JP2013112650A - Liquid composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a liquid composition for oral cavity that has a high effect of removing an already adhered colored dirt for effectively preventing an exogenous discoloration of teeth, and has high stability.SOLUTION: The liquid composition for oral cavity includes the following components (A), (B) and (C): (A) 0.02-0.5 mass% of acyl sarcosine or its salt; (B) 0.5-5 mass% of polyphosphoric acid or its salt; and (C) 75-95 mass% of water. The liquid composition does not include sulfate or its salt as an anionic surfactant, or its content is 0.001 mass% or less. The mass ratio (B/A) between the contents of the component (A) and the component (B) is 2-50.

Description

  The present invention relates to a liquid oral composition.

  In addition to intrinsic coloring that colors due to aging, trauma, etc., human teeth are colored by tartar, plaque, or customary food and drink such as tea, oil, tobacco, etc. There is extrinsic coloring to which coloring dirt adheres. For the purpose of preventing such exogenous coloring, Patent Document 1 discloses a liquid oral composition containing polyphosphoric acid or a salt thereof and an acyl taurine salt, and Patent Document 2 discloses polyphosphoric acid or a salt thereof. In addition, liquid oral compositions containing disaccharides, malic acid and the like are disclosed, and by applying these, coloring stains are prevented from adhering to the tooth surface.

  On the other hand, in preventing exogenous coloring, it is more effective not only to prevent the adhesion of colored stains but also to remove the colored stains already attached. Discloses a dentifrice composition containing granular zeolite and polyphosphoric acid, an amphoteric surfactant, and an anionic surfactant.

JP 2009-051734 A JP 2005-343794 A JP 2006-116222 A

  However, in the case of the dentifrice composition described in Patent Document 3, since colored stains are removed by an additive effect with the brushing action, there is a possibility that the effect of removing the portion where the brush does not reach may be insufficient. Moreover, even when a liquid oral composition that does not require brushing is produced by simply increasing the proportion of moisture based on the prescription of the dentifrice composition disclosed in the document, precipitates are produced at low temperatures. May form or may become cloudy due to precipitates. On the other hand, if it is a composition for liquid oral cavity described in Patent Documents 1 and 2, while exhibiting the effect of preventing coloring stains from adhering to the teeth while having good stability, it has already been achieved. There is still room for improvement with respect to the effect of removing the attached colored stains.

  Therefore, the subject of this invention is providing the composition for liquid oral cavity which is excellent in the effect (exogenous coloring removal effect) which removes the already adhering colored stain | pollution | contamination, and also has high stability.

  Therefore, the present inventor contains polyphosphoric acid or a salt thereof, and sarcosine or a salt thereof in a specific mass ratio, and adjusts the content of sulfate ester or a salt thereof, thereby causing tea astringency that causes extrinsic coloring of teeth. It has been found that a liquid composition for oral cavity can be obtained which exhibits a sufficient effect of removing various colored stains such as varnish of tobacco and tobacco, and which is excellent in stability.

That is, the present invention includes the following components (A), (B) and (C):
(A) acyl sarcosine or a salt thereof 0.02 to 0.5% by mass,
(B) polyphosphoric acid or its salt 0.5-5 mass%, and (C) water 75-95 mass%
And (D) does not contain a sulfate ester or a salt thereof as an anionic surfactant, or the content is 0.001% by mass or less,
The composition for liquid oral cavity whose mass ratio (B / A) of content of a component (B) and a component (A) is 2-50 is provided.

  According to the composition for liquid oral cavity of the present invention, it is possible to sufficiently remove not only colored stains such as tea astringents attached to teeth but also various colored stains such as tobacco stains, and at low temperatures. Combines high stability. In particular, it exhibits a remarkable removal effect (exogenous color removal effect) against colored stains that adhere to teeth due to a mixture of pigment components such as tea astringents and oily components such as food and tobacco or tobacco. Can do. Therefore, the composition for liquid oral cavity of the present invention exhibits an excellent appearance while sufficiently removing various colored stains, and can provide a good feeling of use.

Hereinafter, the present invention will be described in detail.
The composition for liquid oral cavity of the present invention contains 0.02 to 0.5% by mass of acyl sarcosine or a salt thereof (A). Acyl sarcosine or a salt thereof (A) is a kind of anionic surfactant, and this specific amount of acyl sarcosine or a salt thereof (A) and a specific amount of polyphosphoric acid or a salt thereof (B) having a specific mass ratio Combined with colored stains such as tea astringents on teeth, especially those that are mixed with multiple components of oil stains such as polyphenols and tar, such as tea astringents and food and tobacco dust. However, a sufficient removal effect can be exhibited.

