JP3490625B2 - Hair restorer raw material and hair restorer composition - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair-growth agent material and a hair-growth agent composition, and an object thereof is to have an excellent hair-growth effect and to have a safety without causing unfavorable irritation to the scalp. It is intended to provide a high hair growth material and a hair growth composition.

[0002]

2. Description of the Related Art Conventionally, many hair cosmetics, pharmaceuticals, and quasi-drugs used for the purpose of hair growth and hair nourishment have been created. Expands blood vessels, promotes blood circulation, and further stimulates the papilla to promote hair production, hair-growth ingredients, ingredients that give a refreshing feeling, ingredients that have a bactericidal action, ingredients that prevent dandruff and itchiness, etc. There is. Specifically, as a hair growth ingredient, female hormone, vitamin E, pantothenic acid, capsicum tincture,
Ginseng tincture, cembran extract, cepharanthine, photosensitizer, etc. give a refreshing sensation, ethanol as a component having a bactericidal action, anti-dandruff components such as resorcin, salicylic acid, zinc pyridione, etc. There are many compounds containing histamine and the like.

[0003]

However, a hair-growth composition containing the conventional hair-growth ingredients as described above cannot provide a sufficient hair-growth effect, and also gives an unfavorable irritation to the scalp. There was a problem that sometimes.

Therefore, it has been desired to create a raw material for a hair-growth agent which has an excellent hair-growth effect and is highly safe without giving an unpleasant stimulus to the scalp. As a result of earnest research on a highly safe hair-growth ingredient derived from a product, Linacanthus, a kind of medicinal plant
It was found that Nastus (Rinacanthus nasutusu) has an excellent hair-growth effect, and that it exhibits an excellent hair-growth effect even in a small amount, and the present invention has been completed.

[0005]

[Means for Solving the Problems] That is, the invention according to claim 1 relates to Rinacanthus nasutus.
u) is not included as an active ingredient for hair growth effects.
Relates hair tonic material, characterized in that that, the invention according to claim 2, hair tonic composition, characterized in that claim 1, wherein the hair tonic material, which are contained cosmetics, pharmaceuticals, and quasi-drugs Regarding things.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, an extract of Rinacanthus nasutusu is used as a hair restorer raw material.

Rinacanthus na
sutusu) is a kind of medicinal plant belonging to the genus Rinacanthus Nees of the family Acanthaceae and is a herbaceous plant having a height of 50 to 150 cm. It is cultivated mainly in tropical Africa, India, Thailand, and Malaysia, and can be seen in the wild in these areas. This Rinacanthus nasutusu is sometimes used for appreciation, but it is also used as a folk medicine for skin diseases in India, Malaysia, and southern China, and as a cancer drug in Thailand. It is particularly widespread in Thailand and naturally scattered around the evergreen forest.
It is widely used for appreciation in general, but in the literature of Thai traditional medicine, Rinacanthus
nasutusu) is described to have various medicinal effects and is widely used as a medicinal plant. Specifically, it is said to be effective as a therapeutic drug for tinea versicolor, ringworm, skin diseases and cancer, an antipyretic drug, and an anti-snake venom drug. The stem is also used for health promotion, and the leaves are used for abscess pain. Also used as a therapeutic drug. It is also used for longevity. In addition, various studies have been conducted on the medicinal effects of extracts of Rinacanthus nasutusu. The fact that 50% alcoholic extract of whole plants has antipyretic effect, chloroform extract of branches and leaves and 95% ethanol It has already been shown that the extract has inhibitory activity against filamentous fungi. It has also been shown that 50% alcoholic extracts of whole plants are non-toxic.

In the present invention, all of the above-ground and underground parts of Rinacanthus nasutusu can be used, and even if whole grass is used, flowers, leaves, stems, roots, etc. can be used. You may use it individually or in mixture.

