JPH10158119A - Cosmetic and quasi drug - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic and a quasi drug each containing the vacuum- retorted product of a bamboo and common salt, having no toxicity, little in skin irritativity, and excellent in an antimicrobial property and in a safe property. SOLUTION: The objective cosmetic and quasi drug each contains (A) a bamboo vacuum-retorted product distilled out on the retorting of bamboo under a vacuum condition, preferably in the amount of 0.0001-10wt.% (based on the distillate of the vacuum retorting), and (B) common salt preferably in an amount of 0.01-20wt.%. The cosmetic and the quasi drug preferably further contains surfactants, respectively.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to cosmetics and quasi-drugs having excellent antibacterial properties and being safe.

[0002]

2. Description of the Related Art The purpose of adding an antibacterial agent to cosmetics and quasi-drugs is to prevent deterioration of the cosmetics and quasi-drugs themselves, and to disinfect and sterilize the skin surface to be applied. The purpose is to maintain the cleanliness of the two.

Examples of antibacterial agents that are acceptable for cosmetics and quasi-drugs include benzoic acid or a salt thereof, paraoxybenzoic acid ester, salicylic acid or a salt thereof, sorbic acid or a salt thereof, dehydroacetic acid or a salt thereof, chloride Benzalkonium, orthophenylphenol, chlorhexidine gluconate, isopropylmethylphenol and the like.

Attempts have been made to add naturally occurring antibacterial agents in place of synthetic antibacterial agents, but their antibacterial properties are not always sufficient.

[0005] JP-A-6-227931 discloses an antibacterial component comprising a dry distillate of a plant selected from the group consisting of perilla, bamboo, ginger, mugwort and garlic. The use of this antibacterial component is mainly for food additives, but there is a statement that it is applicable to cosmetics as one of the uses.

[0006] Although not related to the vacuum-distilled product of bamboo, Japanese Patent Application Laid-Open No. 7-187990 discloses a cosmetic mainly comprising an extract of a trunk or a branch of bamboo. The extract is an aqueous extract, the purpose of which is to add sebum deficiency,
It is in the treatment of diseases such as inflammatory dermatitis. JP-A-3-937
Japanese Patent Application Laid-Open No. 10-18001 discloses an external preparation or cosmetic for skin or hair containing an extract of bamboo or the like as an active ingredient.
No. 2 discloses a hair tonic containing an extract of bamboo as an active ingredient, and JP-A-3-251518 discloses a skin, scalp and hair preparation containing a dandruff growth inhibitory component extracted from bamboo. Japanese Patent No. 306232 discloses a topical deodorant and sanitizer containing bamboo plant powder or granules or an extract thereof as an essential component.

[0007]

SUMMARY OF THE INVENTION Synthetic antibacterial agents that are accepted for cosmetics and quasi-drugs have various restrictions on the amount of addition and usage (whether they are immediately washed away) from the viewpoint of safety. Many of the synthetic antibacterial agents often do not exhibit the original antibacterial activity in a system in which a surfactant is present. Preferably, a non-synthetic antimicrobial agent is used.

Therefore, as described above, attempts have been made to add a naturally occurring antibacterial agent in place of the synthetic antibacterial agent. However, the naturally occurring antibacterial agent generally has an antibacterial activity as compared with the synthetic antibacterial agent. In addition, there is a problem that the antibacterial activity is considerably insufficient, and even in the case of a naturally occurring antibacterial agent, a system in which a surfactant is present often does not exhibit the original antibacterial activity. Therefore, it is conceivable to increase the amount of the natural antibacterial agent to increase the antibacterial activity.However, even if the amount is increased, the antibacterial activity does not increase beyond a certain limit and causes odor and coloring. The value as cosmetics or quasi-drugs may decrease. Even though it is a natural antibacterial agent, it is desirable to avoid extremely increasing the amount of addition as much as possible.