  As the acyl sarcosine or a salt thereof (A), an acyl sarcosine having an acyl group derived from a saturated fatty acid or a salt thereof is preferable. As the saturated fatty acid, a saturated fatty acid having 12 to 18 carbon atoms is preferable. A saturated fatty acid having 12 to 14 carbon atoms is more preferable because it is excellent in the effect of removing colored stains such as adhering to a tooth in a mixture of a plurality of components such as cigarette or tobacco. As the acyl sarcosine or a salt thereof (A), N-acyl sarcosine or a salt thereof is preferable, and more specifically, for example, N-lauroyl sarcosine, N-myristoyl sarcosine, N-palmitoyl sarcosine, N-stearoyl sarcosine, N -One or more kinds of N-acyl sarcosine or a salt thereof (A) selected from isostearoyl sarcosine, N-oleoyl sarcosine, and salts thereof are preferable, and from N-lauroyl sarcosine salt and N-myristoyl sarcosine salt One or more selected are more preferable. Moreover, as a salt of N-acyl sarcosine salt, a sodium salt and a potassium salt are preferable, and a sodium salt is more preferable.

  The content of the acyl sarcosine or its salt (A) increases the storage stability, improves the exogenous coloring removal effect, and does not impair the filling property and refreshing feeling of the container, so that the liquid oral cavity of the present invention 0.03-0.4 mass% is preferable in a composition, 0.05-0.3 mass% is more preferable, 0.08-0.3 mass% is further more preferable.

  The liquid composition for oral cavity of the present invention contains 0.5 to 5% by mass of polyphosphoric acid or a salt thereof (B). When polyphosphoric acid or a salt thereof (B) is used alone, it does not exhibit a sufficient exogenous coloring removal effect, and in particular, a plurality of components such as tea astringents, foods and drinks, tobacco crabs and the like are mixed. Therefore, it is difficult to remove stubborn colored stains attached to the teeth. However, in the present invention, acyl sarcosine having a specific amount and a specific mass ratio or a salt thereof (A) and polyphosphoric acid or a salt thereof (B) can be combined to exert an excellent exogenous color removal effect, Even stubborn colored stains can be removed sufficiently.

  The polyphosphoric acid is preferably one or more selected from pyrophosphoric acid, tripolyphosphoric acid, tetrapolyphosphoric acid, and metaphosphoric acid, and the salt thereof is preferably a salt selected from sodium and potassium, sodium pyrophosphate, pyrophosphoric acid One or more selected from potassium, sodium tripolyphosphate, and potassium tripolyphosphate are more preferable, and one or two selected from sodium pyrophosphate and sodium tripolyphosphate are more preferable.

  The content of polyphosphoric acid or a salt thereof (B) is preferably 0.6 to 3% by mass, preferably 0.8 to 2% by mass, in the liquid oral composition of the present invention from the viewpoint of exogenous color removal effect and taste. % Is more preferable.

  In the liquid oral cavity composition of the present invention, the mass ratio (B / A) between the content of polyphosphoric acid or a salt thereof (B) and the content of acyl sarcosine or a salt thereof (A) is a taste and exogenous coloring. From the point which improves a dirt removal effect, it is 2-50, it is more preferable that it is 2.5-40, and it is further more preferable that it is 3-30. As described above, the liquid oral composition of the present invention contains the acyl sarcosine or its salt (A) and the polyphosphoric acid or its salt (B) in a specific amount and a specific mass ratio, thereby causing extrinsic coloring. Excellent exogenous not only for single colored stains, but also for composite stains with multiple colored stains attached, that is, for colored stains similar to the exogenous colored stains present on the actual tooth surface There is a color removal effect.

  The composition for liquid oral cavity of the present invention contains 75 to 95% by mass of water (C). The water (C) includes water contained in purified water and ion exchange water, as well as water contained in sorbitol water. The content of water (C) is preferably 80 to 95% by mass and more preferably 80 to 90% by mass in the liquid oral composition of the present invention from the viewpoint of dispersibility and usability.

  The composition for liquid oral cavity of the present invention does not contain or contains a sulfate ester or a salt thereof (D) as an anionic surfactant other than the component (A). % Or less. Since the sulfate ester or its salt (D) as an anionic surfactant tends to form a complex with polyphosphoric acid or its salt (B), a precipitate may be formed during storage depending on the content of the component (D). There is a possibility that the exogenous coloring removal effect may be impaired due to turbidity or white turbidity, and such a situation tends to become remarkable particularly at low temperatures. Therefore, the liquid oral composition of the present invention does not contain such a component (D) or has a content of 0.001% by mass or less, so that good storage stability can be obtained without impairing the exogenous coloring removal effect. Can demonstrate its sexuality.

