JPH10167988A - Oral liquid preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oral liquid preparation masked in strong bitterness and specific bitterness, improved in flavor and capable of readily ingesting without accompanying pain by including a bitterness ingredient and maple flavors. SOLUTION: This oral liquid preparation reduced in bitterness and capable of readily ingesting is obtained by including a bitterness ingredient such as remedy for the cold, antipyretic, analgesic, antiphlogistic, antitussive agent, expectorant, antihistamic agent, hemostatic agent or vitamin Bs and maple flavors and preferably further, coffee flavors.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an orally drinkable liquid preparation with reduced bitterness.

[0002]

2. Description of the Related Art Oral solutions are easy to take,
Many products have been developed and put to practical use so far. However, some substances having a medicinal effect have an intense bitterness or a peculiar bitterness, and a strong bitterness is expressed only by adding a very small amount in a liquid preparation. In such a case, it is painful at the time of drinking, and the advantage of the oral solution, which is easy to take, is completely impaired. In addition, the bitter substance often has a unique odor, which impairs the flavor of the liquid preparation, which further results in difficulty in drinking. In order to solve this problem, a method of masking bitterness has conventionally been devised. In general, a method of masking bitterness and specific odor by blending a sweetener, an acidifier, a flavoring agent, a flavoring agent, and the like has been adopted. However, when the masking cannot be sufficiently performed depending on the bitterness component, or when the amount of the flavoring agent is limited in order to ensure the stability and safety of the quality of pharmaceuticals, a more advanced masking technique (for example, 60-246325, JP-A-5-146253, JP-A-4-247024, JP-A-5-4921, and the like.

[0003]

In the case where the degree of bitterness is very strong or the quality of the bitterness is specific and it is difficult to drink, the conventionally proposed technology overcomes the bitterness and improves the taste and ease of drinking. There were limits to improvement. In particular, when the oral liquid preparation is a drug, the compounding amount is restricted from the viewpoint of safety, and the flavoring agent causes a decrease in the stability of the medicinal component. Further, the stability of the flavoring agent itself may be impaired and the masking effect may be reduced, so that further measures have been demanded.

[0004]

Means for Solving the Problems As a result of diligent studies, the present inventors have found that if maple flavors are added to liquids which contain bitter components and cause pain during drinking, the prior art is not sufficient. The present inventors have found that the bitter taste masking effect is enhanced, the specific odor is alleviated due to the improved flavor, and that the liquid preparation containing the bitter component is improved to be easy to drink, and further studies have been completed to complete the present invention. Furthermore, they have found that further effects can be obtained by using various flavors, particularly coffee flavors in combination.
That is, the present invention provides (1) an oral liquid preparation comprising a bitter component and maple flavors, (2) an oral liquid preparation according to the above (1), further comprising coffee flavors,
(3) The oral liquid preparation according to the above (1), wherein the bitter component is a cold remedy, and (4) the oral solution according to the above (1), wherein the bitter component is a fever-relieving agent, an analgesic, an anti-inflammatory, an antitussive, an expectorant, an antihistamine or a hemostatic agent. The present invention relates to an oral liquid preparation and (5) the oral liquid preparation according to the above (1), wherein the bitter component is a vitamin B group.

[0005] Maple flavors in the present invention mean those having a characteristic flavor of maple syrup, and may be natural, semi-synthetic, or synthetic flavors, and are generally used as maple flavors or maple essences. Can be obtained. Although maple syrup or maple sugar itself can be blended, it can also be used in combination with maple flavor.
In addition, maple oil, maple extract, and maple extract can also be used. Various blended flavorings containing components having a maple flavor can also be used. Among the various compounded flavors mentioned here, for example, drink flavor, molasses flavor, sweet flavor, sweet essence and the like can be mentioned. Although depending on the type of the bitter component, a compounded flavor having a maple flavor may be more preferable in suppressing bitterness, and a drink flavor is particularly preferable. The amount of the maple flavors can be adjusted appropriately according to the bitter intensity of the bitter component, the quality of the bitter taste, and the concentration of the bitter components, and the optimum amount can be compounded. Usually, the maple flavor is 0.1 ppm to 5%, preferably 10 ppm.
~ 0.5%, 0.001-10 as maple flavor component
00 ppm, preferably 0.01 to 100 ppm. The oral liquid preparation of the present invention preferably further contains coffee flavors. The coffee flavors in the present invention mean those having a coffee-specific flavor, and may be any of natural products, semi-synthetic products, and synthetic products, and are generally obtained as coffee flavors or coffee essences. Can be. In addition, coffee extract and coffee extract can be used, but can also be used in combination with coffee flavor. The amount of the coffee flavor is not particularly limited, but may be selected in the same range as the amount of the maple flavor.

