JPH11349476A - Medical pasting material - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a medical pasting material which has not only sufficient stretch but also excellent pasting workability, gives no tensive touch after pasting and then exfoliating the support material and shows excellent adhesion to skin by forming an adhesive layer containing medicines on the surface of a pliable elastic base material and improving the handling of the pasting material obtained by strippably adhering the support material laminated on the base material. SOLUTION: This pasting material is composed of a base material consisting of elastic polymers and a support material which is laminated on a surface of this base material and has stretch, the adhesive layer containing percutaneous absorptive medicines is formed on the surface of the base material at the back side on which this support material is laminated, the base material and the support material are strippably adhered in the range of 2-50% per 2 cm<2> of the area of the base material, and the exfoliation strength between the base material and the support material is in the range of 3-80 g/cm.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical patch, and more particularly, to a medical patch which is excellent in handleability at the time of application, has excellent skin adhesion after application and elasticity, and has almost no discomfort after application. For a patch for use

[0002]

2. Description of the Related Art Conventionally, a large number of medical patch materials such as transdermal absorption preparations containing a drug in an adhesive layer and adhesive plasters have been produced. Since these adhesive materials are used by being directly attached to the skin, a number of adhesive materials using an elastic nonwoven fabric have been developed so as to follow the movement of the human body after the application (Japanese Patent Application Laid-Open No. JP-A-63-122621, JP-A-1-121214, JP-A-1-197434
And Japanese Patent Application Laid-Open No. 1-228911).

Further, in order to reduce the feeling of discomfort after pasting, a thinner base material has been used for the pasting material. However, in addition to the problem that the pressure-sensitive adhesive layer and the base material holding it are made thinner, the pressure-sensitive adhesive layers are stuck to each other when the adhesive is stuck, and that it is difficult to appropriately stick to the affected area.
There were also many problems in appearance, such as an unfavorable state such as wrinkling of the substrate.

[0004] In order to solve such a problem, a method has been proposed in which a peelable layer is provided on the back side of the surface of the substrate on which the pressure-sensitive adhesive layer is formed, and the layer is peeled off after application to the skin. For example, in Japanese Patent Publication No. 1-51260, a flexible supporting member can be directly provided on the back surface side of the film-like base material having good flexibility without using a pressure-sensitive adhesive. It has been proposed to prevent the base material from being stretched until the completion of the attaching operation by laminating the substrates in a peelable state, thereby improving the handleability.

However, in this method, when the support member is peeled off from the base material after the base material is adhered to the skin, it is necessary to peel off the support member from the edge portion. The peeling operability was poor for difficult parts.

As a method of improving the operability of peeling a support member from a substrate, Japanese Patent Application Laid-Open No. Sho 62-77314 discloses a method in which a flexible support member having a cut on the back surface of a substrate is releasably attached. There has been proposed a method of improving the handleability by attaching and separating the support member from the cut portion. Further, in Japanese Patent Application Laid-Open No. 64-16719, when a base material is attached to the skin, a support having low adhesiveness is temporarily attached to the back surface of the base, and then the support is peeled off. Thus, a method for improving the handling property has been proposed.

However, in these methods, although the operability of peeling the support member from the base material and the workability of attaching the base material are improved to some extent, the base material such as the joints such as elbows and knees can be removed to some extent. For places that need to be attached while stretching, the support members and supports with the cuts laminated on the back of the base material cannot sufficiently cope with the elasticity of the base material. Difficult to do,
Alternatively, there is a problem in that when the joint is bent after the sticking operation, a sense of incongruity such as a tightness is generated.

[0008]

SUMMARY OF THE INVENTION According to the present invention, a pressure-sensitive adhesive layer containing a drug is formed on the surface of a flexible and stretchable base material, and a support member laminated on the back side thereof can be peeled off. Is to improve the handling of the adhesive material adhered to the
With sufficient elasticity and excellent sticking workability,
It is still another object of the present invention to provide a medical adhesive material having no tightness and excellent skin adhesion after the support member is peeled off after application.

[0009]

SUMMARY OF THE INVENTION The present invention relates to a base material comprising an elastic polymer, having a thickness in the range of 5 to 5000 μm, and a stretchable support member laminated on one side of the base material. The adhesive material, wherein the surface on which the support member is laminated forms a pressure-sensitive adhesive layer containing a transdermal absorbable agent on the back surface of the substrate, and the substrate and the support member are Area: 1 to 50% / cm ^{2 in} a range of 2% to 50%, and a peeling strength between the substrate and the support member is in a range of 3 to 80 g / cm. is there.

