JPH1038766A - Methods for sampling and examining urine, apparatus for the same and parts thereof - Google Patents

Abstract

PROBLEM TO BE SOLVED: To automatically sample and dilute urine and enable sugar to be automatically measured with a sensor by using a sampling pipe having diluted liquid and pressure reduced to take in a fixed amount of the urine of a vessel and mix the same with the diluted liquid. SOLUTION: A sampling pipe 1 fills a glass pipe 3 with diluted liquid to reduce pressure, and the upper and lower portions of the cylindrical glass pipe 3 are sealed up with rubber plugs 4. While a pipe 12 of a sample holder 12 is put into urine 22 in a vessel 21, the rubber plugs of the sampling pipe 1 are pressed against a needle 13 of a sample holder 11 to be penetrated thereby so that the urine 22 is taken in by an amount corresponding to the pressure reduction in the sampling pipe 1 from the pipe 12 communicating to the needle 13 to be mixed with the diluted liquid 2. When the sampling pipe 1 is attached between a circuit part and stirring part, the stirring part stirs the diluted urine 22 in the sampling pipe 1, while the circuit part measures sugar in the sampling pipe 1 by a sensor. Thus, the sugar can be automatically measured and indicated after the urine is automatically sampled and diluted without staining the hands.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a urine collecting method, a test method and an apparatus therefor.

[0002]

2. Description of the Related Art Conventionally, when measuring the sugar content in a liquid, for example, the sugar content in urine, generally, urine is collected in a container, a test paper is put in the container, and the discoloration of the test paper is checked. The sugar content in urine was determined visually or by measuring with a measuring instrument.

In addition, a so-called biosensor in which an enzyme (for example, glucose oxidase) is attached to an electrode such as oxygen or hydrogen peroxide is put in a dilute solution of collected urine for measurement.

Further, using a measuring device such as LC-MS,
Sugar in the collected urine was analyzed.

[0005]

The method for measuring the sugar content according to the degree of discoloration by placing the first test paper in the collected urine as described above is simple in operation, but the measurement is performed for measuring the degree of discoloration. There is a problem that accuracy is poor.

[0006] Further, the method of measuring the sugar content in urine using the second biosensor is based on the method of quantitatively measuring urine collected during measurement because interfering substances (uric acid, ascorbic acid, etc.) in urine deteriorate the measurement accuracy. It is necessary to measure after dilution, and there is a problem that it is difficult to perform dilution quantitatively.

In addition, the use of the third various measuring devices (liquid chromatographs) has the problem that the measurement is expensive, the handling is difficult, and the measurement can only be performed by a specialist.

Further, in the first to third methods, when the urine is collected and the sugar content is measured, there is a tendency that the urine is disliked to be attached to a hand or the like, and there is a problem that anyone cannot easily measure the sugar content.

[0009] The present invention solves these problems,
The purpose is to automatically measure the sugar content by a sensor after automatically collecting and diluting urine.

[0010]

Means for solving the problem will be described with reference to FIGS. 1 to 16. 1 to 1
In 6, the sampling tube 1 is the one in which the diluent is put and the pressure is reduced.

[0011] The dilution cell 51 is a container containing a diluent. The circuit unit 31 includes components necessary for measuring sugar such as a sensor 32 and a measurement circuit.

The stirrer 41 contains a motor or the like necessary for stirring. Next, the operation will be described. As shown in FIG. 1 and FIG.
With the tip of the pipe attached to the container inserted into the urine contained in the container, the rubber portion of the collection tube 1 into which the diluent has been put and the pressure has been reduced is applied to the other sharp end of the pipe in the sample holder 11. The urine in the container is inserted into the collection tube 1 via the pipe, and a predetermined amount is taken and mixed with a diluent to dilute the urine.

As shown in FIGS. 6 and 7, for example, the variable nozzle 14 attached to the sample holder 11 is extended and the tip thereof is inserted into urine placed in a container. The rubber part of the collection tube 1 into which the diluent is put and the pressure is reduced is inserted into the other end having a sharp point, and a certain amount of urine in the container is taken into the collection tube 1 through the variable nozzle to dilute the diluent. To mix and dilute.

As shown in FIGS. 9 and 10, urine is sprinkled on an absorption pad or inserted into urine placed in a container to absorb a certain amount of the absorption pad, and then a dilution cell containing a diluting liquid. The absorption pad is put into the inside 51 and mixed with a diluent to dilute it.

As shown in FIGS. 12 and 13, etc., a predetermined amount is absorbed into an absorbent pad soaked in urine collected on urine collecting paper attached to a toilet seat, and then a dilution cell 51 containing a diluting liquid.
The said absorption pad is put in it, and it mixes with a diluting liquid and it is made to dilute.

As shown in FIGS. 1 to 8 and the like, a sampling tube 1 for storing collected and diluted urine and a sensor 32 for measuring the sugar content in the urine are provided in a pipe. A circuit unit 31 for measuring the sugar content by using the same, a stirring unit 41 for stirring the urine in the collection tube 1, and when the collection tube 1 is mounted between the circuit unit 31 and the stirring unit 41 and both are pushed in The stirring unit 41 stirs the urine diluted with the diluent in the collection tube 1 and the circuit unit 31 measures the sugar content in the collection tube 1 by the sensor 32 in the pipe.

As shown in FIGS. 6 to 8 and the like, the collection tube 1 containing the collected and diluted urine has a configuration in which a sensor 32 for measuring the sugar content in the urine is placed in a pipe. Is attached between the circuit unit 31 for measuring the sugar content using the stirrer 41 and the stirrer 41, and when both are pushed in, the stirrer 4
1 stirs the urine diluted with the diluent in the collection tube 1, and the circuit unit 31 measures the sugar content in the collection tube 1 by the sensor 32 in the pipe.

