JPH11286414A - Hair tonic raw material and hair tonic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain both a safe hair tonic raw material and hair tonic composition having excellent hair growing effects, not causing an allergic reaction on a scalp. SOLUTION: This hair tonic raw material comprises at least one or Clerodendron trichotomum Thunb., Nothopanax scutellarium Mer., Aleurites moluccana Willd., Melaleuca leucadendra L., and Elaeagnus glabra Thunb., or their extract or pressed oil.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair restorer raw material and a hair restorer composition, and an object of the present invention is to provide a safe hair restorer having an excellent hair restorer effect and not causing an allergic reaction to the scalp. It is to provide a raw material and a hair restorer composition.

[0002]

2. Description of the Related Art Many hair cosmetics, pharmaceuticals, and quasi-drugs used for the purpose of hair restoration and hair growth have been created, and general hair restorer compositions penetrate hair roots. Contains a hair-growing component that promotes blood circulation, promotes blood circulation, and stimulates the hair nipple to promote hair generation, a component that gives a refreshing sensation, a component that has a bactericidal action, and a component that prevents dandruff and Kayumi. I have. Specifically, as a hair growth component, female hormone, vitamin E, pantothenic acid, pepper tincture,
Ginger tincture, assembly extract, cepharanthin, photosensitizers and the like, ethanol and the like as components having a refreshing sensation and a bactericidal action, resorcinol, salicylic acid, zinc pyridione and the like as anti-dandruff components, and antihistamine as a kayumi prevention component There are a large number of compounds containing the same.

[0003]

However, the conventional hair restorative composition as described above does not provide a sufficient hair restoring effect and sometimes gives an unpleasant stimulus to the scalp. Therefore, creation of a safe hair restorer material and a hair restorer composition that has an excellent hair restorer effect and does not give undesired irritation to the scalp is desired. Japanese Patent Application No. 8-153371
In the issue, Takasaburo (Eclipta alba (L.) Hassk)
It has been found that the extract with an organic solvent has an excellent hair-growth effect and is safe for the scalp.

[0004] The present inventors have further conducted intensive studies on a hair restorer material having an excellent hair restorer effect and having a high safety on the scalp, which is derived from a natural product.
endron trichotomum Thunb.), Notopanax scutellarium Mer., Kukinoki (Aleurites moluccana Willd.), Cayupte (Melale)
uca leucadendra L.), Tsurugumi (Elaeagnus glabra T)
hunb.), and found that these extracts and pressed oil have an excellent hair-growth effect, and have completed the present invention.

[0005]

Means for Solving the Problems That is, the invention according to claim 1 is characterized in that the heron (Clerodendron trichotomum Thunb.), Notopanax scutellarium (Nothopanax scutellar)
ium Mer.), Alderites moluccana Will
d.), a hair restorer material characterized by comprising at least one of Cayupte (Melaleuca leucadendra L.) and Tsurugumi (Elaeagnus glabra Thunb.). The invention according to claim 2, wherein the invention relates to the aleurites molucc
ana Willd.) is a kuku nut oil obtained by squeezing the seeds thereof, and relates to the raw material for hair growth agent according to claim 1.

According to a third aspect of the present invention, there is provided an
odendron trichotomum Thunb.), Nothopanax scutellarium Mer., Kukinoki (Aleurites moluccana Willd.), Cajupte (Mela)
leuca leucadendra L.) or Tsurugumi (Elaeagnus gl)
abra Thunb.) A hair restorer raw material comprising at least one of the respective extracts.
The invention according to the above, wherein the extract is at least one selected from a monohydric alcohol, a polyhydric alcohol or a derivative thereof, a ketone, an ester, an ether, a petroleum ether, an aliphatic hydrocarbon or a halide thereof, and an aromatic hydrocarbon. 4. A hair restorer raw material according to claim 3, wherein the extract is an extract obtained by using an anhydrous or aqueous organic solvent.

A fifth aspect of the present invention is a hair restorer, which is a cosmetic, pharmaceutical or quasi-drug containing at least one of the hair restorer raw materials according to the first to fourth aspects. Composition.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The raw materials for a hair restorer according to the present invention include smelt (Clerodendron trichotomum Thunb.) And Nothopanax scutellarium Me.
r.), Kukinoki (Aleurites moluccana Willd.), Kajupute (Melaleuca leucadendra L.), Tsurugumi (Elae)
agnus glabra Thunb.).

