JPH0977605A - Dispersion of agent and its production - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a dispersion of an agent containing the agent homogeneously dispersed in a solvent and having slow releasing property by thickening the viscosity of a dispersing liquid by adding a specific polymer and alkali salt and subsequently adding an inorganic porous fine particles carrying the agent to the dispersing liquid to disperse them. SOLUTION: This dispersion of an agent is obtained by compounding an inorganic porous fine particles carrying an agent, a dispersing liquid, an acrylic polymer and an alkali salt. The dispersing liquid is at least one selected from between water and an alcohol. A 1-3C alcohol is suitable to the alcohol. A repellent is preferable as the agent. An inorganic porous fine particle obtained by interface reaction is suitable to the inorganic porous fine particle. The agent is preferably carried on the inorganic porous fine particles at 1-500wt.%. The content of the inorganic porous fine particles in the dispersing liquid of the agent is 0.01-60wt.%. The content of the acrylic polymer is about 0.0001-6wt.%. The alkali compound is used for neutralizing the acrylic polymer, and an example of the alkali compound is poly(oxyethylene)oleylamine.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a dispersion liquid in which a drug is uniformly dispersed, and more specifically to a drug dispersion liquid in which a drug is supported on inorganic porous fine particles and further dispersed in the dispersion liquid.

[0002]

2. Description of the Related Art Conventionally, drugs such as repellents, pesticides, and fragrances are
It is used for various purposes. For example, pesticides, repellents, etc. are used as insect or animal repellents, and fragrances, etc. are used as aromatic agents. As a usage form of a water-soluble or water-insoluble repellent, a fragrance, or the like, the drug is dissolved in water or an organic solvent, which is soluble in the drug, and used as a drug solution. Then, the solution was sprayed in a dissolved state. Further, when the drug is not dissolved in water, an organic solvent, or the like, a surfactant or an emulsifier was used to prepare a dispersion liquid, which was then dispersed.

[0003]

[Problems to be Solved by the Invention] Therefore, there are various problems. That is, in the case of the conventional solution, the drug volatilizes immediately when it is sprayed in a relatively high temperature period such as summer or in an environment with a high temperature, and its efficacy is short and lasts around 10 days There was a problem. Further, even in a state of being an emulsion, the content of the drug is limited, and when sprayed in an environment with a high temperature like the solution, there is a problem that the agent volatilizes immediately. In addition, when the inorganic porous fine particles are dispersed in a liquid such as a dispersion liquid, they are dispersed immediately after stirring, but they settle out with the passage of time and are separated from the liquid even when transferred by a pump or the like. However, there was a problem that it was not uniform.

[0004]

Therefore, the present invention has improved the drug dispersion and has a sustained-release function. Furthermore, by using an acrylic acid polymer, it is possible to uniformly disperse the drug in water or an organic solvent in which it is difficult to dissolve. It is intended to provide a drug dispersion liquid having a sustained release property, and a method for producing the drug dispersion liquid.

That is, the above-mentioned problem can be solved by a drug dispersion liquid comprising inorganic porous fine particles carrying a drug, a dispersion liquid, an acrylic acid polymer, and an alkali salt. In the drug dispersion liquid, the dispersion liquid may be at least one of water and alcohols, or the alcohols may have 1 to 3 carbon atoms. In addition, the drug may be used as a repellent.
Further, the inorganic porous fine particles used in the present invention obtained by an interfacial reaction method can also be used. As the drug dispersion liquid, one containing 0.01 to 60% by weight of the inorganic porous fine particles is used, or
It is also possible to support 500% by weight of the drug. The method for producing the drug dispersion is performed by adding an acrylic acid polymer and an alkali salt to the dispersion to increase the viscosity, and further adding inorganic porous fine particles carrying a drug to disperse the dispersion.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The drug used in the present invention is particularly 10 ° C to 100 ° C, preferably 25 ° C to 50 ° C.
A compound that easily volatilizes in an environment of ° C can be used. Specific agents include fragrances, repellents, pesticides, deodorants, plant extracts, UV shielding agents, antioxidants, antipruritics, hair growth promoters, vitamins, antiperspirants, sunscreens. Agents, preservatives, moisturizers, astringents, oiliness agents and the like. Also, fragrances, repellents, pesticides, deodorants, plant extracts, UV shielding agents, antioxidants, antipruritics, hair growth promoters, vitamins, antiperspirants, sunscreens, preservatives, moisturizers. Agent, astringent,
One or two or more selected from oiliness agents and the like can also be used.

As the fragrance, it is harmless to the human body that has an odor. It is divided into natural flavors and synthetic flavors, and natural flavors are further divided into plant flavors and animal flavors. It is also possible to use a mixed fragrance having a odor adjusted by mixing a natural fragrance and a synthetic fragrance.