Under such a background, the present invention has excellent antibacterial properties, exhibits antibacterial properties even in a system in which a surfactant is present, and has no toxicity and little skin irritation, so that the safety is low. It is intended to provide high cosmetics and quasi-drugs.

[0010]

Means for Solving the Problems The cosmetics and quasi-drugs of the present invention contain both a bamboo vacuum-distilled product (A) and a salt (B) which are distilled off when bamboo is carbonized under reduced pressure conditions. It is characterized by doing.

[0011]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail.

As the bamboo vacuum distillation product (A), a vacuum vacuum distillation product obtained by crushing and drying bamboo (especially Moso bamboo) as necessary, and then distilling it under vacuum conditions is used.

As the reduced pressure condition, a condition of 100 mmHg or less, preferably 10 to 60 mmHg, particularly 15 to 45 mmHg is suitably adopted. The initial fraction at the time of vacuum distillation may be appropriately cut, or the vacuum distillation product may be further purified.
The distillate obtained by dry distillation under normal pressure or dry distillation under a condition of a small degree of reduced pressure has insufficient antibacterial ability and cannot sufficiently achieve the object of the present invention.

The distillation temperature of the dry matter at the time of vacuum distillation depends on the degree of vacuum (low when the vacuum is large and high when the vacuum is small), for example, around 300 ° C. in the case of vacuum distillation at 20 mmHg. Becomes

The vacuum-distilled product (A) obtained by the above operation
Since is usually a viscous liquid, it is appropriate to temporarily receive the distillate with water, ethanol, propylene glycol or the like, and then adjust the concentration with water or ethanol for convenience of handling.

[0016] The extract of bamboo with water or a solvent is not suitable for the purpose of the present invention because it has an extremely low antibacterial activity as compared with the above-mentioned bamboo vacuum distillate (A).

The cosmetics and quasi-drugs of the present invention contain the above-mentioned bamboo vacuum-distilled product (A) and salt (B). If one of the bamboo vacuum distillate (A) and the salt (B) is missing, satisfactory results cannot be obtained in terms of antibacterial properties.

The amount of bamboo vacuum distillate (A) occupied in cosmetics and quasi-drugs is 0.0001 based on the distillate at vacuum vacuum distillation.
10 to 10% by weight, preferably 0.0005 to 5% by weight, more preferably 0.001 to 2% by weight, and the amount of salt (B) added to cosmetics and quasi-drugs is 0.01 to 20% by weight, preferably Is 0.05 to 15% by weight, more preferably
0.1 to 10% by weight is suitable.

Here, cosmetics and quasi-drugs include:
Cosmetics, medicated cosmetics, and quasi-drugs as exemplified below are exemplified. Although these are generally intended for the human body, the present invention includes not only humans but also animals such as pets.

As cosmetics, cosmetics for hair (hair oil,
Hair dyes, skim oils, set lotions, tics, oils with bottles, hair creams, hair tonics, hair liquids, hair sprays, pomades, etc.), cosmetics for hair washing (hair washing powder,
Shampoo, etc.), lotions (after shaving lotion, general lotion, cologne, shaving lotion, hand lotion, tan lotion, sunscreen lotion, etc.), cream emulsions (after shaving cream, cleansing cream, cold cream, shaving cream, Emulsions, burnishing creams, hand creams, sun creams, sun creams, etc.), packs (cosmetics for packs, etc.), foundations (creamy foundation, liquid foundation, solid foundation, etc.), powdered white powder (cream paste, solid) White powder, powder powder, talcum powder, paste paste, baby powder, body powder, water powder, etc., lipsticks (lipstick, lip balm, etc.), eyebrows and cheek cosmetics (Eye cream, eye shadow,
Eyeliner, blusher, mascara, eyebrows, etc.), nail cosmetics (beautiful nail enamel, beautiful nail enamel remover, etc.), perfumes (general perfumes, condensed perfumes, powdered perfumes, etc.), bath cosmetics (bath oil, bath salt) And the like, cosmetic oils (cosmetic oil, baby oil, etc.), facial cleansers (facial cleansing cream, skin wash powder, facial cleansing foam, etc.), soaps (cosmetic soap, etc.), toothpastes, and the like.

