JPH10137327A - Antifouling composition for contact lens and antifouling method of contact lens using the composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an antifouling composition for contact lenses which has low toxicity to the eye and can be safely used while reducing to preventing the fouling of contact lenses, especially the adhesion of protein, and also to provide an antifouling method of contact lenses in which such an antifouling composition for contact lenses is used. SOLUTION: An antifouling composition for contact lenses contains at least one kind of compound selected from the group consisting of 2-amino-2- methyl-1,3--propanediol and 2-amino-2-methyl-1-propanol, as well as the salts thereof, as an effective component for preventing the adhesion of fouling to the contact lenses. Further, by bringing the contact lenses into contact with the treatment solution using such an antifouling composition for contact lenses, the adhesion of fouling to the contact lenses can be prevented.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for preventing the adhesion of stains to contact lenses, particularly to the adhesion of protein stains, and to a method for preventing the adhesion of contact lenses using such a composition. It is.

[0002]

2. Description of the Related Art Contact lenses are broadly classified into hydrated contact lenses and non-hydrated contact lenses. Dirt such as proteins, lipids, and minerals derived from liquids and eye oils adhere to contact lenses. And, due to these stains, not only the feeling of wearing the contact lens is deteriorated, but also the eyesight such as a decrease in visual acuity and further conjunctival congestion may be caused. Therefore, when the contact lens is used continuously. Requires regular cleaning of those stains.
Particularly, when a water-containing contact lens is used, bacteria and the like easily adhere and proliferate, so that it is necessary to perform a disinfection treatment in addition to the above-mentioned washing.

[0003] The above-mentioned various types of dirt are subjected to corresponding cleaning. As a specific cleaning method, first, for protein dirt, a proteolytic enzyme or the like is used. A method is used in which a contact lens is immersed in a contained solution, and protein stains accumulated on the contact lens surface are decomposed and removed by the protease. For lipid stains, using a solution containing a surfactant, immersing the contact lens in the solution, or rubbing with fingers or the like,
A method of removing dirt is adopted. Furthermore, with respect to inorganic stains, a method is employed in which a contact lens is immersed in a solution containing a metal chelating agent to seal metal ions such as calcium ions and remove the inorganic stains. It is.

[0004] On the other hand, as a disinfection method, a heat disinfection method in which a contact lens is subjected to boiling disinfection using a dedicated boiling device or the like for each housing case has been used in recent years. In addition to such a heat disinfection method, a chemical disinfection method in which a contact lens is immersed in a solution containing a disinfectant has been put to practical use and has been adopted.

[0005] However, among the various cares described above, the protease used for protein stains is unstable in a dilute solution, and is supplied to the user in the form of tablets or a concentrated solution. Will be done. Therefore,
At the time of washing protein stains, it is necessary to dissolve or dilute the protein stains, so that the user's labor is not a little troublesome. Further, even if such protein stains are regularly cleaned, it is difficult to completely remove the protein stains once adhered to the contact lens. Therefore, it is difficult to use the contact lens for a long time. In addition, protein stains accumulate on the contact lens, and it is inevitable that the wearing feeling of the contact lens deteriorates as the period of use increases.

Therefore, in recent years, as a method of avoiding such a problem that the wearing feeling of the contact lens is deteriorated due to accumulation of dirt, a system (frequent replacement system) for periodically replacing the contact lens has been introduced. And disposable contact lenses are commercially available. According to such a method, since the contact lens is used for a shorter period of time and is replaced with a new lens before the protein stain is accumulated on the contact lens, a good feeling of wearing is always obtained with simple care. It is made possible. However, in such a scheme,
The problem is that maintenance costs are inevitably higher than conventional contact lenses, and there is an inherent problem that the economic burden on the user is unavoidable.

[0007]

The present invention has been made in view of the above circumstances, and it is an object of the present invention to solve the problem that it is safe for the human body, and that the contact lens is stained, particularly, protein. To provide a dirt adhesion preventing composition for contact lenses that reduces or prevents the adhesion of dirt on a contact lens, and to provide a dirt adhesion preventing method for a contact lens using such a dirt adhesion preventing composition for contact lenses. Doing so is also an issue.

[0008]

The present inventors have conducted intensive studies in order to solve such problems, and as a result, as a result, 2-amino-2-methyl-1, which has been conventionally known as a neutralizing agent or an emulsifier, has been developed.
3-propanediol or 2-amino-2-methyl-1-
It has been found that propanol or salts thereof can effectively reduce or prevent the attachment of stains, especially protein stains, to contact lenses, and based on such findings, completed the present invention. That's what happened.

