JPH10158119A - Cosmetic and quasi drug - Google Patents
Cosmetic and quasi drugInfo
- Publication number
- JPH10158119A JPH10158119A JP8321360A JP32136096A JPH10158119A JP H10158119 A JPH10158119 A JP H10158119A JP 8321360 A JP8321360 A JP 8321360A JP 32136096 A JP32136096 A JP 32136096A JP H10158119 A JPH10158119 A JP H10158119A
- Authority
- JP
- Japan
- Prior art keywords
- bamboo
- vacuum
- cosmetics
- salt
- quasi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、抗菌性にすぐれか
つ安全な化粧品および医薬部外品に関するものである。The present invention relates to cosmetics and quasi-drugs having excellent antibacterial properties and being safe.
【0002】[0002]
【従来の技術】化粧品や医薬部外品に抗菌剤を添加する
目的には、化粧品や医薬部外品自体の変敗の防止を図る
目的と、適用対象となる皮膚面を消毒殺菌して身体の清
潔を維持する目的との2つがある。2. Description of the Related Art The purpose of adding an antibacterial agent to cosmetics and quasi-drugs is to prevent deterioration of the cosmetics and quasi-drugs themselves, and to disinfect and sterilize the skin surface to be applied. The purpose is to maintain the cleanliness of the two.
【0003】化粧品や医薬部外品用に許容されている抗
菌剤の例は、安息香酸またはその塩、パラオキシ安息香
酸エステル、サリチル酸またはその塩、ソルビン酸また
はその塩、デヒドロ酢酸またはその塩、塩化ベンザルコ
ニウム、オルトフェニルフェノール、グルコン酸クロル
ヘキシジン、イソプロピルメチルフェノールなどであ
る。Examples of antibacterial agents that are acceptable for cosmetics and quasi-drugs include benzoic acid or a salt thereof, paraoxybenzoic acid ester, salicylic acid or a salt thereof, sorbic acid or a salt thereof, dehydroacetic acid or a salt thereof, chloride Benzalkonium, orthophenylphenol, chlorhexidine gluconate, isopropylmethylphenol and the like.
【0004】合成抗菌剤に代えて天然由来の抗菌剤を添
加することも試みられているが、その抗菌性は必ずしも
充分でない。Attempts have been made to add naturally occurring antibacterial agents in place of synthetic antibacterial agents, but their antibacterial properties are not always sufficient.
【0005】特開平6−227931号公報には、シ
ソ、タケ、ショウキョウ、ヨモギおよびニンニクよりな
る群から選ばれた植物の乾留物からなる抗菌性成分につ
き開示がある。この抗菌性成分の用途は主として食品添
加用であるが、用途の一つとして化粧品にも適用できる
旨の一言の記載がある。[0005] JP-A-6-227931 discloses an antibacterial component comprising a dry distillate of a plant selected from the group consisting of perilla, bamboo, ginger, mugwort and garlic. The use of this antibacterial component is mainly for food additives, but there is a statement that it is applicable to cosmetics as one of the uses.
【0006】タケの減圧乾留物に関するものではない
が、特開平7−187990号公報には、竹類の幹また
は枝の抽出物を主成分とする化粧料が示されている。抽
出物とは水抽出物であり、その添加目的は皮脂欠乏症、
炎症性皮膚炎等の疾患の治療にある。特開平3−937
10号公報には竹等の抽出エキスを有効成分とする皮膚
または頭髪用外用剤または化粧料、特開平4−1801
2号公報には竹類のエキスを有効成分として含有する養
毛剤、特開平3−251518号公報には竹から抽出さ
れたフケ菌発育阻害成分を含有する皮膚・頭皮・頭髪
剤、特開平5−306232号公報には竹類植物体の粉
粒物またはそのエキスを必須成分としてなる外用脱臭除
菌剤が示されている。[0006] Although not related to the vacuum-distilled product of bamboo, Japanese Patent Application Laid-Open No. 7-187990 discloses a cosmetic mainly comprising an extract of a trunk or a branch of bamboo. The extract is an aqueous extract, the purpose of which is to add sebum deficiency,
It is in the treatment of diseases such as inflammatory dermatitis. JP-A-3-937
Japanese Patent Application Laid-Open No. 10-18001 discloses an external preparation or cosmetic for skin or hair containing an extract of bamboo or the like as an active ingredient.
No. 2 discloses a hair tonic containing an extract of bamboo as an active ingredient, and JP-A-3-251518 discloses a skin, scalp and hair preparation containing a dandruff growth inhibitory component extracted from bamboo. Japanese Patent No. 306232 discloses a topical deodorant and sanitizer containing bamboo plant powder or granules or an extract thereof as an essential component.
【0007】[0007]
【発明が解決しようとする課題】化粧品や医薬部外品用
に許容されている合成抗菌剤は、安全性の点から、添加
量や使い方(すぐに洗い流すかどうか)に種々の制限が
ある。また合成抗菌剤の多くは、界面活性剤が存在する
系においては本来の抗菌力が奏されないことが多い。で
きれば合成でない抗菌剤を用いることが望ましい。SUMMARY OF THE INVENTION Synthetic antibacterial agents that are accepted for cosmetics and quasi-drugs have various restrictions on the amount of addition and usage (whether they are immediately washed away) from the viewpoint of safety. Many of the synthetic antibacterial agents often do not exhibit the original antibacterial activity in a system in which a surfactant is present. Preferably, a non-synthetic antimicrobial agent is used.
