JPH11209266A - Internal liquid medicine haying reduced bitterness - Google Patents

Abstract

PROBLEM TO BE SOLVED: To solve such a problem that an internal liquid medicine containing thiamine has a characteristic unpleasant flavor and is thereby difficult to take. SOLUTION: This internal liquid medicine containing thiamine or its salt and having reduced bitterness is obtained by adding a perfume containing a monoterpene hydrocarbon, an oxygen-containing monoterpenoid and a sesquiterpene hydrocarbon as essential components and further containing one or more kinds of compounds selected from the group consisting of zingerone, shogool and gingerol to an internal liquid medicine containing thiamine or its salt.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an oral liquid preparation having an improved flavor.

[0002]

2. Description of the Related Art Thiamine is known for its various medicinal effects and is widely used in medicines, foods and the like. However, when thiamine was added to the liquid for oral administration, the flavor was not satisfactory due to its unique bitterness. Various methods have been proposed for improving the bitterness of thiamine, but none have been satisfactory.

[0003]

An object of the present invention is to improve the flavor of a thiamine-containing oral liquid preparation.

[0004]

As a result of various studies, the present inventors have found that a ginger-based fragrance specifically reduces the bitterness of thiamine, and have completed the present invention.

[0005] That is, the present invention relates to a liquid preparation containing thiamine or a salt thereof, in which bitterness is reduced by adding a ginger-based flavor.

[0006] The effect of the present invention is presumed to be caused by the fact that the ginger-based flavor combines the citrus flavor-like top note and the body note exhibiting unique spiciness with the bitterness of thiamine.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, a thiamine salt has substantially the same bitterness as thiamine when converted into a salt. Specifically, the salts to which the present invention is applied include nitrates and hydrochlorides.

The amount of thiamine or a salt thereof is generally 0.004 to 0.02 W / V% of the whole liquid preparation, and the present invention can reduce bitterness within the range.

The ginger-based flavor used in the present invention includes ginger flavor, ginger ale flavor and the like.

The ginger-based fragrance used in the present invention generally comprises 0.5 to 5% by weight of a substantial fragrance component and 95 to 99.5% by weight of a solvent component in a fragrance preparation.

[0011] The substantial odor component of the ginger perfume contains monoterpene hydrocarbons, oxygen-containing monoterpenoids and sesquiterpene hydrocarbons as essential components, and is one or two selected from the group consisting of gingerone, shogaol and gingerol. Those containing at least one species are preferred, and particularly preferred are α-
0.5-5% by weight of pinene and 10-50 of Zingiberene
%, And one or more selected from the group consisting of zingerone, shogaol and gingerol even in trace amounts.

Although the amount of the fragrance varies depending on the content of the substantial fragrance component of the fragrance, it is generally preferably from 5 to 80 parts by weight, more preferably from 10 to 30 parts by weight, per part by weight of thiamine.

The oral liquid preparation of the present invention preferably has a pH of 2 to 6, and particularly preferably has a pH of 2 to 4, from the viewpoint of improving bitterness. For adjusting the pH, a general pH adjuster can be used, but phosphoric acid, citric acid or malic acid is particularly preferred.

The oral liquid preparation of the present invention can contain components such as sweeteners, other vitamin preparations, crude drug extracts, amino acids and the like, and can be produced by a usual method for producing liquid preparations.

[0015]

According to the present invention, an oral solution having an improved thiamine bitterness can be obtained, so that an oral solution having improved compliance can be provided.

[0016]

The present invention will be described below in detail with reference to examples and test examples. In addition, the ginger ale flavor used in the examples had a substantial flavor component of 1.0% by weight.

Example 1 Thiamine was dissolved in purified water so that 0.02 W / V% and ginger ale flavor became 0.1 W / V%, pH was adjusted to 3 with phosphoric acid and sodium hydroxide, and the solution was prepared. Obtained.

Example 2 Thiamine 0.02 W / V%, Sigoka dried extract 0.24 W / V
% (Concentration in crude drug equivalent: 0.48 W / V%), Cistanche salsa extract 0.18 W / V% (concentration in crude drug equivalent: 0.6 W / V%), Kokushi flow extract 0.6 W / V% (conversion in crude drug) Concentration 0.6W / V
%), Mashed juice extract 0.3W / V% (concentration of crude drug equivalent 0.3W / V%), ginger ale flavor 0.1W / V% dissolved in purified water, phosphoric acid and sodium hydroxide Was adjusted to pH = 3 to obtain a liquid preparation.

Comparative Example 1 A liquid preparation was obtained in the same manner as in Example 1 except that the fragrance was omitted.

COMPARATIVE EXAMPLE 2 The flavor of Example 1 was mixed with a mixed fruit flavor at 1.0 W / V%.
And a liquid preparation was obtained in the same manner.