[0010]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail.
The base material used in the present invention is made of an elastic polymer having high flexibility, and any type of elastic polymer can be used as long as it shows elasticity. For example, polyolefin-based elastomers, polyester-based elastomers, polyamide-based elastomers, polyurethane-based elastomers, and fluorine-based elastomers are preferably exemplified. Among these, thermoplastics are preferred in terms of moldability. These may be used alone or as a mixture.

Since the adhesive material of the present invention may use various chemicals, more preferred elastic polymers include those which absorb substances such as a chemical or a chemical absorption enhancer contained in the adhesive layer. It is preferable that the material does not affect the material, and the material cost is not so high. For example, the crystalline segment is mainly composed of an aromatic polyester, and the amorphous segment is aromatic or aliphatic, or a block-type polyester system composed of an aliphatic polyester. Elastomers are particularly preferred.

The term "crystalline segment" as used herein refers to a site which exhibits crystallinity in a polymer and serves as a tethering portion of an amorphous segment, and comprises an aromatic dicarboxylic acid and an aliphatic diol as main components. It is mainly made of polyester. Further, the non-crystalline segment refers to a site in which the main chain is freely deformed and shows elasticity in the polymer, and an aromatic dicarboxylic acid and an aliphatic diol, or a polyester component composed of an aliphatic dicarboxylic acid and an aliphatic diol. Point. 20 to 70 crystalline segments for the polymer
It is preferable from the viewpoint of elasticity to use those having an amorphous segment in the range of 80 to 30% by weight.

Preferred examples of the crystalline segment include polytetramethylene terephthalate, and preferred examples of the amorphous segment include terephthalic acid and HO (CH
_{2 CH 2 0) n H;} (n = 2~5) of the long-chain diol may be a polyester is more than 60 mol% per the dicarboxylic acid component.

The flexible substrate made of the polymer of the elastic polymer may be in any form such as a film, a nonwoven fabric, a paper and a woven or knitted fabric as long as it has a thin sheet shape.
It is preferable to use the one in the range of ~ 1000%, more preferably in the range of 30-500%, and even more preferably in the range of 50-200%. When the elongation is less than 20%, the adhesion to the skin becomes inferior, and there is a possibility that a problem such as discomfort after sticking or peeling off from the skin during use may occur. 100
If it exceeds 0%, it is not preferable because it is excessively elongated and the form stability is poor.

Further, the thickness of the substrate is 5 to 5000 μm.
Are preferably used in terms of reducing discomfort after application, more preferably in the range of 10 to 2000 μm. When the thickness of the substrate is less than 5 μm, the substrate may be broken due to friction or the like after application, and the handleability is deteriorated. When the thickness is more than 5000 μm, discomfort such as thickness after application is increased, which is preferable. Absent.

Next, the support member used in the present invention is used for improving the handleability between the time when the patch is attached to the affected area and the time it is used. It is important to adhere to the substrate so that it can be separated from the substrate. This is to apply while sticking while expanding and moderately expanding and contracting integrally with the base material when sticking, and after peeling, the support member is peeled off from the base material, so that after peeling it does not cause discomfort such as a tight feeling It is to be.

Examples of the support member include stretchable sheet materials, for example, films, nonwoven fabrics, woven and knitted fabrics, and paper. Particularly, the support member has sufficient stretchability and improves the handleability of thin substrates. It is preferable to use a bulky knitted fabric or nonwoven fabric for the purpose. The elongation of the support member is
Those having a range of 50 to 500% and an extension stress at 50% elongation of 20 to 5000 g / cm are preferably used.

If the elongation is less than 50%, or if the elongation stress at 50% elongation exceeds 5000 g / cm, the support member cannot be stretched together with the base material, and the elongation at the time of sticking is moderate. This is not preferable because it makes it difficult to apply the adhesive to the affected area, and it tends to hinder the adhesion of the base material to the skin. The elongation is 50
0% or the extension stress at 50% extension is 20%.
If it is less than g / cm, it is not preferable because it tends to be too stretched and difficult to peel off from the substrate. More preferably,
The elongation of the support member is in the range of 60 to 200%, and
Tensile stress at 50% elongation is in the range of 100 to 3000 g / cm.

It is preferable to use a support member having a stiffness in the range of 0.5 to 5.0 cm from the viewpoint of improving the handleability at the time of sticking, and more preferably, It is in the range of 1.0 to 4.0 cm.
If the softness is less than 0.5 cm, the stiffness of the entire adhesive material becomes weak, and the role as a support base material is not sufficient,
When the softness exceeds 5 cm, the rigidity is too high, and the adherence of the patch to the skin surface at the time of sticking becomes poor, resulting in poor adhesion.