  Examples of the sulfate ester (D) as the anionic surfactant include alkyl sulfate esters and polyoxyalkylenated alkyl sulfate esters. Examples of the alkyl sulfate ester salts include sodium lauryl sulfate and sodium myristyl sulfate. In the case of containing the sulfate ester or a salt thereof (D) and polyphosphoric acid or a salt thereof (B), the sulfate ester or a salt thereof (D) is more reliably prevented from forming a precipitate or clouding. It is preferable that content is 0.0001 mass% or less in the composition for liquid oral cavity of this invention.

  The liquid oral composition of the present invention preferably contains a fragrance (E) from the viewpoint of flavor and refreshment. As the fragrance (E), in addition to synthetic fragrances such as menthol, carvone, anethole, eugenol, cineol, thymol, methyl salicylate, plegon, menthone, pinene, limonene, menthyl acetate, peppermint oil, spearmint oil, mint oil, etc. Mint oil; citrus oils such as lemon, orange, grapefruit, lime; herbal oils such as eucalyptus, sage, rosemary, thyme, laurel, basil, perilla, bay, estragon, parsley, celery, coriander; cinnamon, pepper, nutmeg, Natural essential oils such as spice oil such as mace, clove, ginger, cardamom, anise; apple, banana, melon, grape, peach, strawberry, blueberry, raspberry, blackcurrant, lychee, star fruit, puff Yonfurutsu, can be used plum, pineapple, two or more selected from fruit flavors, such as Muscat. Among these fragrances, one or more kinds selected from menthol, carvone, peppermint oil, spearmint oil, peppermint oil, methyl salicylate, cineol, limonene, and pinene from the viewpoint of imparting a refreshing feeling and a refreshing feeling to the oral cavity. It preferably contains a fragrance, and preferably contains two or more in combination. It is preferable that content of a fragrance | flavor (E) is 0.05-1 mass% in the liquid oral cavity composition of this invention from the point of stability, a taste, and a flavor, 0.1-0.6 The mass% is more preferable.

  The composition for liquid oral cavity of the present invention is the total mass ratio ((B + E) / A) of the content of polyphosphoric acid or its salt (B) and the content of fragrance (E) to acyl sarcosine or its salt (A). ) Is preferably from 3 to 50, more preferably from 4 to 40, from the standpoint of exogenous color removal effect and stability. Furthermore, the mass ratio (B / E) of the content of the polyphosphoric acid or its salt (B) to the content of the fragrance (E) is 2 to 2 in terms of stability, exogenous coloring stain removal and salty taste suppression. 20 is preferable, 3 to 16 is more preferable, and 3.5 to 10 is more preferable.

  The liquid oral composition of the present invention is preferably a transparent liquid oral composition having transparency. In the present invention, having transparency means being colorless or colored, transparent or translucent, not being clouded, having no precipitate or precipitate formed therein, and specifically, an optical path length of 10 mm. In the cell (made of polystyrene), the transmittance of light having an absorption wavelength of 550 nm is preferably 80% or more, and more preferably 90% or more.

  The composition for liquid oral cavity of the present invention can contain an anionic surfactant other than acyl sarcosine or a salt thereof (A) and a sulfate ester or a salt thereof (D). Other anionic surfactants include acyl amino acids other than acyl sarcosine or salts thereof, acyl taurines or salts thereof such as sodium lauroylmethyltaurine, alkyl phosphate esters, polyoxyalkylenated alkyl phosphate esters, polyoxyalkylenated esters One or more selected from acylamino acids, amino fatty acids, and salts thereof are preferable. From the viewpoint of maintaining the filling property of the liquid oral composition into the container and the refreshing feeling during use, The content is preferably 1% by mass or less, more preferably 0.5% by mass or less, further preferably 0.1% by mass or less, or may not be contained.

  The liquid oral cavity composition of the present invention can contain a nonionic surfactant. Nonionic surfactant is polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, sucrose fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene Sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene glycol fatty acid ester, polyoxyethylene phytosterol and phytostanol, polyoxyethylene lanolin and lanolin alcohol, polyoxyethylene alkylamine and fatty acid amide, Polyoxyethylene alkylphenyl formaldehyde condensate, polyoxyethylene polyoxypropylene 1 type or 2 or more types selected from polyalkylethylene, polyoxyethylene alkylphenyl ether, polyoxyethylene alkylphenyl ether and fatty acid ethanolamide are preferable, and fatty acid esters having 8 to 20 carbon atoms of fatty acid from the viewpoint of aftertaste From the viewpoint of stability, solubility of the fragrance (E), and transparency, one or more selected from polyoxyethylene hydrogenated castor oil and polyglycerin fatty acid ester are preferred. The nonionic surfactant may not be contained, but is preferably contained in the liquid oral composition of the present invention in an amount of 0.01 to 1% by mass, and 0.02 to 0.7% by mass. Is more preferable, and it is further more preferable to contain 0.05-0.5 mass%.

