JPH1087815A - ポリアルキレンオキシドカルボン酸の改良製造方法 - Google Patents
ポリアルキレンオキシドカルボン酸の改良製造方法Info
- Publication number
- JPH1087815A JPH1087815A JP22114896A JP22114896A JPH1087815A JP H1087815 A JPH1087815 A JP H1087815A JP 22114896 A JP22114896 A JP 22114896A JP 22114896 A JP22114896 A JP 22114896A JP H1087815 A JPH1087815 A JP H1087815A
- Authority
- JP
- Japan
- Prior art keywords
- polyalkylene oxide
- carboxylic acid
- acid
- alkyl
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 238000004519 manufacturing process Methods 0.000 title claims description 6
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- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 46
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims abstract description 26
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000002253 acid Substances 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 8
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 7
- 125000003118 aryl group Chemical group 0.000 claims abstract description 4
- 229910052794 bromium Inorganic materials 0.000 claims abstract description 3
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 3
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 70
- 229920000642 polymer Polymers 0.000 claims description 33
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 9
- -1 succinimidyl ester Chemical class 0.000 claims description 9
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- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims description 6
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical group [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims description 6
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- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical group C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 3
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- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
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- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 2
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| JP22114896A JPH1087815A (ja) | 1996-08-22 | 1996-08-22 | ポリアルキレンオキシドカルボン酸の改良製造方法 |
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| JP22114896A JPH1087815A (ja) | 1996-08-22 | 1996-08-22 | ポリアルキレンオキシドカルボン酸の改良製造方法 |
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| JPH1087815A true JPH1087815A (ja) | 1998-04-07 |
| JPH1087815A5 JPH1087815A5 (enExample) | 2004-08-12 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002515418A (ja) * | 1998-05-20 | 2002-05-28 | エクスプレッション・ジェネティックス・インコーポレーテッド | 肝細胞を標的とするポリエチレングリコール接合ポリ−ｌ−リシンのポリマー遺伝子キャリヤー |
| JP2002520288A (ja) * | 1998-07-13 | 2002-07-09 | エンゾン，インコーポレーテッド | クマリン及び関連芳香族系ポリマープロドラッグ |
| WO2005047366A1 (en) * | 2003-11-06 | 2005-05-26 | Nektar Therapeutics Al, Corporation | Method of preparing carboxylic acid functionalized polymers |
| JP2007538111A (ja) * | 2004-01-21 | 2007-12-27 | ネクター セラピューティクス アラバマ，コーポレイション | プロピオン酸末端ポリマーの調製方法 |
| JP2009523191A (ja) * | 2006-01-10 | 2009-06-18 | エンゾン ファーマスーティカルズ インコーポレイテッド | ポリアルキレンオキシド・カルボン酸の高効率製法 |
-
1996
- 1996-08-22 JP JP22114896A patent/JPH1087815A/ja active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002515418A (ja) * | 1998-05-20 | 2002-05-28 | エクスプレッション・ジェネティックス・インコーポレーテッド | 肝細胞を標的とするポリエチレングリコール接合ポリ−ｌ−リシンのポリマー遺伝子キャリヤー |
| JP2002520288A (ja) * | 1998-07-13 | 2002-07-09 | エンゾン，インコーポレーテッド | クマリン及び関連芳香族系ポリマープロドラッグ |
| JP4999226B2 (ja) * | 1998-07-13 | 2012-08-15 | エンゾン ファーマシューティカルズ，インコーポレーテッド | クマリン及び関連芳香族系ポリマープロドラッグ |
| WO2005047366A1 (en) * | 2003-11-06 | 2005-05-26 | Nektar Therapeutics Al, Corporation | Method of preparing carboxylic acid functionalized polymers |
| JP2007510800A (ja) * | 2003-11-06 | 2007-04-26 | ネクター セラピューティクス アラバマ，コーポレイション | カルボン酸官能化重合体の調製方法 |
| CN100580005C (zh) | 2003-11-06 | 2010-01-13 | 阿拉巴马耐科塔医药公司 | 制备羧酸官能化聚合物的方法 |
| US8067505B2 (en) | 2003-11-06 | 2011-11-29 | Nektar Therapeutics | Method of preparing carboxylic acid functionalized polymers |
| KR101157007B1 (ko) * | 2003-11-06 | 2012-06-21 | 넥타르 테라퓨틱스 | 카르복시산 작용기화 중합체 제조 방법 |
| US10011682B2 (en) | 2003-11-06 | 2018-07-03 | Nektar Therapeutics | Method of preparing carboxylic acid functionalized polymers |
| US11111335B2 (en) | 2003-11-06 | 2021-09-07 | Nektar Therapeutics | Method of preparing carboxylic acid functionalized polymers |
| JP2007538111A (ja) * | 2004-01-21 | 2007-12-27 | ネクター セラピューティクス アラバマ，コーポレイション | プロピオン酸末端ポリマーの調製方法 |
| JP2009523191A (ja) * | 2006-01-10 | 2009-06-18 | エンゾン ファーマスーティカルズ インコーポレイテッド | ポリアルキレンオキシド・カルボン酸の高効率製法 |
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