JPH10251132A - Method for transportation of material into skin and composition used for the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To enable to change a material to skin, protect the skin and maintain the skin in a healthy state by applying a composition obtained by combining a specific material, a carrier and/or a microcarrier to the skin of a subject. SOLUTION: A composition obtained by combining an effective amount of (A) preferably a humectant, an emollient, an antimicrobial agent, an antimicrobial function-enhancer, a nonbonded/excess lipid-eliminant, a vitamin, a protein or their derivatives, a plant extract, a natural perfume, water, etc., with (B) a carrier and/or a microcarrier is applied to the skin of a subject. As the ingredient B, it is preferable to use hydroxyapatite ceramics containing uniform spherical macroporus particles, having about 1-10μm average diameter, about 0.05-0.10μm pore size and make the composition contain 0.001-10wt.% of the ingredient B.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD OF THE INVENTION

FIELD OF THE INVENTION The present invention relates generally to methods of making skin care products and methods of using such products. The present invention also relates to skin care products that hydrate the skin and prevent excessive drying of the skin.

[0002] The invention further relates to skin care products which are antimicrobial and help prevent infection by pathogenic microorganisms and reduce the spread of such pathogens.

In particular, the present invention is an antimicrobial formulation for cleaning and moisturizing the skin, comprising a water base and a microcarrier for delivering a substance into the skin. Including formulation. The formulation is free of alcohol, lanolin, fragrances, petroleum-based components, or animal by-products.

[0004] The invention further relates to a skin cleansing product that is antimicrobial and non-irritating and non-drying on the skin even after frequent use. The present invention further relates to a skin moisturizing product which is antimicrobial, non-greasy, rapidly penetrates the outer layers of the skin and forms a protector which prevents loss of moisture from the skin.

BACKGROUND OF THE INVENTION Excessive drying of the skin is a common problem, many of which include wind, sunlight and low humidity,
Or exposure to a combination of these factors. Frequent hand washing also results in excessive drying. Abrasive soaps, alcohol-based products, and other harsh chemicals
This is especially the case when s) is used for cleaning.

[0006] Excessively dry skin is not only unsightly, but also tends to exfoliate and crack, resulting in abrasion of the skin surface. Since the skin plays an important role as a physical barrier to the invasion of parasites and pathogens, excessive drying can lead to the destruction of the barrier and infection by pathogenic bacteria and fungi.
Thus, cracks and openings in the skin provide entry points for pathogens and potential pathogens. Even non-pathogenic organisms can result in opportunistic infections in individuals with impaired immune function. Infections can be mild or severe, and can be localized at the initial site of infection, or can be systemic and diffuse throughout the body. Such diffusion can occur by direct expansion into adjacent tissues or via lymphatic vessels and ultimately via the bloodstream.

[0007] Frequent application of many prior art skin cleansing ingredients can therefore contribute to skin damage and thus indirectly increase the risk of skin infections. Many prior art humectants contain many petroleum products, which dissolve latex gloves, as warned by researchers in various fields, including the healthcare field.

Similarly, many prior art humectants contain animal-derived products such as lanolin. Products from certain animals can cause skin allergies and / or dermatitis.

[0009] The skin care products of the present invention enable the frequent use of the products to protect the skin and prevent drying damage. In such respects, the skin care products of the present invention help to prevent infections of the skin itself and the invasion of pathogens through the skin. in this case,
Pathogens can infect the underlying tissues of the skin.

[0010] The skin cleansing products of the present invention not only provide continuous frequent use without causing skin dryness and cracking, but also by including one or more antimicrobial agents, provide a pathogenic microorganism or It is formulated to prevent the transmission and spread of potentially pathogenic microorganisms.

[0011] The skin care products of the present invention are formulated so that absorption of the composition by the skin is effected. In particular, the skin care products of the present invention include a microcarrier material that provides for absorption. The most preferred absorbing microcarrier material of the present invention is in the form of hydroxyapatite ceramics. The hydroxyapatite ceramics of the present invention are in the form of macropore spheres in a given size range and are chemically pure. It is formed by crystals of hydroxyapatite agglomerating into spherical particles in the size range of 0.05-0.10 micrometers and then sintering at high temperature to provide mechanically, physically, and chemically stable spheres . Hydroxyapatite ceramics useful in the practice of the present invention are Asahi Opti
Exemplified by hydroxyapatite ceramics manufactured by Cal Company, Tokyo. Hydroxyapatite ceramics are widely used as chromatographic separation media (eg, R. Kasai et al.,
J. Chromatography 407, 205 (1987); S. Tsuru et al., J. I.
mmunol Methods 106, 169 (1988); T. Kadoya et al., J. Liq
uid Chromatography 9, 3543 (1986); T. Kadoya et al., J.
Liquid Chromatography 11, 2951 (1986)).

In addition to the hydroxyapatite ceramics described above, hydroxyapatite is produced in several other forms, each of which has a distinctive particle morphology, size distribution, and surface structure, as observed by scanning electron microscopy. (T. Kadoya et al., J. Liquid Chromat
ography 9, 3543 (1986)).

[0013] Hydroxyapatite has also provided various non-chromatographic applications. For example, Japanese Patent No. 254415 discloses cosmetic substances containing spherical hydroxyapatite. Japanese Patent No. 2660
No. 66 teaches a melanin reducing composition comprising ethyl alcohol and sodium hydroxide. Japanese Patent No. 007409 teaches the use of hydroxyapatite for the selective removal of proteins from the body surface. Japanese Patent No. 179074 discloses the use of hydroxyapatite as an abrasive, which is useful in cleaning dead surfaces. Japanese Patent No. 238429 includes polystyrene beads coated with hydroxyapatite,
A blending agent is disclosed.

SUMMARY OF THE INVENTION The present invention is a method for delivering a substance into the skin of a subject, comprising a composition comprising the substance in combination with at least one effective amount of a carrier or microcarrier. A method comprising applying to the skin is provided.

The present invention is a method for effecting absorption of a substance applied to the skin of a subject, comprising a composition comprising the substance in combination with an effective amount of at least one carrier or microcarrier. Providing a method comprising the steps of:

[0016] Preferably, the method further comprises the step of removing said composition from the skin.

[0017] Preferably, the method performs a rapid penetration of the composition through the outer layer of the skin and / or absorption of the substance of the composition into the skin and / or uptake of the components of the composition by the skin. The method further includes a step.

Preferably, the microcarrier contains hydroxyapatite ceramics and / or hyaluronic acid.

Preferably, the hydroxyapatite ceramic contains about 0.001 to 10% by weight of the composition.