The bitter component according to the present invention includes, for example, cold remedies, especially antipyretics, analgesics, anti-inflammatory agents, antitussives, expectorants,
Components having a bitter taste such as an antihistamine or a hemostatic agent can be exemplified. Specifically, for example, acetaminophen, phenacetin, mefenamic acid, antipyrine, phenylbutazone, sulpyrine, diclofenac sodium, ibuprofen, ketoprofen, naproxen, epirizole, tiaramid hydrochloride, indomethacin, pentazocine, acetylcholine chloride, alimemazine tartrate, cyproheptadine hydrochloride, Diphenhydramine,
Diphenhydramine hydrochloride, chlorpheniramine maleate, codeine phosphate, dihydrocodeine phosphate, dextromethorphan hydrobromide, pentoxiverine citrate, theophylline, aminophylline, ephedrine hydrochloride, epinephrine hydrochloride, salbutamol sulfate, trimethokinol hydrochloride, hydrochloride Procaterol, methylephedrine hydrochloride, phenylpropanolamine hydrochloride, guaifenesin, tranexamic acid, caffeine anhydride, caffeine and the like are mentioned, and the present invention is preferably applied to an oral solution containing these bitter components. The oral liquid preparation of the present invention may contain two or more of these bitter components.

Further, vitamin B is used as a bitter component of the present invention.
Groups can be mentioned. As such, vitamin B ₁ group [e.g. thiamine, thiamine mononitrate, thiamine hydrochloride, vitamin B ₁ derivatives (thiamine propyl disulfide, thiamine tetrahydrofurfuryl disulfide (fursultiamine) and thiamine-8- (methyl-6-
Acetyldihydrothioctoate) disulfide and hydrochlorides thereof, such as thiamine disulfide, O-benzoyl thiamine disulfide, thiamine monophosphate disulfide, O, S-dibenzoyl thiamine, S-benzoyl thiamine-O-monophosphate, O, S- radical Viet carboxymethyl thiamine, etc.)], vitamin B ₂ group (eg riboflavin, riboflavin sodium phosphate, riboflavin butyrate and the like), vitamin B ₆ group (e.g. pyridoxine, pyridoxal, pyridoxamine and the like of these phosphoric acid or hydrochloride), ₁₂ groups of vitamin B (eg, cobalamin,
Cyanocobalamin, methylcobalamin, adenosylcobalamin, hydroxocobalamin and the like, and one or more of these can be selected. When these components having a bitter taste are used as active ingredients, they are blended in an effective amount range that exhibits a medicinal effect according to each purpose.