In the medical patch of the present invention, the support member is adhered to the substrate, and is peeled off after being adhered in use. The method of bonding the substrate and the support member is such that the support member is peeled off after the application.
The bonding method is not limited, and a method of bonding with an adhesive, a method of bonding by heat fusion, and the like can be used.

However, the area of adhesion of the support member to the substrate is ^{2 to} 50 units per square meter of the substrate.
% And must be releasably adhered. Here is the unit area of measurement:
1 cm ² satisfies the above-mentioned range of adhesion area even when 1 cm ^{2 of} an arbitrary portion of the patch is measured.

If the ratio of the bonding area is less than 2%, the supporting member does not sufficiently follow the substrate at the time of bonding, and the elongation of the supporting member cannot be fully utilized, so that the bonding is performed. After that, a sense of incongruity occurs. Conversely, if the adhesion area exceeds 50%, peeling becomes difficult, and in particular, at the time of sticking to an invisible site such as the back of the body, when the support member is peeled from the base material, The peeling operation becomes difficult, for example, it is necessary to peel off from the end, which is not preferable. It is preferable that the ratio of the bonding area is in the range of 2 to 50% so that there is no sense of incongruity after sticking the sticking material, and in order to facilitate peeling in the case of sticking to any site, Preferably it is in the range of 5 to 20%.

The shape and size of the bonding portion (location) are not particularly limited, but those which are distributed in a dot shape, a line shape, a stripe shape, a lattice shape, etc. with respect to the bonding surface. It is preferable from the viewpoint of handleability. The distance between the bonding points depends on the area and shape of the bonding surface. For example, in the case of a square dot shape, the distance is about 2 to 5 times larger than one side of the dot-shaped bonding surface. This is preferable from the viewpoint of easy peeling.

The peel strength between the substrate and the support member is smaller than the adhesive strength between the pressure-sensitive adhesive layer and the skin according to the adhesive strength between the pressure-sensitive adhesive layer and the skin. What is necessary is just to make it larger than the adhesive force with a separator, such as a release film for protecting a layer. In the present invention, the peel strength between the substrate and the support member is preferably adjusted to be in the range of 3 to 80 g / cm, more preferably, and more preferably,
It is in the range of 5 to 50 g / cm, more preferably 7 g / cm.
-20 g / cm.

That is, if the peel strength is less than 3 g / cm, there is a possibility that the support member will be peeled off before sticking. If the peel strength exceeds 80 g / cm, it becomes difficult to peel the support member from the substrate after sticking. However, depending on the thickness of the base material, it may cause breakage at the bonded portion, which is not preferable.
Therefore, it is preferable that the peel strength between the base material and the support member is set in the above-described range, and that the relationship between the adhesive forces at the boundary surfaces of the other layers is adjusted as described above.

Next, in the adhesive material of the present invention, an adhesive layer containing a transdermally absorbable drug is formed on the substrate surface opposite to the surface on which the support member is laminated. As a preferable pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer, if necessary, an acrylic pressure-sensitive adhesive, a rubber-based pressure-sensitive adhesive, a silicon-based pressure-sensitive adhesive, and the like are used.
It is appropriately selected according to the purpose of use of the patch. That is,
When the patch is used as a transdermal absorbent, an adhesive may be selected so that the drug is most effectively absorbed from the skin and the skin is less irritating.

As the acrylic pressure-sensitive adhesive, homopolymers or copolymers of alkyl (meth) acrylates obtained from fatty acid alcohols having 4 to 18 carbon atoms and (meth) acrylic acid can be used. Alternatively, a copolymer of the alkyl (meth) acrylate and another functional monomer is preferably used.

The above (meth) acrylic esters include butyl acrylate, isobutyl acrylate,
Hexyl acrylate, octyl acrylate, 2-ethylhexyl acrylate, isooctyl acrylate, decyl acrylate, isodecyl acrylate, lauryl acrylate, stearyl acrylate, methyl methacrylate, ethyl methacrylate, butyl methacrylate, isobutyl methacrylate , 2-ethylhexyl methacrylate, isooctyl methacrylate, decyl methacrylate, isodecyl methacrylate, lauryl methacrylate, stearyl methacrylate and the like.

Further, examples of the above-mentioned functional monomer include a monomer having a hydroxyl group, a monomer having a carboxyl group, and a monomer having an amide group. Examples of the monomer having a hydroxyl machine include hydroxyalkyl (meth) acrylates such as 2-hydroxyethyl (meth) acrylate and hydroxypropyl (meth) acrylate.

Examples of the monomer having a carboxyl group include α-β unsaturated carboxylic acids such as acrylic acid and methacrylic acid, monoalkyl esters of maleic acid such as butyl maleate, maleic acid, fumaric acid, crotonic acid and the like. . Maleic anhydride also provides the same (co) polymerization component as maleic acid.