[0020] Preferably, the hydroxyapatite ceramic comprises uniform spherical macropore particles, the particles having an average diameter of about 1 micrometer to about 10 micrometers.

[0021] Preferably, the hydroxyapatite ceramic is made of a mechanical,
It includes physically and chemically stable pores, and the pore size ranges from about 0.05 micrometer to 0.10 micrometer.

Preferably, the uniform macropore structure of the hydroxyapatite ceramics allows a slow release of a relatively large volume of liquid phase binder following bonding.

Preferably, said carrier or microcarrier comprises water, charged molecules, lipids, emollients, anti-inflammatory agents, humectants, sunscreens, plant extracts, vitamins and their derivatives, proteins and their derivatives. Binds to at least one substance of the group consisting of derivatives, as well as nucleic acids.

[0024] Preferably, the composition comprises a humectant.

Preferably, the composition includes a water-based humectant, is free of organic solvents or petroleum-based components, and is free of animal products or by-products.

Preferably, the humectant composition comprises a humectant, an emollient, an antimicrobial agent, an antimicrobial function enhancer, a non-binding /
It comprises at least one substance from the group consisting of excess lipid removing agents, anti-inflammatory agents, emulsifiers, sunscreens, vitamins and their derivatives, proteins and their derivatives, plant extracts, natural flavors and water.

The present invention provides a composition for use in the present method, wherein said composition comprises at least one of a carrier and / or a microcarrier.

[0028] Preferably, the microcarrier contains hydroxyapatite ceramics and / or hyaluronic acid.

Preferably, said carrier or microcarrier comprises water, charged molecules, lipids, emollients, antimicrobial or anti-inflammatory agents, humectants, sunscreens, plant extracts, vitamins and derivatives thereof, It binds to at least one substance of the group consisting of proteins and their derivatives, and nucleic acids.

The present invention is directed to a pharmaceutical composition for the topical treatment of the skin of a subject, comprising an effective amount of an antimicrobial agent, wherein the composition is a composition that retains the skin. provide.

The present invention is a topical, water-based skin care composition comprising at least one of a carrier or microcarrier or an antimicrobial agent, wherein the composition is an organic solvent or a petroleum based composition. And compositions containing no animal products or by-products.

The present invention is a pharmaceutical composition for the topical treatment of the skin of a subject, which inhibits or prevents the transmission of skin infections or pathogens to promote and maintain healthy skin. A subject in need of such a moisturizing treatment to inhibit or prevent the loss of water from the skin, for dry, injured, itchy, damaged, or infected skin A composition for promoting healing, wherein the humectant composition comprises at least one
One carrier or microcarrier or antimicrobial agent and their water-based medium, and the humectant is free of organic solvents or petroleum-based components and animal products or by-products A composition is provided.

[0033] Preferably, the composition further comprises at least one carrier and / or microcarrier, and at least one antimicrobial agent.

The present invention is a topical, water-based skin cleansing composition comprising at least one of an antimicrobial agent, an antimicrobial function enhancer, or an unbound / excess lipid remover. A composition is provided wherein the detergent does not contain organic solvents or petroleum based components and animal products or by-products.

The present invention is a pharmaceutical composition for topically cleaning the surface of the skin of a subject, which is continuously exposed to frequent cleaning, and which is for promoting and maintaining healthy skin. A composition for inhibiting or preventing the transmission of skin infections or pathogens, for inhibiting or preventing dry, injured or itchy skin of a subject, wherein the cleaning agent The composition comprises at least one of an antimicrobial agent, an antimicrobial function enhancer, and an unbound / excess lipid removing agent.
Two effective amounts and provides a composition wherein the detergent is free of organic solvents or petroleum based components and animal products or by-products.

Preferably, the cleaning composition further comprises at least one antimicrobial function enhancer and / or unbound / excess lipid remover, and at least one antimicrobial agent.

[0037] Preferably, the composition is retained on the skin.

Preferably, the composition is washed off the skin after washing.

[0039] Preferably, the antimicrobial agent, if present, comprises from about 0.001% to about 5.0% by weight of the composition.

[0040] Preferably, said antimicrobial agent comprises triclosan.

Preferably, the microcarrier contains hydroxyapatite ceramics and / or hyaluronic acid.

[0042] Preferably, the antimicrobial function enhancer and / or the unbound / excess lipid remover comprises hydroxyapatite ceramics.

Preferably, the hydroxyapatite ceramic, when present, comprises from about 0.001% to 10% by weight of the composition.

Preferably, the hydroxyapatite ceramic comprises uniform spherical macropore particles, the particles having an average diameter of about 1 micrometer to about 10 micrometers.

Preferably, the hydroxyapatite ceramic is of a mechanical, uniform size and shape.
It includes physically and chemically stable pores, and the pore size ranges from about 0.05 micrometer to 0.10 micrometer.

Preferably, the uniform macropore structure of the hydroxyapatite ceramics allows a slow release of a relatively large volume of liquid phase binder following bonding.

Preferably, the composition comprises a wetting agent, emollient, antimicrobial function enhancer, unbound / excess lipid remover, antimicrobial or anti-inflammatory agent, emulsifier, sunscreen, vitamins and derivatives thereof. , Proteins and derivatives thereof, plant extracts, natural flavors, nucleic acids, thickeners, preservatives, citric acid, and at least one of the group consisting of water.
It further contains two substances.

[0048] Preferably, the composition has no damaging effect on the latex.

The present invention is a method of preparing a skin moisturizer composition, comprising the following steps: i) measuring an appropriate volume of deionized water and supplying it to a first container; Activating the mixer of one vessel; iii) adding the remaining components of the first phase of the composition to the first vessel; iv) heating the contents of the first vessel to between 30C and 95C. Heating to a first predetermined temperature in the range of: v) formulating a second phase of the composition, comprising: a) transferring the second phase in a second container. Combining the components; and b) vigorously mixing the contents of the second container; vi) the contents of the second container when the first phase reaches the first predetermined temperature. Adding to the first container; vii) formulating a third phase of the composition,
The following steps: a) combining the components of the third phase in a third container; and b) heating the contents of the third container to the first predetermined temperature while heating the contents of the third container to the first predetermined temperature. Mixing the contents of the first and second containers; viii) when both the contents of the first container and the contents of the third container reach the first predetermined temperature;
Adding the contents of the third container to the first container; ix) interrupting the heating of the first container; x) formulating a fourth phase of the composition; The following steps: a) combining the components of the fourth phase in a fourth vessel; and b) removing the contents of the fourth vessel to a second predetermined temperature in the range of 30 ° C to 60 ° C. Heating to a temperature; xi) adding the contents of the fourth container to the first container when the contents of the first container reach the second predetermined temperature; xii) Adding a natural flavor to the first container when the contents of the first container reach a third predetermined temperature in the range of 20C to 40C; and xiii) the first container Vigorously mixing the contents of
Is provided.

