 minutes, it was not dissolved.

100 m of purified water maintained at 80 to 90 ° C.
To this, 200 μg of biotin was added while stirring, and the dissolution was attempted, but it was not dissolved after 60 minutes.

Claims (12)

[Claims] 1. A method for dissolving biotin, comprising dissolving biotin in an aqueous solution of a benzoate. 2. A method for dissolving biotin, comprising dissolving biotin in an aqueous solution in which benzoate and caffeine are dissolved. 3. A method for dissolving biotin, comprising dissolving biotin in an aqueous solution in which benzoate, caffeine and aspartate are dissolved. 4. The method for dissolving biotin according to claim 1, wherein the benzoate is sodium benzoate. 5. An oral liquid preparation characterized in that biotin is dissolved in an aqueous solution of benzoate and the pH is in the range of 2 to 5. 6. An oral solution, wherein biotin is dissolved in an aqueous solution of benzoate and caffeine, and the pH is in the range of 2 to 5. 7. An oral liquid preparation, wherein biotin is dissolved in an aqueous solution of benzoate, caffeine and aspartate, and the pH is in the range of 2 to 5. 8. The liquid preparation according to claim 5, wherein the benzoate is sodium benzoate. 9. An oral solution containing biotin and a benzoate for dissolving biotin. 10. An oral solution containing biotin and a benzoate and caffeine for dissolving biotin. 11. An oral solution containing biotin and benzoate, caffeine and aspartate for dissolving biotin. 12. The liquid preparation for oral administration according to claim 9, wherein the benzoate is sodium benzoate.