JPH1045176A - Non-adsorption material - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a non-adsorption material that is used as a layer to be in contact with such contents as medicines, cosmetics, foods, etc., and does not adsorb effective ingredients contained in the contents in very small quantity within the term of validity of use of the contents. SOLUTION: A layer of a non-adsorption material, that comes in contact with such contents as medicines, cosmetics, foods, etc., containing very small quantities of effective ingredients, is formed of an aluminum foil or a vacuum metallized layer of such an inorganic substance as aluminum, silicon oxide, aluminum oxide 2, etc. A heat-adhesive resin layer 3 is formed partly on the surface of the aluminum foil or the vacuum metallized layer of such an inorganic substance as aluminum, silicon oxide, aluminum oxide 2, etc., of the non-adsorption material.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to pharmaceuticals, cosmetics,
With respect to the prevention of the decrease over time of the trace amount of the active ingredient contained in the contents such as foods, more specifically, the material for packaging or protecting the contents absorbs the trace amount of the active ingredient contained in the contents. And to prevent the trace amount of the active ingredient from decreasing with time.

[0002]

2. Description of the Related Art Pharmaceuticals containing a trace amount of an active ingredient,
Contents such as cosmetics and foods are protected by packaging materials such as packaging bags, such as a packaging bag that heat seals the required margins, with a laminate of various plastic films or a laminate using paper or aluminum foil as appropriate. Have been.

[0003] Further, for example, when the content is a poultice or the like, a trace amount of an active ingredient is contained in the adhesive layer having an adhesive function. A material with releasability is attached.

[0004] In general, packaging materials such as these packaging bags and materials having a releasable property usually have a layer in contact with the contents, such as a polyolefin resin such as polyethylene or polypropylene, an ionomer, or an ethylene-based resin. It is formed of a copolymer resin such as a methyl acrylate copolymer, an ethylene-acrylic acid copolymer, an ethylene-methacrylic acid copolymer, or a sheet obtained by forming these into a film by a known technique.

However, if the layer in contact with the contents is formed of the resin described in the preceding paragraph or a sheet of the resin, the trace amount of the active ingredient contained in the contents is reduced by the resin or the resin. It will be adsorbed to the sheet over time, and the amount of trace active ingredients required during use will decrease,
There is a problem that efficacy is reduced.

[0006] For this purpose, it is necessary to preliminarily contain an amount of a small amount of active ingredient which will be adsorbed and reduced during the effective use period in accordance with the effective use period of the contents. There is also a problem that the quality increase of the contents is unstable due to the related cost increase and the decrease in the amount of the trace amount of the active ingredient due to the time-dependent adsorption caused by the effective use period.

[0007]

Accordingly, the present invention provides a material which does not adsorb a trace amount of active ingredient contained in the content during the effective use period.
That is, to provide a non-adsorbing material.

[0008]

The present inventors have conducted various studies to solve the above problems, and as a result, have found that menthol, limonene, methyl salicylate, indomethacin,
Pharmaceuticals, cosmetics, etc. containing trace amounts of active ingredients such as morphine
When the layer in contact with the contents such as food is formed of aluminum foil or a vapor-deposited layer of an inorganic substance such as aluminum, silicon oxide, or aluminum oxide, the inventors discovered that the trace amount of the active ingredient was not adsorbed, and The invention has been completed.

Further, by forming a heat-adhesive resin layer partially on the surface of the above-mentioned aluminum foil or a vapor-deposited layer of an inorganic substance such as aluminum, silicon oxide or aluminum oxide,
The present invention has been completed by discovering a packaging material in which a trace amount of an active ingredient contained in a content is not adsorbed.

That is, according to the present invention, a layer containing a trace amount of an active ingredient and in contact with contents such as pharmaceuticals, cosmetics, and foods is formed of an aluminum foil or a vapor-deposited layer of an inorganic substance such as aluminum, silicon oxide, or aluminum oxide. The present invention relates to a non-adsorbing material, wherein an aluminum foil of the non-adsorbing material or a heat-adhesive resin layer is partially formed on a vapor-deposited layer surface of an inorganic substance such as aluminum, silicon oxide, and aluminum oxide. The present invention relates to a non-adsorbing material.