The oral liquid preparation of the present invention contains other active ingredients, flavoring agents, preservatives, preservatives, flavoring agents, fragrances, fresheners, surfactants, surfactants, and the like, which are generally incorporated into oral liquid preparations. Select one or more of solubilizers, emulsifiers, solvents, pH adjusters, buffers, suspending agents, thickeners, colorants, stabilizers, solubilizers, etc. in the amounts to be mixed with conventional oral liquids. It can also be added. Examples of the other active ingredients include antipyretic, analgesic, and anti-inflammatory agents (aspirin, etenzamid, choline salicylate,
Sodium salicylate, aluminoprofen, loxoprofen sodium, tinolidine hydrochloride, acemethasin,
Graphenin, dimethothiazine mesylate, piroxicam, salicylamide, etc.), antihistamines (promethazine, triprolidine hydrochloride, dimethindene maleate, carbinoxamine maleate, doxylamine succinate, pyrilamine maleate, etc.), antitussive expectorant, bronchodilator,
Other antiallergic agents (dimemorphan phosphate, tipepidine hibenzate, isoaminyl citrate, cloperastine hydrochloride, noscapine, kyounin water, shazensou,
Senega, carbocysteine, ambroxol hydrochloride, terbutaline sulfate, tulobuterol hydrochloride, fenoterol hydrobromide, formoterol fumarate, oxatomide, bromhexine hydrochloride, etc., enzyme preparations (lysozyme chloride, etc.), hemostatic agents (sodium alginate, etc.), Vitamin preparations (vitamin A group, vitamin D group, vitamin E group, nicotinamide, etc.), amino acids (glycine, alanine,
Sodium glutamate, lysine, etc.), crude drugs (carrots, senega, kikyo, shokyo, royal jelly, etc.)
04, 314, 315, 316, 317, and 318) and other active ingredients (such as sodium chondroitin sulfate and taurine). As a flavoring agent,
For example, sweeteners (sucrose, fructose, glucose, lactose, reduced maltose aqueous candy, powdered reduced maltose aqueous candy, glucose fructose liquid sugar, fructose dextrose liquid sugar, honey, sorbitol, maltitol, mannitol, xylitol, erythritol, aspartame, palatinose , Coupling sugar, stevioside, dipotassium glycyrrhizinate,
Saccharin, saccharin sodium, durutin, thaumatin, miraculin, etc.) and acidulants (citric acid, tartaric acid,
Malic acid, lactic acid and edible salts thereof), fruit juice and the like. Examples of preservatives and preservatives include sodium sorbate, benzoic acids (such as benzoic acid and sodium benzoate), and parabens (such as ethyl paraoxybenzoate, butyl paraoxybenzoate, and propyl paraoxybenzoate).

Examples of the flavoring agent, fragrance and cooling agent include orange oil, menthol, various flavors (strawberry flavor, pineapple flavor, banana flavor, cherry flavor, orange flavor, apple flavor, lemon flavor, lime flavor, melon). Flavors, Acerola Flavors, Grape Flavors, Tea Flavors, Bitter Flavors, Herb Mint Flavors, Cocoa Flavors, Chocolate Flavors, Sugar Flavors, Chili Flavors,
Spice flavor, crude drug flavor, etc.). Examples of surfactants, solubilizers, emulsifiers and solvents include sucrose fatty acid esters, non-ionic surfactants such as polyoxyethylene hydrogenated castor oils, polysorbates and pluronics, glycerin, propylene glycol, polyethylene glycols , Ethanol, distilled water for injection, purified water and the like. Examples of the pH adjusting agent and the buffer include phosphoric acid, lactic acid, acetic acid, carbonic acid and edible salts thereof, hydrochloric acid, sodium hydroxide, potassium hydroxide, sodium hydrogen carbonate and the like. Examples of the suspending agent and the thickening agent include gum arabic, crystalline cellulose, veegum, xanthan gum, gelatin, metrose and its edible salt, carmellose and its edible salt and the like. Examples of coloring agents include caramel, β-carotene, and various food colorings (food yellow No. 1, food red No. 2, etc.).
And the like. Examples of the stabilizer include an edible acid edible acid salt, sodium chloride, and an edible salt of pyrosulfite. Examples of the solubilizer include cyclodextrin and arginine.

The oral solution of the present invention can be prepared by a conventional method, and the method is not particularly limited.
Usually, each component and a part of a solvent such as purified water are mixed and dissolved, and the remaining solvent is added to adjust the liquid volume. For example, the pH is adjusted using an acid or an alkali as necessary to obtain the optimum pH of the preparation or to remove or solubilize insolubles. When a fat-soluble component such as vitamin E is contained, the aforementioned surfactant, solubilizer, emulsifier, and suspending agent are selected and solubilized by adding an appropriate amount generally used. It can be emulsified and suspended. Also, if necessary, heat the solvent such as purified water according to the general oral liquid preparation method during dissolution, perform nitrogen replacement of the head space when filling the container, or perform filtration or sterilization. Sometimes. Flavors can be compounded at the final stage of preparation so as not to impair the flavor. Since the liquid preparation of the present invention has low toxicity and is safe, it can be administered to mammals including humans for prevention and treatment of effective diseases of each active ingredient. In particular, it is suitably applied orally to the prevention and treatment of diseases associated with cold and vitamin B deficiency. Each is administered at a known dose according to the active ingredient. The present invention can be applied as a medical oral liquid such as a drink, a syrup, an extract, an elixir, a limonade, a soft capsule, a capsule capable of holding an aqueous content, and a bitter component containing vitamins. When it is a group B, it can be used as various drinks such as functional drinks.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, a formulation example and a preparation method of an oral liquid preparation will be specifically described with reference to Examples and Comparative Examples. The effects of the present invention will be described with reference to test examples.