The present invention is a method for preparing a skin cleansing composition, comprising the following steps: i) measuring an appropriate volume of deionized water and supplying it to a first container; Activating the mixer of one container; iii) adding the remaining components of the first phase of the composition to the first container; iv) formulating the second phase of the composition. The following steps: a) combining the components of the second phase in a second container; and b) mixing the contents of the second container vigorously; Adding contents to the first container; vi) formulating a third phase of the composition, comprising the following steps: a) Components of the third phase in a third container. B) heating the contents of the third container to the first predetermined temperature in a range of 35 ° C. to 95 ° C. Mixing the contents of the third container, while vii) adding the contents of the third container to the first container; viii) continuously adding the remaining components of the composition. Process;
And ix) vigorously mixing the contents of said first container.

The present invention provides a composition prepared by the present method.

[0052] The skin moisturizing products of the present invention are formulated to protect the skin and maintain the skin in a healthy condition. The skin moisturizing products of the present invention are also formulated to be antimicrobial, thereby further reducing the risk of infection by a pathogen. In addition, the antimicrobial properties of the moisturizing products of the present invention reduce the risk of transmission of pathogenic and potentially pathogenic microorganisms. The skin care products of the present invention are further formulated to penetrate the skin quickly, whereby the components of the formulation are more effective.

The compositions and methods of the present invention can be used to protect the integrity of the skin. The compositions and methods of the present invention can be used to promote and maintain healthy skin. The skin cleansing compositions of the present invention can also be frequently used to prevent the spread of pathogenic or potentially pathogenic microorganisms. The skin cleansing compositions of the present invention can also be used constantly and frequently with minimal risk to cause dryness, irritation, irritation, or damage to the skin. The antimicrobial skin moisturizer composition of the present invention can be used to minimize the risk of irritation and infection. The skin cleansing and moisturizing product of the present invention does not dissolve latex and is well suited for use with latex gloves. Thus, the skin moisturizer composition of the present invention can be used with latex gloves without the risk of dissolution of the latex and other damage to the latex barrier.

The methods and compositions of the present invention can further be used to effect rapid absorption of biologically active compositions by the skin. As in one embodiment of the present invention,
The skin moisturizer composition may be used as a single application or, if necessary, the application may be repeated periodically over an extended period.

As in another method of the present invention, the skin moisturizer composition of the present invention provides smaller cuts, cracks,
Or it can be applied specifically or selectively to the location or area of the abrasion. Such an application protects the epidermis and dermis from further damage and / or prevents skin infections.

DETAILED DESCRIPTION OF THE INVENTION The skin or integumentary system is an essential, physiologically and anatomically differentiated boundary membrane. It covers the entire outer surface of the body. The total area of adult skin is 1.2-2.2 m ² and about 10
Make up the largest organs of the human body. Functionally, the skin acts as an interface between the internal and external environments, and performs temperature control, sensation, and other functions, and as a highly effective physical barrier to infectious agents and dehydration Plays an important role. Skin also acts as a barrier to mechanical, chemical, osmotic, thermal, and light barriers.

Physicians and non-professionals believe that skin conditions generally reflect the health, age, and other aspects of life of an individual.

Histologically, three major tissue layers have been identified. The top layer, the epidermis, is a relatively thin stratified squamous epithelium, which itself is composed of five layers.
The dermis, which is a dense fibroelastic connective tissue stroma, is adjacent to the epidermis. The third layer, located below the dermis, is a subcutaneous layer consisting of loose connective tissue and fatty connective tissue.

There are three basic cell types in the epidermis: keratinocytes that produce keratin, melanocytes involved in pigmentation, and Langerhans cells that help the immune system by blocking foreign bodies in the skin. In the epidermis, its base fission layer provides keratinocytes and continuously replaces keratinocytes shed on the skin surface.

The epidermis can be stratified according to the stage of maturation of the keratinocytes therein. These layers, in order from deep to surface, are as follows: basal layer, spiny layer,
Granular, pale, and stratum corneum. The first three of these layers
First, the metabolism is active, while the two upper layers, which have reached terminal keratinization, constitute the keratinized area. The cells of the stratum corneum eventually detach from the epidermal surface and displace the underlying. Typically, the time it takes for newly formed keratinocytes to migrate to the surface and shed is 45-
75 days. However, under certain pathological conditions, the rotational replacement rate is quite high. As a result, keratinization is incomplete and
And the normal barrier function of the skin is lost.

[0061] The dermis constitutes a strong and more flexible layer consisting mainly of collagen. This layer contains nerves, blood vessels,
It includes hair follicles, sebaceous glands, and apocrine glands, and plays a pivotal role in temperature control and sensory perception.
Sebaceous glands produce sebum, a natural lipid material, that helps prevent the outer layers of skin from drying, cracking, and excessive shedding.

The composition for cleaning and moisturizing the skin of the present invention comprises an antimicrobial agent, an emollient and a microcarrier in combination as described below.

I. Antimicrobial Components The present invention provides a composition for cleaning and moisturizing the skin, which inhibits the growth of pathogenic or potentially pathogenic bacteria and fungi, or so. Antimicrobial agents that function to kill various organisms. Thus, an antimicrobial agent can be bacteriostatic, bactericidal, fungistatic, or fungicidal in its action.

A preferred antimicrobial agent for use in the present invention is triclosan. This drug used in the formulation,
The entire genus of microorganisms (eg: bacteria, fungi, Pseudomonas aer
uginosa, Pseudomonas capacia, Staphylococcus aureu
s, Escherichia coli, Candida albicans, Aspergillus
niger, Salmonella typhimurium, etc.). Therefore, the antimicrobial component in the composition is effective both in preventing infection through the skin and in preventing the spread and spread of pathogenic microorganisms. The antimicrobial agent is usually present in an amount of 0.001-5% by weight, preferably 0.05-2% by weight, more preferably 0.1-1% by weight.

Ii. Water Activity Inhibitors The compositions according to the invention may also contain one or more water activity inhibitors, the function of which is to inhibit, in part, the growth of microorganisms during storage of the product, and It is to protect the product. Water activity inhibitors help prevent the growth of spoilage organisms, with or without the inclusion of antibiotics. Examples of water activity inhibitors include sorbitol, propylene glycol, sugar,
And alkali metal salts, including carboxylate, halide, and sulfate. A preferred water activity inhibitor is sorbitol. The sorbitol component of the composition is preferably 1 to 20% by weight, more preferably 1 to 20% by weight.
It is present at a concentration of 10% by weight, most preferably 1-2% by weight.

