JPH1121216A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition capable of sufficiently chemically removing foulings on the tooth surface by including a surfactant, a specific water-soluble polyphosphate and/or a phytate and a specified alcohol therein. SOLUTION: This composition is obtained by including (A) a surfactant (e.g. sodium lauryl sulfate), (B) a linear or a cyclic water-soluble polyphosphate represented by the formula Mn+2 Pn O3n+1 or the formula (MPO3 )m [M is Na or K; (m)>=3; (n)>=2] (e.g. sodium pyrophosphate) and/or (C) a phytate (e.g. sodium phytate) and (D) a 3-4C monohydric alcohol (e.g. propyl alcohol). The amounts of the contained ingredients based on the whole composition are preferably 0.01-7 wt.% ingredient A, 1-10 wt.% ingredient B, 0.01-10 wt.% ingredient C and 0.1-10 wt.% ingredient D.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for an oral cavity which has a high effect of chemically cleaning tooth surfaces and an excellent whitening effect on teeth surfaces.

[0002]

2. Description of the Related Art
Stains, plaques, food debris attached or deposited on the tooth surface,
Background Art Dirt on tooth surfaces such as cigarette tar is removed by mechanical action of an abrasive compounded in a dentifrice.
The properties required for the abrasive include a high cleaning effect on the tooth surface and a low wear on the tooth surface. In general dentifrice compositions, inorganic powders such as calcium phosphate and calcium carbonate are compounded as abrasives. It was inevitable that they would wear.

In recent years, the following proposals have been made to remove dirt on the tooth surface not by mechanical action but by chemical action. However, these effects are not sufficient, and the tooth face is not satisfactory. At present, most of the removal of dirt depends on mechanical action. (1) An oral composition containing a specific organic peroxide (US Pat. No. 3,988,433). (2) An oral composition using a combination of a cationic surfactant and malic acid (US Pat. No. 4,183,916). (3) An oral composition containing an ester having an aromatic ring (Japanese Patent Publication No. 48-43869). (4) An oral composition containing a chelating agent having a stability coefficient of Fe> Ca (Japanese Patent Laid-Open No. 51-139,939). (5) An oral composition using a combination of a polyphosphate and a polyvalent metal cation (JP-A-52-108029). (6) An oral composition using phytic acid and an organic acid in combination (JP-A-56-18911). (7) tartronic acid, glyceric acid, hydroxy-n-
An oral composition containing butyric acid and dihydroxymalonic acid (JP-A-60-4117). (8) A composition for oral cavity using a combination of carvone, anethole or 3-octanol and a solvent extract of a botanical genus plant (JP-A-61-286315). (9) An oral composition containing 2-octanol (JP-A-62-151498). (10) An oral composition containing a specific monoterpene (JP-A-62-181212). (11) An oral composition containing an aliphatic ester having a total carbon number of 7 to 11 (JP-A-62-189233). (12) An oral composition containing citric acid, a polyphosphate and a nonionic surfactant (JP-A-7-126131). (13) Oral composition containing polyphosphate, orthophosphate and anionic surfactant (JP-A-9-12437)
No.). (14) An oral composition containing a polyphosphate, an orthophosphate and an amphoteric surfactant (JP-A-9-12438).

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an oral composition capable of sufficiently and satisfactorily removing dirt on tooth surfaces.

[0005]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to achieve the above object, and as a result, the following composition represented by the following general formula (1) was added to an oral composition containing a surfactant. Or (2) M _{n + 2} P _n O _{3n + 1} (1) (MPO ₃ ) _m (2) (where M represents Na or K, m is 3 or more, and n is an integer of 2 or more. ) Is combined with a linear or cyclic water-soluble polyphosphate and / or phytate and a monohydric alcohol having 3 or 4 carbon atoms to chemically remove stains on the tooth surface. This significantly increases the ability to remove stains such as stains, plaque, food debris, and tobacco tar that have adhered or settled on the tooth surface by chemical action with a small number of brushing cycles. An oral group with excellent tooth whitening effect that can be cleaned And it found that the object can be obtained, leading to completion of the present invention.

[0006] Accordingly, the present invention provides a composition for oral cavity containing a surfactant, which comprises a linear or cyclic water-soluble polyphosphate and / or phytate represented by the above general formula (1) or (2). And one or two monohydric alcohols having 3 or 4 carbon atoms
Provided is a composition for oral cavity which is characterized by being combined with at least one species.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention comprises, as described above, a surfactant, a water-soluble polyphosphate and / or a phytate and a monovalent having 3 or 4 carbon atoms. It is obtained by combining with alcohol.