As shown in FIGS. 9 to 11, for example, a dilution cell (collection tube 1) for putting an absorption pad having absorbed a certain amount of urine into a diluent, and a sensor 32 for measuring the sugar content in the urine are provided in the pipe. And a stirrer 41 that stirs urine in the dilution cell, and a dilution cell is mounted between the circuit unit 31 and the stirrer 41. When both are pushed in,
Is stirred in a state in which a certain amount of urine in the dilution cell is absorbed in the diluent, and the circuit unit 31 measures the sugar content in the dilution cell by the sensor 32 in the pipe.

As shown in FIGS. 12 and 13, a dilution cell in which a certain amount of urine is absorbed in a diluent is provided with a sensor 32 for measuring the sugar content in the urine in a pipe. The stirrer 41 was attached between the circuit unit 31 for measuring the sugar content using the sensor 32 and the stirrer 41, and when both were pushed in, the stirrer 41 absorbed a certain amount of urine in the dilution cell. The absorption pad is stirred in a state of being put in the diluent, and the circuit unit 31 measures the sugar content in the dilution cell by the sensor 32 in the pipe.

At this time, when the stirrer 41 is pushed in with the stirrer, the stirrer rod is inserted into the collection tube 1 and rotated to stir the urine in the collection tube 1, or the stirrer 41 is electromagnetically driven. The urine in the collection tube 1 is stirred by rotating or vibrating the metal piece placed in the collection tube 1 by the guidance.

The circuit unit 31 includes a power supply unit for supplying power, a control circuit unit for measuring a sugar content based on a signal from the sensor 32, and a display unit for displaying the measured result.

Further, as shown in FIG. 14, a power supply unit, which is a component comprising a measurement terminal connected to a signal line taken out from the other end of the sensor penetrating the waterproof pad, is constituted.

As shown in FIGS. 17 and 18,
After the sampling tube 1 is inserted in a state where the space between the circuit unit 31 and the stirring unit 41 is stretched by the mechanism that allows the contraction between the circuit unit loaded with the sensor and the stirring unit, and the circuit unit 31 The sensor is automatically inserted into the sampling pipe 1 in response to the movement in the direction of compressing the agitator 41.

As shown in FIGS. 19 and 20,
A cylindrical cylinder having a reservoir at the distal end and having a hole at a predetermined distance from the distal end, and sliding inside the cylinder to the position of the hole, urine from the hole into the reservoir, and then And a piston that slides to the bottom.

At this time, the tip of the cylinder is made spherical. Therefore, after the urine is collected and diluted, the sugar content can be automatically measured by the sensor.

[0026]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, the configuration and operation of one embodiment of the present invention will be described in detail according to the order shown in the flow chart of FIG. 1 and with reference to FIGS.

FIG. 1 is a flowchart illustrating the operation of the present invention. In FIG. 1, S1 prepares a sample.
In this case, as shown in FIG. 2, urine which is a sample to be tested is put in a container 21 and prepared.

In step S2, the pipe of the sample holder is put into the sample. This puts the pipe 12 of the sample holder 11 into the urine 22 in the container 21 as shown in FIG. S
3 inserts the collection tube into the needle of the sample holder. In this case, as shown in FIG. 2D, the rubber stopper at the bottom of the collection tube 1 is inserted into the needle 13 of the sample holder 11 with the pipe 12 placed in the urine 22 in S2.

In step S4, a fixed amount of the sample is taken into the collection tube and mixed with the diluent. This corresponds to the insertion of the sampling tube 1 into the needle 13 of the sample holder 11 in S3, as shown in FIG. Because of this pressure reduction, the urine 22 is sucked into the collection tube 1 by a fixed amount (a fixed amount corresponding to the reduced pressure and the volume) through the pipe 12 and the urine is mixed with the diluent by the sucking force.

In step S5, the collection tube is mounted between the circuit section and the stirring section, and both are pushed into the collection tube. This is shown in FIG.
As shown in (4), after a certain amount of urine in the collection tube 1 is taken and mixed in S4, the circuit portion 31 is placed from above the collection tube 1 from which the needle 13 has been removed, and the stirring portion 41 is sandwiched from below from both sides. Then, the needles 33 and 43 are inserted from the upper and lower rubber portions of the sampling tube 1 respectively, and the sensor 3 in the needle 33 is inserted.
2 and the stirring rod in the needle 43 are inserted into the collection tube 1 respectively, as shown in FIG. Thus, the preparation for starting the measurement of the sugar content while stirring the liquid in the collection tube 1 is completed.

In step S6, a switch is pressed. In this case, a switch provided on the upper part of the circuit unit 31 shown in FIGS. 3A and 3B is pressed to supply power to the circuit unit 31 and the stirring unit 41.

In step S7, stirring is performed. This is shown in FIG.
As shown in (2), the motor of the stirring unit 41 is rotated, and the rod protruding into the collection pipe 1 connected thereto is rotated to stir the liquid so that the liquid circulates and flows to the sensor 32.

At S8, measurement is performed. In this method, a current corresponding to the sugar content in the liquid is measured by the sensor 32 using a circuit 31 shown in FIG. S9 is
Displays the sugar concentration. This displays the measured sugar concentration on the display unit 36 provided in the circuit unit 31, as shown in FIG. 3 (c).

As described above, urine is prepared in a container, a predetermined amount is automatically taken into the collection tube 1 simply by inserting a pipe into the container, and a predetermined dilution is performed with the internal diluent. When the circuit unit 31 and the stirring unit 41 are pushed in from both sides and the switch is pressed, the liquid in the sampling tube 1 is automatically stirred, and the sugar concentration is accurately measured by the sensor 32 and displayed. Accordingly, the troublesome operation of quantitatively diluting urine is not required, and the sugar concentration can be accurately measured automatically and displayed.

FIG. 2 shows an example of a sampling tube / sample holder of the present invention. FIG. 2A shows a configuration example of the collection tube. In FIG. 2 (a), a collection tube 1 is obtained by filling a diluent 2 into a glass tube 3 and depressurizing the same.
The upper and lower parts are sealed with a rubber stopper 4 as shown in the figure.