【0008】そこで、先にも述べたように合成抗菌剤に
代えて天然由来の抗菌剤を添加することも試みられてい
るが、天然由来の抗菌剤は合成抗菌剤に比すれば一般に
抗菌力がかなり不足するという問題点がある上、天然由
来の抗菌剤にあっても界面活性剤が存在する系において
は本来の抗菌力が奏されないことが多い。そこで天然由
来の抗菌剤の添加量を多くして抗菌力を高めることが考
えられるが、添加量を多くしても一定限界以上には抗菌
力は上がらない上、においや着色の原因となって化粧品
や医薬部外品としての価値が低下することもある。また
いくら天然由来の抗菌剤であるとは言え、極端に添加量
を増やすことはできるだけ避けたい。Therefore, as described above, attempts have been made to add a naturally occurring antibacterial agent in place of the synthetic antibacterial agent. However, the naturally occurring antibacterial agent generally has an antibacterial activity as compared with the synthetic antibacterial agent. In addition, there is a problem that the antibacterial activity is considerably insufficient, and even in the case of a naturally occurring antibacterial agent, a system in which a surfactant is present often does not exhibit the original antibacterial activity. Therefore, it is conceivable to increase the amount of the natural antibacterial agent to increase the antibacterial activity.However, even if the amount is increased, the antibacterial activity does not increase beyond a certain limit and causes odor and coloring. The value as cosmetics or quasi-drugs may decrease. Even though it is a natural antibacterial agent, it is desirable to avoid extremely increasing the amount of addition as much as possible.
【0009】本発明は、このような背景下において、抗
菌性にすぐれ、界面活性剤が存在する系においても抗菌
性が発揮され、しかも毒性を有せずかつ皮膚刺激性も小
さいので安全性が高い化粧品および医薬部外品を提供す
ることを目的とするものである。Under such a background, the present invention has excellent antibacterial properties, exhibits antibacterial properties even in a system in which a surfactant is present, and has no toxicity and little skin irritation, so that the safety is low. It is intended to provide high cosmetics and quasi-drugs.
【0010】[0010]
【課題を解決するための手段】本発明の化粧品および医
薬部外品は、タケを減圧条件下に乾留したときに留出す
るタケ減圧乾留物(A) と食塩(B) との双方を含有するこ
とを特徴とするものである。Means for Solving the Problems The cosmetics and quasi-drugs of the present invention contain both a bamboo vacuum-distilled product (A) and a salt (B) which are distilled off when bamboo is carbonized under reduced pressure conditions. It is characterized by doing.
【0011】[0011]
【発明の実施の形態】以下本発明を詳細に説明する。DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail.
【0012】タケ減圧乾留物(A) としては、タケ(殊に
孟宗竹)を、必要に応じて粉砕、乾燥した後、減圧条件
下に乾留したときに留出する減圧乾留物が用いられる。As the bamboo vacuum distillation product (A), a vacuum vacuum distillation product obtained by crushing and drying bamboo (especially Moso bamboo) as necessary, and then distilling it under vacuum conditions is used.
【0013】減圧条件としては、100mmHg以下、好ま
しくは10〜60mmHg、殊に15〜45mmHgの条件が好
適に採用される。減圧乾留時の初留分は適宜カットして
もよく、また減圧乾留物をさらに精製処理してもよい。
常圧下の乾留または減圧度が小さい条件下の乾留で得た
留出物は抗菌能力が不足し、本発明の目的を充分には達
成しえない。As the reduced pressure condition, a condition of 100 mmHg or less, preferably 10 to 60 mmHg, particularly 15 to 45 mmHg is suitably adopted. The initial fraction at the time of vacuum distillation may be appropriately cut, or the vacuum distillation product may be further purified.
The distillate obtained by dry distillation under normal pressure or dry distillation under a condition of a small degree of reduced pressure has insufficient antibacterial ability and cannot sufficiently achieve the object of the present invention.
【0014】上記減圧乾留時の乾留物の留出温度は減圧
度に依存するが(減圧度が大きいときは低く、減圧度が
小さいときは高い)、たとえば20mmHgの減圧乾留の場
合で300℃前後となる。The distillation temperature of the dry matter at the time of vacuum distillation depends on the degree of vacuum (low when the vacuum is large and high when the vacuum is small), for example, around 300 ° C. in the case of vacuum distillation at 20 mmHg. Becomes
【0015】上記の操作により得られた減圧乾留物(A)
は通常は粘稠な液体であるので、取り扱いの便宜上、一
旦留出物を水、エタノール、プロピレングリコールなど
で受け、ついでそれを水やエタノールで濃度調節するよ
うにするのが適当である。The vacuum-distilled product (A) obtained by the above operation
Since is usually a viscous liquid, it is appropriate to temporarily receive the distillate with water, ethanol, propylene glycol or the like, and then adjust the concentration with water or ethanol for convenience of handling.
