JPH11169459A - Syringe with liquid medicine - Google Patents

Abstract

PROBLEM TO BE SOLVED: To previously separate and seal more than two kinds of mutually immisible medicinal liquids and simultaneously or continuously discharge them at the time of usage by providing a projection in a part except a sliding surface with the cylindrical insides of respective gaskets except the inner surface and/or rear end gaskets of a cylindrical body bottom part. SOLUTION: The cylindrical body 1 is held with a harnd, a forefinger and a middle finger are hooked at a flange 3 and a pushing element 8 is pushed in an X-direction by a thumb. Then, a rear chamber 11 where a second medicine 21 is sealed is tightly sealed by a first gasket 5 and a second gasket 7 so that pushing-out is executed in a tip direction while keeping its volume. As a result, a first medicinal liquid 20 inside a front chamber 10 is discharged from an injection needle 9 through a discharge port 2 and the first gasket 5 is positioned in a tip part. At this time, the projection of the first gasket 5 is brought into contact with the bottom part inner surface 4 of the cylindrical body 1, the first gasket 5 is deformed at the time of pressing the pushing element 8 and a gap is formed between the inner surface of the cylindrical body 1. Besides, when the pushing element 8 is pressurized, the second medicinal liquid 21 is pushed-out by the second gasket 7 through the gap.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a prefilled syringe capable of storing a plurality of chemical solutions in advance and discharging the same at the time of use.

[0002]

2. Description of the Related Art Conventionally, when two immiscible drugs are continuously injected, a drug solution is drawn from a vial or an ampule into an individual syringe, and a second injection is performed after the first injection is completed. It has been performed by means, but may be contaminated by bacteria or viruses when sucking or mixing. In addition, many components such as vials, ampules, and syringes are required, which complicates the operation and places a great mental and physical burden on medical staff.In addition, when the viscosity of the drug solution is high, it is drawn from the vials or ampules. There were problems such as the difficulty in transferring to a syringe.

[0003] Therefore, several prefilled syringes have been disclosed in which two or more kinds of drugs can be stored in one syringe in advance and discharged simultaneously or continuously when used. As a typical example, two kinds of chemicals are separately filled and sealed in a syringe outer cylinder in advance, and two kinds of medicines are mixed and discharged by a bypass provided in the syringe outer cylinder at the time of use. Syringes (JP-A-62-5357) are known. However, the syringe having the bypass requires a process for forming the bypass, which makes the manufacturing complicated and increases the manufacturing cost.

[0004]

SUMMARY OF THE INVENTION In view of the above problems, an object of the present invention is to separate, fill, and seal two or more types of inexpensive drugs which are excellent in hygiene, operability, and economy. An object of the present invention is to provide a syringe that can be simultaneously or continuously discharged at the time of use.

[0005]

The above object is achieved by the present invention described below. (1) The present invention comprises a tubular body having a bottom portion having a discharge port at a front end and an opening at a rear end, and a plurality of gaskets sliding inside the tubular body in a liquid-tight manner. In a multi-chamber syringe having a space filled with a medicine between a bottom and a tip gasket and between each gasket, the cylinder of each gasket other than the inner surface of the tubular body bottom and / or the rear end gasket. A double-chambered syringe characterized in that a projection is provided on a portion other than a sliding surface with the inside of the body.

(2) The present invention comprises a tubular body having a bottom having a discharge port at a front end and an opening at a rear end, and a plurality of gaskets sliding inside the tubular body in a liquid-tight manner. In a multi-chamber syringe having a space filled with a medicine between the bottom of the cylindrical body and the gasket at the tip and between the respective gaskets, each gasket other than the inner surface of the bottom of the cylindrical body and / or the gasket at the rear end A projection is provided on a portion other than the sliding surface with the inside of the cylindrical body, and the medicine sealed between the bottom of the cylindrical body and the gasket at the front end by pressing the gasket at the rear end from the discharge port. After being discharged, the inner surface of the bottom of the tubular body comes into contact with the gasket at the tip, and the gasket at the tip is deformed by the protrusion provided on the inner surface of the bottom of the tubular body and / or the gasket at the tip. of A first gap is formed between the surface and the gasket at the front end, and the medicine sealed between the gasket at the front end and the second gasket from the front end is further pressed by pressing the gasket at the rear end. After the gasket is discharged from the discharge port through the gap, the gasket at the front end and the second gasket from the front end are provided on the gasket at the front end and / or the gasket at the second from the front end while deforming the gasket at the front end. A second gap is formed between the inner surface of the tubular body and the second gasket from the front end by deforming the second gasket from the front end by the formed protrusion, and further, the gasket at the rear end is formed. By pressing, the medicine enclosed between the second gasket from the tip and the third gasket from the tip is filled in the second gap. By repeating the operation of discharging from the discharge port through the above, it is possible to finally discharge up to the medicine sealed between the gasket at the rear end and the second gasket from the rear end. The double-chambered syringe according to 1).