[0009] That is, the present invention provides, in order to solve the above-mentioned problems, a group consisting of 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol and salts thereof. At least one selected from
SUMMARY OF THE INVENTION The gist of the present invention is a composition for preventing the adhesion of dirt to a contact lens, comprising a compound as an active ingredient for preventing the adhesion of dirt to a contact lens.

[0010] In short, the composition for preventing the adhesion of dirt to a contact lens according to the present invention contains the above compound as an active ingredient for preventing the adhesion of dirt to a contact lens. It has low toxicity and is safe, and can effectively prevent the adhesion of stains, especially protein stains, to contact lenses.

In the composition for preventing adhesion of dirt for contact lenses according to the present invention, the at least one compound is advantageously contained in a proportion of 0.01 to 3% by weight. By setting the concentration in such a range, the effect of preventing the adhesion of dirt to the contact lens can be advantageously obtained without greatly deviating from the physiological osmotic pressure.

Further, the present invention provides a method for preventing the adhesion of a contact lens using the above-mentioned composition for preventing the adhesion of a contact lens, and more specifically, the composition for preventing the adhesion of a contact lens according to claim 1 or 2. Another object of the present invention is to provide a method for preventing a contact lens from being stained, which comprises preparing a treatment solution using an object and bringing the contact lens into contact with the treatment solution.

According to the method for preventing the adhesion of contact lenses to the contact lens, the contact lens is brought into contact with the treatment liquid using the composition for preventing the adhesion of contact lenses by a predetermined method for a predetermined period of time. In particular, it is possible to easily obtain a contact lens to which protein stains are unlikely to adhere.

According to a preferred embodiment of the method for preventing contact lenses from adhering to stains according to the present invention, the contact lenses are brought into contact with the treatment solution at a temperature of 80 ° C. or more for 5 minutes or more to simultaneously disinfect them. A method of performing the treatment is also adopted, whereby the stain adhesion preventing treatment and the heat disinfection treatment can be simultaneously performed on the contact lens.

According to another preferred embodiment of the method for preventing the adhesion of a contact lens according to the present invention, the treatment solution further contains an effective amount of a bactericide, and the contact of the contact lens is carried out at room temperature. Therefore, a method of simultaneously performing disinfection processing is adopted, and thereby, the dirt adhesion prevention processing and the chemical disinfection processing can be simultaneously performed on the contact lens.

Further, according to another preferred embodiment of the method for preventing the adhesion of a contact lens according to the present invention, the treatment solution further contains an effective amount of a protease, and the contact lens is contacted with the treatment solution. A method of simultaneously performing the lens cleaning process is adopted, whereby the process of preventing the contact lens from adhering the stain and the process of decomposing and cleaning the protein stain can be performed simultaneously. In addition, contact of the contact lens at 80 ° C.
By performing the treatment at the above temperature for 5 minutes or more, the heat disinfection treatment can be simultaneously performed in addition to the treatment for preventing the contact lens from being stained and the treatment for decomposing and cleaning the protein stain.

According to still another preferred embodiment of the method for preventing the adhesion of a contact lens according to the present invention,
The treatment solution further contains an effective amount of a bactericide and a proteolytic enzyme, and the contact of the contact lens is performed at room temperature. The cleaning process and the chemical disinfection process can be performed simultaneously.

[0018]

Briefly, the present invention provides 2-amino-2-methyl-1,3-propanediol or 2-amino-2-methyl-1- excellent in safety to eyes.
It is characterized in that propanol or a salt thereof is used as an active ingredient of the antifouling composition for contact lenses, and the use of the antifouling composition for contact lenses for contact lenses. An object of the present invention is to provide a method for preventing contact lenses from being stained, which can be easily cleaned.

By the way, the active ingredient 2 in the antifouling composition for contact lenses according to the present invention, 2
-Amino-2-methyl-1,3-propanediol and 2-amino-2-methyl-1-propanol are all listed on the basis of cosmetic raw materials, and have been conventionally used in hand creams, emulsions and the like. It is used as an emulsifier and as a neutralizer for hair sprays. In fields other than cosmetics, they have been used as emulsifiers for floor waxes and cleaners, and as brighteners for urea resins and melamine resin enamels. Then, at least one compound selected from the group consisting of these compounds and salts thereof is advantageously used as an active ingredient of the antifouling composition for contact lenses according to the present invention.