The surfactant used in the present invention may be any surfactant which can be used in the oral cavity, and anionic, cationic, amphoteric and nonionic surfactants are preferably used. As the surfactant, anionic surfactants are preferable among them, and specifically, a sulfate ester type represented by sodium lauryl sulfate, a sulfonic acid type represented by sodium dodecylbenzenesulfonate and sodium lauroylmethyltaurine, A carboxylic acid type represented by sodium N-lauroyl sarcosine and deoxycholic acid, a phosphate type represented by sodium myristyl phosphate and the like are suitably used. Examples of the amphoteric surfactant include an amino acid type represented by N-lauryl-diaminoethylglycine, a betaine type represented by lauryldimethylaminoacetic acid betaine, a sulfobetaine type represented by lauryldimethylaminopropanesulfonate, and a 2-alkyl group. -N-carboxymethyl-
An imidazoline type represented by N-hydroxyethylimidazolinium betaine is exemplified. Further, nonionic surfactants can also be suitably used, such as sugar fatty acid esters represented by sucrose fatty acid esters, polyoxyethylene sorbitan fatty acid esters represented by polyoxyethylene sorbitan monolaurate, and polyoxyethylene cured castors. Polyoxyethylene fatty acid ester represented by oil, fatty acid mono- or diethanolamide represented by lauric acid mono- or diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, poly Oxyethylene polyoxypropylene fatty acid esters and the like can be mentioned. The surfactant preferably has an alkyl chain length of 8 to 18.

The amount of the surfactant is preferably 0.01 to 7% by weight, more preferably 0.1 to 5% by weight, based on the whole composition. If the amount is less than 0.01% by weight, a sufficient soil cleaning effect may not be obtained, and if it exceeds 7% by weight, the stability of the preparation may be adversely affected.

The water-soluble polyphosphate used in the present invention is represented by the following general formula (1): M _{n + 2} P _n O _{3n + 1} (1) (where M represents Na or K and n ≧ 2) For example, sodium pyrophosphate, potassium pyrophosphate having a polymerization degree of n = 2, sodium tripolyphosphate having n = 3, potassium tripolyphosphate, sodium tetrapolyphosphate having n = 4, potassium tetrapolyphosphate, and the like. Linear polyphosphates such as sodium metaphosphate and potassium metaphosphate having a degree of polymerization, and the following general formula (2) (MPO ₃ ) _m (2) (where M represents Na or K and m ≧ 3 ), For example, sodium trimetaphosphate, potassium trimetaphosphate having a degree of polymerization m = 3, sodium tetrametaphosphate, potassium tetrametaphosphate having m = 4, and m = 6.
Cyclic polyphosphates such as sodium hexametaphosphate and potassium hexametaphosphate are used.

These polyphosphates may be used alone or as a mixture of two or more. Among them, linear polyphosphates are preferred.

The amount of the polyphosphate in the oral composition of the present invention is preferably 1 to 10% by weight, more preferably 3 to 7% by weight, based on the whole composition. If the compounding amount is less than 1% by weight, a sufficient stain cleaning effect cannot be obtained even when used in combination with the surfactant or alcohol of the present invention, and the object of the present invention may not be achieved. If it exceeds, the taste may deteriorate.

The phytate used in the present invention is obtained by adjusting the pH of phytic acid extracted and treated mainly from grains or plant seeds with a basic substance such as an alkali metal hydroxide or ammonia. Can be obtained by

The amount of the phytate is preferably 0.01 to 10% by weight, more preferably 0.02 to 5% by weight, based on the whole composition. May not be obtained, if more than 10% by weight taste,
The appearance may be adversely affected.

In the present invention, one or more selected from the above polyphosphates and phytates are blended. The polyphosphate or phytate alone or the combination of polyphosphate and phytate is used. May be blended.

The alcohol used in the present invention is selected from monohydric alcohols having 3 or 4 carbon atoms, and propyl alcohol, isopropyl alcohol, isobutyl alcohol and tert-butyl alcohol are preferably used.