(3) The present invention relates to a cylindrical body having a bottom having a discharge port at the front end and an opening at the rear end, and a first gasket on the front end side which slides inside the cylindrical body in a liquid-tight manner. In a two-chamber syringe comprising a second gasket on the end side, a space between the bottom of the tubular body and the first gasket and between the first gasket and the second gasket having a space filled with a drug, A two-chamber syringe, wherein a projection is provided on an inner surface of the cylindrical body bottom and / or a contact surface of the second gasket with the inner surface of the cylindrical body bottom.

(4) The present invention relates to a cylindrical body having a bottom having a discharge port at a front end and an opening at a rear end, a first gasket on a front end side which slides inside the cylindrical body in a liquid-tight manner, and In a two-chamber syringe comprising a second gasket on the end side, a space between the bottom of the tubular body and the first gasket and between the first gasket and the second gasket having a space filled with a drug, A projection is provided on the inner surface of the bottom of the tubular body and / or the contact surface of the second gasket with the inner surface of the bottom of the tubular body, and by pressing the second gasket, the bottom of the tubular body and the first gasket are pressed. After the medicine enclosed between the gasket and the gasket is discharged from the discharge port, the inner surface of the bottom of the tubular body and the first gasket are brought into contact with each other to provide the inner surface of the bottom of the tubular body and / or the first gasket. By the projections The first gasket is deformed, a first gap is formed between the inner surface of the tubular body and the first gasket, and the first gasket and the second gasket are further pressed by pressing the second gasket. The two-chamber syringe according to the above (3), wherein the medicine between the two can be discharged from the discharge port through the gap.

The drug to be enclosed in the drug-containing syringe of the present invention is not limited, but is not limited to various vitamins, antibiotics, drugs for the nervous system, sensory organs, circulatory organs, respiratory organs, digestive organs, hormones, diagnostic drugs. , Skin medicine, nourishing tonic,
Examples include blood drugs, metabolic drugs, tumor drugs, allergy drugs, chemotherapeutic drugs, and the like. In addition, the division of these drugs in the syringe is not particularly limited, and they can be separately enclosed in a water-soluble drug and a fat-soluble drug, and an acid-stable drug and an alkali-stable drug. The form of the drug is desirably a liquid agent, but a solid agent such as a powder or a granule may also be filled with a solid agent in the space on the front end side and a liquid agent in the space on the rear end side. It can be used by discharging while dissolving with the liquid agent.

[0010] It is desirable that the drug-containing syringe of the present invention be supplied after sterilization such as heat sterilization such as high-pressure steam sterilization after the drug is sealed therein. However, these sterilization processes may adversely affect the drug to be sealed. In some cases, it is desirable to aseptically fill a sterilized syringe with the drug and supply it in a sterile condition.

[0011]

DESCRIPTION OF THE PREFERRED EMBODIMENTS (1) An embodiment of a drug-containing syringe of the present invention will be described with reference to the drawings. FIG. 1 is a partial cross-sectional view showing only a cylindrical body 1 of a syringe A having two chambers according to one embodiment of a syringe with a medicine of the present invention. The syringe A is mainly composed of a cylindrical body 1, a first gasket 5 and a second gasket 7 that slide inside the cylindrical body 1 in a liquid-tight manner.
Consists of A discharge port 2 is provided at the distal end of the cylindrical body 1 and its outer shape is formed into, for example, a luer tip shape, a catheter tip shape, or the like, and the injection needle 9 can be attached via a hub. However, as long as it can be attached, a tube or the like can be directly joined without being limited to the injection needle. The cylindrical body 1 has a space sealed by a second gasket 7, and this space is divided into two chambers by a first gasket 5. Each of the second medicines 21 is filled.

As shown in FIG. 2, the first gasket 5 is provided with a projection 16 on a part of the distal end face 6. The size, shape, position and the like of the projection 16 can be arbitrarily selected. When the size is increased, the gasket is greatly deformed during the operation to be described later, and the gap 12 becomes large. Therefore, when the discharged chemical is viscous, it is easy to discharge. Is undesirably increased. The shape is not particularly limited, and examples thereof include a mountain shape, a convex shape, a triangular shape, and a semicircular shape as shown in the figure. In consideration of durability, the projections 16 are preferably integrally formed of the same material as the first gasket 5, but if they do not come off from the first gasket 5, they may be formed of another material or the same material. 5 may be used by fusing or bonding. Further, a presser 8 can be connected to the second gasket 7.