The solvent used for obtaining the extract is not particularly limited, but anhydrous or hydrous organic solvents are preferably used. Specifically, methanol, ethanol, isopropyl alcohol, n-propyl alcohol, isobutanol, n-hexanol, methylamyl alcohol, 2
-Ethyl butanol, n-octanol, etc. having 1 to 1 carbon atoms
8 monohydric alcohols, ethylene glycol, propylene glycol, 1,3-butylene glycol, hexylene glycol, ethylene glycol monomethyl ether,
Polyhydric alcohols having 2 to 6 carbon atoms such as ethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether or derivatives thereof, acetone, methylacetone, ethylmethylketone, isobutylmethylketone, methyl-n-propylketone. Such as a ketone having 3 to 6 carbon atoms, ethyl acetate,
Esters having 4 to 5 carbon atoms such as isopropyl acetate, ethers having 4 to 8 carbon atoms such as ethyl ether, isopropyl ether, n-butyl ether, petroleum ether, n-butane, n-pentane, n-hexane, n-octane, etc. 1 to 4 carbon atoms such as aliphatic hydrocarbons, carbon tetrachloride, chloroform, dichloroethane, trichloroethylene, etc.
1 to 2 of halogenated aliphatic hydrocarbons, aromatic hydrocarbons having 6 to 7 carbon atoms such as benzene and toluene,
Alternatively, an anhydrous or water-containing organic solvent containing two or more kinds can be mentioned as a preferable example.

The hair restorer composition according to the present invention contains a hair restorer raw material comprising an extract of Rinacanthus nasutusu described above. The blending amount of the hair-growth raw material is not particularly limited, but the dry solid content of Rinacanthus nasutusu used for extraction is preferably 0.01 to 30% by weight in the entire composition. This is because if it is less than 0.01% by weight, the effect due to the blending of the hair-growth raw material is not sufficiently exerted, and if it exceeds 30% by weight, no further effect can be expected.

The hair restorer composition according to the present invention contains the following substances in addition to the above hair restorer raw materials. For example, as hair-growth and hair-growth ingredients, blood circulation promoters such as vitamin E and its derivatives, cembran extract, garlic extract, cepharanthin, carpronium chloride, acetylcholine, topical tincture tincture, canthari tincture, ginger tincture, vanillamide nonylate, etc. Stimulants, keratolytic agents such as salicylic acid, resorcin, lactic acid, placenta extract, pentadecanoic acid glyceride, metabolism enhancers such as pantothenyl ethyl ether, biotin, hinokitiol and allantoin, anti-inflammatory agents such as glycyrrhizinic acid and glycyrrhetinic acid, isopropylmethylphenol , Triclosan, zinc pyridione, hinokitiol, and other fungicides, menthol, camphor, and other cooling agents, and other female hormones are appropriately mixed.

Further, within a range that does not impair the effects of the present invention,
Alcohol, polyhydric alcohol, water-soluble polymer, antioxidant, pH adjuster, UV inhibitor, sequestering agent, thickener, surfactant, purified water, perfume, preservative, antibacterial agent, oil agent Ordinary cosmetic ingredients such as higher fatty acids, fatty acid esters, moisturizers, cooling agents, pigments, or hormones, vitamins, amino acids, astringents and placenta extracts, elastin, collagen, mucopolysaccharides, aloe extract, loofah water,
Royal jelly, birch, carrot extract, chamomile extract, licorice extract, salvia extract, altea extract,
Special blending components such as animal and plant extract components including crude drug components such as yarrow extract and the like may be appropriately blended in accordance with the purpose.

The hair restorer composition according to the present invention is a cosmetic product,
It can be used as a quasi drug or a pharmaceutical product, for example, as a hair tonic, a hair cream, or a hair treatment.

[0014]

[Test example] (Example) Rina cantus Nastus (Rinaca
nthus nasutusu) 100g of dried leaves and stems
Ethanol (500 ml) was added to the mixture and the mixture was refluxed for 2 hours. The extract was filtered and the solvent was distilled off to obtain an extract (3.8 g). 99% ethanol was added to 1.5 g of this extract to bring the total amount to 30 g.
What was made into ml was made into the sample solution of the Example.

Comparative Example 30 ml of 99% ethanol was added to
It was used as the sample solution of the comparative example.

[Test Method] C3H / HeN Crj mice (7 weeks old, weight 21-27 g) were acclimated and bred for about one week. The hair was shaved to a size of about 3 cm × 6 cm, and the hair was further removed using a razor to make a site for administration of the sample solution. Ten mice were set as one group, and three days after the hair was removed, the sample solutions of the Examples and Comparative Examples were applied to the mice of each group for 100 days in the morning once a day at 100 μl each for 18 consecutive days. During the test period, the mice are at a temperature of 20-26.
C, humidity 40-70%, ventilation frequency 12 times / hour, irradiation time was set from 6:00 am to 6:00 pm, in a cage made of plastic (14.5 cm x 26 cm x 12.5 c
m) was used for breeding. For the feeding, solid feed (MF, manufactured by Oriental Yeast Co., Ltd.) and drinking water were tap water freely.