  The pH of the liquid oral cavity composition of the present invention is a pH at 25 ° C., and is preferably 5.5 to 9 from the viewpoint of taste and stability.

  The liquid oral composition of the present invention preferably contains trehalose and / or glycerin from the viewpoint of further improving the taste. 0-8 mass% is preferable, as for total content of a trehalose and glycerol, 1-7 mass% is more preferable, and 2-6 mass% is further more preferable.

  The liquid oral composition of the present invention can be applied to the oral cavity as a mouthwash, a mouse spray, a coating agent, etc., and when applied to the oral cavity, it provides an exogenous color removal effect, and at a low temperature. The formation of precipitates and white turbidity are suppressed during storage, and the stability is excellent. As coloring stains that are factors of extrinsic coloring, in addition to oil and tobacco stains, green tea, black tea, oolong tea and other tea stains, and actual mixed colored stains in the oral cavity can be mentioned. High removal effect against dirt. From the viewpoint of improving such effects, the liquid oral composition of the present invention is preferably applied in the oral cavity for 30 seconds to 5 minutes, more preferably 30 seconds to 3 minutes.

  The liquid oral composition of the present invention contains, in addition to the above components, sweeteners, wetting agents, pH adjusters, ethanol, sugar alcohols, bactericides, medicinal ingredients, pigments, etc. within the range not impairing the effects of the present invention. It can contain suitably. Examples of the sweetening agent include saccharin sodium and sucralose. Other wetting agents for the above components include polyethylene glycol, propylene glycol, 1,3-butylene glycol, sorbitol and the like. Examples of the pH adjuster include malic acid, citric acid, sodium hydroxide, and potassium hydroxide. Malic acid and potassium hydroxide are preferable from the viewpoint of taste. Examples of sugar alcohols include xylitol, erythritol, and reduced palatinose. Examples of bactericides include benzethonium chloride, cetylpyridinium chloride, isopropylmethylphenol, and triclosan.

  EXAMPLES Hereinafter, although this invention is demonstrated concretely based on an Example, this invention is not limited to these Examples.

[Examples 1-8 and Comparative Examples 1-8]
According to the formulation shown in Table 1, a liquid oral composition was prepared. These liquid oral compositions were subjected to the following exogenous color removal test and storage stability test, and the taste of the composition before the storage stability test was evaluated according to the following criteria. The results are shown in Table 1.

<Exogenous color removal test>
1 Creation of Exogenous Coloring Model Hydroxyapatite pellets (APP-100 manufactured by PENTAX 1 cm × 1 cm) are polished with water-resistant abrasive paper (No. 360). This is a hydroxyapatite pellet before exogenous coloring. Next, an extract obtained by extracting hydroxyapatite pellets with 50 mL of boiling hot water with respect to one protein solution (BSA 10000 ppm solution) and one black tea (Daily Club daily club) tea bag, artificial saliva (20 mM HEPES, 1 .5 mL CaCl ₂ , 0.9 mM KH ₂ PO ₄ ) were immersed in 10 mL each for 5 minutes in order. After 10 cycles of this treatment, it was naturally dried for 3 hours. The treated hydroxyapatite pellets are placed in a sealed container (capacity 3L, made of plastic) with a suction channel and a suction channel. Two cigarettes (Peace Japan Tobacco Inc.) one by one, one end outside the container The air was sucked to such an extent that one burned out from the suction passage in about 2 minutes. As a result, when air is sucked into the sealed container from the suction path through the cigarette, the smoke of the cigarette is sucked into the container, and the smoke of the cigarette spreads into the container, but the smoke is actively discharged from the suction path. The inside of the sealed container can be filled with tobacco smoke. Immediately after the first cigarette disappeared, the second cigarette was inserted, and the inside of the sealed container was filled with cigarette smoke while sucking in the same manner. After the second cigarette was extinguished, the suction was stopped and left for 1 hour. The cigarette smoke sank below the sealed container. After leaving for 1 hour in this manner, the hydroxyapatite pellets were taken out from the sealed container to obtain hydroxyapatite pellets with tea astringent and tobacco stains attached as an exogenous coloring model.