[0011]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described in more detail below with reference to the drawings and the like. First, in the present invention, menthol, limonene, methyl salicylate,
Indomethacin, pharmaceuticals containing a trace amount of active ingredients such as morphine, cosmetics, when the layer in contact with the contents of foods and the like is an aluminum foil, if it is a commercially available soft material, it fulfills the purpose of the present invention, Taking the cost and workability into consideration, those having a range of 7 to 15 μm are suitable.

On the other hand, as a substrate on which an inorganic substance such as aluminum, silicon oxide, and aluminum oxide is formed,
Paper and various plastic films can be used.For example, a generally used physical vapor deposition method is that the vapor deposition temperature is high, and that a stable and uniform vapor deposition layer is obtained. A biaxially oriented polyethylene terephthalate film or a biaxially oriented polyamide film is suitable. Further, by using a chemical vapor deposition method, a plastic film having a large thermal change such as a biaxially stretched polypropylene film can be used.

Further, considering that the aluminum foil is suitable for the layer in contact with the content containing a trace amount of the active ingredient of the present invention, the thicker the vapor deposition layer, the better. From the relationship between the cost increase by increasing the thickness of the vapor deposition layer and the effect of the present invention, the thickness of the vapor deposition layer is 20
It is preferably 0 to 800 °, particularly preferably 400 to 600 °.

Next, when the present invention is used as a packaging material for a packaging bag or the like, a sealing function is required. However, the present invention relates to a layer containing a trace amount of an active ingredient, which is in contact with the contents of pharmaceuticals, cosmetics, foods and the like. Is formed of an aluminum foil or a vapor-deposited layer of an inorganic substance such as aluminum, silicon oxide, or aluminum oxide, and has no sealing function.

Therefore, since it is necessary to provide a sealing function utilizing the present invention, aluminum foil or aluminum, silicon oxide,
By providing the heat-adhesive resin layer in the heat-adhesive portion forming region on the surface of the vapor-deposited layer of an inorganic substance such as aluminum oxide, good heat sealing can be easily performed.

Examples of the heat-adhesive resin used in the heat-adhesive resin layer described in the preceding paragraph include one or more vehicles such as urethane resins, vinyl chloride-vinyl acetate copolymer resins, acrylic resins, and modified polyolefins. The heat-adhesive resin layer can be formed by printing by a gravure printing method using a resin composition obtained by arbitrarily adding and kneading desired additives. As a printing pattern of the heat-adhesive resin layer, for example, a lattice pattern is used, and since the heat-adhesive resin layer is formed on a lattice portion, a necessary rectangular heat A large number of bonded portion forming regions are arranged vertically and horizontally. The thickness of the heat-adhesive resin layer is preferably in the range of ² to 10 g / m ² . The resin composition may be colored by adding a desired pigment as needed.

The layer structure of the non-adsorbing material of the present invention will be described in more detail with reference to the drawings. FIGS. 1 and 2 show the layer structure when the non-adsorbing material of the present invention is used as a packaging material such as a packaging bag. It is sectional drawing. First, as shown in FIG. 1, the non-adsorption material according to the present invention has a heat-adhesive resin layer 3 directly and partially formed on one surface of an aluminum foil 1. 4 is a surface layer laminated on the other surface of the aluminum foil 1. When a packaging bag is manufactured using this packaging material, the facing thermo-adhesive resin layers 3 may be folded at the center of the packaging material, overlapped, and heat-sealed to form a packaging bag. The two sheets may be made into a packaging bag by laminating the heat-adhesive resin layers 3 together and heat-sealing, so that only the periphery of the packaging bag becomes a heat-sealed packaging bag,
The surface in contact with the contents is only one aluminum foil.

The non-adsorption material according to the present invention is shown in FIG.
As shown in FIG. 3, the inorganic vapor-deposited plastic film 2 comprising a plastic film 2a having an inorganic vapor-deposited layer 2b such as aluminum, silicon oxide, and aluminum oxide is coated on the surface of the inorganic vapor-deposited layer 2b such as aluminum, silicon oxide, and aluminum oxide. The heat-adhesive resin layer 3 is directly formed partially. Reference numeral 4 in the figure is a surface layer laminated on the surface of the plastic film layer 2a. When a packaging bag is manufactured using this packaging material, it can be manufactured by the manufacturing method described in the preceding section.