Incidentally, 2-amino-2-methyl-1,3-
Specific examples of the salt of propanediol and 2-amino-2-methyl-1-propanol include hydrochloride.

The compounds described above exhibit an effective effect when the concentration of the compounds used ranges from 0.01 to 3% by weight, and preferably 0.05 to 2% by weight, more preferably 0.2 to 2% by weight.
When used in an amount of from 1 to 1% by weight, a particularly effective stain adhesion preventing effect is exhibited. However, if the concentration of such a compound is lower than 0.01% by weight, it is difficult to obtain the desired effect of preventing the adherence of dirt. This is because, apart from the pressure, the human body may be adversely affected, such as stimulating the eyes.

By the way, 2-amino-2-methyl-1,3-propanediol and 2-amino-2-methyl-1-propanol, which are the compounds which provide the antifouling composition for contact lenses according to the present invention, Further, since all of these salts are solid at normal temperature, it is preferable that the salts be in the form of an aqueous solution in order to make contact with a contact lens. In order to obtain such a treatment liquid, it can be obtained by dissolving the above compound supplied as a solid such as powder, granules, tablets and the like in purified water, physiological saline, tap water and the like. Preparation of such a processing solution is as follows.
It may be made by the user at the time of use, or may be made in a state of being previously dissolved in purified water or physiological saline in a container such as plastic or glass,
No problem.

Further, as the pH value suitable for using the antifouling composition for contact lenses according to the present invention, a physiologically acceptable range of 5.0 to 9.0 is effective. And preferably in the range of 6.0 to 8.0. However, if the pH value is lower than 5.0 or higher than 9.0, the eye may be irritated or impaired.

In order to keep the pH of the antifouling composition for contact lenses effectively and in a safe range for the eyes, a pH adjuster is appropriately selected from various conventionally known ones. It will be selected and added.

Incidentally, 2 which is used as an active ingredient of the antifouling composition for contact lenses according to the present invention,
-Amino-2-methyl-1,3-propanediol and 2-amino-2-methyl-1-propanol are free or supplied as salts thereof such as hydrochloride. An aqueous solution of these free ones shows alkaline, and an aqueous solution of hydrochloride or the like shows acidic. Therefore, when it is desired to set the pH of the target processing solution in the neutral region, one or more of an acid and an alkali are appropriately selected and added so as to negate the property of the aqueous solution. Examples of such acids include hydrochloric acid, sulfuric acid, nitric acid, acetic acid, organic acids, boric acid, amino acids and the like, and preferably hydrochloric acid is used. Also,
Examples of the alkali include sodium hydroxide, potassium hydroxide, borax, and the like. Preferably, sodium hydroxide is used.

As a method for preventing a stain from adhering to a contact lens by using a treatment solution containing the antifouling composition for contact lenses prepared as described above, simply contact lenses are added to the treatment solution. It is only necessary to immerse the contact lens and then rinse the contact lens with a liquid such as water, thereby obtaining a contact lens to which stains, especially protein stains, are difficult to adhere. The specific immersion conditions are as follows: room temperature to 110 ° C., 5 minutes to
24 hours.

Further, by appropriately combining the additive component conventionally used in the contact lens solution with the treating solution using the contact lens stain preventing agent adjusted as described above, the present invention can be applied. A disinfecting solution containing such a dirt adhesion preventing composition for contact lenses,
It is possible to prepare a washing liquid, a rinsing liquid, a preserving liquid, or a multipurpose liquid preparation in which these actions are combined. By using such a multipurpose liquid for care of contact lenses and handling it in the same manner as before, in addition to the treatment for preventing adhesion of dirt, a disinfecting treatment, a washing treatment, a rinsing, a preservation and the like are performed with one liquid. You can do it.

For example, the contact of the contact lens with the treatment liquid according to the present invention is carried out at a temperature of 80 ° C. or more for 5 minutes or more, preferably at 80 to 110 ° C. for 5 to 60 minutes, so that a stain adhesion preventing treatment and heat The disinfection process can be performed at the same time. In this case, a known commercially available heating unit which has been conventionally used for the heat disinfection method can be used.