[0009] Egret (Clerodendron trichotomum Thun)
b.) is from 1 m to several meters in height belonging to the genus Egret
Is a deciduous shrub, mainly distributed in Japan, China and Korea.
It is often found on the roadsides of Yamano and the edges of forests. Nothopanax scutellarium Mer.
Is a shrub or shrub with a height of 1.5 to 4 m, and is mainly cultivated in the Javanese lowland of Indonesia.

Kukunoki (Aleurites moluccana Will)
d.) is a sub-tree of the Euphorbiaceae family, widely cultivated in China and Taiwan, and the seed shell is used for crafts.
Cajupte (Melaleuca leucadendra L.) is an evergreen tree with a height of 10 to 20 m belonging to the genus Kobanobrassinoki, which is distributed from Malaysia to northern Australia. Tsurumi (Elaeagnus glabra Thunb.) Is a vine evergreen shrub belonging to the family Gumicaceae, 1.5 to 2 m in height, and is distributed in the mountainous region west of central Honshu.

In the present invention, all parts of the above-mentioned plant, above and below the plant, can be used.
Each part such as a fruit part, a flower part, a leaf part and a stem part may be used alone or in combination. Further, both those in a dry state and those in a non-dry state are suitably used.

The form of use of the above-mentioned plants is not particularly limited, and pulverized or dried powders of the plants may be used as raw materials for hair growth agents as they are. In addition, among the above-mentioned five kinds of plants, Japanese cypress (Al
eurites moluccana Willd.), since Kukui nut oil, which is a drying oil obtained from its seeds, has a particularly excellent hair-growth effect. it can.

The Kukui nut oil is a light yellow transparent liquid, and has been used in Hawaii since ancient times to relieve pain and inflammation caused by sunburn, and is still used as a medicine, a skin rejuvenating agent and a body care oil. In addition, it has the effect of penetrating well into the skin to moisturize the skin and soften dry skin, and also has the effect of relieving damage caused by ultraviolet rays, and is used for cosmetic oils, creams, emulsions, sun care products, makeup cosmetics, etc. In addition to cosmetics for hair, it is also used for cosmetics for hair such as hair treatment and shampoo. Furthermore, since it contains as much as 70% of essential fatty acids, it is also used as an oil material for health foods.

The composition of this kukunut oil is a triglyceride containing unsaturated fatty acids such as oleic acid, linoleic acid and linolenic acid as a main component, and is commercially available as NIKKOL kukunut oil (Nikko Chemical Co., Ltd.). Kukui nut oil is highly safe and has an LD ₅₀ of 16
g / kg or more (oral), no primary skin irritation and no eye irritation.

In the present invention, extracts of the above-mentioned five kinds of plants can be used as raw materials for hair growth agents. Further, the extracts obtained by concentrating and drying can be used as soft extracts and dried extracts. it can.

When the extract is used as a hair restorer raw material, the solvent to be used is not particularly limited. Anhydrous or hydrated organic solvents, particularly monohydric alcohols, polyhydric alcohols or derivatives thereof, ketones, esters, ethers, petroleum ethers, It is preferable to use an anhydrous or water-containing organic solvent containing at least one selected from aliphatic hydrocarbons, halides thereof, and aromatic hydrocarbons, since a hair-growth effect is sufficiently exhibited, and thus it is preferable. Specifically, methanol, ethanol, isopropyl alcohol, n-propyl alcohol, isobutanol, n
A monohydric alcohol having 1 to 8 carbon atoms such as hexanol, methyl amyl alcohol, 2-ethyl butanol, n-octanol, ethylene glycol, propylene glycol, 1,3-butylene glycol, hexylene glycol, ethylene glycol monomethyl ether, ethylene Polyhydric alcohols having 2 to 6 carbon atoms such as glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether or derivatives thereof, acetone, methyl acetone, ethyl methyl ketone, isobutyl methyl ketone, methyl-n-propyl ketone, etc. C4-6 ester such as ketone having 3-6 carbon atoms, ethyl acetate and isopropyl acetate, ether having 4-8 carbon atoms such as ethyl ether, isopropyl ether and n-butyl ether; And petroleum ether, n- butane, n
-Carbon number 4 such as pentane, n-hexane, n-octane, etc.
Of aliphatic hydrocarbons having 1 to 2 carbon atoms, such as aliphatic hydrocarbons having 8 to 8 carbon atoms, carbon tetrachloride, chloroform, dichloroethane, and trichloroethylene, and aromatic hydrocarbons having 6 to 7 carbon atoms such as benzene and toluene. Preferred examples include anhydrous or water-containing organic solvents containing one or more of the above.