The diluent 2 is used to dilute urine and accurately detect
This is a liquid that can be measured by the method 2. The glass tube 3 is a glass tube cut into a cylindrical shape, which is closed with rubber stoppers at the top and bottom, and is used for putting a predetermined amount of diluent therein and reducing the pressure.

The rubber stopper 4 is for sealing the inside of the glass tube 3 and reducing the pressure. The stopper 5 is connected to the sample holder 11
At a predetermined position. As mentioned above,
The upper and lower portions of the cylindrical glass tube 3 are sealed with a rubber stopper 4, and a predetermined amount of the diluent 2 is put therein, and the pressure is reduced. Thus, the needle 13 is inserted into the inside through the rubber stopper 4, and urine in the container 21 described later can be sucked into the glass tube 3 by a predetermined amount by the pipe 12 communicating with the needle 13. .

FIG. 2 (b) shows the sampling tube 1 of FIG. 2 (a).
Shows a state in which is to be inserted into the sample holder 11 with the needle 13. 2 (c) is the same as FIG. 2 (b), and as shown in FIG. 2 (d) on the right side, the rubber stopper 4 of the collection tube 1 is connected to the needle 13 of the sample holder 11. It shows a state in which it has been inserted just before contacting the part.

FIG. 2D shows that the sampling tube 1 is connected to the sample holder 1.
1 shows a state in which the pipe 12 connected to the needle 13 of the sample holder 11 is inserted into the urine 22 in the container 21 while being inserted into the container 1 as shown by an arrow. In this state, the collection tube 1 is further moved downward, and the rubber stopper 4 under the collection tube 1 is penetrated by the needle 13 of the sample holder 11, and the urine 22 is collected by the pipe 12 connected to the needle 13. A certain amount is taken in because the inside of 1 is depressurized.

As shown in FIG. 2D, with the pipe 12 of the sample holder 11 placed in the urine 22 in the container 21, the rubber stopper 4 of the collection tube 1 is connected to the needle of the sample holder 11. When the urine 22 is pressed against the needle 13 and penetrated, the urine 22 is taken in from the pipe 12 connected to the needle 13 by an amount corresponding to the reduced pressure in the collection tube 1 and can be mixed with the diluent.

FIG. 3 shows an example of the circuit section / collecting pipe / stirring section of the present invention. FIG. 3A shows the circuit section 3 from above the sampling tube 1.
1 shows a state of being sandwiched by the stirring unit 41 from below. In this state, the needle 33 of the upper circuit section 31 is prepared to pass through the hole of the cover 34 and penetrates the rubber stopper 4 at the top of the sampling tube 1, and the needle 43 of the lower stirring section 41 is passed through the hole of the cover 42. Thus, it is ready to penetrate the rubber stopper 4 below the collection tube 1.

FIG. 3B shows a state in which the circuit section 31 and the stirring section 41 are pressed against each other from above and below in the state shown in FIG. Stopper 4
And the sensor 32 is further pushed out so that the sugar concentration can be measured by immersing the sensor 32 in the diluent inside the collection tube 1. The needle 43 of the stirring unit 41 is connected to a rubber stopper at the lower part of the collection tube 1. 4 and put into the inside, and the stirring rod is further pushed out so as to be immersed in the diluent inside the collection tube 1 so that stirring can be performed.

FIG. 3C shows a state in which the power is turned on by pressing the switch 35 on the upper part of the circuit unit 1 in the state of FIG. Is turned to circulate the liquid in the collection tube 1, and the sensor 32 of the circuit unit 31 measures the sugar concentration of the circulating liquid in the collection tube 1,
The state displayed on the display unit 36 is shown.

FIG. 4 shows an example of the sensor of the present invention. This is an example of the sensor 32 of FIG. 3 described above, and is a so-called biosensor, which is a sensor for measuring the sugar concentration in the diluent.

In FIG. 4, the cathode is for attaching an enzyme on the electrode to consume O ₂ in the diluent to generate a current corresponding to the sugar concentration. The anode is for detecting a current at the cathode where O ₂ is consumed by the enzyme according to the sugar concentration in the diluent.

The pads are used to connect to the enzyme electrode controller shown in FIG. FIG.
Shows a circuit example of the present invention.

In FIG. 5, the oxygen electrode corresponds to FIG.
Sensor 32. This is, as shown in FIG. 3 (b) described above, immersed in a diluent 2 in which urine is mixed in a collection tube 1 and decomposes sugar in the urine by the action of an enzyme to reduce O _2.
Is consumed, and the current flowing at this time is detected.

The enzyme electrode controller detects a minute current flowing through the enzyme electrode (corresponding to the sensor 32 in FIG. 4). As shown in the figure, a current-voltage conversion unit, a calibration unit, a voltage supply unit, And a display.

The voltage supply unit supplies a constant voltage to the oxygen electrode. This constant voltage to be supplied is Va shown in FIG.
The volume of dj is adjusted to an arbitrary value. Current - voltage converter is converted while applying a constant voltage to the enzyme electrode by the voltage supply unit, a current flowing through the consumption of O ₂ corresponding to the sugar concentration by the action of the cathode on the enzyme at that time, the voltage Is what you do.

The calibrating unit is for calibrating the voltage corresponding to the current converted by the current-voltage converting unit. The calibrating unit performs calibration when the sugar concentration is 0% by the volume of 0% adj, and performs 100% The calibration at the time when the sugar concentration is 100% is repeated by the volume of adj, and the adjustment is repeated so that the correct value is displayed on the display.

The display digitally displays the sugar concentration based on the analog signal from the calibration unit. Here, the sugar concentration is digitally displayed in%. As described above, it is possible to measure and digitally display the sugar concentration of the urine diluted by the diluent 2 in the collection tube 1 with the enzyme electrode (the sensor in FIG. 4 and the sensor 32 in FIG. 3B). Becomes

Next, the configuration and operation of another embodiment of the present invention will be sequentially described in detail with reference to FIGS. 7 and 8 in accordance with the order shown in the flowchart of FIG. FIG. 6 is a flowchart illustrating another operation of the present invention. Here, S1,
S3 to S6, S8, and S9 correspond to the same numbers in FIG.