Further, by adding an effective amount of a conventionally known disinfectant to the treatment liquid as described above, the stain adhesion preventing treatment and the chemical disinfection treatment can be performed simultaneously. The disinfectant is selected from those which do not affect the effect of preventing the adhesion of dirt. Specifically, polyhexamethylene biguanide (PHMB), chlorhexidine, quaternary ammonium (for example, benzalkonium chloride, polyquaterium) 1) and the like or a salt thereof. The concentration of these fungicides is appropriately determined depending on the type of fungicide and the desired fungicidal effect. Specifically, PHMB (salt) is 0.1 to 5 ppm, preferably 0.3 ppm. By setting the chlorhexidine (salt) in the range of 1 to 1 ppm and the quaternary ammonium (salt) in the range of 10 to 100 ppm, an effective bactericidal effect can be obtained. Then, the contact lens is immersed at room temperature for 1 to 24 hours, preferably 2 to 6 hours, so that the treatment for preventing the contact lens from being stained and the chemical disinfection treatment are performed simultaneously.

In general, contact lenses are immersed in an appropriate solution and stored. However, when used for non-hydrated contact lenses, they are usually stored at around room temperature. The processing solution according to the present invention can be used as it is as a storage solution. In addition, when used for water-containing contact lenses, since microorganisms such as bacteria are easy to propagate, it can be used as a preservative solution by adding the bactericide, which also has an antiseptic effect. It becomes.

In order to improve the effect of removing protein stains and lipid stains attached to the contact lens, an enzyme or the like having a function of decomposing protein and lipid stains may be added. Lipolytic enzymes,
In addition to the antifouling composition according to the present invention, by being added, even if the antifouling composition cannot be prevented even with the antifouling composition, even if there is dirt adhering to the contact lens, these enzymes may be used. The dirt can be removed by the cleaning effect, and more effectively, the accumulation of dirt on the contact lens can be prevented. Then, as an enzyme having such a cleaning effect, preferably, a protease is added, and any of the proteases conventionally used for cleaning contact lenses can be used. Preferably, subtilisin, which is a serine enzyme, and papain, which is a thiol enzyme, are added, and the concentration thereof is appropriately determined according to a desired washing effect.

As described above, according to the present invention, the disinfecting treatment and the cleaning treatment can be performed in one step together with the treatment for preventing the contact lens from being stained, so that the contact lens can be maintained by a simple treatment. You can.

Further, in order to use the treatment liquid using the composition for preventing adhesion of dirt for contact lenses according to the present invention as a multipurpose liquid preparation, other additives conventionally used for liquid preparations for contact lenses may be appropriately used. It is more preferable to selectively add them. Examples of such additional components include a surfactant, a chelating agent, a tonicity agent, and the like, which are safe for a living body and adversely affect a material of a contact lens. Can be used as long as it does not give any of the following: 2-amino-2-methyl-1,3-propanediol or 2-amino-2-methyl-1-propanol They can be combined and added as needed within a quantitative range that does not inhibit the effect.

More specifically, for example, in order to further improve the effect of removing lipid stains such as eye oil attached to the contact lens, a predetermined surfactant is added or contained. As this surfactant, any of anionic, amphoteric, and nonionic surfactants can be used as long as they have high safety to living organisms and do not affect the material of contact lenses. Any known one can be selected, but in particular, when used for a hydrous contact lens, it is preferable to employ a nonionic surfactant in order to avoid adsorption to the contact lens. Specific examples of such nonionic surfactants include polyoxyethylene-polyoxypropylene block polymers, polyoxyethylene sorbitan fatty acid esters, and fatty acid polyoxyethylene sorbite. And their use concentration is appropriately selected according to the desired cleaning effect, but is generally 0.005 to 5% by weight, preferably 0.02 to 1% by weight, and more preferably 0 to 5% by weight. .05-0.5
It is contained in a proportion of% by weight.

As a chelating agent for cleaning inorganic dirt, ethylenediaminetetraacetic acid (EDTA), hydroxyethylethylenediaminetriacetic acid (HEDTA),
Although nitrilotriacetic acid and its sodium salt can be mentioned, it is particularly preferable to use EDTA and its sodium salt among them. And its concentration is 0.001 to 1% by weight, preferably 0.01 to 1% by weight.
0.2% by weight, more preferably 0.01 to 0.1% by weight
It is said. If it is less than 0.001% by weight,
There is a possibility that calcium from tears may be deposited,
If the amount is more than the weight%, no further effect is obtained, and conversely, there is a risk of damaging the living body.