The amount of the alcohol in the oral composition of the present invention is preferably 0.1 to 10% by weight, more preferably 0.5 to 5% by weight, and preferably 0.1% by weight, based on the whole composition. If not, a sufficient stain removing effect may not be exhibited, and if it exceeds 10% by weight, taste may be deteriorated.

The composition for oral cavity of the present invention can be prepared and applied as a dentifrice such as toothpaste and an oral cleansing agent such as mouthwash, mouthwash, mucous membrane / tongue cleaner and denture cleaner. In this case, an appropriate component according to the type of the oral composition can be blended as another optional component. For example, in the case of toothpaste, abrasives, binders, thickeners,
A sweetener, a preservative, a flavor, various active ingredients, and the like can be mixed with water and produced according to a conventional method.

Specific examples of the abrasive include crystalline silica, amorphous silica, other silica-based abrasives, aluminosilicate, aluminum oxide, aluminum hydroxide, insoluble sodium metaphosphate, insoluble potassium metaphosphate, and titanium oxide. , Synthetic resin and the like are suitably used as necessary.

The above abrasives may be used alone or in combination of two or more, and the amount of the abrasive may be usually 3 to 90% by weight. In addition, since the composition of the present invention has a high chemical cleaning effect, it is possible to further reduce the amount of the abrasive compounded.

Examples of the binder include cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose and sodium carboxymethylhydroxyethylcellulose.
Alkaline metal alginate such as sodium alginate, propylene glycol alginate, gums such as xanthan gum, tragacanth gum, karaya gum, gum arabic, synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, gelling properties One or more kinds of inorganic binders such as silica, gelling aluminum silica, veegum, and laponite may be blended (the blending amount is usually 0.5 to 10% by weight). As the thickener, one or two or more of sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylit, maltitol, lactit and the like can be blended (the blending amount is usually 1 to 50% by weight). As a sweetener,
Saccharin sodium, stevioside, xylitol, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatyl phenylalanine methyl ester, p-methoxycinnamic aldehyde, sucrose, lactose, fructose, sodium cyclamate, etc. Benzoic acid, p-hydroxyethyl benzoic acid,
Wintergreen oil, spearmint oil, peppermint oil, sassafras oil, T-shaped oil, eucalyptus oil, etc. can be blended as a flavor, such as p-hydroxypropyl benzoic acid, p-hydroxybutyl benzoic acid, sodium benzoate, lower fatty acid monoglyceride and the like. .
In addition, gelatin, peptone, arginine hydrochloride, albumin, whitening agents, silicone, pigments, and other components can be added. Furthermore, epsilon aminocaproic acid, tranexamic acid, dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme, enzymes such as lytec enzyme, sodium monofluorophosphate, alkali metal monofluorophosphate such as potassium monofluorophosphate, Sodium fluoride, fluorides such as ammonium fluoride, chlorhexidine salts, dihydrocholesterol, glycyrrhetin salts, glycyrrhetinic acid,
One or more active ingredients such as chlorophyll, caropeptides, vitamins, antiplaque agents, antibacterial agents, and hypersensitivity desensitizers such as potassium nitrate may be blended.

[0022]

The oral composition according to the present invention is capable of effectively removing stains on tooth surfaces such as stains, plaques, cigarette tars, etc. by chemical action, and also cleaning parts that cannot be reached by the brush. It has a remarkably high chemical cleaning effect in the oral cavity, and has an excellent tooth whitening effect. Further, since such a chemical cleaning effect is high, the amount of the abrasive can be reduced when preparing a dentifrice.

[0023]

EXAMPLES The present invention will be specifically described below with reference to experimental examples and examples, but the present invention is not limited to the following examples. In the following examples,% indicates% by weight.

[Experimental Example 1] A hydroxyapatite disk (HA plate (the same applies hereinafter), manufactured by Asahi Optical Co., Ltd., φ7 × 3 mm) was fixed to a mouthpiece, and was placed in the oral cavity (mandibular tongue side) to form an HA plate. A pellicle was formed on the top. This was placed in an apparatus for alternately immersing it in a stain solution and drying in the air, and operated for 24 hours to deposit stain on the surface of the HA plate. The composition of the stain solution is as follows. Stain solution composition Ferrous chloride n-hydrate 0.05% Instant coffee 0.37% Instant black tea 0.37% The above stain-attached HA plate was added to the sample solution shown in Table 1 for 5%.
10 minutes after soaking for 5 minutes and performing reciprocal brushing 5 times
The stained pellicle was stained with a phloxine solution, and the color difference (Lab color system) was measured. This removal operation (immersion → brushing → color difference measurement) was repeated until the stain was completely removed (until the color difference of the HA plate became equal to that before the stain was attached). The smaller the number of times of brushing, the higher the chemical removal power, and the evaluation was made according to the following criteria. Table 1 shows the results
Shown in Evaluation criteria for brushing ○: Number of times of brushing less than 35 times Δ: Number of times of brushing 35 to less than 50 times ×: Number of times of brushing 50 or more From the results in Table 1, the composition of the present invention has a specific chemical cleaning power of stain. It was found to improve.