In FIG. 6, S1 prepares a sample. In this case, as shown in FIG. 7C, urine which is a sample to be tested is put in a container 21 and prepared. S2-1 is
Extend the nozzle of the sample holder into the sample. this is,
As shown in FIG. 7B, after the contractible nozzle 14 is extended to the sample holder 11, the nozzle 14 is turned down and put into the urine in the container 21.

In step S3, the sampling tube is inserted into the needle of the sample holder. As shown in FIG. 7C, the rubber stopper at the bottom of the collection tube 1 is inserted into the needle 13 of the sample holder 11 with the nozzle 14 put in the urine in S2-1.

In step S4, a certain amount of the sample is taken into the collection tube and mixed with the diluent. This corresponds to the fact that the sampling liquid 1 is inserted into the needle 13 of the sample holder 11 in S3 as shown in FIG. Because of this reduced pressure, urine is sucked into the collection tube 1 through the nozzle 14 by a certain amount (a certain amount corresponding to the reduced pressure and the volume), and the urine is mixed with the diluent at the sucking force.

In step S5, the collection tube is mounted between the circuit section and the stirring section, and both are pushed into the collection tube. This is shown in FIG.
As shown in S4, after a certain amount of urine in the collection tube 1 was taken and mixed in S4, the collection tube 1 with the nozzle with the needle 13 removed was collected.
Push the circuit part 31 from above and the stirring part 41 from below from both sides and insert the needle from above the sampling tube 1,
The sensor 32 in the needle is inserted into the sampling tube 1, and FIG.
As shown. Thus, the preparation for starting the measurement of the sugar content while stirring the liquid in the collection tube 1 is completed.

In step S6, a switch is pressed. In this case, a switch provided above the circuit unit 31 shown in FIG. 8C is pressed to supply power to the circuit unit 31 and the stirring unit 41. S
7-1 is stirred with a magnet in the diluent. this is,
As shown in FIG. 8 (b), the motor of the stirring unit 41 is rotated, whereby the magnet placed at the bottom of the sampling tube 1 is rotated by magnetic induction to stir the liquid and circulate the liquid to the sensor 32. And let it flow.

At S8, measurement is performed. In this method, a current corresponding to the sugar in the liquid is measured by the sensor 32 in the circuit of FIG. S9 displays the sugar concentration. This displays the measured sugar concentration on the display unit 36 provided in the circuit unit 31, as shown in FIG. 8C.

As described above, urine is prepared in a container, and a fixed amount is automatically taken into the collection tube 1 simply by inserting the contractible nozzle 14 therein, and predetermined dilution is performed with the internal diluent. Thereafter, when the sampling tube 1 is pushed into the circuit section 31 and the stirring section 41 from both sides and the switch is pressed, the liquid in the sampling tube 1 is automatically stirred by the rotation of the magnet by electromagnetic induction, and the sugar concentration is accurately detected by the sensor 32. Is measured and displayed. Accordingly, the troublesome operation of quantitatively diluting urine is not required, and the sugar concentration can be accurately measured automatically and displayed.

FIG. 7 shows another configuration of the present invention (an example of a sampling tube / sample holder). FIG. 7A shows a configuration example of the collection tube. In FIG. 7A, the sampling tube 1 is a sample holder 1 having a contractible nozzle 14 and a needle 13 on the opposite side.
1 is a state where the needle 13 is set by a stopper so as not to penetrate the rubber film.

The nozzle 14 is a contractible nozzle.
The needle 13 penetrates the rubber film of the collection tube 1 and takes in a predetermined amount of urine from the nozzle 14.

FIG. 7B shows a state in which the nozzle 14 is extended and the lid is opened to release the stopper that moves the collection tube 1 in the direction of the needle 13. FIG. 7C shows a state in which the nozzle 14 of FIG. 7B is extended and the nozzle 14 is put into the urine in the container 21. It shows a state where the urine is penetrated and a predetermined amount of urine is sucked by the nozzle 14.

FIG. 7D is a perspective view of the appearance in which the sampling tube 1 is fixed in the sample holder 11 with a stopper so as not to penetrate with the needle. FIG. 7E shows a cross-sectional view of FIG. 7D.

FIG. 7F shows an example of a sampling tube. Here, the collection tube 1 is placed in a state where a metal piece (a metal piece for stirring the diluent by electromagnetic induction) is placed at the bottom of a container (a cylindrical container having an open top and a bottom). Put in a fixed amount. Then, a lid is placed on the top, and the top is further sealed with a rubber film. Then, a needle (not shown) is inserted through the rubber membrane to reduce the pressure inside the collection tube 1. As shown in FIGS. 7D and 7E, the collection tube 1 having such a configuration is locked and stored in the sample holder 11 so that the rubber film of the collection tube 1 is not penetrated by the needle with the stopper.

FIG. 8 shows another configuration diagram of the present invention (example of circuit unit / collecting tube / stirring unit). FIG. 8A shows a state where the sampling tube 1 is sandwiched between the circuit unit 31 from above and the stirring unit 41 from below. In this state, the needle 33 of the upper circuit section 31 is ready to penetrate the rubber film on the upper part of the collection tube 1 through the hole of the cover.

FIG. 8B shows a state in which the circuit section 31 and the stirring section 41 are pressed against each other from above and below in the state shown in FIG. And the sensor 32 is further pushed out and immersed in the diluent inside the collection tube 1 so that the sugar concentration can be measured.

FIG. 8 (c) shows the state of FIG. 8 (b) where the switch on the upper part of the circuit section 31 is pressed to turn on the power, the motor of the stirring section 41 is rotated, and the sampling tube 1 is induced by electromagnetic induction.
The state in which the sensor 32 of the circuit unit 31 measures the sugar concentration of the circulating liquid in the collection tube 1 and displays the result on the display unit 36 in a state where the metal pieces inside are rotated and the liquid is circulated is shown.