【Example】

Example 1 Acetaminophen 500 mg Purified sucrose 3 g Citric acid 100 mg Maple flavor (*) 30 μL Hydrochloric acid (pH adjuster) Appropriate amount Purified water Add a total amount of 60 mL Add the above components to a part of purified water at room temperature After dissolving and adjusting the pH to 4, the total amount was adjusted to 60 mL.
(* Ogawa Koryo Co., Ltd. product, in the following examples,
All flavors, such as maple flavor, used the company's products. )

Example 2 Fursultiamine hydrochloride 10 mg Purified sucrose 8 g Citric acid 200 mg Maple flavor 100 μL Hydrochloric acid (pH adjuster) Appropriate amount Purified water 50 mL in total Add the above components to a portion of purified water at room temperature After adjusting to pH 3, the total amount was adjusted to 50 mL.

Example 3 Anhydrous caffeine 150 mg Purified sucrose 5 g Malic acid 100 mg Maple syrup 30 mg Hydrochloric acid (pH adjuster) Appropriate amount Purified water A total amount of 30 mL A part of purified water was added to each part of the purified water at room temperature. Dissolve and adjust pH to 3.
After adjusting to 5, the total amount was adjusted to 30 mL.

Example 4 Dihydrocodeine Phosphate 8 mg Purified Sucrose 5 g Sodium Citrate 100 mg Apple Flavor 60 μL Maple Flavor 10 μL Sodium Hydroxide (pH Control Agent) Appropriate amount Purified Water Addition Total 20 mL Part of Purified Water Was dissolved at room temperature, the pH was adjusted to 5, and the total amount was adjusted to 20 mL.

Example 5 Phenylpropanolamine hydrochloride 38 mg Acetaminophen 900 mg Ascorbic acid 600 mg Purified sucrose 11 g Sodium citrate 500 mg Propylene glycol 2 g Polyethylene glycol 2 g Sodium benzoate 42 mg Ethyl parahydroxybenzoate 7 mg Caramel 120 mg Maple flavor 50 μL Sodium hydroxide (pH adjuster) qs. Purified water added, total volume 60 mL The above components were dissolved in a portion of purified water at room temperature, pH was adjusted to 7, and the total volume was adjusted to 60 mL. It was prepared as follows.

Example 6 Phenylpropanolamine hydrochloride 38 mg Acetaminophen 900 mg Ascorbic acid 600 mg Purified sucrose 11 g Sodium citrate 500 mg Propylene glycol 2 g Polyethylene glycol 2 g Sodium benzoate 42 mg Ethyl paraoxybenzoate 7 mg Caramel 120 mg Coffee flavor 50 μL Maple flavor 50 μL Sodium hydroxide (pH adjuster) qs Purified water Add the total amount 60 mL The above components were dissolved in a part of purified water at room temperature, and the pH was adjusted to 7. The total volume was adjusted to 60 mL.

Example 7 Phenylpropanolamine hydrochloride 12 mg Ascorbic acid 10 mg Chlorpheniramine maleate 3 mg Dihydrocodeine phosphate 8 mg Anhydrous caffeine 25 mg Sodium benzoate 35 mg Granulated sugar 20 g Citric acid 500 mg Caramel 100 mg Black tea Flavor 80 μL Maple flavor 20 μL Hydrochloric acid (pH adjuster) Appropriate amount Sodium hydroxide (pH adjuster) Appropriate amount Purified water Add a total of 50 mL A portion of purified water is heated to 40 ° C to dissolve the above components. After cooling to room temperature, the pH was adjusted to 4, and the total amount was adjusted to 50 mL.