Examples of the monomer having an amide group include alkyl (meth) acrylamide such as acrylamide, dimethylacrylamide and diethylacrylamide, alkyl ether methylol (meth) acrylamide such as butoxymethylacrylamide and ethoxymethylacrylamide, diacetone acrylamide, vinylpyrrolidone and the like. Is exemplified.

Examples of the monomer having an amino group include dimethylaminoethyl acrylate.

As for the other copolymerizable monomers,
Vinyl acetate, vinyl alcohol, styrene, α-methylstyrene, vinyl chloride, acrylonitrile, ethylene,
Propylene, butadiene and the like can also be used. In the adhesive, (meth) acrylic acid alkyl ester is polymerized, or
It is preferable that the content of the copolymer component is 50% by weight or more.

A polyfunctional monomer may be added to the acrylic pressure-sensitive adhesive, if necessary, and may be copolymerized with other monomer components. The addition of this multifunctional monomer causes only slight crosslinking between the resulting polymers, thereby increasing the cohesive force within the tacky interior. Therefore, the adhesive residue phenomenon that is observed when the base material is peeled off from the body is almost eliminated irrespective of the properties of the attached skin and the amount of perspiration. Moreover, this polyfunctional monomer has no adverse effect on the low skin irritation. Examples of such a polyfunctional monomer include, but are not limited to, di (meth) acrylate, tri (meth) acrylate, and tetra (meth) acrylate.

[0035] These polyfunctional monomers may be used in combination of two or more kinds. The polyfunctional monomer has a content of 0.005 in all the monomers used for the production of the pressure-sensitive adhesive.
Used at a rate of .about.0.5% by weight. When the amount of the polyfunctional monomer is less than 0.005% by weight, the effect of improving internal cohesion by crosslinking is small, and when it exceeds 0.5% by weight, the pressure-sensitive adhesive obtained by polymerization is used. Is not preferred because the crosslinking force is too large and the adhesive strength is reduced.

Further, as the rubber-based pressure-sensitive adhesive, for example,
Rubber elastic body 1 such as natural rubber, styrene-isoprene-styrene block copolymer, polyisoprene, polybutene, polyisobutylene, ethylene-vinyl acetate copolymer
What added 20-200 weight part of tackifiers and the appropriate amount of softeners, stabilizers, etc. to 00 weight part is used.

As the silicone-based pressure-sensitive adhesive, for example, a pressure-sensitive adhesive mainly containing polydimethylsiloxane or the like is used.

In the pressure-sensitive adhesive layer, for example, a tackifier such as rosin resin, polyterpene resin, cumarone-indene resin, petroleum resin, terpene-phenol resin, liquid polybutene, mineral oil, lanolin, liquid Plasticizers such as polyisobutylene and liquid polyacrylate, and additives such as fillers and antioxidants can be added as necessary.

As the drug contained in the pressure-sensitive adhesive layer, any drug can be used as long as it can be absorbed transdermally into the living body, and examples thereof include the following drugs.

(1) Corticosteroids: hydrocortisone, prednisolone, paramethasone, beclomethasone propionate, flumethasone, betamethasone, betamethasone valerate, dexamethasone, triamcinolone, triamcinolone acetonide, fluocinolone,
Fluocinolone acetonide, fluocinolone acetonide acetate, clobetasol propionate and the like.

(2) Antiinflammatory and sedative analgesics: indomethacin, ketoprofen, acetaminophenone, mefenamic acid,
Flufenamic acid, diclofenac, diclofenac sodium, alclofenac, oxyphenbutazone, phenylbutazone, ibuprofen, flurbiprofen, salicylic acid, methyl salicylate, 1-menthol, camphor, sulindac, tolmetin sodium, naproxen, fenbufen Such.

(3) Hypnotic sedative; phenobarbital,
Amobarbital, cyclobarbital, triazolam, nitrazepam, flunitrazepam, lorazepam, haloperidol and the like.

(4) tranquilizers: fluphenazine, theorytazine, diazepam, fludiazepam, flunitrazepam, chlorpromazine and the like.

(5) Antihypertensive agents: clonidine, clonidine hydrochloride, pindolol, propranolol, propranolol hydrochloride, bufuranol, indenolol, nivadipine, nimodipine, lophexin, nitrendipine, nipradilol, fugumorol, nifedipine and the like.

(6) Antihypertensive diuretics such as hydrothiazide, bendroflumethiazide, cyclobenziazide and the like.

(7) Antibiotics: penicillin, tetracycline, oxytetracycline, fradiomycin sulfate, erythromycin, chloramphenicol and the like.

