JPH10265333A - Oil-in-water type emulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oil-in-water type emulsion composition which has stability with time in emulsion and improved touch in use and is free from substantial surfactants by formulating two kinds of specific acids thereto. SOLUTION: This oil-in-water type emulsion composition contains a glycyrrhetinic acid derivative (0.001-5 wt.%) and acetylated hyaluronic acid (the number of substitution of acetyl group is 2-4, 0.0001-10 wt.%, per hyaluronic acid construction unit) in addition to an oily component (0.5-50 wt.%). The acetylated hyaluronic acid and the glycyrrhetinic acid derivative are preferably formulated in a weight proportion of 100:1-1:500. As the oily component, e.g. lanolin, liquid paraffin and squalane are illustrated. Vitamins, ultraviolet ray absorbents, antiseptics and bactericides can be added to this composition.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an oil-in-water emulsion composition, and more particularly to an improvement in the stability over time.

[0002]

2. Description of the Related Art Conventionally, as emulsifying compositions for cosmetics, creams emulsifying various oily and aqueous raw materials,
Emulsion and the like are widely used. In order to obtain such an emulsified composition, it has been essential to use a surfactant in order to guarantee the stability over time of the emulsified composition.

However, many surfactants have skin irritation. On the other hand, in recent years, further safety is expected for cosmetics. From these viewpoints, a situation has arisen in which the formulation of the surfactant is problematic. Therefore, a method of obtaining an emulsion composition without using a surfactant has also been proposed (Japanese Patent Publication No. 2-38253, Japanese Patent Publication No. Sho 62-3).
No. 1681, JP-B-61-38166).

[0004]

However, emulsified compositions not using these surfactants are not always satisfactory in terms of long-term stability of emulsification. The present invention has been made in view of the above-mentioned problems of the related art, and an object of the present invention is to provide an oil-in-water emulsion composition having high safety and excellent emulsion stability over time.

[0005]

Means for Solving the Problems As a result of repeated studies to solve the above-mentioned problems, the present inventors have found that the blending of a glycyrrhizic acid derivative and acetylated hyaluronic acid improves the stability over time of emulsification and the feeling of use. The inventors have found that the present invention is improved, and have completed the present invention.

That is, the oil-in-water emulsion composition according to the present invention contains 0.001 to 5% by weight of a glycyrrhizic acid derivative.
And 0.5 to 50% by weight of an oily component, and 0.0001 to 10% by weight of acetylated hyaluronic acid having a substitution number of acetyl group of 2 to 4 per hyaluronic acid structural unit. . In addition, in the oil-in-water emulsion composition according to the present invention, those containing substantially no surfactant are also suitable.

[0007]

Embodiments of the present invention will be described below in detail. The glycyrrhizic acid derivative used in the present invention includes monoammonium glycyrrhizinate, dipotassium glycyrrhizinate, trisodium glycyrrhizinate and the like.

The amount of the glycyrrhizic acid derivative is preferably 0.001 to 5% by weight, more preferably 0.01 to 1% by weight in the emulsified composition. If the amount is less than 0.001% by weight, the emulsion stability may be low. If the amount exceeds 5% by weight, no increase in the emulsifying action and the effect of improving the emulsion stability can be expected, and the cost is increased and the cost is uneconomical. Further, from the viewpoint of usability, the range of 0.01 to 1% by weight is most preferable.

The acetylated hyaluronic acid used in the present invention preferably has a molecular weight of about 10,000 to 1,000,000 in terms of hyaluronic acid. The acetylated hyaluronic acid used in the present invention preferably has 2 to 4 acetyl groups per hyaluronic acid constituent unit. If the number of substitution of the acetyl group is less than 2, the effect of the present invention may not be sufficiently obtained, and if the number of substitution of the acetyl group is more than 4, it is difficult in the production method. The method for producing the acetylated hyaluronic acid used in the present invention is as follows.