【0016】なお、タケの水や溶剤による抽出物は、上
記のタケ減圧乾留物(A) に比し抗菌力が著しく小さいの
で、本発明の目的には適していない。[0016] The extract of bamboo with water or a solvent is not suitable for the purpose of the present invention because it has an extremely low antibacterial activity as compared with the above-mentioned bamboo vacuum distillate (A).
【0017】本発明の化粧品および医薬部外品は、上記
のタケ減圧乾留物(A) と食塩(B) とを含有するものであ
る。タケ減圧乾留物(A) と食塩(B) のどちらか一方を欠
くときは、抗菌性の点で満足のいく結果が得られない。The cosmetics and quasi-drugs of the present invention contain the above-mentioned bamboo vacuum-distilled product (A) and salt (B). If one of the bamboo vacuum distillate (A) and the salt (B) is missing, satisfactory results cannot be obtained in terms of antibacterial properties.
【0018】化粧品や医薬部外品に占めるタケ減圧乾留
物(A) の添加量は、減圧乾留時の留出物基準で、0.0001
〜10重量%、好ましくは0.0005〜5重量%、さらに好
ましくは 0.001〜2重量%が適当であり、化粧品や医薬
部外品に占める食塩(B) の添加量は、0.01〜20重量
%、好ましくは0.05〜15重量%、さらに好ましくは
0.1〜10重量%が適当である。The amount of bamboo vacuum distillate (A) occupied in cosmetics and quasi-drugs is 0.0001 based on the distillate at vacuum vacuum distillation.
10 to 10% by weight, preferably 0.0005 to 5% by weight, more preferably 0.001 to 2% by weight, and the amount of salt (B) added to cosmetics and quasi-drugs is 0.01 to 20% by weight, preferably Is 0.05 to 15% by weight, more preferably
0.1 to 10% by weight is suitable.
【0019】ここで化粧品および医薬部外品としては、
次に例示するような化粧品、薬用化粧品、医薬部外品が
あげられる。なおこれらは一般には人体を対象とするも
のであるが、本発明においては人のみならずペット等の
動物を対象とする場合も含むものとする。Here, cosmetics and quasi-drugs include:
Cosmetics, medicated cosmetics, and quasi-drugs as exemplified below are exemplified. Although these are generally intended for the human body, the present invention includes not only humans but also animals such as pets.
【0020】化粧品としては、頭髪用化粧品類(髪油、
染毛料、スキ油、セットローション、チック、びん付
油、ヘアクリーム、ヘアトニック、ヘアリキッド、ヘア
スプレー、ポマード等)、洗髪用化粧品類(髪洗い粉、
シャンプー等)、化粧水類(アフターシェービングロー
ション、一般化粧水、オーデコロン、シェービングロー
ション、ハンドローション、日焼けローション、日焼け
止めローション等)、クリーム乳液類(アフターシェー
ビングクリーム、クレンジングクリーム、コールドクリ
ーム、シェービングクリーム、乳液、バニシングクリー
ム、ハンドクリーム、日焼けクリーム、日焼け止めクリ
ーム等)、パック類(パック用化粧料等)、ファンデー
ション類(クリーム状ファンデーション、液状ファンデ
ーション、固形ファンデーション等)、白粉打粉類(ク
リームおしろい、固形おしろい、粉おしろい、タルカム
パウダー、練おしろい、ベビーパウダー、ホディパウダ
ー、水おしろい等)、口紅類(口紅、リップクリーム
等)、眉目頬化粧品類(アイクリーム、アイシャドー、
アイライナー、頬紅、マスカラ、眉墨等)、爪化粧品類
(美爪エネメル、美爪エナメル除去液等)、香水類(一
般香水、練香水、粉末香水等)、浴用化粧品類(バスオ
イル、バスソルト等)、化粧油類(化粧用油、ベビーオ
イル等)、洗顔料類(洗顔クリーム、肌洗い粉、洗顔フ
ォーム等)、石けん類(化粧石けん等)、歯みがき類な
どがあげられる。As cosmetics, cosmetics for hair (hair oil,
Hair dyes, skim oils, set lotions, tics, oils with bottles, hair creams, hair tonics, hair liquids, hair sprays, pomades, etc.), cosmetics for hair washing (hair washing powder,
Shampoo, etc.), lotions (after shaving lotion, general lotion, cologne, shaving lotion, hand lotion, tan lotion, sunscreen lotion, etc.), cream emulsions (after shaving cream, cleansing cream, cold cream, shaving cream, Emulsions, burnishing creams, hand creams, sun creams, sun creams, etc.), packs (cosmetics for packs, etc.), foundations (creamy foundation, liquid foundation, solid foundation, etc.), powdered white powder (cream paste, solid) White powder, powder powder, talcum powder, paste paste, baby powder, body powder, water powder, etc., lipsticks (lipstick, lip balm, etc.), eyebrows and cheek cosmetics (Eye cream, eye shadow,
Eyeliner, blusher, mascara, eyebrows, etc.), nail cosmetics (beautiful nail enamel, beautiful nail enamel remover, etc.), perfumes (general perfumes, condensed perfumes, powdered perfumes, etc.), bath cosmetics (bath oil, bath salt) And the like, cosmetic oils (cosmetic oil, baby oil, etc.), facial cleansers (facial cleansing cream, skin wash powder, facial cleansing foam, etc.), soaps (cosmetic soap, etc.), toothpastes, and the like.