(8) Anesthetics: lidocaine, dibucaine hydrochloride, benzocaine, ethyl aminobenzoate and the like.

(9) Antibacterial substances: benzalkonium chloride, nitrofurazone, nystatin, acetosulfamine, clotrimazole and the like.

(10) Antifungal agents: pentamycin, amphotericin B, pyrrolnitrin, clotrimazole and the like.

(11) Vitamin preparations such as vitamin A, vitamin E, vitamin K, ergocalciferol, cholecalciferol, octothiacin, riboflavin butyrate and the like.

(12) Antiepileptic agents; nitrazepam, meprobamate, clonazepam and the like.

(13) Coronary vasodilators: nitroglycerin, nitroglycol, isosorbide dinitrate,
Erythritol tetranylate, propachilnylate, dipyridamole, molycidamine and the like.

(14) Antihistamines: diphenhydramine hydrochloride, chlorpheniramine, diphenylimidazole and the like.

(15) Antitussives: dextromethorphan hydrobromide, dextromethorphan, terbutaline,
Terbutason sulfate, ephedrine, ephedrine hydrochloride,
Salbutamol sulfate, salbutamol, isoproterenol hydrochloride, isoproterenol, isopreterenol sulfate and the like.

(16) Sex hormones: progesterone, estradiol and the like.

(17) Antidepressants; doxepin and the like.

(18) Cerebral circulation improving agents: Hydergine, ergot alkaloid, ifenprodil and the like.

(19) antiemetic, antiulcer; metoclopramide, clevopride, domperidone, scopolamine,
Scopolamine hydrobromide and the like.

(20) Biopharmaceuticals; polypeptides and the like.

(21) Others: fentanyl, desmopressin, digoxin, 5-fluorouracil, mercaptopurine and the like.

Such a drug is contained in the adhesive layer in an amount of 0.05 to 0.05%.
These agents can be used in a range of 40% by weight, and two or more of these drugs can be used in combination depending on the purpose of treatment, action and the like.

Further, in the pressure-sensitive adhesive layer used for the medical patch of the present invention, in order to improve the transdermal absorbability of the drug,
A higher fatty acid ester compound may be contained. Examples of the higher fatty acid ester include isopropyl myristate, isooctyl palmitate, ethyl oleate, diethyl sebacate and the like. Such a higher fatty acid ester compound is contained in the pressure-sensitive adhesive layer in an amount of 0.1 to 50.
It can be contained in the range of weight%. When the amount of the higher fatty acid ester compound is less than 0.1% by weight, the effect of improving the transdermal absorbability of the drug is reduced,
If it exceeds 300, the self-aggregating ability of the pressure-sensitive adhesive layer will decrease, and a part of the pressure-sensitive adhesive layer will remain on the skin when the substrate is peeled off from the body, which is not preferable.

In order to further improve the transdermal absorbability of the drug, in addition to the higher fatty acid ester compound, an auxiliary for promoting the transdermal absorbability, for example, glycols and their alkyl esters, alkyl ethers, oils and fats, A urea derivative, various surfactants, and the like may be contained in a range that does not impair the skin adhesive properties of the pressure-sensitive adhesive layer and the stability of the drug.

When the above-mentioned pressure-sensitive adhesive is used, the pressure-sensitive adhesive layer may be destructed by cohesion due to lack of internal cohesion, after application to the skin.
If there is a risk of causing adhesive residue on the skin surface due to this, a commonly used crosslinking agent may be blended, or a crosslinking monomer may be blended as a copolymer component to improve cohesion, Crosslinking can also be promoted by irradiation with an electron beam, ultraviolet light, or the like.

The pressure-sensitive adhesive used in the present invention must be variously selected depending on the type of the drug used in order to minimize the decomposition of the drug contained therein. When a simple substance having a reactive site such as a group, an amino group, or an acid amide group is used, the amount thereof may be reduced or the reactivity may be reduced by masking the site.

The pressure-sensitive adhesive layer is formed by, for example, adding a solution containing a higher fatty acid ester compound and a drug to the pressure-sensitive adhesive solution, and coating the resulting mixed solution on a release film. Is used, and a conventionally known method for forming a drug-containing pressure-sensitive adhesive layer can be used as long as it does not violate physical or chemical properties such as measuring the stability of the higher fatty acid ester compound and the drug contained in the pressure-sensitive adhesive. . The thickness of the pressure-sensitive adhesive layer is not particularly limited, but is preferably in the range of 5 to 1000 μm, more preferably 10 to 5 μm.
It is in the range of 00 μm. In the medical patch of the present invention, an additional layer may be provided between the substrate and the pressure-sensitive adhesive layer, for example, if necessary.