Next, the configuration and operation of another embodiment of the present invention will be sequentially described in detail with reference to FIGS. 10 and 11 in accordance with the order shown in the flowchart of FIG. FIG. 9 is a flowchart illustrating another operation of the present invention. Where S
1, S5 to S9 correspond to the same numbers in FIG.

In FIG. 9, a step S1 prepares a sample. This is accomplished by preparing urine, which is a sample to be inspected, in a container as shown in FIG.
(C) As shown in (c), a preparation is made so as to be directly attached to the absorption pad.

In step S2-2, the sampler is immersed in the sample.
Or attach the sample directly to the sampler. This is accomplished by immersing the absorption pad, which is a sampler, as shown in FIG. 10 (d) in a container containing urine, or directly attaching it to the absorption pad as shown in FIG. 10 (c).

In step S3-2, the sampler is inserted into the dilution cell, and the rod of the sampler is removed. This is because, as shown in FIG. 10 (e), the absorbent pad 73 is placed in the dilution cell 51 while the urine is soaked in the absorbent pad according to (c) or (d) of FIG. Insertion,
Turn rod 71 off.

In step S5, a collection tube (dilution cell) is mounted between the circuit section and the stirring section, and both are pushed into the collection tube. this is,
As shown in (f) of FIG. 10, the dilution cell 51 in S3-2.
After taking in a certain amount of urine in the absorption pad 73 (corresponding to the collection tube 1), the urine is pushed in from both sides in such a manner as to sandwich the circuit section 31 from above the dilution cell and the stirring section 41 from below. Insert the needle from above and connect the sensor in the needle to the dilution cell 5
1 and the needle is inserted from below the dilution cell 51, and the stirring rod in the needle is inserted into the dilution cell 51. Thus, the preparation for starting the measurement of the sugar content while stirring the liquid in the dilution cell 51 is completed.

In step S6, a switch is pressed. This is shown in FIG.
(F) Press the switch provided on the upper part of the circuit unit 31,
Power is supplied to the circuit unit 31 and the stirring unit 41. S7
Is stirred. In this case, the motor of the stirring unit 41 is rotated, and a rod protruding into the collection pipe 1 connected thereto is rotated to stir the liquid so that the liquid circulates and flows to the sensor.

At S8, measurement is performed. In this method, the current corresponding to the sugar in the liquid is measured by the sensor in the circuit of FIG. S9 displays the sugar concentration. This displays the measured sugar concentration on the display unit 36 provided in the circuit unit 31, as shown in FIGS. 11 (a) and 11 (b).

As described above, after a certain amount of urine is taken into the diluent in the dilution cell 51 by the absorption pad 73 and is diluted with the internal diluent by a predetermined amount, the dilution cell 51 is moved from both sides to the circuit unit 31 and the stirring unit. When the switch is pressed by pressing the part 41, the liquid in the dilution cell 51 is automatically stirred, and the sugar concentration is accurately measured and displayed by the sensor. Accordingly, the troublesome operation of quantitatively diluting urine is not required, and the sugar concentration can be accurately measured automatically and displayed.

FIG. 10 shows another configuration of the present invention. FIG. 10A shows an absorbent pad and a rod. this is,
An absorption pad 73 for taking in a certain amount of urine and a rod 71 for soaking or pouring urine into the absorption pad 73 are provided.

FIG. 10B shows an example of a dilution cell.
(B-1) of FIG. 10 shows a front view, and (b-) of FIG.
2) shows a side view. Here, the dilution cell 51 corresponds to the collection tube 1 described above, and a certain amount of urine is absorbed by the absorption pad 73, and the absorption pad 73 is directly put into the inside, and taken into the diluent. It is for diluting urine, which is provided with a take-in port for taking in an absorption pad and contains a predetermined amount of diluent therein.

FIG. 10C shows a direct equation. In this method, urine is directly applied to the absorption pad 73 to collect a certain amount of urine. FIG. 10D shows an indirect expression.
In this method, urine is put in a cup, and the absorbent pad 73 is immersed in the cup to collect a certain amount of urine.

FIG. 10E shows a state in which an absorption pad 73 containing a certain amount of urine is inserted into the dilution cell by a rod 71. FIG. 10F shows a state where the dilution cell 51 is sandwiched between the circuit unit 31 from above and the stirring unit 41 from below. Further, when the dilution cell 51 is pushed in from both sides by the circuit section 31 and the stirring section 41, the needle of the circuit section 31 penetrates from the rubber portion of the dilution cell 51 to the inside, and the sensor is located in the diluting solution, and The stirrer rod is positioned in the diluent with the needle 41 penetrating from the rubber part of the dilution cell 51 to the inside. Then, when the power is turned on, the motor of the stirring unit 51 is rotated, and the stirring rod connected thereto is rotated to circulate the diluent, and the circuit unit 41 measures the sugar concentration by the sensor and displays the sugar concentration on the display unit 36. I do.

FIG. 11 shows another configuration of the present invention. FIG. 11A shows a state where the dilution cell 51 is sandwiched between the circuit section 31 and the stirring section 41.

FIG. 11B shows the state of FIG. 11A in which the circuit section 31 and the stirring section 51 are pushed in from both sides, the needle of the circuit section 31 is inserted into the dilution cell 51, and the sensor is diluted with the diluent. While the stirrer is inserted into the dilution cell 51 and the stirrer is slightly pushed out, and when the power is turned on, the motor of the stirrer is rotated to stir the diluent with the stirrer. The measured value can be displayed on the display unit 36.

Next, the configuration and operation of another embodiment of the present invention will be described in detail according to the order shown in the flowchart of FIG. 12 and with reference to FIG. FIG. 12 is a flowchart illustrating another operation of the present invention. Here, S1, S
5, S6, S8 and S9 correspond to the same numbers in FIG.