Iii. Microcarriers The compositions of the present invention may also include one or more microcarriers. The function of such a microcarrier is, in part, to take up the product by the skin. Product uptake prevents excessive loss of water from the skin surface and promotes the product's contact with dermal and epidermal metabolic active cells under the stratum corneum of the light and stratum corneum .

A preferred microcarrier is a hydroxyapatite ceramic. Hydroxyapatite ceramics also function as removers of unbound / excess lipids and as antimicrobial function enhancers. The hydroxyapatite ceramics used in the present invention is one form of chemically pure calcium phosphate (molecular formula Ca ₁₀ (PO ₄ ) ₆ (OH) ₂ ) and is produced as spheres with a controlled diameter. The intermediate diameter of the hydroxyapatite ceramic of the present invention is in the range of 1 to 10 μm, more preferably 2 to 10 μm.
６6 μm. Hydroxyapatite ceramic spheres are small crystals (size range of 50-100nm)
Agglomeration followed by sintering at high temperature.
As a result of this process, each sphere is porous and can act as small sponges. This feature of the hydroxyapatite ceramic spheres allows for absorption, transport, and subsequent release of the components of the binding composition.

Hydroxyapatite ceramics having an average particle diameter in the range of 2 to 6 μm can act as an effective absorption agent for liquid phase materials. The carrier and absorption enhancing properties of hydroxyapatite ceramics are due to both their porosity and their affinity for various materials. For example, hydroxyapatite ceramics have the ability to bind water, charged molecules, lipids, proteins, and nucleic acids. The porosity of the hydroxyapatite ceramics allows a relatively large volume of liquid phase binding material to be bound and then released gradually.

Since the hydroxyapatite ceramic particles are small spheres, they can also act as lubricants.

Conventional hydroxyapatite (ie, not ceramics) is known to bind biological molecules, including proteins, lipoproteins, lipids, and nucleic acids (eg, D. Josic et al., Biol. Chem. .
Hoppe-Seyler 372,149 (1991); KJPrimes et al. J. Chrom
atography, 236, 519 (1982); S. Hjerten, Biochim. Bioph
ys. Acta, 31, 216 (1959); G. Bernardi and WHCook, ibid., 44, 96 (1960); RKMain et al., J. Am. Chem. Soc. 81, 64.
90 (1959); A. Tiselius et al. Arch. Biochem. Biophys. Acta 6
5,132 (1956)). However, compared to hydroxyapatite ceramics, conventional hydroxyapatite is more irregular in morphology and size and is produced as even more brittle particles. Hydroxyapatite ceramics are also superior to conventional hydroxyapatite in that hydroxyapatite ceramics are resistant to high temperatures and pressures and are much more physically stable than conventional hydroxyapatite (T.Kadoya J. Liquid Chromatography,
9,3543 (1986)). This physical stability allows for agitation or mixing of the hydroxyapatite ceramic without disintegration of the particles. Hydroxyapatite ceramics are also more chemically stable than conventional hydroxyapatite and are stable for at least 5 years when stored at room temperature in dry or hydrated form.

Hydroxyapatite binds to lipids (eg, KJPrimes et al., J. Chromatography, 236, 519).
(1982)), hydroxyapatite ceramics, in the present invention, can bind to the lipid component of the composition, as well as to the lipid component of the skin. Hydroxyapatite ceramics have the further advantage of binding much more strongly to proteins in the present invention than conventional hydroxyapatite. In binding the skin to proteins,
The hydroxyapatite ceramics of the present invention may act as a bridge between skin cell proteins and bound lipids. The resulting layer of bound lipid molecules can serve as an effective protective film that prevents skin dehydration and damage to the skin.

Finally, hydroxyapatite ceramics, due to their property of binding to biological molecules, can bind to various surface components of microbial cells and promote the immobilization and inactivation of microorganisms.

The hydroxyapatite ceramics
Preferably, in the present invention, it is present in the composition at a concentration of 0.001 to 10% by weight, more preferably 0.01 to 5% by weight, even more preferably 0.05 to 1% by weight.

Iv. Vehicle or Delivery System The compositions of the present invention also include a vehicle or carrier that is physiologically liquid, solid, or liquid and is cosmetically acceptable. Suitable vehicles, in the present invention, can act variously as solvents, diluents, or dispersants for the components of the composition, and allow for even application of the components to the skin at appropriate dilutions To It is clear to a person skilled in the art that the range of possible vehicles is very wide.
In general, the compositions of the present invention may contain at least one physiologically and cosmetically acceptable vehicle.

Vehicles that can be used in the compositions of the present invention can be liquids or solids, including emollients, various solvents, powders, and wetting agents. Carriers can be used alone or in combination. Suitable carriers may include, but are not limited to, the following examples: castor oil, ethylene glycol monobutyl ether, diethylene glycol monoethyl ether, corn oil, dimethyl sulfoxide, ethylene glycol, isopropanol, soybean oil, glycerin, soluble collagen, Zinc oxide, titanium dioxide, talc, kaolin, hyaluronic acid.

The active ingredients of the skin care composition of the present invention include:
It can be soluble or insoluble in the liquid carrier. If the active constituent is soluble in the carrier, the carrier acts as a solvent for the active ingredient. If the active ingredients are insoluble in the carrier, they are dispersed in the carrier, for example, by suspension, emulsion, gel, cream, or paste. Various oils (eg, vegetable oils obtained from any of corn, sunflower, safflower, soybean, canola, etc.) can also be used as vehicles, either alone or in combination. Various oils may also be used in the following emulsification in combination with water.

V. Water In general, the compositions of the present invention may contain water. If water is used in the present invention, preferably the water is deionized. Water is a suitable solvent and / or diluent for the active ingredient in the compositions of the present invention. Water may be used alone or in combination with another solvent and / or diluent.

Vi. Wetting Agents The compositions of the present invention optionally contain one or more wetting agents, such as: dibutyl phthalate, gelatin, glycerin, soluble collagen, sorbitol, sodium 2-pyrrolidone-5-carboxylate. I can do it.

The preferred humectant of the present invention is glycerin.