As a method of providing the pressure-sensitive adhesive layer on the substrate, more specifically, a method of directly applying a pressure-sensitive adhesive to the substrate, or forming the pressure-sensitive adhesive layer on a release film. Conventional methods such as a method in which the release film is overlaid on a substrate and the adhesive layer is transferred can be appropriately selected and employed. In the method of applying a pressure-sensitive adhesive to a substrate, the pressure-sensitive adhesive layer is applied to a pattern such as a streak, a mesh, or a dotted pattern, on one side of the substrate, or partially. . Usually, a knife over roll coater is used for applying the pressure-sensitive adhesive to such a substrate, but other methods may be used.

The adhesive patch for medical use of the present invention preferably has a separator on the surface of the pressure-sensitive adhesive layer in order to protect the surface of the pressure-sensitive adhesive layer before use. As the separator, those obtained by treating a polyethylene terephthalate film with silicon are often used.
It is not limited to this. The thickness of the separator is preferably 500 μm or less, more preferably in the range of 5 to 100 μm.

[0069]

Thus, according to the present invention, there is provided a flexible substrate made of an elastic polymer having sufficient elasticity, an adhesive layer containing a drug provided on one side of the substrate, The pressure-sensitive adhesive layer is formed by laminating a stretchable support member that can be easily peeled off and partially adhered to the base material on the back surface of the base material, thereby improving the handleability at the time of sticking, and the invisible portion. Therefore, it is possible to provide a medical adhesive material in which the support member can be easily peeled off from the base material even in an affected part where it is difficult to visually check the affected part. In particular, it is not necessary to separate the support member from the base material from the end of the adhesive material as in the related art, and the support member can be easily separated from any location.

Further, since the support member has elasticity, it can be attached while being stretched. After the support member is peeled off after being attached to the affected part, there is no feeling of tightness and skin adhesion. It was able to be an excellent medical patch, such a medical patch, for example,
It can be suitably used for applications such as transdermal absorption agents, adhesive bandages, and bandages.

[0071]

EXAMPLES The present invention will be described in more detail with reference to the following examples, but the present invention is not limited by these examples. In addition, the part in an Example shows a weight part, and each physical property value was measured by the following method.

(1) Peeling strength The substrate to which the support member was adhered was length: 8 cm, width: 2.5
cm of a rectangular sample, a support member at one end on the short side of the sample: about 1 cm was peeled off from the substrate, and the peeled both ends were gripped with chucks, respectively, and the stretching speed was 200.
The peel strength of the sample when the chuck interval was increased at a rate of% / minute was measured, and the width was expressed as the strength per 1 cm.

(2) Elongation and Tensile Stress at 50% Elongation A sheet-like material serving as a support member is 8 cm long and 2.5 cm wide.
cm of a rectangular sample piece, and two
When the short side of the sides is gripped by a chuck, and the distance between the chucks is set to 5 cm, and the distance between the chucks is increased at an elongation speed of 200% / minute, the elongation when the sample breaks is determined. Ask. At that time, the elongation stress corresponding to 50% elongation (stress per 1 cm of the short side: g / c)
m).

(3) Flexibility A sheet-like material serving as a support member is 8 cm long and 2 cm wide.
, And the measurement was performed by the cantilever method using the sample. That is, JIS L-1096
Is measured by a 45-degree cantilever method based on the measurement method described in (1).

(4) Characteristics of Adhesive Material As the characteristics of the adhesive material, the operability during the attaching operation, the releasability of the support member, and the discomfort after the application were evaluated by the following methods. <Operability at the time of sticking> The operability at the time of sticking the sample of the patch to the elbows of five adult males was determined by the following criteria and evaluated by the average value of the five males. 4 points: Easy to stick 2 points: Difficult to stick 0 points: Difficult to stick <Releasability of support member> Affix sample sticker to elbow and waist (back side) of 5 adult males The operability at the time of peeling the supporting member was judged according to the following criteria, and evaluated by an average value of five persons. 4 points: easy to peel 2 points: slightly difficult to peel 0 points: hard to peel <discomfort after pasting> The discomfort after peeling off the support member after applying a sample of the pasting material to the elbows of five adult males Judgment was made based on the following criteria, and evaluated by the average value of five persons. 4 points: Uncomfortable feeling or no wrinkling of base material 2 points: Slightly uncomfortable or wrinkling of base material 0 point: Uncomfortable feeling or wrinkling of base material