The materials used for the syringe with a drug of the present invention include the following. As the tubular body 1,
Low or high density polyethylene, polypropylene,
Polyolefins such as polybutadiene-1, polyvinyl chloride, polyvinylidene chloride, vinylidene chloride copolymer,
Examples include plastics such as polymethyl methacrylate, polyvinyl alcohol, ethylene-vinyl alcohol copolymer, acrylonitrile copolymer, and polyethylene terephthalate, and glass.

First gasket 5 and second gasket 7
Is, for example, natural rubber, butyl rubber, isoprene rubber,
Butadiene rubber, styrene-butadiene rubber, silicone
Various rubber materials such as rubber (especially vulcanized)
And, polyurethane-based, polyester-based, polyamide-based,
Any olefin-based or styrene-based elastomer, or a mixture thereof may be used as long as it is liquid-tight with the inner wall of the cylindrical body 1 and has such an elasticity that it can be deformed later.

Next, a method of operating the syringe A will be described.
First, holding the cylindrical body 1, the index finger and the middle finger are hooked on the flange 3, and the pusher 8 is pushed in the X direction with the thumb, whereby the second medicine 2 is obtained.
Since the chamber 11 is sealed with the first gasket 5 and the second gasket 7, the chamber 11 is pushed out in the distal direction while maintaining its volume. As a result, the front room 10
The first chemical solution 20 is discharged from the injection needle 9 through the discharge port 2, and the first gasket 5 is located at the distal end as shown in FIG. At this time, the projection 16 of the first gasket 5 comes into contact with the inner surface 4 at the bottom of the tubular body 1, and when the pusher 8 is further pushed, the protrusion 16 in FIG.
As shown in (1), the first gasket 5 is deformed, and a gap 12 is formed between the first gasket 5 and the inner surface of the tubular body 1. FIG. 5 shows an enlarged view of the tip portion at that time. When the pusher 8 is further pressed, the second chemical solution 21 is pushed out by the second gasket 7 through the gap 12 (arrow Y in FIG. 5), and the rear end of the first gasket 5 and the front end of the second gasket 7 as shown in FIG. Then, the operation ends.

(2) A second embodiment of the drug-containing syringe of the present invention will be described with reference to the drawings. FIG. 7 is a partial cross-sectional view showing only a cylindrical body 31 of a syringe B having two chambers according to one embodiment of the syringe with a medicine of the present invention. The configuration of each part of the syringe B is the same as that of the syringe A except for a part as shown in FIG. The materials are the same. The difference is that there is no projection 16 provided on a part of the distal end surface 6 of the first gasket 5, and as shown in an enlarged view of FIG.
The projection 44 is provided on a part of the bottom inner surface 34 of the tubular body 31. The projections 44 are preferably integrally formed of the same material as the cylindrical body 31 in consideration of durability. However, if the protrusions 44 do not come off from the cylindrical body 31, they may be formed of another material or the same material. 31 may be used by fusing or bonding.

Next, a method of operating the syringe B will be described.
First, hold the cylindrical body 31 and hold the forefinger and the middle finger on the flange 3.
3 and push the pusher 38 in the X direction with the thumb, the second
After the medicine 51 is sealed, the chamber 41 is sealed by the first gasket 35 and the second gasket 37, so that the chamber 41 is pushed out toward the distal end while maintaining its volume. As a result, the first liquid medicine 40 in the front chamber 50 is discharged from the injection needle 39 through the discharge port 32, and the first gasket 35 is located at the tip as shown in FIG. At this time, the projection 44 provided on a part of the bottom inner surface 34 of the tubular body 31 comes into contact with the distal end surface 36 of the first gasket 35, and when the pusher 38 is further pressed, as shown in FIG. 35 is deformed, and a gap 42 is formed between the first gasket 35 and the inner surface of the tubular body 31. FIG. 11 shows an enlarged view of the tip at that time. When the pusher 38 is further pressed, the second chemical liquid 41 is pushed out by the second gasket 37 through the gap 42, and the rear end of the first gasket 35 and the front end of the second gasket 37 hit as shown in FIG. .