Further, although the surface layer 4 in the figure is not particularly limited, for example, paper, biaxially stretched polyethylene terephthalate film, biaxially stretched polyamide film, biaxially stretched polypropylene film, or these films are subjected to vapor deposition. It is possible to adopt a structure in which one or more kinds of deposited films, aluminum foils and the like are arbitrarily laminated. In addition, a printing layer may be appropriately provided on the surface layer 4.

FIG. 3 is a cross-sectional view showing the layer structure when the non-adsorbing material of the present invention is used as a releasing material for protecting an adhesive layer containing a trace amount of an active ingredient such as a poultice. As shown in FIG. 3, a plastic film 2 'is provided with an inorganic vapor-deposited layer in which an inorganic vapor-deposited layer 2'b such as aluminum, silicon oxide, or aluminum oxide is formed on one surface of a plastic film 2'a. The surface of the deposited layer 2'b is attached to an adhesive layer containing a trace amount of an active ingredient such as a poultice, and the surface of the deposited layer 2'b is a surface having releasability. Although the cross-sectional view of this layer configuration shows that the plastic film 2'a is provided with a vapor deposition layer on one surface, it is also possible to provide the plastic film 2'a with vapor deposition layers on both surfaces. Similarly, aluminum foil can also be used as a protective material having the releasability for the purpose of the present invention, but currently used materials are polypropylene, polyester, etc., resulting in high cost and poor workability, which is preferable. Absent.

FIG. 4 shows a case where the non-adsorbent material of the present invention is used as a packaging material in a packaging bag, and a content such as a cataplasm using the non-adsorbent material of the present invention as a protective material is enclosed therein. It is sectional drawing which shows a layer structure. As shown in FIG.
The content (7) such as a poultice comprises a base layer (6) and a pressure-sensitive adhesive layer (5) containing a trace amount of active ingredient, and the surface of the pressure-sensitive adhesive layer (5) is coated with the non-adsorbed material of the present invention shown in FIG. The surface of an inorganic vapor deposition layer 2'b of an aluminum, silicon oxide, aluminum oxide or the like of a plastic film 2 'having an inorganic vapor deposition layer is adhered, and the plastic film 2' uses the non-adsorbing material of the present invention shown in FIG. The heat-adhesive resin layers 3 of the non-adsorbing material are overlapped and sealed in a heat-sealed packaging bag (8).

[0022]

The present invention will be described in more detail with reference to the following examples. Example 1 An anchor coat was applied to the non-deposited layer surface of a silicon oxide-deposited biaxially stretched polyethylene terephthalate film (deposited layer: 400 °) of 12 μm, and then 12 μm
After performing anchor coating on one surface of the biaxially stretched polyethylene terephthalate film, the anchor coating layers of both films are opposed to each other, and a high-pressure low-density polyethylene is extruded with a thickness of 15 μm between the two to perform lamination by sand lamination. The body was made. Furthermore, when a urethane-based thermo-adhesive resin layer is formed on the silicon oxide vapor-deposited layer of the laminate by using a gravure printing method, the bag inner size is 130 mm × 180 mm, and the bag outer size is 140 mm × 190 mm. Thus, a packaging material of the non-adsorbing material of the present invention was obtained by forming a 5 mm width on the peripheral edge of the bag. The coating amount of the heat-adhesive resin layer at the time of drying was 5 g / m ² . Example 2 One side of high-quality paper of 52.3 g / m ² and a glossy surface of an aluminum foil of 7 μm were extruded with a high-pressure low-density polyethylene to a thickness of 15 μm and subjected to lamination to produce a laminate. A urethane-based heat-adhesive resin layer was formed on the matte surface of the aluminum foil by the same method as in the preceding section, to obtain a packaging material for the non-adsorbing material of the present invention. Example 3 The thickness of the silicon oxide deposition layer was 200, 600, and 800 degrees.
Except for using the three kinds of 12 μm silicon oxide vapor-deposited biaxially stretched polyethylene terephthalate films, a packaging material of the non-adsorbing material of the present invention was obtained. Comparative Example 1 A high-pressure method low-density polyethylene was extruded at a thickness of 15 μm from one side of a coated paper of 79 g / m ² and a glossy surface of an aluminum foil of 7 μm to perform lamination to produce a laminate. An ethylene-methyl acrylate copolymer was extruded over the entire matte surface of the foil to a thickness of 20 μm and subjected to lamination to obtain a packaging material to be compared with the present invention.

