JPH10151185A - On-skin sticking adhesive tape - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a moderate on-skin adhesive property, and eliminate the remainder of an adhesive by forming a cross-linking rubber type adhesive layer formed by applying and cross-linking an adhesive composition by containing specific pts.wt. of liquid oil compatible with a rubber component to specific pts.wt. of a rubber component containing rubber having a functional group. SOLUTION: Rubber having a functional group is an essential component to cross-link an adhesive layer, and a carboxyl group can be cited as a desirable example of a functional group. Though it is not particularly limited if it is liquid oil which is compatible with a rubber component and is safe for the skin, a fat and oil and the like and a plasticizer or the like can be cited as liquid oil. An adhesive composition is formed by containing liquid oil 20 to 80 pts.wt. Though the adhesive composition is cross-linked after being applied to at least one surface of a base material, a cross-linking agent is normally used for cross-linking. A multifunctional cross-linking agent to react with a functional group of functional group-containing rubber is used as the cross- linking agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pressure-sensitive adhesive tape for sticking to the skin, and more particularly, it has good adhesiveness to the skin, has little rash when applied to the skin, and adheres to the skin when peeled off. The present invention relates to a pressure-sensitive adhesive tape for adhering to the skin on which no agent remains. The pressure-sensitive adhesive tape of the present invention is suitable as a medical pressure-sensitive adhesive tape.

[0002]

2. Description of the Related Art Conventionally, various types of pressure-sensitive adhesive tapes for sticking to the skin have been developed for protecting the affected skin and transdermal absorption of drugs. Generally, the pressure-sensitive adhesive tape for application to the skin has a constitution in which a pressure-sensitive adhesive composition containing a drug is applied on one surface of a flexible base material as necessary. In general, the pressure-sensitive adhesive composition used in such a pressure-sensitive adhesive tape for skin application includes:
It is required to have the following characteristics. (1) Since the pressure-sensitive adhesive tape for skin application needs to be kept in an applied state for a predetermined time without peeling off from the skin surface, the adhesive tape can relatively strongly adhere to the skin surface with the pressure-sensitive adhesive composition. Skin adhesion is required. (2) On the other hand, if the adhesive tape for applying to the skin has too strong an adhesive force to the skin, when the adhesive tape is peeled off from the skin surface after use, it feels pain due to physical irritation or hair on the body surface is peeled off. Or exfoliation, or adhesive residue on the skin surface. Therefore, the pressure-sensitive adhesive composition is required to have appropriate skin adhesiveness and to be easily peeled off after a certain time without residual pressure-sensitive adhesive. (3) If the adhesive tape for skin application has strong skin irritation,
Causes skin irritation. Therefore, the adhesive composition is required to have low skin irritation.

[0003] Conventionally, for example, Japanese Patent Application Laid-Open No. 3-220120 discloses an acrylic resin having a crosslinked gel layer containing an acrylate polymer and a liquid component compatible with the polymer formed on at least one surface of a support. A gel material and an acrylic gel preparation containing a drug in the acrylic gel material are disclosed. As the liquid component, for example, glycols, fats and oils, organic solvents, liquid surfactants, plasticizers, liquid paraffin, isopropyl myristate, N-vinyl-2-pyrrolidone, octyl palmitate, isotridecyl myristate and the like are used. Have been. The acrylic gel material is obtained by crosslinking an acrylate polymer with a crosslinking agent such as a metal alcoholate. This acrylic gel material prevents the decrease in cohesive force and reduces / disperses the stress on the skin surface by cross-linking and gelling the acrylate-based polymer layer containing an excessive amount of liquid components. Let me. However, this acrylic gel material has a disadvantage that its adhesiveness to the skin is not yet sufficient.

JP-A-2-295565 discloses a gel-type pressure-sensitive adhesive composition comprising, on one surface of a support, a pressure-sensitive adhesive, a compound having a plasticizing effect on the pressure-sensitive adhesive, and finely divided silica. An adhesive patch provided with a layer is disclosed.
Examples of the adhesive include an acrylic adhesive, a rubber adhesive, and a silicone adhesive. Compounds having a plasticizing action include esters, ethers, ketones,
Liquid compounds such as hydrocarbons, alcohols and amides are indicated. However, this gel-like pressure-sensitive adhesive composition is
A liquid compound and fine powdered silica are added to a non-crosslinked adhesive, and the fine powdered silica has a cohesive strength.However, since the liquid compound is absorbed by the fine powdered silica, an appropriate gel is used. And adhesiveness to the skin is not sufficient.