(3) A third embodiment of the drug-containing syringe of the present invention will be described with reference to the drawings. FIG. 13 is a partial cross-sectional view showing only a cylindrical body 61 of a syringe C having three chambers according to one embodiment of the syringe with a medicine of the present invention. The basic operation is a syringe A having two chambers as described above.
And B, by pushing the pusher 69 in the X direction, the medicines 80, 81 and 82 sealed in the front chamber 70, the middle chamber 71 and the rear chamber 72 are sequentially discharged. At this time, as shown in FIG.
The first gasket 65 is deformed by itself when the front projection 76 contacts the bottom inner surface 64 of the cylindrical body 61, and the second gasket 67 comes into contact with the rear projection 77. You can transform it when you do. In the case of a syringe having three chambers, the present invention is not limited to using the first gasket as described above, and a projection may be provided on each of the first gasket and the second gasket. The embodiments of the present invention have been described above, but the present invention is not limited to these.

[0019]

According to the present invention, two or more kinds of drugs which are unstable when mixed in advance can be separated and filled and sealed, and can be discharged simultaneously or continuously at the time of use, thereby improving hygiene and operability. An excellent syringe that can be easily manufactured can be provided. That is, the drug-containing syringe of the present invention,
While preserving sterile or aseptic condition, two or more kinds of drugs that are unstable if premixed are separated and filled and sealed. Can be discharged. Furthermore, a complicated manufacturing process such as forming a bypass in the cylindrical body of the syringe is not required, and the syringe can be manufactured by an easy process of providing projections inside the cylindrical body or on the gasket.

[Brief description of the drawings]

FIG. 1 is a partial cross-sectional view of a syringe A according to one embodiment of the present invention.

FIGS. 2A and 2B are external views of a first gasket 5 used for a syringe A, wherein FIG. 2A is a front view, and FIG.

FIG. 3 is an explanatory view of the completion of discharging a first chemical solution of a syringe A;

FIG. 4 is a partial cross-sectional view of the syringe A when the first gasket is deformed.

FIG. 5 is an enlarged partial sectional view of the vicinity of a first gasket 5 of FIG.

FIG. 6 is a partial cross-sectional view of the syringe A when the operation of discharging the second chemical solution is completed.

FIG. 7 is a partial cross-sectional view of a syringe B according to one embodiment of the present invention.

FIG. 8A is a cross-sectional view near the bottom of the distal end of the syringe B,
(B) is sectional drawing of line segment ab.

FIG. 9 is an explanatory diagram of the completion of discharging the first chemical solution of the syringe B.

FIG. 10 is a partial cross-sectional view of the syringe B when the first gasket is deformed.

FIG. 11 is an enlarged partial sectional view of the vicinity of a first gasket 35 of FIG.

FIG. 12 is a partial cross-sectional view of the syringe B when the operation of discharging the second chemical solution is completed.

FIG. 13 is a partial cross-sectional view of a syringe C according to one embodiment of the present invention.

FIGS. 14A and 14B are external views of a first gasket 5 used for a syringe C, wherein FIG. 14A is a front view, and FIG.

[Explanation of symbols]

 A, B, C: Syringe with medicine 1, 31, 61 ... Cylindrical body 2, 32, 62 ... Outlet 3, 33, 63 ... Flange 4, 34, 64 ... Tip Bottom part 5, 35, 65 ... First gasket 6, 36, 66 ... Tip face of first gasket 7, 37, 67 ... Second gasket 68 ... Third gasket 8, 38, 69 ··· Presser 9, 39, 79 ··· Injection needle 10, 40, 70 ··· Front chamber 71 ··· Middle chamber 11, 41, 72 ··· Rear chamber 20, 50, 80 ··· First Chemical liquid 21, 51, 81 ... second chemical liquid 82 ... third chemical liquid

Claims (2)

[Claims] 1. A tubular body having a bottom having a discharge port at a front end and an opening at a rear end, and a plurality of gaskets sliding inside the tubular body in a liquid-tight manner. In a multi-chamber syringe having a space filled with a medicine between a gasket at the front end and between the gaskets, the cylindrical body of each gasket other than the inner surface of the cylindrical body bottom and / or the gasket at the rear end. A double-chambered syringe characterized in that a projection is provided on a portion other than a sliding surface with the inside. 2. A cylindrical body having a bottom portion having a discharge port at a front end and an opening at a rear end, a first gasket on a front end side and a second gasket on a rear end side sliding inside the cylindrical body in a liquid-tight manner. A two-chamber syringe comprising a gasket and having a space filled with a medicine between the bottom of the tubular body and the first gasket and between the first gasket and the second gasket; A two-chamber syringe, wherein a projection is provided on an inner surface of the second gasket and / or a contact surface of the second gasket with an inner surface of the bottom of the cylindrical body.