As described above, the osmotic pressure of the treatment liquid according to the present invention in which the above-mentioned additives are appropriately contained is as follows:
Ultimately, it is preferably within a physiologically acceptable range, and specifically, it is adjusted to about 200 to 600 mOsm, preferably 220 to 450 mOsm. As the tonicity agent used for adjusting the osmotic pressure, any agent that is safe for the human body can be used, but in general, sodium chloride, potassium chloride, sodium bicarbonate, One or more selected from glycerin and the like are used. And the addition concentration of these tonicity agents will be determined so that it may become the target osmotic pressure in consideration of the addition amount of other additional components.

[0037]

EXAMPLES In order to clarify the present invention more specifically, some examples of the present invention will be shown below.
It goes without saying that the present invention is not subject to any restrictions by the description of such embodiments. In addition, in addition to the following examples, the present invention, in addition to the above-described specific description, various changes, corrections, and modifications based on the knowledge of those skilled in the art without departing from the spirit of the present invention. It should be understood that improvements can be made.

Example 1 << Adhesion Prevention Effect Test >> First, test liquids containing the antifouling compositions for contact lenses of Examples 1 to 8 of the present invention were prepared so as to have the component compositions shown in Table 1 below. Was prepared according to the following procedure.

That is, 2-amino-2-methyl-1,
3-propanediol (AMPD) or 2-amino-
A predetermined amount of 2-methyl-1-propanol (AMP) hydrochloride was added to about 80 g of purified water together with 0.5 g of sodium chloride.
Dissolve in mL. Next, the present invention example 1 using AMPD,
For 3 and 4, 3N hydrochloric acid aqueous solution
Inventive Examples 2, 5, and 6 using MP were adjusted to pH 7.0 with a 3N aqueous sodium hydroxide solution, respectively.
And the volume was adjusted to 100 mL to prepare a test solution. Further, with respect to Examples 7 and 8 of the present invention, the pH was adjusted to 6.0 or 8.0 with hydrochloric acid, respectively, and then the volume was adjusted to 100 mL to prepare a test solution.

The pH of each of the test solutions of Invention Examples 1 to 8 was measured with a glass electrode pH meter, and the osmotic pressure was further measured with a freezing point falling osmometer. The respective measured values are also shown in Table 1 below.

Next, ¹²⁵ I was used as a radioactive tracer.
A 1% lysozyme solution was prepared using lysozyme containing radioactively labeled lysozyme at about 10,000 cpm per 100 μg. Then, 0.2 mL of the lysozyme solution was accommodated in each contact lens case, and the test liquid according to Examples 1 to 8 of the present invention was also 1.8 m.
L was added and stored in each contact lens case. Then, a water-containing contact lens (Menicon Soft MA; Menicon Co., Ltd.) is further inserted into the lens case one by one, and is heated to about 100 ° C. with a contact lens boiler (thermolyzer; manufactured by Tanika Denki Co., Ltd.).
For about 15 minutes. After this boiling disinfection, the contact lens was taken out of the contact lens case, rinsed sufficiently with a physiological saline solution, and then inserted into a vial for a gamma counter, and the radioactivity of the test lens was measured with an autowell gamma counter. (Acpm) was measured. As a control, the radioactivity (Bcpm) of 100 μg of lysozyme chloride and the background (BKcpm) in an empty vial bin were measured in the same manner, and the amount of lysozyme attached to each contact lens was calculated by the following formula. Are also shown in Table 1 below. Amount of lysozyme attached (μg) = ΔA (cpm) −B
(Cpm)｝ × 100 ÷ ｛B (cpm) -BK (cp
m)｝

The test solutions according to Comparative Examples 1 to 5 were also prepared according to the same procedure as in Examples 1 to 8 of the present invention so as to have the component compositions shown in Table 2 below, and the pH and osmotic pressure were measured. After that, the same operation was performed to determine the amount of lysozyme attached to the contact lens. The results are shown in Table 2 below.

[0043]

[0044]

From the above results, when the antifouling compositions for contact lenses according to Examples 1 to 8 of the present invention were used, the amount of lysozyme adhering to the contact lenses was higher than that of Comparative Examples 1 to 5. Has been done very little,
It can be seen that an effective stain adhesion preventing effect can be obtained.