Examples of the medicated cosmetics include shampoos, rinses, lotions, creams, emulsions, hand creams, cosmetic oils, shaving agents, sunscreens, packs, medicated soaps, etc., which belong to the medicated cosmetics. .

Quasi-drugs include mouth fresheners, anti-armpit odor agents, starches, hair restorers (hair restorers), hair removers, hair dyes (bleaching agents, destaining agents), bath agents, cosmeceuticals ( Medicated soaps), medicated dentifrices, insecticides (repellents), rodenticides, permanent waving agents, sanitary cotton, and the like.

<Action> Cosmetic products and quasi-drugs to which the bamboo vacuum-distilled product (A) is added alone exhibit some antibacterial activity, but their antibacterial activity is not sufficient. Antibacterial activity is also exhibited in cosmetics and quasi-drugs to which salt (B) is added alone, but the antibacterial activity is not sufficient when the concentration is low. However, bamboo vacuum distillation products for cosmetics and quasi-drugs
When both (A) and salt (B) are contained, a synergistic effect can be obtained in terms of antibacterial properties even when both addition amounts are relatively small.

Since the bamboo vacuum-distilled product (A) is derived from a natural product and is also edible,
It is safe.

As described above, the cosmetics and quasi-drugs of the present invention have excellent antibacterial activity, and exhibit excellent antibacterial activity even in a system in which a surfactant is present. The cosmetics and quasi-drugs of the present invention are gentle on the skin and have virtually no skin irritation.

[0026]

The present invention will be further described with reference to the following examples. Hereinafter, “parts” and “%” are expressed on a weight basis.

<Acquisition of Bamboo Vacuum Vacuum Distillate> Bamboo (Moso bamboo)
Is supplied to a vacuum distillation apparatus, and the pressure is about 20 mmHg,
The residue was distilled under reduced pressure at a temperature of about 300 ° C., and the distillate (containing moisture) was received with water and the concentration was further adjusted with water to obtain an aqueous solution having a distillate concentration of about 20%. The nonvolatile content of this aqueous solution was about 3%.

<Samples> The following three samples were prepared as test samples. -No.1: An aqueous solution obtained by adding 1.25 parts of the aqueous solution having a distillate concentration of about 20% and 3.75 parts of salt to sterilized water to make 100 parts.・ No.2: An aqueous solution obtained by adding 1.25 parts of the above aqueous solution having a distillate concentration of about 20% to sterilized water to make 100 parts.・ No.3: An aqueous solution obtained by adding 3.75 parts of salt to sterilized water to make 100 parts.

<Used bacterial species> The following three types of bacteria were prepared.・ Echerichia coli IFO 3806 ・ Bacillus subtilis IFO 3009 ・ Staphyrococcus aureus IFO 13276

<Test operation> In a sterilized plastic petri dish having a diameter of 90 mm, 100 µl of the bacterial solution pre-cultured and diluted 1000 times was added, and 20 g of the above aqueous solution was further added. The solution after the contact for 1 hour and 24 hours was taken, and a 10-fold dilution was performed. The solution was spread on an agar plate medium having the following composition, and the number of viable bacteria was measured. The initial number of bacteria is about 100-500 cells / ml, and the medium composition is 1.00 part of glucose, 0.50 part of peptone, 0.30 part of powdered yeast extract, 0.03 part of KH ₂ PO ₄ , K ₂ HPO ₄ 0.03 part.
Parts, MgSO ₄ 0.01 parts, agar 1.50 parts, purified water 96.93 parts, pH
7.0.

<Test Results> The test results are shown in Table 1 below.
In the table, “<1” means 1 or less, and “<10” means 10 or less. No. 1 is an example, No. 2 and No. 3 are comparative examples, and No. 4 is a control.