The extract obtained by distilling off the solvent from the extract obtained with the above-mentioned extraction solvent can be used as a raw material for a hair growth agent. Because of high safety, it can be used as a hair restorer raw material without distilling off the solvent from the extract.

The hair restorer composition according to the present invention contains one or more of the above hair restorer raw materials. The amount of the hair restorer raw material is not particularly limited, but if the amount is too small, the effect of the hair restorer raw material combination will not be sufficiently exerted.
The content is desirably from 0.01 to 100% by weight, and it is also possible to use only a plant dry powder, cucumber oil, or a plant extract as a hair restorer composition.

In the hair restorer composition according to the present invention, besides the above hair restorer raw materials, as a hair restorer / hair restorer component, for example, vitamin E and its derivatives, assembly extract, garlic extract, cepharanthin, carpronium chloride, acetylcholine, etc. Blood circulation promoter, local stimulants such as tincture tincture, tincture tincture, ginger tincture, vanillamide nonylate, keratolytic agents such as salicylic acid, resorcinol and lactic acid, placenta extract, glyceride pentadecanoate, pantothenyl ethyl ether, biotin, hinokitiol , Allantoin and other metabolic activators, anti-inflammatory agents such as glycyrrhizic acid and glycyrrhetinic acid, bactericides such as isopropylmethylphenol, triclosan, zinc pyrithione, hinokitiol, fresheners such as menthol and camphor, and other female hormones It can be appropriately blended.

Further, as long as the effects of the present invention are not impaired,
Alcohol, polyhydric alcohol, water-soluble polymer, antioxidant, pH adjuster, UV inhibitor, sequestering agent, thickener, surfactant, purified water, fragrance, preservative, antibacterial, oil Ordinary cosmetic ingredients such as, higher fatty acids, fatty acid esters, humectants, fresheners, pigments, or hormones, vitamins, amino acids, astringents and placental extracts, elastin, collagen, mucopolysaccharides, aloe extracts, loofah water,
Royal jelly, birch, carrot extract, chamomile extract, licorice extract, salvia extract, altea extract,
Specially formulated components such as animal and plant extracts, including crude drug components such as Yarrow Extract, may be appropriately blended according to the purpose.

The hair restorer composition according to the present invention is used for cosmetics,
It can be used as a quasi-drug or a pharmaceutical, for example, it can be used as a hair tonic, a hair cream, or a hair treatment.

[0022]

[Test Example: Hair Restoring Effect of Extract]

Example 1 Dried Heron (Clerodendron trichotom)
um Thunb.) 100% crushed leaf and 70% ethanol 5
Add 100 ml and immerse and extract for 7 days.
The solvent was distilled off to obtain 15.5 g of an extract. 99% ethanol was added to 1.5 g of this extract to make the total amount 30 ml, thereby obtaining a sample solution of Example 1.

Example 2 500 g of methanol was added to 100 g of ground leaf of dried Nothopanax scutellarium Mer., And the mixture was refluxed and extracted for 2 hours. The extract was filtered and the solvent was distilled off. Thing 1
3.5 g were obtained. 99% ethanol was added to 1.5 g of this extract to make the total amount 30 ml, thereby obtaining a sample solution of Example 2.

(Example 3) Dried Japanese cypress (Aleuri)
(tes moluccana Willd.) was added with 100 ml of chloroform and extracted with reflux for 2 hours. The extract was filtered and the solvent was distilled off to obtain 41.1 g of extract. 0.18 g of polyoxyethylene hydrogenated castor oil (HC50) was added to 1.5 g of this extract, and then 99% ethanol was added to make a total volume of 30 ml. Thus, a sample solution of Example 3 was obtained.