[0005]

SUMMARY OF THE INVENTION An object of the present invention is to form a pressure-sensitive adhesive layer which has an appropriate skin adhesiveness, can be easily peeled off with no adhesive remaining, and has a small skin irritation. To provide an adhesive tape for applying to the skin. The present inventors have conducted intensive studies to overcome the problems of the prior art, and as a result, a pressure-sensitive adhesive composition comprising a rubber component containing a rubber having a functional group, and a liquid oil compatible with the rubber component. It has been found that the above object can be achieved by applying the product to at least one surface of a flexible base material and crosslinking it to form a crosslinked rubber-based pressure-sensitive adhesive layer. Since the crosslinked rubber-based pressure-sensitive adhesive layer contains liquid oil in the crosslinked rubber network, the pressure-sensitive adhesive layer does not become hard and can maintain a good holding force as a whole, and can adhere to the skin. The properties are also good. ADVANTAGE OF THE INVENTION The adhesive tape for skin sticking of this invention does not have an adhesive on the skin surface at the time of peeling, and can be peeled off easily. In addition, this adhesive tape for applying to skin has low skin irritation. The present invention has been completed based on these findings.

[0006]

According to the present invention, at least one side of a flexible substrate is coated with a liquid oil 20 compatible with a rubber component containing a rubber having a functional group per 100 parts by weight of the rubber component. There is provided a pressure-sensitive adhesive tape for applying to the skin, characterized in that a crosslinked rubber-based pressure-sensitive adhesive layer formed by applying and cross-linking a pressure-sensitive adhesive composition containing 80 parts by weight is formed. Further, according to the present invention, there is provided the above-mentioned pressure-sensitive adhesive tape for applying to skin, wherein the rubber having a functional group is at least one selected from the group consisting of a carboxyl group-containing styrene butadiene rubber and a carboxyl group-containing polyisoprene. Furthermore, according to the present invention, the total displacement speed between the base material and the crosslinked rubber-based pressure-sensitive adhesive layer is 0.5 to 1.8 mm / 12.
The above-mentioned pressure-sensitive adhesive tape for application to the skin, which has a size of mm × 20 mm · 100 g · 5 minutes, is provided.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, a flexible substrate is used as a substrate in consideration of sticking properties to the skin.
As the flexible substrate, for example, plasticized soft polyvinyl chloride, non-plasticized soft polyvinyl chloride, polyethylene, polypropylene, polybutene, ethylene-methyl methacrylate copolymer, ethylene-vinyl acetate copolymer, ethylene-propylene rubber And films or sheets made of synthetic resins such as polyamide, polyethylene terephthalate, polyurethane, polyvinylidene chloride and polyvinyl alcohol. Also, a flexible film or sheet such as a nonwoven fabric, a plastic foam sheet, cellulose, or cellulose acetate can be used. The rubber having a functional group used in the present invention is an essential component for crosslinking the pressure-sensitive adhesive layer, and a preferable example of the functional group is a carboxyl group. Specific examples of the rubber having a functional group include carboxyl group-containing styrene butadiene rubber (carboxylated SBR),
Carboxyl group-containing polyisoprene;
These can be used alone or in combination of two or more.

[0008] As the rubber component, other rubbers can be contained together with the rubber having a functional group. Other rubbers include natural rubber (NR), polyisoprene (IR), styrene-isoprene-styrene block copolymer (SI
S), styrene-butadiene-styrene block copolymer (SBS), styrene-butadiene rubber (SBR), ethylene-propylene-non-conjugated diene terpolymer (EP
DM), butyl rubber and the like. These other rubber components are selected and used as needed. For example, natural rubber is used to increase the adhesiveness, and SIS block copolymer is used to increase the holding power. The other rubber components can be used alone or in combination of two or more. For example, natural rubber and SI
It is preferable to use an S block copolymer in combination. The ratio in the rubber component is such that the rubber having a functional group is usually 30 to 100.
% By weight, preferably 40 to 90% by weight, more preferably 50 to 80% by weight, and the other rubber is usually 0 to 70% by weight.
% By weight, preferably 10 to 60% by weight, more preferably 20 to 50% by weight. It is preferable to use both of them because the balance of various properties is improved.