Test Example 1 With respect to the aqueous solutions of Examples and Comparative Examples, the degree of bitterness was evaluated by a two-way arrangement method in a sensory evaluation test by a specialized panel of 20 persons.

The evaluation of bitterness is made in the following five stages,
The average bitterness masking point was calculated as A: 2, B: 4, C: 6, D: 8, E: 10 points. The test results are shown in Table 1.

A: unpleasant, intense bitterness, very difficult to drink B: unpleasant bitterness, difficult to drink C: somewhat unpleasant bitterness, but no pain or resistance to drinking D: subtle bitterness Feel, but no pain or resistance to drinking E: No bitterness, easy to drink

[0024]

[Table 1]

Table 2 and FIG. 1 show the analysis results by the two-way analysis of variance and the results of the student test.

[0026]

[Table 2]

Example 3 Thiamine nitrate 5 mg Riboflavin sodium phosphate 5 mg Pyridoxine hydrochloride 5 mg Inositol 50 mg Anhydrous caffeine 50 mg Taurine 1000 mg Nicotinamide 20 mg Sucrose 10 g Maltitol 2 g Sodium benzoate 60 mg Ginger ale flavor 100 mg Purified water 100 mL Mix and dissolve the above formulation, pH with citric acid and malic acid
= 3.

Example 4 Thiamine hydrochloride 5 mg Sodium riboflavin phosphate 5 mg Pyridoxine hydrochloride 5 mg Inositol 50 mg Anhydrous caffeine 50 mg Taurine 1000 mg Nicotinamide 20 mg Sucrose 10 g Maltitol 2 g Sodium benzoate 60 mg Ginger ale flavor 100 mg Purified water (total amount) 100mL Mix and dissolve the above formulation, pH with citric acid and malic acid
= 3.

Example 5 Thiamine nitrate 7 mg Riboflavin sodium phosphate 5 mg Pyridoxine hydrochloride 5 mg Shigoka dried extract 25 mg (600 mg of crude drug equivalent) Citrus extract 180 mg (600 mg of crude drug equivalent) 300 μL of trash extract (600 mg of crude drug equivalent) Flue extract 150 μL (150 mg in terms of crude drug) DL-carnitine chloride 50 mg Inositol 100 mg Anhydrous caffeine 50 mg Taurine 2000 mg Nicotinamide 30 mg Sucrose 10 g 70% sorbitol solution 2500 mg Povidone K30 1000 mg Sodium benzoate 60 mg Ginger ale perfume 100 g 100mL Mix and dissolve the above formulation, pH with citric acid and malic acid
= 3.

Example 6 Thiamine nitrate 5 mg Sodium riboflavin phosphate 2 mg Pyridoxine hydrochloride 10 mg DL-carnitine chloride 100 mg Anhydrous caffeine 50 mg Taurine 1000 mg Nicotinamide 30 mg L-sodium aspartate 125 mg Chondroitin sulfate 120 mg Sucrose 10 mg Stevia 25 mg Benzoate Sodium 60mg Ginger ale flavor 100mg Purified water (total) 100mL Mix and dissolve the above formulation, pH with citric acid and malic acid
= 3.

Example 7 Thiamine Nitrate 10 mg Riboflavin Sodium Phosphate 5 mg Pyridoxine Hydrochloride 10 mg Kukoshi Flow Extract 600 μL (prototype equivalent 600 mg) Eucalyptus Flow Extract 150 μL (prototype conversion 150 mg) Muirapuama Extract 15 mg (prototype conversion 300 mg) DL-chloride Carnitine 100mg Anhydrous caffeine 50mg Taurine 1000mg Nicotinamide 30mg Sodium L-aspartate 125mg Sodium chondroitin sulfate 120mg Sucrose 15g Stevia 25mg Sodium benzoate 60mg Ginger ale flavor 100mg Purified water (all amounts) 100mL And pH with malic acid
= 3.

[Brief description of the drawings]

FIG. 1 is a diagram showing an analysis result of a masking test by a two-way arrangement method. In the figure, (*) indicates that Examples 1 and 2 are superior to Comparative Example at the 5% significance level.

Claims (4)

[Claims] 1. A liquid preparation containing thiamine or a salt thereof, wherein the bitterness is reduced by adding a ginger-based flavor. 2. An oral liquid preparation comprising thiamine or a salt thereof and a ginger-based flavor. 3. A ginger-based fragrance comprising a monoterpene hydrocarbon, an oxygen-containing monoterpenoid and a sesquiterpene hydrocarbon as essential components, and one or more selected from the group consisting of gingerone, shogaol and gingerol. The liquid preparation for oral administration according to claim 1 or 2, which is a fragrance contained. 4. The solution according to claim 1, wherein the pH of the solution is in the range of 2 to 6.
The liquid medicine for oral administration according to any one of claims 1 to 3.