Example 1 Dimethyl terephthalate: 24
Part and 22.5 parts of trimethylene glycol were subjected to a transesterification reaction with a dibutyltin diacetate catalyst, followed by polycondensation under reduced pressure to obtain a starch-like polyester having an intrinsic viscosity of 0.76. To the polyester, 15 parts of a dry chip of polytetramethylene terephthalate having an intrinsic viscosity of 0.98, which was separately obtained by polycondensation, was added, and the mixture was further reacted at a temperature of 250 ° C. for 75 minutes. To 0.
The reaction was stopped by adding 02 parts. The polyester block copolymer was taken out and made into chips. The melting point of the chip was 176 ° C. and the intrinsic viscosity was 0.84. The chip thus obtained is extruded into a sheet at a temperature of 240 ° C. by an extruder equipped with a T-die, cooled by a cooling drum at a temperature of 10 ° C., and a film (thickness: 30 μm, elongation: 110%) (substrate) ) Got.

On the other hand, a tricot knitted fabric composed of a polyester multifilament yarn (40 denier / 20 filaments) was passed through a finishing step including heat setting to obtain a basis weight of 90%.
g / m ² , elongation: 150%, 50% elongation stress: 2200
A stretchable fabric (supporting member) having a g / cm and a softness of 1.9 cm was obtained.

Laminating the stretchable fabric and the film,
For the upper roller, a metal roller engraved so that square dots having a depth of 0.6 mm and each side of 1 mm are distributed at an interval of 2 mm in a direction parallel to the sides of the square is used. Using a flat metal roller, the upper roller is heated to a temperature of 210 ° C., the lower roller is set to a temperature of 80 ° C., and the laminated body is sandwiched between upper and lower rollers pressed to a linear pressure of 50 kg / cm. Upon supply, the stretchable fabric was supplied at a speed of 2 m / min so as to contact the upper roller, and the film and the stretchable fabric were thermally bonded. At this time, the adhesion area between the film and the stretchable fabric was 25% on average per 1 cm ^{2 of the} film area, and the peel strength between the stretchable fabric and the film was 10 g / cm.

Separately, a copolymer consisting of 7.5% by weight of methyl methacrylate, 90% by weight of 2-ethylhexyl acrylate, and 2.5% by weight of acrylic acid:
A solution obtained by mixing a 3% by weight ethyl acetate solution: 96 g, isopropyl myristate: 2 g, and ketoprofen: 1 g was applied onto a silicone-coated release film so that the thickness of the dried adhesive layer was 30 μm. And a release film having a drug-containing pressure-sensitive adhesive layer formed by drying at a temperature of 60 ° C. for 30 minutes.

A film (substrate) to which the above-mentioned stretchable fabric (support member) is adhered is applied to the thus obtained pressure-sensitive adhesive layer.
Is transferred from the release film onto the surface of the above (the back side of the support member laminating surface), and the obtained laminate is 8 cm long and 8 cm wide.
It was cut into 10 cm to obtain a transdermal absorption preparation (paste) having a pressure-sensitive adhesive layer containing a transdermal absorption agent. The performance of this patch was measured, and the results are shown in Table 2.

Example 2 A nonwoven fabric (average fiber diameter: 7 μm, elongation: 450) prepared by melt-blowing from the same polyester block copolymer as in Example 1
%, Basis weight: 40 g / m ² , thickness by a Peacock thickness gauge: 150 μm) as a base material, the stretchable fabric used in Example 1 as a support member, and a grid having a width of 1 mm and a side of 10 mm. A patch containing a transdermal absorbent was prepared in the same manner as in Example 1 except that the upper surface roller having an embossed pattern was used so that the bonding area was 19% on average with respect to the area of the nonwoven fabric: 1 cm ² . Obtained. The peel strength between the stretchable fabric and the nonwoven fabric was 7 g / cm. The performance of this adhesive material was measured, and the obtained results are shown in Table 2.

[Comparative Example 1] In Example 2, when the base member and the support member were laminated and bonded, the upper roller was set to a depth of:
Except for using a metal roller engraved so that square dots of 0.3 mm and a side of 0.4 mm are distributed at intervals of 0.55 mm in a direction parallel to the sides, heat bonding is performed in the same manner as in Example 1, and a supporting member is used. A percutaneous absorption agent (paste) containing a percutaneous absorption agent such that the bonding area of the substrate was 52% on average with respect to the area of the substrate: 1 cm ² was obtained (Comparative Example 1). The peel strength between the stretchable fabric and the nonwoven fabric was 32 g / cm. The performance of the patch was measured, and the obtained results are shown in Table 2.