[0032]

[Table 1] Test of viable cell count (cells / ml) after 1 hour and 24 hours Active ingredient E. coli B. subtilis S. aureus sample 1 hr 24 hr 1 hr 24 hr 1 hr 24 hr No. 1 Bamboo vacuum distilled distillate + salt < 10 <1 10 10 30 <1 No.2 Bamboo vacuum dry distillate 50 40 30 30 50 10 No.3 Salt 190 <1 30 30 50 <1 No.4 Physiological saline 500 480 110 103 108 100

<Analysis> Regarding Echerichia coli, No. 2 sample containing only the vacuum-distilled product of bamboo (Comparative Example 1)
No significant decrease in the bacterial count was observed after 1 hour and 24 hours. In the sample of No. 3 containing only salt (Comparative Example 2), the number of bacteria decreased remarkably after 24 hours, but after 1 hour, the number of bacteria was not sufficiently reduced. On the other hand, both bamboo vacuum distillation and salt are included
In the sample of No. 1 (Example 1), the number of viable cells was remarkably reduced even after 1 hour, and it was found that a synergistic effect was exhibited by using both of them. In addition, Echerichia col measured separately
The MIC (minimum growth inhibitory concentration) of the bamboo reduced-pressure distillate relative to i was 1.25%.

With regard to Bacillus subtilis, the reduction in the number of bacteria was limited in the No. 2 sample (Comparative Example 1) containing only the bamboo vacuum destillate. Also in the sample of No. 3 containing only salt (Comparative Example 2), there was a limit to the decrease in the number of bacteria. On the other hand, both bamboo vacuum distillation and salt are included
In the sample of No. 1 (Example 1), it was found that the viable cell count was remarkably reduced by breaking such a limit, and a synergistic effect was exhibited by the combination of the two. In addition, Baci measured separately
The MIC (minimum growth inhibitory concentration) of the bamboo vacuum distillate with respect to llus subtilis was 2.50%.

Looking at Staphyrococcus aureus,
In the No. 2 sample (Comparative Example 1) containing only the bamboo reduced-pressure distillate, there was a limit to the decrease in the number of bacteria. N containing only salt
In the o.3 sample (Comparative Example 2), the number of bacteria significantly decreased after 24 hours, but after 1 hour, the number of bacteria was not always sufficient. On the other hand, in the sample of No. 1 (Example 1) containing both the bamboo vacuum-dried matter and the salt, the viable cell count was considerably reduced even after 1 hour, and the cell count was remarkable after 24 hours. It was found that a synergistic effect was exhibited by the combination of the two. In addition, Staphyro measured separately
The MIC (minimum inhibitory concentration) of the bamboo vacuum distilled product against coccus aureus was 5.00%.

From the overall tendency, it can be seen that when both the bamboo reduced-pressure dried product and the salt are contained, a synergistic effect which cannot be attained by each of the products alone can be obtained.

<Examples of Formulation> In order to apply the present invention to a typical cosmetic formula, “Cosmetic Science, published by Nanzando Co., Ltd., 198
In accordance with a typical prescription such as the prescription described in "March 1, 3rd Edition, 4th Printing Issuance", cosmetics having the following prescription were prepared, but despite the fact that no conventional preservatives were added, In each case, the antibacterial property was favorable (and even in a system in which a surfactant was present), and no skin irritation was observed.

(Neutral cream) According to a typical formulation of a nonionic emulsified neutral cream, stearyl alcohol 7.
0%, stearic acid 2.0%, hydrogenated lanolin 2.0%, squalane 5.0%, 2-octyldodecyl alcohol 6.0
%, Polyoxyethylene cetyl alcohol ether 3.0
%, Non-self-emulsifying glyceryl monostearate
A neutral cream containing 2.0%, propylene glycol 5.0%, the above-mentioned No. 1 preparation containing bamboo vacuum distillate and salt, 5.0%, fragrance 0.3%, and the remainder being purified water (total 100%) was prepared. .

