JPH1072486A5 - - Google Patents

Info

Publication number
JPH1072486A5
JPH1072486A5 JP1997185142A JP18514297A JPH1072486A5 JP H1072486 A5 JPH1072486 A5 JP H1072486A5 JP 1997185142 A JP1997185142 A JP 1997185142A JP 18514297 A JP18514297 A JP 18514297A JP H1072486 A5 JPH1072486 A5 JP H1072486A5
Authority
JP
Japan
Prior art keywords
alkyl
formula
compound
group
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1997185142A
Other languages
English (en)
Japanese (ja)
Other versions
JPH1072486A (ja
JP4435878B2 (ja
Filing date
Publication date
Priority claimed from DE19627898A external-priority patent/DE19627898A1/de
Application filed filed Critical
Publication of JPH1072486A publication Critical patent/JPH1072486A/ja
Publication of JPH1072486A5 publication Critical patent/JPH1072486A5/ja
Application granted granted Critical
Publication of JP4435878B2 publication Critical patent/JP4435878B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP18514297A 1996-07-11 1997-07-10 オリゴヌクレオチドの固相合成 Expired - Fee Related JP4435878B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19627898A DE19627898A1 (de) 1996-07-11 1996-07-11 Festphasensynthese von Oligonucleotiden
DE19627898:8 1996-07-11

Publications (3)

Publication Number Publication Date
JPH1072486A JPH1072486A (ja) 1998-03-17
JPH1072486A5 true JPH1072486A5 (https=) 2005-05-19
JP4435878B2 JP4435878B2 (ja) 2010-03-24

Family

ID=7799510

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18514297A Expired - Fee Related JP4435878B2 (ja) 1996-07-11 1997-07-10 オリゴヌクレオチドの固相合成

Country Status (11)

Country Link
US (1) US5936077A (https=)
EP (1) EP0818460B1 (https=)
JP (1) JP4435878B2 (https=)
AT (1) ATE231162T1 (https=)
AU (1) AU716391B2 (https=)
CA (1) CA2210031C (https=)
DE (2) DE19627898A1 (https=)
DK (1) DK0818460T3 (https=)
ES (1) ES2188826T3 (https=)
NO (1) NO317853B1 (https=)
PT (1) PT818460E (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
EP1095054B1 (en) 1998-07-09 2006-10-25 Biocept, Inc. Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation
DE19842164B4 (de) * 1998-09-15 2004-06-03 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren zur Qualitätskontrolle beim Aufbau von Oligomerrastern
US6175001B1 (en) * 1998-10-16 2001-01-16 The Scripps Research Institute Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same
US6465628B1 (en) 1999-02-04 2002-10-15 Isis Pharmaceuticals, Inc. Process for the synthesis of oligomeric compounds
DK1149109T3 (da) 1999-02-05 2010-01-11 Ge Healthcare Bio Sciences Fremgangsmåde til afbeskyttelse af oligonukleotider
JP2004521628A (ja) * 2001-03-08 2004-07-22 アプレラ コーポレイション オリゴヌクレオチドの切断および脱保護のための試薬
WO2006025154A1 (ja) * 2004-08-30 2006-03-09 Gifu University 修飾オリゴヌクレオチド
DE102006016473A1 (de) * 2005-12-08 2007-06-14 Continental Teves Ag & Co. Ohg Druckregelventil
US8513404B2 (en) * 2008-04-24 2013-08-20 Nitto Denko Avecia, Inc. Process for the manufacture of oligonucleotides
JP6794258B2 (ja) * 2013-09-30 2020-12-02 ジェロン・コーポレーションＧｅｒｏｎ Ｃｏｒｐｏｒａｔｉｏｎ オリゴヌクレオチドについてのホスホロジアミデート骨格結合
WO2017066782A1 (en) * 2015-10-16 2017-04-20 Modernatx, Inc. Hydrophobic mrna cap analogs
WO2017066781A1 (en) 2015-10-16 2017-04-20 Modernatx, Inc. Mrna cap analogs with modified phosphate linkage
US11866754B2 (en) 2015-10-16 2024-01-09 Modernatx, Inc. Trinucleotide mRNA cap analogs
JP2019532027A (ja) 2016-08-17 2019-11-07 ソルスティス バイオロジクス，リミティッド ポリヌクレオチド構築物
WO2019006455A1 (en) 2017-06-30 2019-01-03 Solstice Biologics, Ltd. AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF
KR20190090301A (ko) * 2018-01-24 2019-08-01 에스티팜 주식회사 신규한 뉴클레오사이드 또는 뉴클레오타이드 유도체 및 이들의 용도
CN115772201B (zh) * 2021-09-08 2024-11-26 苏州金唯智生物科技有限公司 一种固相合成rna的后处理方法及其应用
CN117362370B (zh) * 2023-12-07 2024-03-05 北京百力格生物科技有限公司 核苷亚磷酰胺单体及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI115214B (fi) * 1992-01-22 2005-03-31 Hoechst Ag Menetelmä oligonukleotidianalogien valmistamiseksi ja niiden käyttö
US5623068A (en) * 1994-03-07 1997-04-22 Beckman Instruments, Inc. Synthesis of DNA using substituted phenylacetyl-protected nucleotides

Similar Documents

Publication Publication Date Title
JPH1072486A5 (https=)
JP4098356B2 (ja) 標識結合パートナーのためのピリミジン誘導体
US6143877A (en) Oligonucleotides including pyrazolo[3,4-D]pyrimidine bases, bound in double stranded nucleic acids
AU716391B2 (en) Solid phase synthesis of oligonucleotides
JP7164540B2 (ja) 立体的に規定されたホスホロチオエートオリゴヌクレオチドの調製のための直交保護基
JP7777452B2 (ja) 核酸オリゴマーの製造方法
JP2003517467A (ja) ホスホチオエーテトリエステル及びオリゴヌクレオチドの調製方法
WO2000014048A1 (en) Oligonucleotide protecting groups
Ohkubo et al. New thermolytic carbamoyl groups for the protection of nucleobases
US12391716B2 (en) Process of preparing nucleic acid oligomer
US20230242570A1 (en) Method for producing nucleic acid oligomer
US6329519B1 (en) Intermediates for oligonucleotide synthesis
WO2024024873A1 (ja) チオ化溶液
KR20240082343A (ko) 정제 디클로로아세트산의 제조 방법
WO2006094963A1 (en) Synthesis of oligonucleotides
US20040157794A1 (en) Calix[4]arene-nucleoside and calix[4]oligonucleotide hybrids
RU2440364C2 (ru) Синтез фосфитилированных соединений с использованием четвертичного гетероциклического активатора
US7741471B2 (en) Reagents for the improved synthesis of isoguanosine containing oligonucleotides
KR20250128304A (ko) 올리고뉴클레오티드의 제조 방법
Szmanda et al. Polyaminooligonucleotides and their combinatorial libraries
Repkova et al. Oligoribonucleotides containing an aminoalkyl group at the N (4) atom of cytosine as precursors of new reagents for site-specific modifications of biopolymers
WO2003045969A1 (en) Coupling reagent for h-phosphonate chemistry