Example 4 Dried Caeupte (Melaleuc)
a. leucadendra L.), 100 ml of ground leaf was added with 500 ml of methanol and refluxed for 2 hours. The extract was filtered and the solvent was distilled off to obtain 12.7 g of extract. 99% ethanol was added to 1.5 g of this extract, and the total amount was 30 ml.
The sample solution of Example 4 was obtained.

(Example 5) Dried blackberry (Elaeagnu)
s glabra Thunb.) was added to 100 g of ground leaf and 500 ml of 70% ethanol was added for immersion extraction for 7 days. The extract was filtered, and the solvent was distilled off to obtain 11.2 g of the extract. 99% ethanol was added to 1.5 g of this extract, and the total amount was 30 m.
As l, the sample solution of Example 5 was obtained.

Comparative Example 1 30 ml of 99% ethanol was used as a sample solution of Comparative Example 1.

[Test Method] C3H / HeN Crj mice (8 weeks old, body weight: 21 to 26 g) were acclimated and bred for at least one week, and if there were no abnormalities, the back hair was covered with an electric hair clipper at 2 cm × Sheared to 4cm area,
Furthermore, the hair was removed by an electric shaver to obtain a sample solution administration site. Three days after hair removal, the sample solutions of Examples 1 to 5 and Comparative Example 1 were applied to 10 mice each for 19 consecutive days.
0 μl was applied once a day in the morning. During the test period,
C3H / HeN Crj mice were cultured in a plastic cage (14.5 cm ×) in a breeding room with a temperature of 22 ± 2 ° C., a relative humidity of 55 ± 15%, a ventilation rate of 20 times / hour, and an irradiation time of 6:00 am to 6:00 pm. (26 cm x 12.5 cm).

The state of the sample application site was periodically observed, scored according to the following evaluation criteria, and the average score of 10 animals was calculated. Skin turns pink ... 0 point Skin changes to gray (less than 100%) ... 1 point Skin changes to gray (100%) ... 2 points Hair changes to brown (less than 100%) ... 3 points Hair growth Changes to brown (100%) ... 4 points Hair growth changes to black ... 5 points

The results are shown in Table 1.

[Table 1]

[Test Example; Hair Growth Effect of Kukui Nut Oil]
30 ml of Kukui nut oil obtained by squeezing the seeds of Kukuinoki (Aleurites moluccana Willd.) Was used as the sample solution of Example 6, and this Kukui nut oil and polyoxyethylene hydrogenated castor oil (HC50) were added to 99% ethanol. The sample solution of Example 7 was used. Example 7
In, the concentration of kukui nut oil was adjusted to 5%, and the concentration of polyoxyethylene hydrogenated castor oil (HC50) was adjusted to 0.7%. 30 ml of 99% ethanol was used as the sample solution of Comparative Example 2.

The hair growth effect of Kukui nut oil was examined in the same manner as in the above Test Example. Table 2 shows the results.

[Table 2]

From the results of Tables 1 and 2, it can be seen that
endron trichotomum Thunb.), Notopanax scutellarium Mer., Kukinoki (Aleurites moluccana Willd.), Cayupte (Melale)
uca leucadendra L.) and thrush (Elaeagnus glabra)
Thunb.) Extract, and also Kukui nut oil have an excellent hair-growth effect.

The following is a formulation example of a hair restorer composition containing the hair restorer raw material according to the present invention.

(Formulation Example 2) Hair restorer compounding ratio (% by weight) Notopanax scutellarium extract obtained in Example 2 5.0 Tocopherol acetate 0.1 Pantothenyl alcohol 0.2 Dipotassium glycyrrhizinate 0.1 Kina extract 0 .5 polyoxyethylene (EO60) hydrogenated castor oil 0.3 perfume 0.1 propylene glycol 2.0 ethanol 60.0 purified water balance part total 100.0

[0036]

[0037] Propellant mix ratio (% by weight) LPG (20 ° C, 1.5 kg / cm ² ) 86.2 Nitrogen 13.8 total 100.0 Stock solution 97.11 Propellant 2.89 total 100.0