Vii. Emollients The compositions under the present invention may optionally contain one or more emollients, such as butane-1.3-diol, cetyl palmitate, dimethylpolysiloxane, glyceryl monoricinoleate, glyceryl. Monostearate, isobutyl palmitate, isocetyl stearate, isopropyl palmitate, isopropyl stearate, butyl stearate, isopropyl laurate, hexyl laurate,
Decyl oleate, isopropyl myristate, lauryl lactate, octadecane-2-ol, caprylic triglyceride, caprated glyceride, palmitic acid,
Polyethylene glycol, propane-1,2-diol, stearic acid, triethylene glycol, sesame oil, coconut oil, safflower oil, isoamyl laurate, nonoxynol-9, panthenol, hydrogenated vegetable oil, tocopheryl acetate, tocopheryl linole Eate, allantoin, propylene glycol, arachis oil, castor oil, isostearic acid, palmitic acid, isopropyl linoleate, lauryl lactate, myristyl lactate, decyl oleate, myristyl myristate.

May be contained.

Viii. Sunscreen According to the present invention, the composition may optionally contain a sunscreen. A preferred sunscreen under the present invention is octyl palmitate.

Ix. Anti-inflammatory agent According to the present invention, the composition may optionally contain an anti-inflammatory agent. Anti-inflammatory agents of the present invention include Aloe vera extract, panthenol, tocopheryl acetate, and tocopheryl linoleate.

X. Preservatives In addition to water activity inhibitors and antimicrobial components such as triclosan, according to the present invention, the compositions may optionally comprise polymethoxybicyclic oxazolidines (polymethylene oxazolidine).
It may contain one or more preservatives such as ethoxy bycyclic oxazolidine), methyl paraben, propyl paraben, and DMDM hydantoin.

Xi. Thickeners or Thickeners According to the present invention, the compositions may, if desired, contain thickeners or thickeners. Various classes of thickeners can be selected, including microbial polysaccharides such as xanthan gum; cellulose derivatives such as methylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose and hydroxyethylcellulose; and sorbitol.

Xii. Emulsifiers In accordance with the present invention, the compositions may also contain one or more emulsifiers. Suitable emulsifiers under the present invention include polysorbate-60, sorbitol, and sorbitan stearate. Such emulsifiers may be incorporated into the composition alone or in any combination.

Xiii. Vitamins, proteins, and derivatives thereof According to the present invention, the composition is also a vitamin, protein, or derivative thereof, other than those that may be present in other components of the composition. It may contain one or more of the components.
Vitamins, proteins, or derivatives thereof, can be incorporated into the compositions of the present invention, either alone or in combination. Examples of vitamins, proteins, or derivatives thereof that may be included in the compositions of the present invention include tocopheryl acetate, tocopheryl linoleate, panthenol, wheat oligosaccharides, and hydrolyzed wheat proteins.

Xiv. Surfactants According to the present invention, the compositions may optionally contain one or more surfactants. The surfactant used in the present invention is preferably a mild or very mild surfactant. Sodium lauryl sulfate (sodium lauret) is a preferred surfactant under the present invention.
h sulfate), and cocamide DEA.

Xv. Citric Acid The compositions of the present invention may also contain citric acid, which is naturally present in both plants and animals and in relatively high concentrations in citrus fruits, as an intermediate in the tricarboxylic acid cycle. . Preferably, only plant and animal by-products are used. In the present invention, citric acid is 0-10% by weight, more preferably 0-5% by weight, and most preferably 0-10% by weight.
Preferably it is present at a concentration of from about 2% by weight. The concentration of citric acid can be adjusted slightly to provide a suitable pH.

Xvi. Allantoin The compositions of the present invention may also contain allantoin. Allantoin is a natural product present in both plants and animals, where it is preferably a plant. Allantoin is believed to stimulate cell proliferation and promote skin healing. The allantoin component of the composition is preferably present at a concentration of 0-5% by weight, preferably 0.01-2% by weight.

Xvii. Aloe vera Ingredients The compositions of the present invention may also contain cosmetic and physiologically acceptable preparations obtained from Aloe vera.
The plant constituents are reported to prevent infection, promote wound healing, and have antifungal properties.
Gels obtained from Aloe vera leaves are said to be useful for dryness of the skin. Aloe vera gel has also been recommended for treating fungal skin infections. The Aloe vera component of the composition is preferably present at a concentration of 0.1 to 10%, more preferably 0.2 to 5%, and most preferably 0.5 to 1.5% by weight.

Xviii. Natural Flavors The compositions of the present invention may also contain one or more natural flavors. The natural fragrances added to the skin care compositions under the present invention are formulated to provide a pleasant, mild irritant and to avoid any negative effects on the skin such as dryness, irritation or allergies. For example, natural flavors
The process of fractionation can be obtained from plant material in the form of essential oils, thus avoiding procedures involving organic solvents.

Ixx. Other Plant or Herbal Extracts The compositions of the present invention may also contain one or more natural plant or herbal extracts, including chamomile extract, comfrey extract, and cucumber extract. In the present invention, the natural plant extract is preferably present at a concentration of 0-5% by weight, more preferably 0-2% by weight, more preferably 0-about 0.8% by weight.

The medicinal use of herbs known as comfrey dates back at least to the times of ancient Egyptian civilizations,
It has been widely used as a herbal remedy for hundreds, if not thousands, of years (see, for example, P. Ody (1993) The Comp
lete Medicinal Herbal, Dorling Kindersley, London,
See New York, Stuttgart). Queen Elizabeth's herbalologist Nicholas Culpeper described Comfrey as the most effective natural remedy of many.
Charles J. Macalister, MD, a British doctor, has used the Comfrey topically to treat severe skin lesions with remarkable results (CJ Macalister (1936) Narrative
of an Investigation Concerning an Ancient Medicin
al Remedy and its Modern Utilities, reprinted in 1955, The
Lee Foundation for Nutritional Research, Milwauke
e, WI). One component of comfrey that is believed to be responsible for its medical properties is allantoin.

Chamomile is another herb that has been used medically since ancient times. Among the skin symptoms, chamomile has been recommended for various sores and wounds, eczema, and inflammation.

Without being limited by the theory of the mode of action of any of these compositions, topical use of the present skin care compositions not only helps to maintain the treated skin in healthy condition, Promotes healing of dry, cracked or damaged skin.

Xx. PH For skin cleansing components, the preferred pH is in the range of 6.0 to 8.0, more preferably in the range of 6.5 to 7.5.

The preferred pH of the skin moisturizer composition is between 5.0 and 8.0
And more preferably in the range of pH 6.0 to 7.0.

In one embodiment, the skin moisturizing composition of the present invention comprises, for example, wetting agents, emollients, carriers or microcarriers, antimicrobial agents, antimicrobial function enhancers, unbound / excess lipid removal. Agents, vitamins, proteins or their derivatives, plant extracts, natural flavors,
And water.