Example 2 {Effects of Additives} Test solutions according to Examples 9 to 12 of the present invention and Comparative Example 6 were prepared in the same manner as in Example 1 according to the components shown in Table 3 below. In this example, as shown in Table 3 below, sodium edetate as a chelating agent, polyoxyethylene-polypropylene glycol as a nonionic surfactant, or polyoxyethylene sorbitan monooleate, preservatives Polyhexamethylene biguanidine hydrochloride as an agent is added.

By performing the same operation as in Example 1, the amount of lysozyme adhering to the contact lens was determined, and the values are shown in Table 3.

[0048] * 1: Sodium edetate * 2: Polyoxyethylene (196) polyoxypropylene (67) glycol * 3: Polyoxyethylene (20) sorbitan monooleate * 4: Polyhexamethylene biguanidine hydrochloride

From the above results, it can be seen that when the antifouling composition for contact lenses according to the present invention is used, even when additives such as a chelating agent, a surfactant and an antiseptic are added, excellent fouling is obtained. It can be seen that it has an adhesion preventing effect.

Example 3 {Combined Use of Chemical Disinfection} A liquid preparation for contact lenses having the composition shown in Table 4 below was prepared in the same manner as in Example 1. In this example, as shown in Table 4 below, by adding polyhexamethylene biguanidine hydrochloride or chlorhexidine gluconate as a preservative or disinfectant, a chemical disinfection treatment can be performed at the same time. It has been done.

As a radioactive tracer, ¹²⁵ I
A 1% lysozyme solution was prepared using lysozyme containing radioactively labeled lysozyme at about 60,000 cpm per 100 μg. Then, 0.2 mL of the lysozyme solution was stored in each contact lens case, and then 1.8 mL of the test solution according to Examples 13 to 15 of the present invention and Comparative Example 7 was added to each contact lens case. Housed. Further, a water-containing contact lens (Menicon Soft MA; Menicon Co., Ltd.) is inserted one by one into the contact lens case, and the contact lens is heated to about 25 ° C.
The substrate was left at room temperature for 16 hours to perform an immersion treatment. Then, the contact lens was taken out, and Example 1 was obtained.
The amount of lysozyme adhering to the contact lens was measured by the same operation as described above, and the value is shown in Table 4 below.

On the other hand, as a radioactive tracer, lysozyme radiolabeled with ¹²⁵ I was 100 μl.
A 1% lysozyme solution was prepared using lysozyme contained at about 17500 cpm per gram. Then, 0.2 mL of the lysozyme solution was stored in each contact lens case, and then 1.8 mL of the test solution according to Examples 13 to 15 of the present invention and Comparative Example 7 was added to each contact lens case. Housed. In addition to this contact lens case, a hydrated contact lens (Sureview; Johnson & Johnson Vision Products. Inc.
) Was inserted one by one and left at room temperature of about 25 ° C. for 16 hours to perform an immersion treatment. Thereafter, the contact lens was taken out, and the amount of lysozyme attached to the contact lens was measured by the same operation as in Example 1, and the value was also shown in Table 4 below.

Further, the following experiment was conducted to examine the bactericidal efficacy of these contact lens solutions. First, Staphylococcus aureus (Sa: Staphyloco
ccus aureus ATCC 6538), Pseudomonas aeruginosa (Pa: Pseudomona)
su aeruginosa ATCC 9027), Escherichia coli (Ec: Eschrich
ia coli ATCC 8739), Serratia marcesens (S.
m .: Serratia marcescens ATCC 13880), Candida albicans (Ca: Candida albicans ATCC 10231),
Aspergillusfumi
gatus ATCC 10894) using a suspended those cultured in each saline in a predetermined way, 10 ^{108 to 109}
It was prepared so as to be a cfu / mL test bacterial solution. on the other hand,
9.9 of test liquid according to inventive examples 13 to 15 and comparative example 7
mL into separate sterilized test tubes.
By adding 0.1 mL of each of the above-mentioned test bacteria, the final concentration of each of the various test-bacteria mixed solutions is 10 ⁶ to 1.
It was adjusted to be 0 ⁷ cfu / mL. 23 ℃
After 4 hours, the number of viable cells in 1 mL was calculated for each of the mixture and the bacterial species by the agar plate dilution method.