For example, a method of dispersing powdery hyaluronic acid in acetic acid and reacting by adding trifluoroacetic anhydride as a catalyst, a method of dispersing in acetic acid, adding p-toluenesulfonic acid and further reacting by adding acetic anhydride, A method of suspending in acetic anhydride solvent and adding concentrated sulfuric acid to cause a reaction is known (JP-A-6-9707, JP-A-8-53501).

The amount of the acetylated hyaluronic acid used in the present invention is preferably 0.0001 to 10% by weight,
More preferably, it is 0.001 to 5% by weight. 0.0
If the amount is less than 001% by weight, the effect may not be exhibited. If the amount exceeds 10% by weight, stickiness may be caused in terms of usability, which is not preferable. The weight ratio of the acetylated hyaluronic acid and the glycyrrhizic acid derivative used in the present invention is preferably 100: 1 to 1: 500.

As the oily component used in the present invention, any of the polar and non-polar ones usually used in cosmetics can be used. For example, macadamia nut oil, evening primrose oil, olive oil, mink oil, jojoba oil, lanolin, squalene And other natural animal and vegetable oils and fats, liquid paraffin, squalane, petrolatum and other hydrocarbons, paraffin wax, spermaceti, beeswax, candelilla wax, carnauba wax and other higher alcohols, cetanol, stearyl alcohol, higher alcohols such as cetyl alcohol , Myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid, oleic acid, linolenic acid, linoleic acid,
Higher fatty acids such as linoleic acid and oxystearic acid,
Esters such as pentaerythritol tetra-2-ethylhexanoate, isopropyl myristate, isopropyl palmitate, isopropyl isostearate, glyceryl 2-ethylhexanoate, diethylene glycol monopropyl ether, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxypropylene Polar oils such as butyl ether and ethyl linoleate, and other silicone oils can also be added. Of these, if a large amount of solid or semi-solid oily components is blended, the coagulation action becomes strong and the appearance and the state of the particles deteriorate, so it is desirable to use a large amount of liquid oil. The ratio of the liquid oil to the entire oil component is preferably 50% by weight or more. Further, the blending amount of the whole oil component to the emulsified composition is suitably 0.5 to 50% by weight.

The oil-in-water emulsion composition of the present invention includes:
Vitamins such as vitamin A, vitamin B, vitamin D, vitamin E, tocopherol acetate, ascorbic acid ester, vitamin A acid, lecithin, γ-oryzanol, folic acid, and vitamin-like action substances, estradiol, estradiol valerate, ethinylestradiol, Hormones such as prostaglandin and testosterone propionate, benzophenone, 4-tert-butyl-4-methoxy-dibenzoylmethane, glyceryl ethyl hexanoate dimethoxycinnamate, p-aminobenzoate,
Contains UV absorbers such as octyl paramethoxycinnamate and phenyl salicylate, anti-inflammatory agents such as L-menthol and camphor, preservatives such as methylparaben, ethylparaben and butylparaben, and disinfectants such as triclosan and dibutylhydroxytoluene. can do.

The oil-in-water emulsified composition of the present invention may further contain, if necessary, an appropriate fragrance, coloring agent or the like within a range that does not impair the emulsion stability and usability. Further, when a small amount of a lipophilic activator such as monoglyceride, sorbitan fatty acid ester or diglycerin isostearate is used in combination, the emulsion stability is further improved.

[0015]

EXAMPLES The present invention will be described below in more detail with reference to Examples and Comparative Examples, but the present invention is not limited thereto. The amounts shown below are all weight%.
It is. The acetylation degree indicates the number of acetyl groups substituted per hyaluronic acid constituent unit of acetylated hyaluronic acid.