In a preferred embodiment, the composition of the skin moisturizer of the invention comprises, for example, the following: wetting agents, for example glycerin; carriers or microcarriers, for example hyaluronic acid or hydroxyapatite ceramics, antimicrobial function enhancement Agents such as hydroxyapatite ceramics, unbound / excess lipid removing agents such as ceramics hydroxyapatite; emollients such as glyceryl stearate, allantoin or nonoxynol-9; antimicrobial agents such as triclosan; anti-inflammatory agents; For example, Aloe vera extract or panthenol; emulsifier, such as polysorbate 60; preservative, such as
DMDM hydantoin; sunscreen, such as octyl palmitate; vitamins or their derivatives, such as tocopheryl acetate or wheat oligosaccharides; proteins or their derivatives, such as hydrolyzed wheat protein; plant extracts, such as comfrey extract, or chamomile extract Natural flavors, such as citrus fruit oils; and water.

In the present invention, a method for preparing a skin moisturizer composition comprises formulating the components of each composition as four separate phases, and then mixing the phases.

The skin moisturizer composition can be formulated according to the following examples.

[0103]

【Example】

Example 1 Formulation of a Skin Moisturizing Composition a) 1M Phase At room temperature, an appropriate volume of deionized water was weighed into a first stainless steel container or tank and the mixer was activated. Next, the components of the 1M phase (nonoxynol-9, Al
oe vera extract and panthenol)
Then, the mixture was gradually heated to a predetermined temperature. Preferably the 1M phase of the composition is in the range of 30 ° C to 95 ° C, more preferably
In the range of 40 ° C to 90 ° C, and most preferably 50 ° C to 80 ° C
Is heated to a predetermined temperature in the range described above. In a preferred embodiment, after the start of heating, the temperature of the 1M phase ranges from 30 ° C to 95 ° C,
More preferably, when the temperature of the 1M phase is in the range of 40 ° C to 90 ° C, and most preferably when the temperature of the 1M phase is in the range of 50 ° C to 80 ° C, methyl paraben is added.

B) 2M phase The components of the 2M phase, including glycerin and hydroxyapatite ceramics, were combined in a suitable second vessel and mixed well until completely homogenous. When the predetermined temperature for the 1M phase was achieved, the 2M phase was added to the first vessel.

C) 3M phase The components of the 3M phase, including stearic acid, octyl palmitate, tocopheryl acetate, safflower oil and hydrogenated vegetable oil, are combined in a third stainless steel container and the mixture To a temperature of. Preferably, the predetermined temperature for the 3M phase is in the range 30C to 95C, more preferably in the range 40C to 90C, and most preferably in the range 50C to 80C.

When most of the solid constituents have melted, the third
The mixer in the container was activated. Third container and first
When the temperature of the contents of each of the containers reached the respective predetermined temperature, the 3M phase was added to the first or main container and the contents were mixed well.

After thorough mixing, heating was discontinued and the contents of the first vessel were cooled.

D) 4M phase Tocopherol linoleate, chamomile extract (matricar
ia extract and comfrey extr
The components of the 4M phase, including act), were combined in a suitable fourth vessel and heated to the prescribed temperature. Preferably, the predetermined temperature for the 4M phase is in the range 30C to 60C, more preferably in the range 35C to 55C, and most preferably 40C to 55C.
In the range. When the temperature of the contents of the first vessel was the same or similar to the predetermined temperature for the four phases, the components of the four phases were transferred from the fourth vessel to the first vessel with thorough mixing. Heating was discontinued and the mixture was cooled.

When the mixture is at a suitable temperature (preferably 20 ° C to 40 ° C)
(In the range of 25 ° C., more preferably in the range of 25 ° C. to 35 ° C.), the natural fragrance was added and the mixture was thoroughly stirred until homogeneous.

The skin moisturizer composition of the present invention provides a smooth moisturizer that is white or off-white in color and has an elegant aroma of citrus fruits. At 25 ° C, the composition has a pH in the range of 6-7, within the range of 3500-6500 centipoise,
Viscosity, preferably in the range of 4,400-5,100 centipoise,
And a specific gravity of around 1.0.

In one embodiment, the skin cleansing composition of the present invention comprises, for example, an antimicrobial agent, a thickener, a carrier or microcarrier, an antimicrobial function enhancer, and an unbound / excess lipid remover, a vitamin. , Proteins or their derivatives, plant extracts, natural flavors, and water.

In a preferred embodiment, the skin cleansing composition according to the invention comprises, for example: antimicrobial agents,
Triclosan; antimicrobial function enhancers such as hydroxyapatite ceramics; and unbound / excess lipid removers such as hydroxyapatite ceramics; emollients such as propylene glycol, nonoxynol-9; anti-inflammatory agents such as Aloe vera extract , Panthenol; surfactants such as cocamid DEA (cocamid
e DEA), sodium laureth sulfate
emulsifiers, such as polysorbate 60, sorbitan stearate; preservatives, such as propyl paraben, methyl paraben; sunscreens, such as octyl palmitate; vitamins or derivatives thereof, such as tocopheryl linoleate or wheat oligosaccharides; proteins or derivatives thereof; Plant extracts such as comfrey extract or chamomile extract; natural flavors such as cucumber oil; and water.

The method of the present invention for preparing a skin cleansing composition comprises formulating the composition of each composition as four phases,
Subsequently, a step of continuously combining the phases is included.

A skin cleansing composition may be formulated according to the following examples.

Example 2 Formulation of Skin Cleanser Composition a) Phase 1C An appropriate volume of deionized water was weighed at room temperature into a first stainless steel container or tank, and the mixer was turned on. Then, sodium lauryl sulfate, Aloe vera
The ingredients of phase 1C including extract, citric acid and panthenol were added and the mixture was stirred well.

B) 2C Phase The two phase components, including sorbitol and hydroxyapatite ceramics, were combined in a suitable second vessel and mixed thoroughly until completely homogeneous. Two phases first
Was added to the container.

C) 3C Phase The components of the 3C phase, including propylene glycol, Polymethoxy Bicyclic Oxazolidine, and Triclosan, are combined in a suitably sized third container and the components are thoroughly mixed. did. Mixing was continued and the mixture was heated until the mixture became homogeneous and reached the required temperature. Preferably, the predetermined temperature for the 3C phase ranges from 35 ° C to 95 ° C, more preferably
It is in the range 45C to 85C, and most preferably in the range 55C to 75C. Heating was discontinued and the mixture was cooled.
When the temperature of the 3C phase in the third container is in the range of 15 ° C to 35 ° C, and preferably in the range of 18 ° C to 25 ° C, transfer the 3C phase to the first container and transfer the contents. Mix well.