The liquid oil is not particularly limited as long as it is compatible with the rubber component and is safe for the skin. For example, olive oil, sesame oil, castor oil,
Fats and oils such as lanolin; plasticizers such as dioctyl phthalate, dibutyl phthalate, diethyl sebacate and diisopropyl adipate; hydrocarbons such as liquid paraffin; medium-chain triglycerides, liquid polyisoprene, liquid terpene resins, polyethylene glycol and the like. The mixing ratio of the liquid oil is usually 20 to 80 parts by weight, preferably 25 to 75 parts by weight, per 100 parts by weight of the rubber component.
Parts by weight. If the mixing ratio of the liquid oil is too small,
The adhesive becomes hard and the irritation to the skin increases. If the mixing ratio of the liquid oil is too large, the pressure-sensitive adhesive layer becomes too soft, and the pressure-sensitive adhesive remains on the skin when the pressure-sensitive adhesive tape is peeled off.

The pressure-sensitive adhesive composition is applied on at least one side (usually one side) of the substrate and then crosslinked. Usually, a crosslinking agent is used for crosslinking. As the crosslinking agent, a polyfunctional crosslinking agent that reacts with the functional group of the functional group-containing rubber is used. Specific examples of the crosslinking agent include amine-based, epoxy-based, and isocyanate-based crosslinking agents. The addition amount of the crosslinking agent is used in an amount ratio at which the functional group-containing rubber is appropriately crosslinked,
Usually, from 0.01 to 10 parts by weight of the rubber component.
Parts by weight, preferably about 0.1 to 5 parts by weight, more preferably about 0.2 to 2 parts by weight. The pressure-sensitive adhesive composition of the present invention may optionally contain a general-purpose compounding agent which is generally added to a pressure-sensitive adhesive. For example, a tackifying resin, an antioxidant, a filler, a colorant, a softener, and the like can be used.

Examples of the tackifying resin include natural products such as rosin resin and terpene resin and derivatives thereof; aliphatic petroleum resins, alicyclic petroleum resins, aromatic petroleum resins, cumarone indene resins, Synthetic resins such as styrene-based resins, phenol-based resins, and xylene-based resins; These can be used alone or in combination of two or more. The tackifying resin is
It is used in a proportion of usually 20 to 150 parts by weight, preferably 30 to 100 parts by weight, based on 100 parts by weight of the rubber component.
If the proportion of the tackifier resin is too small, it is difficult to obtain sufficient tackiness, and if it is too large, the tack tends to decrease. Examples of the anti-aging agent include phenol-based, amine-based, thioether-based, and phosphite-based anti-aging agents.

The pressure-sensitive adhesive composition of the present invention may optionally contain a transdermally absorbable drug.
Drugs include, for example, angina pectoris, corticosteroids, analgesics and anti-inflammatory agents, hypnotic analgesics, anti-inflammatory agents, anti-allergic agents, antihistamines, coronary vasodilators, antibacterial agents, humectants,
Examples include vitamins, antitussives, anesthetics, antitumor agents, fragrances and the like. These are compounded in an effective amount as required. The pressure-sensitive adhesive tape for application to the skin of the present invention has a total displacement speed between the base material and the crosslinked rubber-based pressure-sensitive adhesive layer of 0.5 to 1.
It is preferably 8 mm / 12 mm × 20 mm · 100 g · 5 minutes. If the displacement speed is too low, the pressure-sensitive adhesive layer becomes too hard, irritation to the skin increases, and rash is likely to occur. Conversely, if the displacement speed is too high, the pressure-sensitive adhesive layer becomes too soft and the pressure-sensitive adhesive tends to remain on the skin surface.

The pressure-sensitive adhesive composition comprises toluene, n-
It is dissolved or dispersed in a solvent such as hexane, applied to at least one surface of the substrate, dried, and then crosslinked. In order to crosslink the rubber component, it is usually heated to about 30 to 70 ° C. After applying the adhesive composition to the release paper and drying,
A method of superimposing on a substrate can also be adopted. Further, when a synthetic resin film or sheet is used as the base material, if the perforation is provided by the method disclosed in JP-A-61-53380, the pressure-sensitive adhesive tape can be provided with air permeability. It is preferable because rash can be more effectively prevented and hand-cutting property can be given.

[0014]

EXAMPLES The present invention will be described more specifically with reference to examples and comparative examples, but the present invention is not limited to these examples. In the following,
Parts and percentages are by weight unless otherwise specified.

The method of evaluating physical properties is as follows. (1) Adhesion to skin Adhesive tape (19 mm x 30 mm) is attached to the upper arm,
The bonding state after 6 hours was evaluated by the bonding area ratio. The number of subjects was 30, and the average of the scores evaluated according to the following evaluation criteria was obtained. 5 points: 95% or more, 4 points: 90% to less than 95%, 3 points: 80% to less than 90%, 2 points: 70% to less than 80%, 1 point: 60% to less than 70%, 0 points: Less than 60%.