Using the packaging materials of Examples 1, 2, 3 and Comparative Example 1, the inner dimensions of the bag were 130 mm × 180 mm, and the outer dimensions of the bag were 1 mm.
A three-sided seal pouch of 40 mm × 190 mm was prepared. The obtained three-side seal pouch was separately filled with a preparation containing a trace amount of active ingredient L-menthol and 23 g of a preparation containing d-limonene, and then the opening was sealed by heat sealing to obtain a sealed package sample. . After leaving these sealed package samples in an atmosphere of 37 ° C. for 60 days, they were opened, and the retention rates of the initial concentrations of L-menthol and d-limonene contained in the preparation were quantified by gas chromatography. Are summarized in Table 1.

[0024]

[Table 1] As is evident from Table 1, the packaging material using the non-adsorbent material of the present invention has excellent results in which both L-menthol and d-limonene in the preparation have extremely little decrease over time, compared to the conventional packaging material. Was done. Although excellent results are obtained when the thickness of the deposited layer of silicon oxide is 400 ° or more, it is sufficiently good at 600 ° or less in consideration of cost effectiveness.

As described above, since the non-adsorbing material of the present invention does not adsorb L-menthol and d-limonene, which are trace active components, it is possible to almost completely suppress the decrease of the trace active components over time due to adsorption. Further, the non-adsorption material of the present invention is
It has a releasable property to the adhesive layer such as a poultice containing a small amount of the above-mentioned active ingredient, and is extremely useful as a substitute for conventionally used polypropylene and polyester.

[0026]

By using the non-adsorbing material of the present invention for the innermost layer which is in direct contact with the content containing a trace amount of active ingredient, as is clear from the results shown in Table 1, the ethylene As compared with a methyl acrylate copolymer or the like, the decrease over time due to adsorption of a trace amount of an active ingredient can be almost completely suppressed. As a result, it is not necessary to previously contain an excess amount of the trace amount of the active ingredient which will be adsorbed and reduced during the effective use period in accordance with the effective use period of the contents, and the cost associated therewith is increased. Can be prevented, and the quality stability of the contents can be improved.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view showing an example of a layer configuration when a non-adsorbing material according to the present invention is used as a packaging material.

FIG. 2 is a cross-sectional view showing an example of a layer configuration when a non-adsorbing material according to the present invention is used as a packaging material.

FIG. 3 is a cross-sectional view showing an example of a layer configuration when a non-adsorbing material according to the present invention is used as a protective material.

FIG. 4 is a cross-sectional view showing an example of a case where the contents protected by the non-adsorbing material of the present invention shown in FIG. 3 are enclosed in a packaging bag using the non-adsorbing material according to the present invention shown in FIG.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 Aluminum foil 2, 2 'Plastic film provided with inorganic substances, such as aluminum, silicon oxide, aluminum oxide, etc. 2a, 2'a Plastic film layer 2b, 2'b Deposition layer of inorganic substances, such as aluminum, silicon oxide, aluminum oxide, etc. 3 Heat Adhesive resin layer 4 Surface layer 5 Adhesive layer (containing L-menthol) 6 Base layer 7 Contents 8 Packaging bag using non-adsorbing material

Claims (3)

[Claims] 1. A non-adsorptive material, wherein the layer in contact with the contents is formed of an aluminum foil or a vapor-deposited layer of an inorganic substance such as aluminum, silicon oxide, or aluminum oxide. 2. The non-adsorbing material according to claim 1, wherein a heat-adhesive resin layer is partially formed on the aluminum foil surface or the vapor deposition layer surface. 3. The method according to claim 1, wherein the content is menthol, limonene,
3. The non-adsorbing material according to claim 1, wherein the non-adsorbing material is a drug, a cosmetic, a food or the like containing a trace amount of an active ingredient such as methyl salicylate, indomethacin, and morphine.