In FIG. 12, S1 prepares a sample. In this case, as shown in FIG. 13A, urine, which is a sample to be inspected, is collected and prepared on urine collection paper. S2-3
Soak the absorbent pad with the string in urine collection paper. In this case, as shown in FIG. 13 (a), a string-absorbing pad 62, which is a sample collecting device, is immersed in a portion of the urine collecting paper 61 where urine has accumulated.

In step S3-3, the lid of the plastic bottle is removed, and an absorbent pad with a string is inserted. This is opened by pulling the lid of the plastic bottle, as shown in FIG.
An aliquot of urine is placed in the diluent.

In step S5, a collection tube (plastic bottle) is mounted between the circuit section and the stirring section, and both are pushed into the collection tube. As shown in FIG. 8A, after a certain amount of urine in the dilution cell 51 (collection tube 1) is taken in by the absorption pad 62 in S3-3, the dilution cell (collection tube 1) Circuit part 3 from above
Push in from both sides with the stirrer 41 sandwiched between 1 and below,
A needle is inserted from above the dilution cell 51, a sensor in the needle is inserted into the dilution cell 51, and a needle is inserted from below the dilution cell 51, and a stirring rod in the needle is inserted into the dilution cell 51. Thus, the preparation for starting the measurement of the sugar content while stirring the liquid in the dilution cell 51 is completed.

In step S6, a switch is pressed. This is shown in FIG.
As shown in (f), the switch provided on the upper part of the circuit unit 31 is pressed to supply power to the circuit unit 31 and the stirring unit 41.

In S7, stirring is performed. In this case, the motor of the stirring unit 41 is rotated, and a rod protruding into the collection pipe 1 connected thereto is rotated to stir the liquid so that the liquid circulates and flows to the sensor.

At S8, measurement is performed. In this method, the current corresponding to the sugar in the liquid is measured by the sensor in the circuit of FIG. S9 displays the sugar concentration. This displays the measured sugar concentration on the display unit 36 provided in the circuit unit 31, as shown in FIGS. 11 (a) and 11 (b).

As described above, a certain amount of urine is taken into the diluent in the plastic bottle (dilution cell 51) by the absorption pad 62 with a string, and is diluted with the diluent therein. 51), when the circuit part 31 and the stirring part 41 are pushed in from both sides and the switch is pressed, the liquid in the plastic bottle (dilution cell 51) is automatically stirred, and the sugar concentration is accurately measured by the sensor and displayed. It will be. Accordingly, the troublesome operation of quantitatively diluting urine is not required, and the sugar concentration can be accurately measured automatically and displayed.

FIG. 13 shows another configuration of the present invention. FIG. 13A shows an example of urine collection paper. This urine collection paper 6
1 is that a hole is provided in the toilet seat from a lower portion of the urine collection paper 61 to a slightly upper portion thereof to discharge urine.
Is to prevent damage. The urine collection paper 61 is lightly adhered to the toilet seat on both sides with a double-sided tape so as not to fall.

FIG. 13B shows a string-attached pad. The string-attached absorbing pad 62 is immersed in the urine collected at the bottom of the urine collecting paper 61 of FIG. 13A to collect a certain amount of urine, and is a plastic container containing the diluent of FIG. 13C. For dilution into

FIG. 13C shows an example of a dilution cell.
Here, a predetermined amount of diluent is put into a plastic bottle, urine is absorbed and put into the string-attached absorbing pad 62, and a certain amount of urine is put into the diluent. In this way, the circuit unit 31 and the stirring unit 41 are pushed in from above and below the plastic bottle containing a certain amount of urine in the diluent, and the diluent in the diluting cell (plastic bottle) is agitated. Is measured and displayed.

FIG. 14 shows an example of an electrode unit according to the present invention. FIG. 14A shows an electrode unit. this is,
It is the perspective view which assembled the sensor as an electrode unit.
The sensor of FIG. 4 described above is attached to a tip portion.

FIG. 14B and an enlarged view of an essential part of FIG. 14C show a structural example of the lower side when the electrode unit of FIG. 14A is vertically separated. Here, as shown in the figure, the electrodes (sensors in FIG. 4) are connected to external lead wires with conductive paste, and are waterproofed with a waterproof resin and a waterproof pad.

FIG. 14D shows how the electrode unit of FIG. 14A is assembled. Here, the electrode unit is
As shown in the figure, the unit upper cover, waterproof sheet, unit lower cover, waterproof pad, electrodes and the like are assembled as shown in the figure.

FIG. 15 shows another configuration of the present invention. FIG. 15A shows a configuration diagram of a main part of the circuit unit 31. Here, in the hole portion of the circuit portion 31, the previously described FIG.
The power supply unit is inserted from the top down, and slightly protrudes from the end of the hole into the diluent in the collection tube 1, and the sugar concentration in the diluent is measured by a sensor.
At this time, a stirrer 41 is attached to the lower portion of FIG. 15A to stir the diluent to measure accurately.

FIG. 15B shows the stirring section 41. This is inserted into and attached to the lower part of FIG. 15A, and agitates the diluent inside the collection tube 1 and the like. As shown in FIG. A mechanism such as positioning with respect to the sampling tube 1) is provided. Here, the magnet is rotated by a small motor, and the iron piece (magnet) placed in the bottom of the sample container is rotated by magnetic induction with the rotation of the magnet, so that the diluent diluted with urine is stirred. I have. The power source is usually a battery, which drives a motor to stir the diluent, measures the sugar concentration based on a signal from the sensor, and displays the measured sugar concentration. The lower power supply cover is for storing the battery when the battery is used as a power supply.

FIG. 16 shows another configuration of the present invention. FIG. 16A shows an appearance in which the above-described circuit unit 31, the sampling tube 1, and the like of FIG. 15 and the stirring unit 41 are combined and the measured sugar concentration is displayed on the display unit.

FIG. 16 (b) shows the main configuration of FIG. 16 (a) in an easily understandable manner. Here, the power supply, the electrode replacement port, the circuit section 31, the sample insertion port, the stirring section 41, and the power supply cover are configured in this order from the top.