(2) Persistence on skin Adhesive tape (19 mm × 30 mm) is attached to the upper arm,
After 6 hours, the adhesive was peeled off, and the state of the adhesive remaining on the skin was evaluated according to the following criteria. The number of subjects was 30, and the average of the scores evaluated according to the following evaluation criteria was obtained. 5 points: No residue at all, 4 points: Slightly left on the edge, 3 points: Adhesive residue, 2 points: Adhesive residue is noticeable, 1 point: Adhesive residue is severe, 0 points: Adhesive residue on the entire surface.

(3) Skin irritation index Adhesive tape (19 mm × 30 m) was applied to 30 subjects.
m) was attached to the upper arm, peeled 24 hours later, and a skin reaction rating was given based on the following “Paste Test Judgment Criteria and Ratings”, and the skin irritation index (SI) was calculated according to Equation 1. <Paste test judgment criteria and score> 0 point: no response, 0.5 point: slight erythema, 1 point: clear erythema, 2 points: erythema + edema or papule, 3 points: erythema + edema or papule + vesicle 4 points: large blisters. (Equation 1) SI = Σ [Score of strong reaction 1 hour and 24 hours after peeling] × 100 / total number of subjects

(4) Overall speed of displacement between the base material and the pressure-sensitive adhesive layer As shown in FIG. 1, a pressure-sensitive adhesive tape (12 mm width) was placed over the cut of a 75th-thick polyethylene terephthalate film (PET # 75). × 40 mm length), and then fix one end of the PET film,
A weight of 100 g was hung on the other end, and the displacement after 5 minutes was measured.

Example 1 An adhesive solution having the composition shown in Table 1 was applied to a release paper so as to have a coating thickness after drying of 35 μm, and was dried by heating at 120 ° C. for 3 minutes. Plasticized soft polyvinyl chloride film (5% modulus =
(250 gf / 15 mm) and aged at 50 ° C. for 3 weeks to prepare an adhesive tape. Physical properties of the obtained pressure-sensitive adhesive tapes were evaluated. Table 1 shows the results.

[0020]

[Table 1] (Footnotes) (* 1) Nipol 1009 manufactured by Zeon Corporation (* 2) Kariflex TR1107 manufactured by Shell Chemical Company (* 3) Klaprene LIR-403 manufactured by Kuraray (* 4) YTR # 20 manufactured by Yashara Chemical (* 5) Mitsubishi Gas Chemical Co., Ltd. Tetrado C (* 6) Arakawa Chemical Co., Ltd., Alcon P-100 (* 7) Nippon Zeon Co., Ltd. Quinton U185 (* 8) Seiko Chemical Co., Ltd., Swanox BHT

[0021]

According to the present invention, there is provided a skin adhering agent having an appropriate skin adhesive property, which can be easily peeled off without leaving an adhesive, and in which an adhesive layer having a small skin irritation is formed. An adhesive tape is provided.

[Brief description of the drawings]

FIG. 1 is a schematic view showing a method for measuring an overall displacement speed between a base material and a crosslinked rubber-based pressure-sensitive adhesive layer.

[Explanation of symbols]

 1: Adhesive tape (12mm width x 40mm length) 2: PET # 75 film with cuts

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Hiromitsu Fujisawa Nichiban Co., Ltd. 2-3-3 Sekiguchi, Bunkyo-ku, Tokyo

Claims (3)

[Claims] 1. An adhesive comprising at least one surface of a flexible base material and 20 to 80 parts by weight of a liquid oil compatible with a rubber component containing 100 parts by weight of a rubber component containing a rubber having a functional group. A pressure-sensitive adhesive tape for application to the skin, comprising a crosslinked rubber-based pressure-sensitive adhesive layer formed by applying and cross-linking the composition. 2. The pressure-sensitive adhesive tape for application to skin according to claim 1, wherein the rubber having a functional group is at least one selected from the group consisting of carboxyl group-containing styrene butadiene rubber and carboxyl group-containing polyisoprene. 3. The total displacement speed between the base material and the crosslinked rubber-based pressure-sensitive adhesive layer is 0.5 to 1.8 mm / 12 mm × 20 mm ·
The pressure-sensitive adhesive tape for application to the skin according to claim 1 or 2, which is 100 g for 5 minutes.