Example 8 Phenylpropanolamine hydrochloride 12 mg Ascorbic acid 500 mg Chlorpheniramine maleate 12 mg Dihydrocodeine phosphate 30 mg Guaifenesin 170 mg Kikyo extract 500 mg Anhydrous caffeine 60 mg Sodium benzoate 20 mg Purified sucrose 12 g Citric acid Acid 200 mg Grape flavor 50 μL Maple flavor 15 μL Hydrochloric acid (pH adjuster) Appropriate amount Sodium hydroxide (pH adjuster) Appropriate amount Purified water Add a total of 30 mL A part of purified water is heated to 40 ° C. After dissolving the components and cooling to room temperature, the pH was adjusted to 4, and the total amount was adjusted to 30 mL.

EXAMPLE 9 Phenylpropanolamine hydrochloride 50 mg Ascorbic acid 1000 mg Chlorpheniramine maleate 6 mg Anhydrous caffeine 75 mg Sodium benzoate 35 mg Purified sucrose 8 mg Citric acid 300 mg Fruit mix flavor 75 μL Maple flavor 20 μL Sodium hydroxide (pH adjuster) qs Add purified water 50 ml in total The above components are dissolved in a portion of purified water at room temperature, pH is adjusted to 6, and the total volume is adjusted to 50 ml. It was prepared as follows.

Example 10 Phenylpropanolamine hydrochloride 32 mg Acetaminophen 250 mg Ascorbic acid 600 mg Chlorpheniramine maleate 2 mg Pentoxiverine citrate 13 mg Sodium benzoate 35 mg Propyl parahydroxybenzoate 5 mg Sucrose 20 g Citric acid Acid 200 mg Herb mint flavor 10 μL Passion fruit flavor 100 μL Maple flavor 50 μL Sodium hydroxide (pH regulator) qs Purified water Add a total of 50 mL A portion of purified water is heated to 85 ° C and preservative components are added. After dissolving, cooling to room temperature and dissolving the other components, the pH was adjusted to 7, and the total amount was adjusted to 50 mL.

Example 11 Phenylpropanolamine hydrochloride 38 mg Acetaminophen 900 mg Ascorbic acid 600 mg Dihydrocodeine phosphate 24 mg Caffeine anhydride 150 mg Sodium benzoate 42 mg Butyl parahydroxybenzoate 7 mg Purified sucrose 10 g Sorbitol 1 g Acid 200 mg Malic acid 100 mg Propylene glycol 2 g Polyethylene glycol 2 g Ethanol 100 mg Bitter flavor 80 μL Maple flavor 20 μL Sodium hydroxide (pH adjuster) Appropriate amount Purified water Add all amount 60 mL A part of purified water 50 The mixture was heated to ℃ to dissolve the above components, cooled to room temperature, adjusted to pH 6, and adjusted to a total volume of 60 mL.

Example 12 Phenylpropanolamine hydrochloride 300 mg Acetaminophen 500 mg Ascorbic acid 3000 mg Dextromethorphan hydrobromide 20 mg Guaifenesin 200 mg Sodium benzoate 20 mg Purified sucrose 1000 mg Saccharin sodium 20 mg Citric acid 200 mg Propylene Glycol 1 g Polyethylene glycol 1 g Ethanol 100 mg Strawberry flavor 50 μL Maple flavor 50 μL Sodium hydroxide (pH adjuster) Appropriate amount Purified water Add all 30 mL Dissolve each of the above components in a part of purified water at room temperature. After adjusting the pH to 7, the total amount was adjusted to 30 mL.

Example 13 Phenylpropanolamine hydrochloride 18 mg Acetaminophen 450 mg Ascorbic acid 300 mg Dihydrocodeine phosphate 12 mg Caffeine anhydride 75 mg Sodium benzoate 21 mg Ethyl parahydroxybenzoate 4 mg Sucrose 6 g Caramel 60 mg Citric acid Acid 180 mg Propylene glycol 1 g Polyethylene glycol 1 g Coffee flavor 30 μL Maple flavor 4 μL Sodium hydroxide (pH adjuster) Appropriate amount Purified water Add all 30 mL Purified water is partially heated to 40 ° C. After dissolving the components and cooling to room temperature, the pH was adjusted to 7, and the total amount was adjusted to 30 mL.