D) 4C Phase While continuing to mix the contents of the first vessel, the components of the 4C phase, including non-oxynol-9, cocamide DEA, comfrey extract, and chamomile extract, were continuously added at room temperature. First
Was added to the container.

Finally, the natural flavor was added to the mixture in the first container and the mixture was thoroughly stirred until uniform.

The skin cleansing composition of the present invention provides a smooth and viscous liquid that is transparent or slightly opaque and has a slight cucumber scent. At a temperature of 25 ° C,
The liquid has a pH in the range of 6.5 to 7.5, a viscosity in the range of 3,000 to 4,000 centipoise, more preferably in the range of 3200 to 3800 centipoise, and a specific gravity of about 1.0.

Preferred embodiments of the skin moisturizer composition of the present invention include the compositions shown in the following examples.

Example 3 Skin Moisturizer Composition One phase comprises: deionized water (up to 100% w / w); panthenol (up to 10% w / w); methyl paraben (5% w / w) / w); and Aloe vera extract (up to 7% w / w).

The two phases include: glycerin (10
% W / w); and hydroxyapatite ceramics (up to 5% w / w).

The three phases include: stearic acid (up to 10% w / w); tocopherol acetate (5% w / w)
Octyl palmitate (up to 10% w / w); safflower oil (up to 10% w / w); hydrogenated vegetable oil (up to 10% w / w);
Propylparaben (up to 5% w / w); and triclosan (up to 1% w / w).

The four phases include: plant extracts (eg, Comfrey extract, chamomile extract) (5%
w / w); tocopheryl linoleate (up to 5% w / w);
Allantoin (up to 5% w / w); and oligosaccharides and hydrolyzed wheat protein.

A further component of the preferred embodiment of the skin moisturizer composition is a citrus natural oil in the range of 0.01 to 0.1% w / w.

Preferred embodiments of the skin cleansing composition of the present invention include the components shown in the following examples.

Example 4 Skin Cleanser Composition One phase comprises: deionized water (up to 100% w / w); panthenol (up to 10% w / w); Aloe vera extract (7 % Citric acid (up to 10% w / w).

The two phases include: sorbitol (up to 10% w / w); and hydroxyapatite ceramics (up to 5% w / w).

The three phases include: methyl paraben (up to 5% w / w); propyl paraben (up to 5% w / w);
Propylene glycol (up to 10% w / w); disodium ethylenediaminetetraacetate (up to 2% w / w); and triclosan (up to 1% w / w).

The four phases include: plant extracts (eg, Comfrey extract, chamomile extract) (5%
Non-oxynol-9; hydroxypropyl methylcellulose; and wheat oligosaccharides and hydrolyzed wheat protein.

A further component of the preferred embodiment of the skin cleansing composition is cucumber natural oil in the range of 0.01 to 0.1% w / w.

Although the invention has been described in various embodiments, not only can many modifications be made to the invention, but these modifications may utilize the disclosed methods and compositions of the invention. It will be clear to those skilled in the art. The scope of the invention is defined by the appended claims rather than by the above examples.

The present invention relates to a system for delivering a substance to the skin of a subject. The system includes the step of applying to the skin a composition comprising an effective amount of the substance in combination with at least one carrier or microcarrier. The invention also provides a method for achieving absorption of a substance applied to the skin, and a composition comprising a carrier and / or a microcarrier. The present invention provides humectants, cleansers, and pharmaceutical compositions for use in treating the skin,
And methods for their preparation are further provided.

────────────────────────────────────────────────── (5) Int.Cl. ⁶ Identification code FI A61K 7/50 A61K 7/50 (71) Applicant 597035126 828 Port Walk Place, Redwood Shores, CA 94065, U.S.A. S. A.

Claims (38)