Example 1 and Comparative Examples 1 to 3 Cosmetic emulsified compositions having various compositions shown in Table 1 were emulsified by an emulsifying machine while adding an oil phase component (B) to an aqueous phase component (A). And evaluated the stability of the emulsion composition. Table 1 also shows the evaluation results. The evaluation criteria for the stability of the emulsion composition were as follows. [Stability Evaluation Criteria] ○: No oil separation is observed △: Oil separation is slightly observed ×: Oil separation is clearly observed

[0017]

[Table 1] ──────────────────────────────────── Ingredients Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 A. Liquid paraffin 10.0 10.0 10.0 10.0 10.0 Squalane 3.0 3.0 3.0 3.0 B. Dipotassium glycyrrhizinate 0.1-0.1 -carboxyvinyl polymer ^{* 1} 0.1 0.1 0.1 0.1 KOH 0.1 0.1 0.1 0.1 Acetylated hyaluronic acid ^{* 2} 0.2 --0.2 Glycerin 5.0 5.0 5.0 5.0 Ethyl alcohol 5.0 5.0 5.0 5.0 Methylparaben 0.1 0.1 0.1 0.1 0.1 Residue of ion-exchanged water Residual Residual Residual ──────────────────────────────────── 50 ℃, 1 month stability ○ × △ × ──────────────────────────────────── * 1: Hi-His Swako 105 (Wako Pure Chemical) * 2: Acetylation degree 3.5

As is evident from the results in Table 1, the emulsified composition using dipotassium glycyrrhizinate and acetylated hyaluronic acid (Example 1) was the same as the emulsified composition containing neither of them (Comparative Example 1) and the other used together. It can be seen that the stability is better as compared with the emulsified compositions that do not (Comparative Examples 2 and 3). Therefore, it is found that an emulsified composition having good aging stability can be obtained by using a glycyrrhizic acid derivative and acetylated hyaluronic acid in combination.

Next, examples of the present invention will be further described in order to make the present invention more specific. An oil-in-water emulsion composition having the following composition was produced in the same manner as in Example 1. When the same evaluation as in Example 1 was performed, the emulsion composition of each example showed excellent stability as in Example 1.

Example 2 Composition Composition Amount (%) Dimethyl polysiloxane 10 Macadamia nut oil 5 Vaseline 10 B. Monoammonium glycyrrhizinate 1 Acetylated hyaluronic acid (acetylation degree 3.7) 1 Polyethylene glycol 5 Dipropylene glycol 7 Triethanolamine 0.6 Sodium metaphosphate 0.1 Methyl paraben 0.1 Sodium chondroitin sulfate 0.3 Ion exchange water Remaining

Example 3 Composition Composition Amount (%) Liquid paraffin 10 Olive oil 1 Lanolin 3 Glyceryl tri-2-ethylhexanoate 2 2-Ethylhexyl paramethoxycinnamate 1 Vitamin E acetate 0.3 Butylparaben 0.2 Fragrance 0.1 B. Propylene glycol 6 1,3 butylene glycol 4 Acetylated hyaluronic acid (acetylation degree 3.2) 0.001 Trisodium edetate 0.1 Trisodium glycyrrhizinate 0.02 Magnesium ascorbate 1 Placenta extract 0.3 ion Exchange water balance

Example 4 Composition Composition Amount (%) Dimethyl polysiloxane 0.5 Decamethylcyclopentasiloxane 1 Jojoba oil 0.5 Arbutin 1 carrot extract 0.5 dipotassium glycyrrhizinate 0.05 carboxyvinyl polymer ^{* 1} 0.3 acetylated hyaluronic acid (acetylation degree 3) 0.05 ethyl alcohol 8 trisodium edetate 0.1 methyl paraben 0.1 phenoxyethanol 0 .2 KOH 0.15 ion exchange water residue

[0023]

According to the present invention, an oil-in-water emulsion composition having excellent long-term stability of emulsification can be obtained by blending a glycyrrhizic acid derivative and acetylated hyaluronic acid into the emulsion composition. . Further, an oil-in-water emulsion composition having excellent long-term stability of emulsification can be obtained without substantially containing a surfactant in the emulsion composition.

Claims (2)

[Claims] 1. Glycyrrhizic acid derivative 0.001 to 5
% By weight, 0.5 to 50% by weight of an oily component, and 0.0001 to 10% by weight of acetylated hyaluronic acid having 2 to 4 acetyl groups per unit of hyaluronic acid. A characteristic oil-in-water emulsion composition. 2. The emulsion composition according to claim 1, wherein
An oil-in-water emulsion composition substantially free of a surfactant.