Example 14 Phenylpropanolamine hydrochloride 12 mg Ascorbic acid 600 mg Dihydrocodeine phosphate 60 mg Chlorpheniramine maleate 12 mg Methylephedrine hydrochloride 150 mg Lysozyme chloride 12 mg Guaifenesin 100 mg Senega flow extract 1000 mg Sodium benzoate 70 mg Ethyl paraoxybenzoate 5 mg Propyl parahydroxybenzoate 5 mg Purified sucrose 25 g Sodium citrate 500 mg Drink flavor 100 μL Maple flavor 10 μL Sodium hydroxide (pH regulator) qs Purified water Add to the total volume 120 mL Purified water The mixture was heated to 80 ° C. to dissolve the preservative components, cooled to room temperature, and then dissolved with the other components. Then, the pH was adjusted to 5.5, and the total volume was adjusted to 120 mL. It was prepared.

Example 15 Fursultiamine hydrochloride 10 mg Riboflavin sodium phosphate 10 mg Pyridoxine hydrochloride 20 mg Nicotinamide 60 mg Anhydrous caffeine 50 mg Cyanocobalamin 60 μg Taurine 2000 mg Carnitine chloride 100 mg Chondroitin sodium sulfate 120 mg Sodium benzoate 35 mg Ethyl parahydroxybenzoate 3 mg Purified sucrose 9 g Reduced maltose aqueous candy 2 g Citric acid 250 mg Cherry flavor 100 μL Sugar flavor 50 μL Maple flavor 5 μL Hydrochloric acid (pH regulator) Appropriate amount Purified water plus 50 mL Purified The above components were dissolved in a part of water at room temperature, the pH was adjusted to 3, and the total amount was adjusted to 50 mL.

Example 16 Phenylpropanolamine hydrochloride 2 mg Ascorbic acid 20 mg Kikyo flow extract 200 mg Senega flow extract 500 mg Kyokyo flow extract 100 mg Benzoic acid 10 g Purified sucrose 3 g Sodium citrate 50 mg Tartaric acid 50 mg Shimizu liquor Flavor 50 μL Maple flavor 3 μL Sodium hydroxide (pH adjuster) qs Purified water Add to total 20 mL After dissolving each of the above components in a part of purified water at room temperature, adjust pH to 6, then add total 20 mL It was prepared so that

Example 17 Phenylpropanolamine hydrochloride 300 mg Acetaminophen 900 mg Ascorbic acid 3000 mg Dextromethorphan hydrobromide 20 mg Guaifenesin 200 mg Sodium benzoate 20 mg Purified sucrose 1000 mg Saccharin sodium 20 mg Citric acid 200 mg Propylene Glycol 5 g Glycerin 2 g Polyethylene glycol 8 g Cherry flavor 30 μL Maple flavor 30 μL Sodium hydroxide (pH adjuster) Appropriate amount Purified water Add all 30 mL Dissolve each of the above components in a part of purified water at room temperature. After adjusting the pH to 7, the total amount was adjusted to 50 mL.

Example 18 Fursultiamine hydrochloride 10 mg Riboflavin sodium phosphate 10 mg Pyridoxine hydrochloride 20 mg Nicotinamide 60 mg Anhydrous caffeine 50 mg Taurine 1500 mg Carnitine chloride 100 mg Sodium chondroitin sulfate 120 mg Sodium L-aspartate 125 mg Royal jelly 150 mg Sodium benzoate 35 mg Ethyl parahydroxybenzoate 3 mg Purified sucrose 6.5 g Powdered reduced maltose water candy 4 g Citric acid 250 mg Drink flavor 170 μL Sodium hydroxide (pH adjuster) Suitable amount Hydrochloric acid (pH adjuster) ) Appropriate amount Purified water was added, and the total amount was 50 mL. The above components were dissolved in a part of purified water at room temperature, the pH was adjusted to 3, and the total amount was adjusted to 50 mL.