According to the method described above, the number of viable bacteria immediately after inoculation,
From the viable cell count 4 hours after the preparation of the mixture, the bacterial reduction rate (Log Reduction) was converted to logarithm according to the following formula.
And the results are shown in Table 4. Bacterial decrease = log {(viable cell count in 1 mL of the mixture immediately after inoculation)-(viable cell count in 1 mL of the mixture after treatment)}

[0055] * 1: Sodium edetate * 2: Polyoxyethylene (196) polyoxypropylene (67) glycol * 3: Polyhexamethylene biguanidine hydrochloride * 4: Chlorhexidine gluconate

From the above results, it can be seen that the bactericidal effect of the bactericide added is not reduced at all, but rather tends to be improved, by the antifouling composition for contact lenses according to the present invention. .

Example 5 << Effect on Hard Lens >> The test liquid according to Examples 1 and 2 of the present invention prepared in Example 1 and Comparative Example 1, and the test according to Example 15 of the present invention prepared further in Example 4 Prepare the solution.

As a radioactive tracer, ¹²⁵ I
A 1% lysozyme solution was prepared using lysozyme containing radioactively labeled lysozyme at about 60,000 cpm per 100 μg. Then, 0.2 mL of the lysozyme solution was accommodated in each contact lens case, and then 1.8 mL of the test solution according to Examples 1, 2, 15 and Comparative Example 1 was added to each contact lens case. Added and contained. In addition to this contact lens case, a hard contact lens (Menicon E
X; Menicon Co., Ltd.) was inserted one by one, and allowed to stand at room temperature of about 25 ° C. for 16 hours to perform immersion treatment. Thereafter, the contact lens was taken out, and the amount of lysozyme attached to the contact lens was measured by the same operation as in Example 1, and the value was also shown in Table 5 below.

[0059]

From these results, it can be seen that when the antifouling composition for contact lenses according to the present invention is used, an extremely effective antifouling effect can be obtained even for hard lenses.

[0061]

As is apparent from the above description, the use of the antifouling composition for contact lenses according to the present invention allows the fouling of contact lenses, especially
This has a very effective effect on preventing or preventing protein stains.

In addition, by appropriately selecting and adding additional components to the treatment solution using the contact lens stain-preventing composition of the present invention, the stain-preventing treatment, heat disinfection treatment, chemical Necessary treatments for contact lenses, such as disinfection treatment and cleaning treatment, can also be performed at the same time, so that the stain adhesion prevention effect and the sterilization effect are not hindered to each other, and each treatment is extremely good. The result is obtained.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI C11D 17/00 C11D 17/00 17/08 17/08 G02C 13/00 G02C 13/00 (72) Inventor Takako Ozawa Nagoya, Aichi Prefecture Tome Technology Co., Ltd. (72) Inventor Keiko Tsuboi 2--11-3, Noritake Shinmachi, Nishi-ku, Nagoya City, Aichi Prefecture

Claims (8)

[Claims] 1. Contacting at least one compound selected from the group consisting of 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol and salts thereof. An antifouling composition for contact lenses, which is contained as an active ingredient for preventing fouling of a lens. 2. The method of claim 2, wherein the at least one compound is
The composition according to claim 1, wherein the composition is contained at a ratio of 1 to 3% by weight. 3. A treatment solution is prepared using the composition for preventing soiling of a contact lens according to claim 1 or 2,
Then, a method for preventing contact lenses from adhering, comprising contacting the contact lens with the treatment solution. 4. The contact lens according to claim 3, wherein the contact lens is brought into contact with the treatment solution at a temperature of 80 ° C. or more for 5 minutes or more to simultaneously perform a disinfection treatment. Prevention method. 5. The contact lens according to claim 3, wherein the treatment solution further contains an effective amount of a bactericide, and the contact lens is brought into contact with the contact lens at room temperature to perform a disinfection treatment at the same time. To prevent adhesion of dirt. 6. The contact lens according to claim 3, wherein the treatment solution further contains an effective amount of a protease, and the contact lens is brought into contact with the treatment solution, whereby the contact lens is washed simultaneously. To prevent adhesion of dirt. 7. The method according to claim 6, wherein the contact lens is contacted at a temperature of 80 ° C. or more for 5 minutes or more to simultaneously perform a disinfection treatment. 8. The treatment solution further comprises an effective amount of a bactericide and a proteolytic enzyme, and the contact lens is brought into contact with the contact lens at room temperature to simultaneously carry out a disinfection treatment and a washing treatment. Item 3
3. The method for preventing adhesion of dirt on a contact lens described in 1.