[0038] Propellant mix ratio (% by weight) LPG (20 ° C, 1.5 kg / cm ² ) 86.2 Nitrogen 13.8 total 100.0 Stock solution 97.11 Propellant 2.89 total 100.0

[0039]

[0040]

As has been described in detail above, the invention according to claim 1 is based on the followings: a heron (Clerodendron trichotomum Thunb.), A notopanax scutellarium (Nothopanax scutellariu)
m Mer.), Kukunoki (Aleurites moluccana Will)
d.), a hair restorer material characterized by comprising at least one of Cayupte (Melaleuca leucadendra L.) and Tsurugumi (Elaeagnus glabra Thunb.). The invention according to claim 2, wherein the invention relates to the aleurites molucc
ana Willd.) is a kuku nut oil obtained by squeezing the seeds thereof, so that it has an excellent hair-growth effect. In addition, since it is derived from natural products, it has an excellent effect of being safe without causing an allergic reaction to the scalp.

According to a third aspect of the present invention, a hare (Cler
odendron trichotomum Thunb.), Nothopanax scutellarium Mer., Kukinoki (Aleurites moluccana Willd.), Cajupte (Mela)
leuca leucadendra L.) or Tsurugumi (Elaeagnus gl)
abra Thunb.) A hair restorer raw material comprising at least one of the respective extracts.
The invention according to the above, wherein the extract is at least one selected from a monohydric alcohol, a polyhydric alcohol or a derivative thereof, a ketone, an ester, an ether, a petroleum ether, an aliphatic hydrocarbon or a halide thereof, and an aromatic hydrocarbon. 4. An extract comprising an anhydrous or water-containing organic solvent containing the same, wherein the active ingredient in a plant exhibits a hair-growing effect efficiently, because the hair-growing agent raw material according to claim 3 is used. To play.

A fifth aspect of the present invention is a hair restorer, which is a cosmetic, pharmaceutical or quasi-drug containing at least one of the hair restorer raw materials according to the first to fourth aspects. Since it relates to a composition, it has an excellent effect of having an excellent hair-growth effect and being safe without causing an allergic reaction to the scalp.

 ──────────────────────────────────────────────────続 き Continuing from the front page (72) Inventor Yoshihiro Matsuyama 5-12, Junkencho, Chuo-ku, Osaka City Inside Mandom Central Research Institute Co., Ltd. (72) Inventor Yuya Okamoto 5-12, Junkencho, Chuo-ku, Osaka City No. Mandom Central Research Laboratories Co., Ltd. No. 5-12 Inside Mandom Central Research Institute Co., Ltd. 5-12 Machi, Mandom Central Research Laboratory Co., Ltd.

Claims (5)

[Claims] 1. A heron (Clerodendron trichotomum Thu)
nb.), Notopanax scutellarium (Nothopanax scu
tellarium Mer.), Kukunoki (Aleuritesmoluccana W)
illd.), at least one of Cajupte (Melaleuca leucadendra L.) and Tsurugumi (Elaeagnus glabra Thunb.). 2. A method according to claim 1, wherein said mulberry tree (Aleurites moluccana)
The hair restorer raw material according to claim 1, wherein Willd.) Is kukui nut oil obtained by squeezing the seed. 3. A heron (Clerodendron trichotomum Thu)
nb.), Notopanax scutellarium (Nothopanax scu
tellarium Mer.), Kukunoki (Aleuritesmoluccana W)
illd.), a hair restorer material comprising at least one of the extracts of Cajupte (Melaleuca leucadendra L.) and Tsurugumi (Elaeagnus glabra Thunb.). 4. The extract is at least one selected from a monohydric alcohol, a polyhydric alcohol or a derivative thereof, a ketone, an ester, an ether, a petroleum ether, an aliphatic hydrocarbon or a halide thereof, and an aromatic hydrocarbon. 4. A hair restorer raw material according to claim 3, wherein the extract is an anhydrous or hydrated organic solvent-containing extract. 5. A hair restorer composition comprising at least one of the hair restorer raw materials according to claims 1 to 4, which is a cosmetic, pharmaceutical or quasi-drug.