Example 19 Fursultiamine hydrochloride 10 mg Riboflavin 2 mg Pyridoxine hydrochloride 10 mg Nicotinamide 30 mg Anhydrous caffeine 50 mg L-sodium aspartate 125 mg Carnitine chloride 100 mg Locus tincture (conversion of crude drug: 300 mg) 1100 μL Royal jelly 150 mg Carrot stream extract 600 μL Eucalyptus stream extract 500 μL Purified sucrose 9 g Honey 2.5 g Citric acid 150 mg Sodium benzoate 35 mg Ethyl paraoxybenzoate 3 mg Caramel 100 mg Polyoxyethylene hydrogenated castor oil 5010 mg Pluronic F68 300 mg Drink flavor 140 μL Chili flavor 15 μL Sodium hydroxide (pH adjuster) Appropriate amount Hydrochloric acid (pH adjuster) Appropriate The amount of purified water was added, and the total amount was 50 mL. The above components were dissolved in a part of purified water at room temperature, the pH was adjusted to 3, and the total amount was adjusted to 50 mL.

COMPARATIVE EXAMPLE 1 Acetaminophen 500 mg Purified sucrose 3 g Citric acid 100 mg Hydrochloric acid (pH adjuster) Appropriate amount Purified water was added, and the total amount was 60 mL. Was adjusted to 4, and the total amount was adjusted to 60 mL. Comparative Example 2 Fursultiamine hydrochloride 10 mg Purified sucrose 8 g Citric acid 200 mg Hydrochloric acid (pH adjuster) Appropriate amount Purified water Add 50 mL in total The above components were dissolved in a part of purified water at room temperature, and the pH was adjusted to 3 After adjusting to, the total amount was adjusted to 50 mL.

Comparative Example 3 150 mg of anhydrous caffeine 5 mg of purified sucrose 5 mg of malic acid 100 mg of hydrochloric acid (pH regulator) Appropriate amount of purified water 30 ml in total The above components were dissolved in a part of purified water at room temperature, and the pH was adjusted. 3.
After adjusting to 5, the total amount was adjusted to 30 mL. Comparative Example 4 Dihydrocodeine Phosphate 8 mg Purified Sucrose 5 g Sodium Citrate 100 mg Apple Flavor 60 μL Sodium Hydroxide (pH Adjuster) Appropriate amount Purified Water Addition Total 20 mL A Part of Purified Water Atmosphere After dissolving and adjusting the pH to 5, the total amount was adjusted to 20 mL.

Comparative Example 5 Phenylpropanolamine hydrochloride 38 mg Acetaminophen 900 mg Ascorbic acid 600 mg Purified sucrose 11 g Sodium citrate 500 mg Propylene glycol 2 g Polyethylene glycol 2 g Sodium benzoate 42 mg Ethyl paraoxybenzoate 7 mg Caramel 120 mg Sodium hydroxide (pH adjuster) qs. Purified water added, total volume 60 mL After dissolving each of the above components in a portion of purified water at room temperature, adjusting the pH to 7, and adjusting the total volume to 60 mL. did.

Test Example 1 The liquid preparations obtained in Examples 1 to 5 and Comparative Examples 1 to 5 were subjected to a sensory test by five panelists, and 0 to 5 points were given for three items of bitterness, smell and comprehensive evaluation. The effect of the present invention was confirmed by the six-point score evaluation.

[Table 1]

[Table 2]

[0034]

[Table 3]

[Table 4] As a result of the organoleptic test, the liquid preparation of the present invention exhibited masking effects of bitterness and odor, and an improvement in the overall evaluation of drinkability was recognized.

[0035]

The oral liquid preparation of the present invention has an improved flavor by masking strong bitterness and specific bitterness, and can be easily drunk without pain.

Claims (5)

[Claims] 1. An oral liquid preparation comprising a bitter component and maple flavors. 2. The oral liquid preparation according to claim 1, further comprising coffee flavors. 3. The oral liquid preparation according to claim 1, wherein the bitter component is a cold medicine. 4. The oral liquid preparation according to claim 1, wherein the bitter component is a fever-relieving agent, analgesic, anti-inflammatory, antitussive, expectorant, antihistamine or hemostatic agent. 5. The method according to claim 1, wherein the bitter component is a vitamin B group.
The oral solution according to the above.