[Comparative Examples 2-3] In Example 1, the temperature of the upper roller when the base material and the supporting member were thermally bonded was set to 22.
A patch containing a transdermal absorbent was obtained in the same manner as in Example 1 except that the temperature was changed to 5 ° C. and 185 ° C. (Comparative Example 2,
3). The peel strengths of the base material and the support member of the obtained adhesive materials were 92 g / cm and 2 g / cm, respectively. The performance of these adhesive materials was measured, and the obtained results are shown in Table 2.

[Comparative Example 4] A polyethylene terephthalate film having a thickness of 50 µm was used as a base material, and the same procedure as in Example 1 was carried out except that an acrylic adhesive was used when laminating and adhering to a support member. A skin absorption preparation (paste) was obtained. The performance of the obtained patch was measured, and the obtained results are shown in Table 2.

[Comparative Example 5] A plain woven fabric (weight: 70 g / m ² ) made of polyethylene terephthalate yarn (75 denier / 36 filaments) in Example 1,
A transdermal absorbent (paste) was obtained in the same manner as in Example 1 except that the material having the physical properties shown in Table 1 was used as a support member, and the bonding temperature between the base material and the support member was set to 195 ° C. . The performance of the obtained patch was measured, and the obtained results are shown in Table 2.

COMPARATIVE EXAMPLE 6 Polyester: 20% by weight of a crystalline part composed of polybutylene terephthalate and 80% by weight of an amorphous part composed of polyoxytetramethylene glycol: 5 g of a polyester elastomer: N-methyl-2-pyrrolidone (NMP) ): A film obtained by dissolving in 15 g at a temperature of 120 ° C., casting it on a glass plate with a doctor blade, and allowing it to cool at room temperature for 30 minutes, which has the physical properties shown in Table 1. A percutaneous absorption preparation (paste) was obtained in the same manner as in Example 1 except that the composition was used as a member and the bonding temperature with the substrate was set at 125 ° C. The performance of the obtained patch was measured, and the obtained results are shown in Table 2.

[0087]

[Table 1]

[0088]

[Table 2]

As shown in Table 1, good evaluations were obtained in Examples 1 and 2; however, as in Comparative Example 1, those having an excessively large adhesion area between the base material and the support member had an affected area. The peelability is poor when it is located in a part that cannot be visually observed. Further, as shown in Comparative Example 2, when the peel strength between the substrate and the support member is too large, the peelability is poor. If the strength was too low, the handleability was inferior, and both had a sense of incongruity after the sticking operation. Further, as shown in Comparative Example 4, the base material has low elongation (not an elastic polymer), and as shown in Comparative Example 5, the support member has too low elongation (having no elasticity). Then, the handleability at the time of sticking work and the incongruity after sticking are inferior, and when the elongation of the support member is extremely large as shown in Comparative Example 6, the handleability and peelability at the time of sticking work, peeling, It was inferior to the discomfort after the work.

 ────────────────────────────────────────────────── ─── Continuing from the front page (72) Inventor Takanori Miyoshi 2-1 Hinodecho, Iwakuni-shi, Yamaguchi Prefecture Teijin Limited Iwakuni Research Center

Claims (7)

[Claims] 1. An elastic polymer having a thickness of 5 to 500
An adhesive material comprising a base material in a range of 0 μm and a stretchable support member laminated on one side of the base material, wherein the surface on which the support member is laminated is a back surface of the base material To form a pressure-sensitive adhesive layer containing a percutaneously absorbable drug, the base material and the support member are releasably bonded in a range of 2 to 50% per cm ^{2 of the} base material, and A medical adhesive material having a peel strength with a support member in a range of 3 to 80 g / cm. 2. The base material having a thickness of 10 to 200
The medical patch according to claim 1, wherein the medical patch has a thickness of 0 µm. 3. The substrate has an elongation of 20 to 1000.
Claim 1 or Claim 2 which uses what is in the range of%
The medical patch described in 1. 4. The support member has an elongation of 50 to 5
And the 50% elongation stress is 20 to 5%.
The medical patch according to any one of claims 1 to 3, wherein the adhesive is used in the range of 000 g / cm. 5. The support member has a softness of 0.5 to 0.5.
The medical patch according to any one of claims 1 to 4, wherein the medical patch is used in a range of 5 cm. 6. The elastic polymer constituting the base material is a polyolefin-based elastomer, a polyester-based elastomer,
The medical patch according to any one of claims 1 to 5, comprising at least one selected from a polyamide elastomer, a polyurethane elastomer, and a fluorine elastomer. 7. The elastic polymer constituting the base material is mainly composed of a block type polyester elastomer, and the crystalline segment of the block type polyester elastomer is mainly composed of an aromatic polyester, and the amorphous segment is aromatic or The medical patch according to any one of claims 1 to 5, comprising an aliphatic polyester.