【0021】薬用化粧品としては、シャンプー、リン
ス、化粧水、クリーム、乳液、ハンドクリーム、化粧用
油、ひげそり用剤、日やけ止め剤、パック、薬用石けん
などのうち薬用化粧品に属するものがあげられる。Examples of the medicated cosmetics include shampoos, rinses, lotions, creams, emulsions, hand creams, cosmetic oils, shaving agents, sunscreens, packs, medicated soaps, etc., which belong to the medicated cosmetics. .
【0022】医薬部外品としては、口中清涼剤、腋臭防
止剤、てんか粉類、育毛剤(養毛剤)、除毛剤、染毛剤
(脱色剤、脱染剤)、浴用剤、薬用化粧品(薬用石けん
を含む)、薬用歯磨類、殺虫剤(忌避剤)、殺鼠剤、パ
ーマネント・ウェーブ用剤、衛生綿類などがあげられ
る。Quasi-drugs include mouth fresheners, anti-armpit odor agents, starches, hair restorers (hair restorers), hair removers, hair dyes (bleaching agents, destaining agents), bath agents, cosmeceuticals ( Medicated soaps), medicated dentifrices, insecticides (repellents), rodenticides, permanent waving agents, sanitary cotton, and the like.
【0023】〈作用〉タケ減圧乾留物(A) を単独で添加
した化粧品や医薬部外品においても若干の抗菌力が奏さ
れるが、その抗菌力は充分ではない。また食塩(B) を単
独で添加した化粧品や医薬部外品においても抗菌力が奏
されるが、濃度が低い状態では抗菌力が充分とは言えな
い。しかるに、化粧品や医薬部外品にタケ減圧乾留物
(A) と食塩(B) との双方を含有させた場合には、双方の
添加量が比較的少ない場合でも抗菌性の点で相乗効果が
得られる。<Action> Cosmetic products and quasi-drugs to which the bamboo vacuum-distilled product (A) is added alone exhibit some antibacterial activity, but their antibacterial activity is not sufficient. Antibacterial activity is also exhibited in cosmetics and quasi-drugs to which salt (B) is added alone, but the antibacterial activity is not sufficient when the concentration is low. However, bamboo vacuum distillation products for cosmetics and quasi-drugs
When both (A) and salt (B) are contained, a synergistic effect can be obtained in terms of antibacterial properties even when both addition amounts are relatively small.
【0024】タケ減圧乾留物(A) は天然物由来のもので
あり、また食用に供してもよいほどのものであるので、
安全性が高いものである。Since the bamboo vacuum-distilled product (A) is derived from a natural product and is also edible,
It is safe.
【0025】このように本発明の化粧品および医薬部外
品はすぐれた抗菌力を有し、しかも界面活性剤が存在す
る系においてもすぐれた抗菌性が発揮される。そして本
発明の化粧品および医薬部外品は、肌にやさしく、皮膚
刺激性を事実上有しない。As described above, the cosmetics and quasi-drugs of the present invention have excellent antibacterial activity, and exhibit excellent antibacterial activity even in a system in which a surfactant is present. The cosmetics and quasi-drugs of the present invention are gentle on the skin and have virtually no skin irritation.
【0026】[0026]
【実施例】次に実施例をあげて本発明をさらに説明す
る。以下「部」、「%」とあるのは重量基準で表わした
ものである。The present invention will be further described with reference to the following examples. Hereinafter, “parts” and “%” are expressed on a weight basis.
【0027】〈タケ減圧乾留物の取得〉タケ(孟宗竹)
の粉砕物を減圧乾留装置に供給して、圧力約20mmHg、
温度約300℃の条件下に減圧乾留し、留出物(水分を
含んでいる)を水で受けると共にさらに水で濃度調節し
て、留出物濃度約20%の水溶液を得た。この水溶液の
不揮発分濃度は約3%であった。<Acquisition of Bamboo Vacuum Vacuum Distillate> Bamboo (Moso bamboo)
Is supplied to a vacuum distillation apparatus, and the pressure is about 20 mmHg,
The residue was distilled under reduced pressure at a temperature of about 300 ° C., and the distillate (containing moisture) was received with water and the concentration was further adjusted with water to obtain an aqueous solution having a distillate concentration of about 20%. The nonvolatile content of this aqueous solution was about 3%.
【0028】〈試料〉供試試料として、次の3種を準備
した。 ・ No.1 : 上記の留出物濃度約20%の水溶液1.25部と
食塩3.75部とを滅菌水に加えて100部となした水溶
液。 ・ No.2 : 上記の留出物濃度約20%の水溶液1.25部を
滅菌水に加えて100部となした水溶液。 ・ No.3 : 食塩3.75部を滅菌水に加えて100部となし
た水溶液。<Samples> The following three samples were prepared as test samples. -No.1: An aqueous solution obtained by adding 1.25 parts of the aqueous solution having a distillate concentration of about 20% and 3.75 parts of salt to sterilized water to make 100 parts.・ No.2: An aqueous solution obtained by adding 1.25 parts of the above aqueous solution having a distillate concentration of about 20% to sterilized water to make 100 parts.・ No.3: An aqueous solution obtained by adding 3.75 parts of salt to sterilized water to make 100 parts.