(Emulsion formulation example) According to a typical O / W emulsion formulation, stearic acid 2.5%, cetyl alcohol 1.5
%, Petrolatum 5.0%, liquid paraffin 10.0%, polyoxyethylene monooleate 2.0%, molecular weight 15
No. 1 polyethylene glycol 3.0%, triethanolamine 1.0%, No. 1 bamboo vacuum-dried preparation containing salt and salt 5.0%, perfume 0.5%, the remainder is purified water (total 100%) Was prepared.

(Example of lotion formulation) According to a typical softening lotion formulation, glycerin 3.0%, propylene glycol
4.0%, dipropylene glycol 4.0%, oleyl alcohol 0.1%, polyoxyethylene sorbitan monolaurate 1.5%, polyoxyethylene lauryl alcohol ether 0.5%, ethanol 15.0%, No. 1 above
Preparation containing bamboo vacuum distillate and salt 5.0%, flavor 0.1
%, With the balance being purified water (100% in total).

(Liquid Pack Formulation Example) Polyvinyl alcohol 15.0 was prepared according to a typical peel-off type liquid pack formula.
%, Carboxymethylcellulose 5.0%, glycerin
A liquid pack was prepared containing 5.0%, ethanol 10.0%, the above-mentioned No. 1 bamboo vacuum-distilled product and 5.0% of a preparation containing salt, and the balance being purified water (total: 100%).

(Example of Transparent Shampoo Formulation) According to a typical clear shampoo formulation, a 40% aqueous solution of polyoxyethylene lauryl sulfate triethanolamine salt 32.0%
%, Lauryl polyoxyethylene sulfate soda salt 30% aqueous solution 21.0%, lauroyl diethanolamide
4.0%, polyethylene glycol with a molecular weight of 400 1.0
%, Preparation containing No. 1 bamboo vacuum-distilled product and salt 5.0
%, Fragrance 0.3%, and the balance is purified water (total 1%)
00%) A clear shampoo was prepared.

(Prescription example of body shampoo) Disodium lauryl sulfosuccinate 50.0%, magnesium sulfate 7
Water salt 20.0%, sodium alpha olefin sulfonate
It consists of 5.0%, hexylene glycol 5.0%, the above-mentioned No. 1 preparation containing bamboo vacuum-distilled product and salt 5.0%, fragrance 1.0%, appropriate amount of pH adjuster, and appropriate amount of purified water (the total is 100
%) A body shampoo was prepared.

(Formulation example of rinse-in shampoo) 8.0% of sodium polyoxyethylene lauryl acetate, 8.0% of coconut oil fatty acid amidopropyl betaine, 20.0% of polyoxyethylene lauryl sulfate sodium, 3.0% of coconut oil fatty acid diethanolamide, aminopropyl ethyl sulfate lanolin fatty acid aminopropyl Ethyldimethylammonium 2.0%, Ethylene glycol monostearate 2.0%, No.1 bamboo vacuum-dried product containing salt and salt 4.0%, Flavor 1.0%, Appropriate amount of pH adjuster, Appropriate amount of purified water (total Is 100%)
A rinse-in shampoo was prepared.

[0045]

As described in the section of action, the cosmetics and quasi-drugs of the present invention have excellent antibacterial properties, exhibit antibacterial properties even in a system in which a surfactant is present, and have toxicity and skin irritation. No safety is observed and safety is high.

Claims (3)

[Claims] 1. Cosmetics and quasi-drugs containing both bamboo vacuum distillate (A) and salt (B) which are distilled off when bamboo is carbonized under reduced pressure conditions. 2. The amount of bamboo vacuum distillate (A) occupying in cosmetics or quasi-drugs is 0.0001 based on the distillate at vacuum vacuum distillation.
The cosmetics and quasi-drugs according to claim 1, wherein the amount of the salt (B) is 0.01 to 20% by weight. 3. The cosmetics and quasi-drugs according to claim 1, wherein the cosmetics and quasi-drugs contain a surfactant.