FIG. 17 shows another configuration of the present invention (part 3).
Is shown. This means that a sample inlet is provided between the circuit unit 31 and the stirring unit 41, and the sample inlet is opened by pulling away from the circuit unit 31 and the stirring unit 41 as shown in the drawing, and the sample is collected at the sample inlet. After inserting the tube 1 as shown by the arrow in the figure, the circuit portion 3
1 and the agitating unit 41 are pressed in a compressing direction, and an electrode unit having a sensor is inserted into a rubber portion on the upper part of the collection tube 1 to be immersed in diluted urine in the collection tube 1. Then, as described above, the content of the sugar in urine is analyzed by the sensor.

FIG. 18 is another configuration diagram (part 4) of the present invention.
Is shown. In this case, a sample inlet is provided between the circuit section 31 and the stirring section 41, and the circuit section 3 is provided as shown in FIG.
1 and the stirring section 41 are pulled apart to open the sample inlet, and the sampling tube 1 is inserted into the sample inlet as shown by the arrow in the drawing and dropped, and the circuit section 31 and the stirring section 41 are compressed. (FIG. 18 (a)), and an electrode unit having a sensor is inserted into the rubber portion on the upper portion of the collection tube 1 to be immersed in the diluted urine in the collection tube 1. Then, as described above, the content of the sugar in urine is analyzed by the sensor.

FIG. 19 shows an example of a sampler according to the present invention. FIG.
In 9, the urine collecting device is composed of a cylinder A and a piston B, and has a hole at a predetermined distance from the lower part of the cylinder A.

FIG. 19A shows a state where the piston B is pushed up from the cylinder A to the position indicated by the mark. In this state, the cylinder A
The urine is directly applied to the hole in the lower hole of the container, and the urine is poured from the hole and collected up to the lower hole of the tube A.

FIG. 19 (b) shows a state where the piston B is pressed down. In this state, the piston B just reaches the lower part of the hole and prevents the urine accumulated in the lower part of the cylinder A from being discharged from the hole.

FIG. 19C shows a state in which the cylinder A and the piston B in the state of FIG. 19B are immersed together in a diluent. 19D, the piston B is raised upward in the state of FIG. 19C, and a predetermined amount of urine stored in the lower part of the cylinder A is diluted in the diluent.

As described above, a hole is formed at a position at a predetermined distance from the lower part of the cylinder A, a reservoir having a predetermined capacity is formed at the lower part of the cylinder A, and urine is directly applied to the hole and a predetermined amount of urine is stored in the pool at the lower part of the cylinder A. And lower the piston B to prevent the urine in the pool from overflowing. Then, after the tube A and the piston B are put together in the collection tube 1, the urine in the tube A is put into the diluent to be diluted by raising the piston B.

FIG. 20 shows another sampler according to the present invention.
FIG. 20A shows an example in which the lower part of the cylinder C is spherical.
This is an example in which a predetermined amount of urine is introduced with high precision up to a portion where a hole is made by making the lower part of the cylinder C spherical. Due to the spherical shape, the spherical diameter is larger than the diameter of the cylinder C in the hole portion, so that urine can be collected from the spherical portion with good accuracy.

FIGS. 20 (b) to (d) show examples in which a hole is formed in the lower part of the piston F as shown in FIG. In FIG. 20 (b), urine is sprinkled into the hole and accumulated in the lower part of the cylinder E in a state where the piston F is lifted and moved upward from the hole in the lower part of the cylinder E.

FIG. 20 (c) shows a state in which the piston F is pulled down to make it lower than the hole in the cylinder E so that urine does not leak. FIG. 20D shows an outline of the piston F. This is because, in (c) of FIG. 20, the pool capacity formed when the piston F is lowered downward is smaller than the pool capacity formed below the hole of the cylinder.
A hole is made in the lower part of the piston F, so that urine passes through the hole of the piston to the upper part and excess urine is discharged from the hole of the cylinder, so that urine can be collected with higher accuracy. It is.

[0110]

As described above, according to the present invention,
After the urine is collected and diluted automatically, the sugar content can be automatically measured by a sensor and displayed. Thereby, (1) urine can be collected and stained quantitatively at the same time without soiling the hands.

(2) It is possible to automatically and quickly measure with a sensor and quantitatively display the sugar concentration quantitatively and with high precision. (3) It is portable and compact, and can easily measure the sugar concentration in urine at any place.

(4) Since a certain amount of urine is collected, the urine is immersed in the absorption pad and put in the diluent, so that a certain amount of urine is easily collected and quantitatively diluted with the diluent, and a simple and simple method is used. The sugar concentration can be measured and displayed with high accuracy.

(5) Using the absorbent pad with a string, the absorbent pad with the string soaked in a slightly accumulated portion of the urine collection paper attached to the toilet seat is put into a container containing a diluent, and the urine is quantitatively diluted. As a result, the sugar concentration can be easily and accurately measured and displayed.

(6) To collect a certain amount of urine, a hole is made at a position at a predetermined distance from the lower part of the cylinder, a certain amount of urine is stored in the lower part, and the urine is put into the collection tube 1 for dilution. A certain amount of urine is collected, and the sugar concentration can be measured simply and with high accuracy.

[Brief description of the drawings]

FIG. 1 is a flowchart illustrating the operation of the present invention.

FIG. 2 is an example of a collection tube / sample holder of the present invention.

FIG. 3 is an example of a circuit unit / collecting tube / stirring unit according to the present invention.

FIG. 4 is an example of a sensor according to the present invention.

FIG. 5 is a circuit example of the present invention.

FIG. 6 is a flowchart illustrating another operation of the present invention.

FIG. 7 is another configuration diagram of the present invention (an example of a sampling tube / sample holder).
It is.

FIG. 8 is another configuration diagram of the present invention (an example of a circuit unit / collecting tube / stirring unit).

FIG. 9 is a flowchart illustrating another operation of the present invention.

FIG. 10 is another configuration diagram of the present invention.