【0029】〈使用菌種〉細菌類として次の3種を準備
した。 ・ Echerichia coli IFO 3806 ・ Bacillus subtilis IFO 3009 ・ Staphyrococcus aureus IFO 13276<Used bacterial species> The following three types of bacteria were prepared.・ Echerichia coli IFO 3806 ・ Bacillus subtilis IFO 3009 ・ Staphyrococcus aureus IFO 13276
【0030】〈試験操作〉直径90mmの滅菌済みプラス
チックシャーレに、前培養し1000倍に稀釈した菌液
100μl を入れ、さらに上記の水溶液20gを添加し
た。1時間および24時間接触後の液をとり、10倍段
階稀釈を行い、下記組成の寒天平板培地に塗沫し、生菌
数を測定した。初発菌数は約100〜500個/ml であ
り、培地組成は、ブドウ糖1.00部、ペプトン0.50部、粉
末酵母エキス0.30部、KH2PO4 0.03部、K2HPO4 0.03
部、MgSO4 0.01部、寒天1.50部、精製水 96.93部、pH
7.0とした。<Test operation> In a sterilized plastic petri dish having a diameter of 90 mm, 100 µl of the bacterial solution pre-cultured and diluted 1000 times was added, and 20 g of the above aqueous solution was further added. The solution after the contact for 1 hour and 24 hours was taken, and a 10-fold dilution was performed. The solution was spread on an agar plate medium having the following composition, and the number of viable bacteria was measured. The initial number of bacteria is about 100-500 cells / ml, and the medium composition is 1.00 part of glucose, 0.50 part of peptone, 0.30 part of powdered yeast extract, 0.03 part of KH 2 PO 4 , K 2 HPO 4 0.03 part.
Parts, MgSO 4 0.01 parts, agar 1.50 parts, purified water 96.93 parts, pH
7.0.
【0031】〈試験結果〉試験結果を次の表1に示す。
表中、「< 1 」は1以下、「<10 」を10以下を意味す
る。No.1は実施例、No.2とNo.3は比較例、No.4は対照で
ある。<Test Results> The test results are shown in Table 1 below.
In the table, “<1” means 1 or less, and “<10” means 10 or less. No. 1 is an example, No. 2 and No. 3 are comparative examples, and No. 4 is a control.
【0032】[0032]
【表1】 1時間後および24時間後の生菌数 (個/ml) 供試 有効成分 E. coli B. subtilis S. aureus 試料 1hr 24hr 1hr 24hr 1hr 24hr No.1 タケ減圧乾留物+食塩 <10 < 1 10 10 30 < 1 No.2 タケ減圧乾留物 50 40 30 30 50 10 No.3 食塩 190 < 1 30 30 50 < 1 No.4 生理食塩水 500 480 110 103 108 100 [Table 1] Test of viable cell count (cells / ml) after 1 hour and 24 hours Active ingredient E. coli B. subtilis S. aureus sample 1 hr 24 hr 1 hr 24 hr 1 hr 24 hr No. 1 Bamboo vacuum distilled distillate + salt < 10 <1 10 10 30 <1 No.2 Bamboo vacuum dry distillate 50 40 30 30 50 10 No.3 Salt 190 <1 30 30 50 <1 No.4 Physiological saline 500 480 110 103 108 100
【0033】〈解析〉Echerichia coli について見る
と、タケ減圧乾留物のみを含むNo.2の試料(比較例1)
においては、1時間後も24時間後も菌数に大きな減少
は認められなかった。食塩のみを含むNo.3の試料(比較
例2)においては、24時間後には菌数が顕著に減少し
たが、1時間後ではまだ菌数の減少は充分ではなかっ
た。これに対し、タケ減圧乾留物と食塩との双方を含む
No.1(実施例1)の試料にあっては、1時間後でも生菌
数は顕著に減少し、両者の併用により相乗効果が奏され
ることがわかった。なお、別途測定したEcherichia col
i に対するタケ減圧乾留物のMIC(最小発育阻止濃
度)は1.25%であった。<Analysis> Regarding Echerichia coli, No. 2 sample containing only the vacuum-distilled product of bamboo (Comparative Example 1)
No significant decrease in the bacterial count was observed after 1 hour and 24 hours. In the sample of No. 3 containing only salt (Comparative Example 2), the number of bacteria decreased remarkably after 24 hours, but after 1 hour, the number of bacteria was not sufficiently reduced. On the other hand, both bamboo vacuum distillation and salt are included
In the sample of No. 1 (Example 1), the number of viable cells was remarkably reduced even after 1 hour, and it was found that a synergistic effect was exhibited by using both of them. In addition, Echerichia col measured separately
The MIC (minimum growth inhibitory concentration) of the bamboo reduced-pressure distillate relative to i was 1.25%.