On the first day, the fifth day after application, and every two days thereafter, 1
The degree of hair growth was visually observed until the 9th day. Scores were assigned according to the following evaluation criteria, and the average value ± standard deviation of 10 animals was calculated. The significance test was performed between the comparative examples and the risk rate of less than 5% (p <0.05) was considered significant. Test is Ma
The nn-Whitney test was used. Skin is pink ... 0 points Skin changes to gray (less than 100%) 1 point Skin changes to gray (100%) 2 points Hair changes to brown (less than 100%) 3 points Hair growth Changes to brown (100%) ... 4 points Hair changes to black ... 5 points

The results are shown in Table 1.

[Table 1]

As is clear from the results in Table 1, the group of mice to which the extract of Rinacanthus nasutusu was applied had a higher score than that of Comparative Example from the 13th day after application, and the Linacanthus It can be seen that Nastus (Rinacanthus nasutusu) has excellent hair growth activity.

The following is an example of prescription of a hair restorer composition containing the hair restorer raw material according to the present invention. (Formulation Example 1) Blending ratio of hair-growth agent (wt%) Linacanthus natustus ethanol extract obtained in Example 5.0 Tocopherol acetate 0.1 Pantothenyl alcohol 0.2 Nicotinamide 0.1 Hinokitiol 0.05 Poly Oxyethylene (EO60) Hydrogenated castor oil 0.3 Perfume 0.1 1,3-Butanediol 2.0 Ethanol 55.0 Purified water Residual total 100.0

(Formulation Example 2) Blending ratio of hair-growth agent (% by weight) Linacanthus natusus ethanol extract obtained in Example 5.0 Tocopherol acetate 0.1 Pantothenyl alcohol 0.2 Dipotassium glycyrrhizinate 0.1 Quina extract 0 .5 Hinokitiol 0.05 Polyoxyethylene (EO60) hydrogenated castor oil 0.3 Fragrance 0.1 Propylene glycol 5.0 Ethanol 60.0 Purified water Residual total 100.0

[0022] (Formulation Example 3) aerosol hair tonic stock blending ratio (wt%) ethanol extract 5.0 Cepharanthin 0.002 glycyrrhizic acid Rinakantsusu Nasutsusu obtained in Example dipotassium 0.1 cinchona 1.0 Glycerin 1 0.0 Polyoxyethylene (EO60) hydrogenated castor oil 0.2 Fragrance 0.05 Ethanol 65.0 Purified water balance 100.0 Propellant blending ratio (wt%) LPG (20 ° C, 1.5kg / cm ² ) 86.2 Nitrogen 13.8 Total 100.0 Stock solution 97.11 Propellant 2.89 Total 100.0

[0023]

As described above in detail, the invention according to claim 1 is the Rinacanthus nasutusu.
The present invention relates to a hair-growth agent raw material characterized in that the extract is blended as an active ingredient for a hair-growth effect, and therefore it has an excellent hair-growth effect even at low concentrations. Further, since it is derived from a natural product, it has an effect of being excellent in safety.

The invention according to claim 2 relates to a hair restorer composition characterized in that it is a cosmetic, a pharmaceutical product, or a quasi drug containing the hair restorer raw material according to claim 1. It has an excellent effect that it has a high hair-growth effect and that it is highly safe without giving an unpleasant stimulus to the scalp.

─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Nobunori Fujiwara 5-12 Juugencho, Chuo-ku, Osaka City Mandom Central Research Institute Co., Ltd. (72) Inventor, Nisiri Luang Lansi Thailand 73000 Nakhon Pathon Province Muang District Kumpil Road 8 (56) References JP 9-143025 (JP, A) JP 2000-239146 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K ^7/ 00- 7/50 CA (STN)

Claims (2)

(57) [Claims] 1. Rinacanthus
nasutusu) extract was added as an active ingredient for hair growth effect.
Hair tonic material characterized by comprising been. 2. A hair restorer composition, which is a cosmetic, a pharmaceutical product, or a quasi drug containing the hair restorer raw material according to claim 1.