JPH10503188A - アミノアゾビシクロアルカンのオキシムからの製法 - Google Patents
アミノアゾビシクロアルカンのオキシムからの製法Info
- Publication number
- JPH10503188A JPH10503188A JP8505433A JP50543396A JPH10503188A JP H10503188 A JPH10503188 A JP H10503188A JP 8505433 A JP8505433 A JP 8505433A JP 50543396 A JP50543396 A JP 50543396A JP H10503188 A JPH10503188 A JP H10503188A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- methyl
- preparation
- azabicyclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Indole Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.式(I): [式中、nは2または3を意味する] で示される化合物の製法であって、 式(II): [式中、R1は水素またはC1-4アルキルであり、nは2または3を意味する] で示される化合物を、ロジウム触媒の存在下、接触水素添加により還元すること を特徴とする方法。 2.nが3である請求項1記載の方法。 3.nが2である請求項1記載の方法。 4.R1が水素またはメチルである請求項1、2または3記載の方法。 5.接触水素添加を、高温25〜70℃および高圧20〜200psi(13 7.9〜1379kPa)で行う請求項1〜4のいずれか1つに記載の方法。 6.約50℃および25〜50psi(172.4〜344.8kPa)で行う 請求項5記載の方法。 7.ロジウム触媒が炭素上で担持されている請求項1〜6のいずれか1つに記 載の方法。 8.反応をアンモニアの存在下で行う請求項1〜7のいずれか1つに記載の方 法。 9.式(I)の化合物のアミド誘導体の製法であって、 i)請求項1〜8のいずれか1つに記載の式(I)の化合物を調製し; ii)式(I)の化合物を適当なカルボン酸またはその反応性誘導体と反応させる ことからなる方法。 10.グラニセトロン(その医薬上許容される塩を含む)の製法であって、 i)nが3である式(I)の化合物を調製し、 ii)その式(I)の化合物を1−メチルインドール−3−カルボン酸またはその 反応性誘導体と反応させ、 所望によりその医薬上許容される塩を形成させてもよいことからなる請求項9 記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9414900.2 | 1994-07-23 | ||
GB9414900A GB9414900D0 (en) | 1994-07-23 | 1994-07-23 | Novel process |
PCT/EP1995/002824 WO1996003401A2 (en) | 1994-07-23 | 1995-07-18 | Process for the production of aminoazobicycloalkanes from oximes |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10503188A true JPH10503188A (ja) | 1998-03-24 |
JP4001380B2 JP4001380B2 (ja) | 2007-10-31 |
Family
ID=10758800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50543396A Expired - Lifetime JP4001380B2 (ja) | 1994-07-23 | 1995-07-18 | アミノアゾビシクロアルカンのオキシムからの製法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5856489A (ja) |
EP (1) | EP0772613B1 (ja) |
JP (1) | JP4001380B2 (ja) |
DE (1) | DE69524100T2 (ja) |
ES (1) | ES2167447T3 (ja) |
GB (1) | GB9414900D0 (ja) |
HK (1) | HK1012349A1 (ja) |
MX (1) | MX9700596A (ja) |
WO (1) | WO1996003401A2 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1313660B1 (it) * | 1999-10-01 | 2002-09-09 | Dompe Spa | Procedimento stereoselettivo per la preparazione di endo-3-amminoazabicicloalcani. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL59004A0 (en) * | 1978-12-30 | 1980-03-31 | Beecham Group Ltd | Substituted benzamides their preparation and pharmaceutical compositions containing them |
NZ197356A (en) * | 1980-06-18 | 1984-05-31 | Beecham Group Ltd | Ar-alkylsulphinyl-n-(azaicycloalkyl(alkyl)) benzamides |
US4432983A (en) * | 1981-04-30 | 1984-02-21 | Research Corporation | Conformationally restricted histamine H2 -receptor antagonists containing a tropane ring |
FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
US5258528A (en) * | 1990-11-30 | 1993-11-02 | Warner-Lambert Company | Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group |
-
1994
- 1994-07-23 GB GB9414900A patent/GB9414900D0/en active Pending
-
1995
- 1995-07-18 WO PCT/EP1995/002824 patent/WO1996003401A2/en active IP Right Grant
- 1995-07-18 DE DE69524100T patent/DE69524100T2/de not_active Expired - Lifetime
- 1995-07-18 ES ES95926937T patent/ES2167447T3/es not_active Expired - Lifetime
- 1995-07-18 US US08/776,451 patent/US5856489A/en not_active Expired - Lifetime
- 1995-07-18 JP JP50543396A patent/JP4001380B2/ja not_active Expired - Lifetime
- 1995-07-18 MX MX9700596A patent/MX9700596A/es unknown
- 1995-07-18 EP EP95926937A patent/EP0772613B1/en not_active Expired - Lifetime
-
1998
- 1998-12-15 HK HK98113460A patent/HK1012349A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GB9414900D0 (en) | 1994-09-14 |
WO1996003401A2 (en) | 1996-02-08 |
EP0772613A2 (en) | 1997-05-14 |
JP4001380B2 (ja) | 2007-10-31 |
HK1012349A1 (en) | 1999-07-30 |
EP0772613B1 (en) | 2001-11-21 |
WO1996003401A3 (en) | 1996-07-04 |
DE69524100T2 (de) | 2002-08-22 |
ES2167447T3 (es) | 2002-05-16 |
MX9700596A (es) | 1997-06-28 |
DE69524100D1 (de) | 2002-01-03 |
US5856489A (en) | 1999-01-05 |
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