【0034】Bacillus subtilis について見ると、タケ
減圧乾留物のみを含むNo.2の試料(比較例1)において
は、菌数の減少に限界があった。食塩のみを含むNo.3の
試料(比較例2)においても、菌数の減少に限界があっ
た。これに対し、タケ減圧乾留物と食塩との双方を含む
No.1(実施例1)の試料にあっては、そのような限界を
破って生菌数が顕著に減少し、両者の併用により相乗効
果が奏されることがわかった。なお、別途測定したBaci
llus subtilis に対するタケ減圧乾留物のMIC(最小
発育阻止濃度)は2.50%であった。With regard to Bacillus subtilis, the reduction in the number of bacteria was limited in the No. 2 sample (Comparative Example 1) containing only the bamboo vacuum destillate. Also in the sample of No. 3 containing only salt (Comparative Example 2), there was a limit to the decrease in the number of bacteria. On the other hand, both bamboo vacuum distillation and salt are included
In the sample of No. 1 (Example 1), it was found that the viable cell count was remarkably reduced by breaking such a limit, and a synergistic effect was exhibited by the combination of the two. In addition, Baci measured separately
The MIC (minimum growth inhibitory concentration) of the bamboo vacuum distillate with respect to llus subtilis was 2.50%.
【0035】Staphyrococcus aureus について見ると、
タケ減圧乾留物のみを含むNo.2の試料(比較例1)にお
いては、菌数の減少に限界があった。食塩のみを含むN
o.3の試料(比較例2)においては、24時間後には菌
数が顕著に減少したが、1時間後ではまだ菌数の減少は
必ずしも充分ではなかった。これに対し、タケ減圧乾留
物と食塩との双方を含むNo.1(実施例1)の試料にあっ
ては、1時間後でも生菌数はかなり減少し、24時間後
には菌数が顕著に減少し、両者の併用により相乗効果が
奏されることがわかった。なお、別途測定したStaphyro
coccus aureus に対するタケ減圧乾留物のMIC(最小
発育阻止濃度)は5.00%であった。Looking at Staphyrococcus aureus,
In the No. 2 sample (Comparative Example 1) containing only the bamboo reduced-pressure distillate, there was a limit to the decrease in the number of bacteria. N containing only salt
In the o.3 sample (Comparative Example 2), the number of bacteria significantly decreased after 24 hours, but after 1 hour, the number of bacteria was not always sufficient. On the other hand, in the sample of No. 1 (Example 1) containing both the bamboo vacuum-dried matter and the salt, the viable cell count was considerably reduced even after 1 hour, and the cell count was remarkable after 24 hours. It was found that a synergistic effect was exhibited by the combination of the two. In addition, Staphyro measured separately
The MIC (minimum inhibitory concentration) of the bamboo vacuum distilled product against coccus aureus was 5.00%.
【0036】全体的な傾向を見ると、タケ減圧乾留物と
食塩との双方を含有させると、それぞれの単品では到達
しえない相乗効果が得られることがわかる。From the overall tendency, it can be seen that when both the bamboo reduced-pressure dried product and the salt are contained, a synergistic effect which cannot be attained by each of the products alone can be obtained.
【0037】〈処方例〉典型的な化粧品処方に本発明を
応用すべく、「化粧品学、株式会社南山堂発行、198
3年3月1日第13版4刷発行」に記載の処方など代表
的処方に従って、次の処方の化粧品を調製したが、従来
使われている防腐剤を全く添加しなかったにもかかわら
ず、いずれの場合も好ましい抗菌性を示し(しかも界面
活性剤が存在する系においても)、肌刺激も認められな
かった。<Examples of Formulation> In order to apply the present invention to a typical cosmetic formula, “Cosmetic Science, published by Nanzando Co., Ltd., 198
In accordance with a typical prescription such as the prescription described in "March 1, 3rd Edition, 4th Printing Issuance", cosmetics having the following prescription were prepared, but despite the fact that no conventional preservatives were added, In each case, the antibacterial property was favorable (and even in a system in which a surfactant was present), and no skin irritation was observed.
【0038】(中性クリーム)典型的なノニオン乳化型
の中性クリームの処方に従い、ステアリルアルコール7.
0%、ステアリン酸 2.0%、水添ラノリン 2.0%、スク
ワラン 5.0%、2−オクチルドデシルアルコール 6.0
%、ポリオキシエチレンセチルアルコールエーテル 3.0
%、非自己乳化型グリセリルモノステアリン酸エステル
2.0%、プロピレングリコール 5.0%、上記No.1のタケ
減圧乾留物と食塩とを含む製剤 5.0%、香料 0.3%を含
み、残余が精製水である(合計は100%)中性クリー
ムを調製した。(Neutral cream) According to a typical formulation of a nonionic emulsified neutral cream, stearyl alcohol 7.
0%, stearic acid 2.0%, hydrogenated lanolin 2.0%, squalane 5.0%, 2-octyldodecyl alcohol 6.0
%, Polyoxyethylene cetyl alcohol ether 3.0
%, Non-self-emulsifying glyceryl monostearate
A neutral cream containing 2.0%, propylene glycol 5.0%, the above-mentioned No. 1 preparation containing bamboo vacuum distillate and salt, 5.0%, fragrance 0.3%, and the remainder being purified water (total 100%) was prepared. .