FIG. 11 is another configuration diagram of the present invention.

FIG. 12 is a flowchart illustrating another operation of the present invention.

FIG. 13 is another configuration diagram of the present invention.

FIG. 14 is an example of a power supply unit of the present invention.

FIG. 15 is another configuration diagram of the present invention.

FIG. 16 is another configuration diagram of the present invention.

FIG. 17 is another configuration diagram (part 3) of the present invention.

FIG. 18 is another configuration diagram (No. 4) of the present invention.

FIG. 19 is an example of a sampler of the present invention.

FIG. 20 is another example of a sampler of the present invention.

[Explanation of symbols]

 1: Collection tube 2: Diluent 3: Glass tube 4: Rubber stopper 5: Stopper 11: Sample holder 12: Pipe 13: Needle 14: Nozzle 21: Container 22: Urine 31: Circuit part 32: Sensor 33: Needle 34: Cover 35: Switch 36: Display unit 41: Stirring unit 42: Cover 43: Needle 44: Motor 61: Urine sampling paper 62: Stringing absorption pad 71: Rod 72: Hole 73: Absorption pad

Claims (14)

[Claims] 1. A urine collection method for collecting urine, wherein a tip of a pipe attached to a sample holder is inserted into urine placed in a container, and the other end of the pipe in the sample holder is A urine collection method, comprising inserting a diluent into a rubber part of a collection tube that has been decompressed, taking a predetermined amount of urine in the container into the collection tube through the pipe, mixing with the diluent, and diluting the urine. . 2. A urine collecting method for collecting urine, wherein a variable nozzle attached to a sample holder is extended, and a tip of the variable nozzle is inserted into urine placed in a container. Insert the rubber part of the collection tube into which the diluent has been placed and decompressed, and take a certain amount of urine in the container through the variable nozzle into the collection tube to mix and dilute with the diluent. A urine collection method characterized by the above-mentioned. 3. A urine collecting method for collecting urine, comprising: attaching a urine to an absorbent pad or immersing the urine in a container to absorb a certain amount of the urine into the urine; A method of collecting urine, comprising adding the absorption pad, mixing with a diluent, and diluting. 4. A urine collecting method for collecting urine, wherein the absorbent pad is immersed in urine collected on urine collecting paper attached to a toilet seat to absorb a predetermined amount, and then the absorbent pad is placed in a dilution cell containing a diluent. A urine collection method, wherein the urine is mixed with a diluent and diluted. 5. An inspection apparatus for measuring the sugar content of urine, comprising: a collection tube for storing collected and diluted urine; and a sensor for measuring the sugar content in urine in a pipe. A stirrer for stirring the urine in the collection tube; and a stirrer when the collection tube is mounted between the circuit unit and the stirrer and both are pushed in. Wherein the urine diluted with the diluent in the collection tube is agitated, and the circuit unit measures the sugar content in the collection tube by a sensor in the pipe. 6. A test method for measuring the sugar content of urine, wherein the collection tube containing the collected and diluted urine has a configuration in which a sensor for measuring the sugar content in urine is placed in a pipe, and the sensor is connected to the pipe. When installed between the circuit unit for measuring the sugar content and the stirring unit and both are pushed in, the stirring unit stirs the urine diluted with the diluent in the collection tube, and the circuit unit An inspection method, wherein a sugar content in the collection pipe is measured by a sensor in the pipe. 7. An inspection apparatus for measuring the sugar content of urine, wherein a collection tube for putting a predetermined amount of urine absorbed into a diluent and a sensor for measuring the sugar content of urine are placed in a pipe. And a circuit unit for measuring the sugar content using the sensor, a stirring unit for stirring the urine in the collection tube, and the collection tube is mounted between the circuit unit and the stirring unit and both are pushed in. When the stirring unit agitates in a state where the absorption pad, which has absorbed a certain amount of urine in the collection tube, is placed in the diluent, the circuit unit measures the sugar content in the collection tube by a sensor in the pipe. An inspection apparatus characterized in that: 8. A test method for measuring the sugar content of urine, wherein a collection tube containing an absorbent pad absorbing a certain amount of urine in a diluent is provided with a sensor for measuring the sugar content in urine in a pipe. An absorption pad that has a configuration and is mounted between a circuit unit for measuring sugar content using the sensor and the stirring unit and when the two are pushed in, the stirring unit absorbs a certain amount of urine in the collection tube. While stirring in the diluent,
An inspection method, wherein the circuit unit measures a sugar content in the collection pipe by a sensor in the pipe. 9. The stirring bar is inserted into the collection tube and rotated when the stirring unit is pushed in by holding the stirring rod, or the urine in the collection tube is stirred, or the stirring unit is placed in the collection tube by electromagnetic induction. The inspection apparatus or the inspection method according to claim 5, wherein the urine in the collection tube is agitated by rotating or vibrating the placed metal piece. 10. A power supply unit for supplying power to the circuit section, a control circuit section for measuring a sugar content based on a signal from a sensor, and a display section for displaying the measurement result. An inspection apparatus or an inspection method according to claim 5. 11. A sensor for measuring sugar content in urine by being put in a diluent, a disc-shaped waterproof pad penetrating the sensor put in urine, and waterproofing at the disc-shaped portion. A component comprising: a measurement terminal connected to a signal line taken out from the other end of the sensor penetrating the waterproof pad. 12. A mechanism for allowing contraction between a circuit section loaded with a sensor and a stirring section, and a mechanism for inserting a sampling tube in a state where the circuit section and the stirring section are stretched by the mechanism, and A mechanism for automatically inserting the sensor into the sampling tube in response to movement of the sensor and the agitator in a direction to compress the sampler. 13. A cylindrical cylinder having a reservoir at the tip and having a hole at a position at a predetermined distance from the tip, and sliding inside the cylinder to the position of the hole, and urine from the hole. A part having a piston that slides to the lower part of the hole after being put into the pool. 14. A component according to claim 13, wherein the tip of said cylinder is spherical.