2 Exogenous coloring removal treatment The exogenous coloring model hydroxyapatite pellets were immersed in the liquid oral composition of each Example or Comparative Example shown in Table 1 at room temperature (25 ° C.) for 30 seconds and washed with water. After that, it was naturally dried.

3. Exogenous coloring removal rate The degree of exogenous coloring was judged by the value of b * in the L * a * b * display of the hydroxyapatite pellets. b * is measured with a dental color shade eye (manufactured by Matsukaze). The b * value of the hydroxyapatite pellet before exogenous coloring is b * 0, and the b * value of the exogenous coloring model after coloring stains are attached. B * 1, the b * value of the extrinsic coloring model after performing the exogenous coloring removal treatment with the liquid oral composition of Example or Comparative Example is b * 2, and the exogenous by the following formula (1) The color removal rate was determined.
Exogenous coloring removal rate = 100 × (1- (b * 2-b * 0) / (b * 1-b * 0))
... (1)

<Storage stability test>
For storage stability, each liquid composition was stored at 5 ° C. for 1 month, and the state of the composition after storage was confirmed. Evaluation was performed according to the following criteria.
○: Transparent with no precipitates, turbidity, separation, etc.
X: Precipitation, turbidity, separation, etc. were observed.

<Evaluation of taste>
The taste was judged according to the following criteria depending on whether or not it tastes salty. Judgment was made by two expert panelists, and the following criteria were determined through consultation.
4: Does not feel salty.
3: Almost no salty taste (feels slightly).
2: Feels salty.
1: Strongly salty.

  As shown in Table 1, the liquid oral compositions of Examples 1 to 8 have a high removal rate of 70% or more against stubborn colored stains (exogenous colored stains) in which a plurality of tobacco and tea astringents are mixed. In addition, it was excellent in storage stability at low temperature, excellent in taste, and refreshing. In contrast, Comparative Examples 2, 3, 6, and 7 had a low removal rate of these colored stains, and separation or cloudiness was confirmed after low-temperature storage. Comparative Examples 1, 4, and 8 have good storage stability and taste, but the removal rate of colored stains is low. In Comparative Example 5, the removal rate of colored stains is high, but deposits of the composition were confirmed after storage. It was.

[Example 9 and Comparative Example 9]
In the same manner as in Example 1, a liquid oral composition was produced according to the formulation shown in Table 2. Next, the feeling of use was evaluated based on the filling properties of the container and the presence or absence of a refreshing feeling during use. The filling property into the container is 450 g of the produced liquid oral composition, and the discharge of a 500 mL container (made of polyethylene terephthalate, the container body is a cylinder with an elliptical cross section and a discharge port diameter of 20 mm). The shortest time required for filling without bubbles overflowing from the outlet was evaluated using 20 seconds as a reference time. The case where the filling time was longer than 20 seconds was marked as x, and the case where filling was possible within 20 seconds was marked as ◯. The evaluation results are shown in Table 2.

  As shown in Table 2, although both Example 9 and Comparative Example 9 do not feel salty, Comparative Example 9 is difficult to feel the flavor and inferior in refreshment when applied to the oral cavity. In contrast, Example 9 had a good flavor and a refreshing feeling. Further, in Comparative Example 9, the filling time of the storage container exceeded the reference time, and there was a problem in manufacturability, whereas Example 9 was able to quickly fill the storage container within the reference time. .

Claims (7)

The following components (A), (B) and (C):
(A) acyl sarcosine or a salt thereof 0.02 to 0.5% by mass,
(B) polyphosphoric acid or its salt 0.5-5 mass%, and (C) water 75-95 mass%
And (D) does not contain a sulfate ester or a salt thereof as an anionic surfactant, or the content is 0.001% by mass or less,
Liquid oral cavity composition whose mass ratio (B / A) of content of a component (B) and a component (A) is 2-50. (E) containing a fragrance,
The composition for liquid oral cavity according to claim 1, wherein the total mass ratio ((B + E) / A) of the content of the component (B) and the component (E) to the content of the component (A) is 3 to 50. . (E) contains a fragrance,
The liquid oral cavity composition according to claim 1 or 2, wherein the mass ratio (B / E) of the content of the component (B) to the content of the component (E) is 2 to 20.   The composition for liquid oral cavity according to any one of claims 1 to 3, which does not contain an anionic surfactant other than the component (A) and the component (D) or has a content of 1% by mass or less. .   pH is 5.5-9, The composition for liquid oral cavity of any one of Claims 1-4.   The composition for liquid oral cavity according to any one of claims 1 to 5, comprising glycerin and / or trehalose.   The liquid oral cavity composition of any one of Claims 1-6 which contains 0.01-1 mass% of nonionic surfactant.