【0039】(乳液処方例)典型的なO/W型乳液の処
方に従い、ステアリン酸 2.5%、セチルアルコール1.5
%、ワセリン 5.0%、流動パラフィン10.0%、ポリオキ
シエチレンモノオレイン酸エステル 2.0%、分子量15
00のポリエチレングリコール 3.0%、トリエタノール
アミン 1.0%、上記No.1のタケ減圧乾留物と食塩とを含
む製剤 5.0%、香料 0.5%を含み、残余が精製水である
(合計は100%)乳液を調製した。(Emulsion formulation example) According to a typical O / W emulsion formulation, stearic acid 2.5%, cetyl alcohol 1.5
%, Petrolatum 5.0%, liquid paraffin 10.0%, polyoxyethylene monooleate 2.0%, molecular weight 15
No. 1 polyethylene glycol 3.0%, triethanolamine 1.0%, No. 1 bamboo vacuum-dried preparation containing salt and salt 5.0%, perfume 0.5%, the remainder is purified water (total 100%) Was prepared.
【0040】(化粧水処方例)典型的な柔軟化化粧水の
処方に従い、グリセリン 3.0%、プロピレングリコール
4.0%、ジプロピレングリコール 4.0%、オレイルアル
コール 0.1%、ポリオキシエチレンソルビタンモノラウ
リン酸エステル 1.5%、ポリオキシエチレンラウリルア
ルコールエーテル 0.5%、エタノール15.0%、上記No.1
のタケ減圧乾留物と食塩とを含む製剤 5.0%、香料 0.1
%を含み、残余が精製水である(合計は100%)化粧
水を調製した。(Example of lotion formulation) According to a typical softening lotion formulation, glycerin 3.0%, propylene glycol
4.0%, dipropylene glycol 4.0%, oleyl alcohol 0.1%, polyoxyethylene sorbitan monolaurate 1.5%, polyoxyethylene lauryl alcohol ether 0.5%, ethanol 15.0%, No. 1 above
Preparation containing bamboo vacuum distillate and salt 5.0%, flavor 0.1
%, With the balance being purified water (100% in total).
【0041】(液状パック処方例)典型的なピールオフ
型液状パックの処方に従い、ポリビニルアルコール15.0
%、カルボキシメチルセルロース 5.0%、グリセリン
5.0%、エタノール10.0%、上記No.1のタケ減圧乾留物
と食塩とを含む製剤 5.0%を含み、残余が精製水である
(合計は100%)液状パックを調製した。(Liquid Pack Formulation Example) Polyvinyl alcohol 15.0 was prepared according to a typical peel-off type liquid pack formula.
%, Carboxymethylcellulose 5.0%, glycerin
A liquid pack was prepared containing 5.0%, ethanol 10.0%, the above-mentioned No. 1 bamboo vacuum-distilled product and 5.0% of a preparation containing salt, and the balance being purified water (total: 100%).
【0042】(透明シャンプー処方例)典型的な透明シ
ャンプーの処方に従い、ポリオキシエチレンラウリル硫
酸エステルトリエタノールアミン塩の40%水溶液32.0
%、ラウリルポリオキエチレン硫酸エステルソーダ塩の
30%水溶液21.0%、ラウロイルジエタノールアミド
4.0%、分子量400のポリエチレングリコール 1.0
%、上記No.1のタケ減圧乾留物と食塩とを含む製剤 5.0
%、香料 0.3%を含み、残余が精製水である(合計は1
00%)透明シャンプーを調製した。(Example of Transparent Shampoo Formulation) According to a typical clear shampoo formulation, a 40% aqueous solution of polyoxyethylene lauryl sulfate triethanolamine salt 32.0%
%, Lauryl polyoxyethylene sulfate soda salt 30% aqueous solution 21.0%, lauroyl diethanolamide
4.0%, polyethylene glycol with a molecular weight of 400 1.0
%, Preparation containing No. 1 bamboo vacuum-distilled product and salt 5.0
%, Fragrance 0.3%, and the balance is purified water (total 1%)
00%) A clear shampoo was prepared.
【0043】(ボディーシャンプー処方例)スルホコハ
ク酸ラウリル二ナトリウム50.0%、硫酸マグネシウム7
水塩20.0%、アルファオレフィンスルホン酸ナトリウム
5.0%、ヘキシレングリコール 5.0%、上記No.1のタケ
減圧乾留物と食塩とを含む製剤 5.0%、香料 1.0%、適
量のpH調整剤、適量の精製水からなる(合計は100
%)ボディーシャンプーを調製した。(Prescription example of body shampoo) Disodium lauryl sulfosuccinate 50.0%, magnesium sulfate 7
Water salt 20.0%, sodium alpha olefin sulfonate
It consists of 5.0%, hexylene glycol 5.0%, the above-mentioned No. 1 preparation containing bamboo vacuum-distilled product and salt 5.0%, fragrance 1.0%, appropriate amount of pH adjuster, and appropriate amount of purified water (the total is 100
%) A body shampoo was prepared.