[Claims] 1. A method for delivering a substance into the skin of a subject, comprising applying to the skin a composition comprising the substance in combination with at least one effective amount of a carrier or microcarrier. how to. 2. A method for performing absorption of a substance applied to the skin of a subject, said composition comprising said substance in combination with an effective amount of at least one carrier or microcarrier, applied to the skin. A method comprising the step of: 3. The method according to claim 1, further comprising removing the composition from the skin. 4. The method further comprises the step of effecting rapid penetration of the composition through the outer layer of the skin and / or absorption of the substance of the composition into the skin and / or uptake of components of the composition by the skin. A method according to any of claims 1 or 2. 5. The method according to claim 1, wherein the microcarrier comprises a hydroxyapatite ceramic and / or hyaluronic acid. 6. The composition of claim 5, wherein said hydroxyapatite ceramic contains about 0.001 to 10% by weight of the composition.
The method described in. 7. The method of claim 5, wherein said hydroxyapatite ceramic comprises uniform spherical macropore particles, said particles having an average diameter of about 1 micrometer to about 10 micrometers. 8. The hydroxyapatite ceramic as claimed in claim 1, wherein said hydroxyapatite ceramic comprises mechanically, physically and chemically stable pores of uniform size and shape, and said pore size ranges from about 0.05 micrometer to 0.10 micrometer. 6. The method of claim 5, wherein the method comprises: 9. The uniform macropore structure of said hydroxyapatite ceramics allows a slow release of a relatively large volume of liquid phase binder following bonding.
The method according to claim 7. 10. The method according to claim 10, wherein the carrier or microcarrier comprises water, charged molecules, lipids, emollients, anti-inflammatory agents,
3. The method according to claim 1 or 2, wherein the method binds to at least one substance of the group consisting of humectants, sunscreens, plant extracts, vitamins and their derivatives, proteins and their derivatives, and nucleic acids. 11. The composition of claim 1, wherein the composition comprises a humectant.
Or the method of any one of 2. 12. The composition is a water-based humectant, which is free of organic solvents or petroleum-based components, and free of animal products or by-products.
The method according to claim 1. 13. The composition of the humectant comprises a humectant, an emollient, an antimicrobial agent, an antimicrobial function enhancer, a non-binding / excess lipid remover, an anti-inflammatory agent, an emulsifier, a sunscreen, a vitamin and 3. The method according to any of claims 1 or 2, comprising at least one substance from the group consisting of their derivatives, proteins and their derivatives, plant extracts, natural flavors, and water. 14. The composition used in the method according to claim 1, wherein the composition comprises at least one of a carrier and / or a microcarrier. 15. The composition according to claim 14, wherein the microcarrier comprises a hydroxyapatite ceramic and / or hyaluronic acid. 16. The method according to claim 16, wherein the carrier or microcarrier is water, charged molecules, lipids, emollients, antimicrobial or anti-inflammatory agents, humectants, sunscreens, plant extracts,
15. The composition according to claim 14, which binds to at least one substance of the group consisting of vitamins and their derivatives, proteins and their derivatives, and nucleic acids. 17. A pharmaceutical skin moisturizer composition for topically treating a subject's skin, comprising an effective amount of an antimicrobial agent, wherein the composition is retained on the skin. ,Composition. 18. A topical, water-based skin care composition comprising at least one of a carrier or microcarrier or an antimicrobial agent, wherein the composition is based on an organic solvent or petroleum. A composition that is free of ingredients and free of animal products or by-products. 19. A pharmaceutical composition for topically moisturizing the skin of a subject, for inhibiting and preventing the spread of skin infections or pathogens to promote and maintain healthy skin. Healing of dry, injured, itchy, damaged or infected skin to inhibit or prevent water loss from the skin, or in need of such a moisturizing treatment A composition for facilitating wherein the humectant composition comprises an effective amount of at least one of a carrier or microcarrier or an antimicrobial agent, and a water-based medium thereof; A composition wherein the agent is free of organic solvents or petroleum-based components and is free of animal products or by-products. 20. The composition according to claim 18 or 19, further comprising at least one of a carrier and / or a microcarrier, and at least one antimicrobial agent. 21. At least one of an antimicrobial agent, an antimicrobial function enhancer, or an unbound / excess lipid removing agent.
A topical, water-based skin cleanser composition,
Wherein the detergent is free of organic solvents or petroleum based components and free of animal products or by-products. 22. A pharmaceutical composition for topically cleaning the surface of the skin of a subject that is continuously exposed to frequent cleaning, wherein the composition is for promoting and maintaining healthy skin.
A composition for inhibiting or preventing skin infection or transmission of a pathogen, for inhibiting or preventing dry, injured, or itchy skin of the subject,
Here, the detergent composition may comprise at least one of an antimicrobial agent, an antimicrobial function enhancer, or an unbound / excess lipid remover.
A composition comprising two effective amounts, and wherein the detergent is free of organic solvents or petroleum-based components and free of animal products or by-products. 23. The cleaning composition according to claim 21, further comprising at least one of an antimicrobial function enhancer and / or an unbound / excess lipid removing agent, and at least one antimicrobial agent. Stuff. 24. The composition according to claim 17, wherein the composition is retained on the skin. 25. The cleaning composition according to claim 21, wherein after washing, the composition is washed off the skin. 26. The composition of any of claims 17-23, wherein the antimicrobial agent, when present, comprises from about 0.001% to about 5.0% by weight of the composition. 27. The composition according to claim 17, wherein said antimicrobial agent comprises triclosan. 28. The composition according to claim 18, wherein the microcarrier comprises a hydroxyapatite ceramic and / or hyaluronic acid. 29. The cleaning composition according to claim 21, wherein the antimicrobial function enhancer and / or the unbound / excess lipid remover comprises a hydroxyapatite ceramic. 30. The hydroxyapatite ceramic, when present, comprises from about 0.001% to 1% by weight of the composition.
30. The composition according to claim 28, comprising 0% by weight. 31. The composition according to claim 28, wherein the hydroxyapatite ceramic comprises uniform spherical macropore particles, the particles having an average diameter of about 1 micrometer to about 10 micrometers. . 32. The hydroxyapatite ceramic comprises uniformly sized and uniformly shaped mechanically, physically and chemically stable pores, and the pore size ranges from about 0.05 micrometer to 0.10 micrometer. 30. The composition according to claim 28 or 29. 33. The composition of claim 28, wherein the uniform macropore structure of the hydroxyapatite ceramic allows for slow release of a relatively large volume of liquid phase binder following bonding. 34. Wetting agents, emollients, antimicrobial function enhancers, unbound / excess lipid removers, antimicrobial or anti-inflammatory agents, emulsifiers, sunscreens, vitamins and their derivatives, proteins and their derivatives Derivatives, plant extracts,
Further comprising at least one substance from the group consisting of natural flavors, nucleic acids, thickeners, preservatives, citric acid, and water;
A composition according to any of claims 17 to 23. 35. The composition according to claim 17, wherein the composition has no damaging effect on latex. 36. A method of preparing a skin moisturizer composition, comprising the steps of: i) metering an appropriate volume of deionized water into a first container; ii) the first container. Activating the mixer of the vessel; iii) adding the remaining components of the first phase of the composition to the first vessel; iv) heating the contents of the first vessel to between 30 ° C and 95 ° C. First in range
Heating to a predetermined temperature of: v) formulating a second phase of the composition, comprising: a) combining the components of the second phase in a second container; and b) vigorously mixing the contents of the second container; vi) when the first phase reaches the first predetermined temperature;
Adding the contents of the second container to the first container; vii) formulating a third phase of the composition, comprising the following steps: a) in a third container. Combining the components of the third phase;
And b) mixing the contents of the third container while heating the contents of the third container to the first predetermined temperature; viii) mixing the contents of the first container and the second When both of the contents of the third container reach the first predetermined temperature, the third
Adding the contents of the container to the first container; ix) stopping the heating of the first container; x) formulating a fourth phase of the composition, comprising: Steps: a) combining the components of the fourth phase in a fourth container;
And b) reducing the contents of the fourth container to a second temperature in the range of 30 ° C to 60 ° C.
Xi) adding the contents of the fourth container to the first container when the contents of the first container reach the second predetermined temperature. Xii) the content of the first container is in the range of 20 ° C. to 40 ° C .;
Adding a natural flavor into said first container when said predetermined temperature is reached; and xiii) mixing the contents of said first container vigorously. 37. A method of making a skin cleanser composition, comprising the steps of: i) metering an appropriate volume of deionized water into a first container; ii) the first container. Activating a mixer in the vessel; iii) adding the remaining components of the first phase of the composition to the first vessel; iv) formulating a second phase of the composition; The following steps: a) combining the components of the second phase in a second vessel;
And b) vigorously mixing the contents of the second container; v) adding the contents of the second container to the first container; vi) formulating a third phase of the composition The steps of: a) combining the components of the third phase in a third vessel;
And b) mixing the contents of the third container while heating the contents of the third container to a first predetermined temperature in the range of 35C to 95C; vii) mixing the contents of the third container; Adding the contents of a container to the first container; viii) continuously adding the remaining components of the composition; and ix) vigorously mixing the contents of the first container. how to. 38. A composition prepared by the method according to claim 36.