[0025]

[Table 1]

Example 1 Toothpaste Precipitable Silica 20.0% Propylene Glycol 3.0 Sorbite 20.0 Sodium Carboxymethyl Cellulose 1.4 Sodium Saccharin 0.1 Stevioside 0.1 Potassium Glycyrrhizinate 1.0 Sodium Lauryl Sulfate 1. 5 Tranexamic acid 0.05 α-alumina anhydride 3.0 Colloidal silica 3.0 Methylparaben 0.05 Fragrance 1.0 Tetrasodium pyrophosphate 5.0 Isopropyl alcohol 3.0 Water Residue 100.0%

Example 2 Toothpaste Modified Aluminum Hydroxide 8.0% Propylene Glycol 2.0 Glycerin 20.0 Sodium Hydroxyethylcellulose 1.4 Saccharin Sodium 0.1 Sodium Lauryl Sulfate 0.5 Sodium Lauryl POE Sulfate 0.5 Colloidal silica 3.0 Sodium monofluorophosphate 0.76 Chlorhexidine gluconate 0.1 Methylparaben 0.05 Fragrance 1.0 Tetrasodium pyrophosphate 2.0 Sodium tetrapolyphosphate 2.0 Propyl alcohol 5.0 Water Balance 100.0%

Example 3 Toothpaste Silicic Anhydride 10.0% Titanium Oxide 0.5 Carboxymethylcellulose Sodium 1.1 Carrageenan 0.2 Sodium Lauryl Sulfate 1.4 Sorvit 20.0 Glycerin 20.0 Propylene Glycol 3.0 Methylparaben 0.05 Saccharin sodium 0.15 Fragrance 1.0 Sodium phytate 5.0 Isobutyl alcohol 4.0 Water Balance 100.0%

Example 4 Liquid Toothpaste 10.0% Silicic Anhydride 60% Sorbitol 25.0 Glycerin 25.0 Propylene Glycol 5.0 Xanthan Gum 0.2 N-Lauroyl Glutamate 0.5 Sodium Lauryl Sulfate 0. 5 Carrageenan 0.5 Alginic acid 1.0 Sodium fluoride 0.22 Dextranase (1 million U / g) 0.5 Saccharin sodium 0.1 Fragrance 1.0 Sodium tripolyphosphate 3.0 Tert-butyl alcohol 3.0 Water 100.0% remaining

Example 5 Dental Cream Sorbit 20.0% Propylene Glycol 3.0 Sodium Carboxymethyl Cellulose 1.1 Sucrose Monolaurate 1.0 Sodium Parahydroxybenzoate 0.1 Sodium Saccharin 0.1 Perfume 0.8 Tetra Sodium polyphosphate 5.0 Isobutyl alcohol 4.0 Water Balance 100.0%

Example 6 Dental Cream Sorbit 20.0% Propylene Glycol 2.5 Sodium Carboxymethyl Cellulose 2.5 Sodium Lauryl Sulfate 1.0 Sodium Paraoxybenzoate 0.1 Sodium Saccharin 0.1 Perfume 0.8 Pyrophosphate 2 Disodium hydrogen 4.0 Isopropyl alcohol 2.0 Isobutyl alcohol 1.0 Water Balance 100.0%

Claims (1)

[Claims] 1. An oral composition containing a surfactant is added to the following general formula (1) or (2): M _{n + 2} P _n O _{3n + 1} (1) (MPO ₃ ) _m (2) (provided that M represents Na or K, m is an integer of 3 or more, and n is an integer of 2 or more.) And a water-soluble linear or cyclic polyphosphate and / or phytate having 3 or 4 carbon atoms. A composition for oral cavity, which is used in combination with one or more monohydric alcohols.