【0044】(リンスインシャンプー処方例)ポリオキ
シエチレンラウリル酢酸ナトリウム 8.0%、ヤシ油脂肪
酸アミドプロピルベタイン 8.0%、ポリオキシエチレン
ラウリル硫酸ナトリウム20.0%、ヤシ油脂肪酸ジエタノ
ールアミド 3.0%、エチル硫酸ラノリン脂肪酸アミノプ
ロピルエチルジメチルアンモニウム 2.0%、モノステア
リン酸エチレングリコール 2.0%、上記No.1のタケ減圧
乾留物と食塩とを含む製剤 4.0%、香料 1.0%、適量の
pH調整剤、適量の精製水からなる(合計は100%)
リンスインシャンプーを調製した。(Formulation example of rinse-in shampoo) 8.0% of sodium polyoxyethylene lauryl acetate, 8.0% of coconut oil fatty acid amidopropyl betaine, 20.0% of polyoxyethylene lauryl sulfate sodium, 3.0% of coconut oil fatty acid diethanolamide, aminopropyl ethyl sulfate lanolin fatty acid aminopropyl Ethyldimethylammonium 2.0%, Ethylene glycol monostearate 2.0%, No.1 bamboo vacuum-dried product containing salt and salt 4.0%, Flavor 1.0%, Appropriate amount of pH adjuster, Appropriate amount of purified water (total Is 100%)
A rinse-in shampoo was prepared.
【0045】[0045]
【発明の効果】作用の項でも述べたように、本発明の化
粧品および医薬部外品は、抗菌性にすぐれ、界面活性剤
が存在する系においても抗菌性が発揮され、しかも毒性
や皮膚刺激性が認められず、安全性が高い。As described in the section of action, the cosmetics and quasi-drugs of the present invention have excellent antibacterial properties, exhibit antibacterial properties even in a system in which a surfactant is present, and have toxicity and skin irritation. No safety is observed and safety is high.
Claims (3)
るタケ減圧乾留物(A) と食塩(B) との双方を含有するこ
とを特徴とする化粧品および医薬部外品。1. Cosmetics and quasi-drugs containing both bamboo vacuum distillate (A) and salt (B) which are distilled off when bamboo is carbonized under reduced pressure conditions.
乾留物(A) の添加量が減圧乾留時の留出物基準で0.0001
〜10重量%であり、食塩(B) の添加量が0.01〜20重
量%である請求項1記載の化粧品および医薬部外品。2. The amount of bamboo vacuum distillate (A) occupying in cosmetics or quasi-drugs is 0.0001 based on the distillate at vacuum vacuum distillation.
The cosmetics and quasi-drugs according to claim 1, wherein the amount of the salt (B) is 0.01 to 20% by weight.
むものである請求項1または2記載の化粧品および医薬
部外品。3. The cosmetics and quasi-drugs according to claim 1, wherein the cosmetics and quasi-drugs contain a surfactant.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP32136096A JP3658626B2 (en) | 1996-12-02 | 1996-12-02 | Cosmetics and quasi drugs |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP32136096A JP3658626B2 (en) | 1996-12-02 | 1996-12-02 | Cosmetics and quasi drugs |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10158119A true JPH10158119A (en) | 1998-06-16 |
JP3658626B2 JP3658626B2 (en) | 2005-06-08 |
Family
ID=18131709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP32136096A Expired - Lifetime JP3658626B2 (en) | 1996-12-02 | 1996-12-02 | Cosmetics and quasi drugs |
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Country | Link |
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JP (1) | JP3658626B2 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010029068A (en) * | 1999-09-29 | 2001-04-06 | 강권중 | Vaginal Troche Containing Jukyum and Mica |
KR100439868B1 (en) * | 2001-04-18 | 2004-07-12 | 주식회사 태평양 | A compositions for skin external application containing the sap of bamboo |
KR100493143B1 (en) * | 2002-11-04 | 2005-06-02 | 이규재 | Soap containing extract of bamboo and manufacturing method of the same |
JP2011079780A (en) * | 2009-10-08 | 2011-04-21 | Nippon Menaade Keshohin Kk | Powder cosmetic |
JP2011162519A (en) * | 2010-02-15 | 2011-08-25 | Nippon Menaade Keshohin Kk | Powdery cosmetic |
JP2014205658A (en) * | 2013-03-21 | 2014-10-30 | 白井松新薬株式会社 | Maillard reaction inhibitor |
CN106625968A (en) * | 2016-11-02 | 2017-05-10 | 赤水智博艺术雕刻工艺有限责任公司 | Method for producing art mobile phone shell by bamboo material |
-
1996
- 1996-12-02 JP JP32136096A patent/JP3658626B2/en not_active Expired - Lifetime
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010029068A (en) * | 1999-09-29 | 2001-04-06 | 강권중 | Vaginal Troche Containing Jukyum and Mica |
KR100439868B1 (en) * | 2001-04-18 | 2004-07-12 | 주식회사 태평양 | A compositions for skin external application containing the sap of bamboo |
KR100493143B1 (en) * | 2002-11-04 | 2005-06-02 | 이규재 | Soap containing extract of bamboo and manufacturing method of the same |
JP2011079780A (en) * | 2009-10-08 | 2011-04-21 | Nippon Menaade Keshohin Kk | Powder cosmetic |
JP2011162519A (en) * | 2010-02-15 | 2011-08-25 | Nippon Menaade Keshohin Kk | Powdery cosmetic |
JP2014205658A (en) * | 2013-03-21 | 2014-10-30 | 白井松新薬株式会社 | Maillard reaction inhibitor |
CN106625968A (en) * | 2016-11-02 | 2017-05-10 | 赤水智博艺术雕刻工艺有限责任公司 | Method for producing art mobile phone shell by bamboo material |
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EXPY | Cancellation because of completion of term |