As the natural flavor, acacia oil, anise seed oil, abies oil, apsins oil, almond bitter oil, angelica oil, amblet seed oil, inondo oil, ylang ylang oil, iris oil, boiled oil, winter green. , Warmwood oil, estragon oil, elemi oil, oak moss oil, okothia oil, onion oil, opopanax oil, dutch oil, oris oil, olibanum oil, orange oil, cassia oil (cinnamon oil, cinnamon oil),
Cassie oil, cananga oil, chamomile oil, chamomile oil, kayak wood oil, kayapte oil, mustard oil, columbus oil, garlic oil, cardamom oil, galbanum oil, yellow mustard oil, caraway oil, bittersweet oil, cumin oil, Clary sage oil, grapefruit oil, clove oil, laurel leaf oil, cilantro oil, costas oil, colander oil, sandalwood oil, cedarwood oil, citronella oil, jasmine oil, ginger oil, ginger oil, ginger oil, ginger oil, ginger Class oil, cinnamon oil, pancreatic oil, star anise oil, spike oil, spearmint oil, sage oil, geranium oil, thyme oil, tangerine oil, tuberose oil, turpentine oil, narcissus oil, nutmeg oil, niogomigi oil, shaving oil, neroli oil , Pine oil, parsley oil, Jill oil, birch oil, patchouli oil, peppermint oil, rose oil, palmarosa oil, sandalwood oil, hyacinth oil, bay oil, bay leaf oil, vetiver oil, penny royal oil, henoposite oil, peppermint oil, beryl oil, scented oil, Perilla oil, hop oil, poray oil, mimosa oil, myrte oil, myrtle oil, mill oil, mint oil, mace oil, eucalyptus oil, lime oil, lavandine oil, lavender oil, lycea cubeba oil, linaloe oil, lemongrass oil. , Lemon oil,
Examples thereof include rosewood oil, rosemary oil, rose oil and lovage oil. And one or two or more selected from the exemplified natural flavors can also be used.

Further, as synthetic fragrances, α-pinene, β
-Pinene, camphene, d-limonene, dipentene, terpinolene, alloocimene, ocimene, p-cymene, β-caryophyllene, green leaf alcohol, 3-octenol, 9-decenol, linalool, geraniol,
Nerol, citonellol, 1-citronellol, dimethyloctanol, hydroxycitronellol, tetrahydrolinalool, lavandulol, alocimerol,
Myrcenol, α-pineol, terpine hydrate, 1-menthol, borneol, isopulegol, nopol,
Bornyl methoxy cyclohexanol, merolidol,
Farnesol, santalol, isoi super,
Sandalol, cedrol, vetiverol, patchouli alcohol, benzyl alcohol, β-phenyl alcohol, γ-phenylpropyl alcohol, cinnamic alcohol, anis alcohol, α-amylcinnamic alcohol, dimethylbenzylcarbinol, methylphenylcarbinol, β- Phenylethyl dimethyl carbinol, dimethyl phenyl carbinol, β-phenyl ethyl methyl ethyl carbinol, phenoxy ethyl alcohol, phenyl glycol, tert-butyl cyclohexanol, anisole, p-acetyl anisole, diphenyl oxide, dimethyl hydroquinone,
p-cresol methyl ether, anethole, dihydroanethole, thymol, carvacrol, eugenol, isoeugenol, methyleugenol, methylisoeugenol, benzylisoeugenol, safrole, isosaflor, β-naphthol methyl ether,
β-naphthol ethyl ether, banitrop, n-heptyl aldehyde, n-octyl aldehyde, n-nonyl aldehyde, n-decyl aldehyde, n-undecyl aldehyde, undecylene aldehyde, dodecyl aldehyde, methyl nonyl acetaldehyde, n-tridecyl aldehyde, n-tetradecyl aldehyde, n-hexadecyl aldehyde, nonadienal, citral, citronellal, hydroxycitronellal, perilaldehyde, benzaldehyde, phenylacetaldehyde,
Phenylpropyl aldehyde, cinnamic aldehyde, α-amyl cinnamic aldehyde, α-hexyl cinnamic aldehyde, anisaldehyde, cumin aldehyde, heliotropin, helional, cyclamen aldehyde, p-tert-α-methylhydrocinnamic aldehyde, salicyl Aldehyde, hydrotropaldehyde, vanillin, ethyl vanillin, γ-undecalactone, ethyl methylphenylglycidate, γ-nonyllactone, ethyl p-methyl-β-phenylglycidate, allyl caproate, allyl caprylate, Lillard,
Mylacaldehyde, citronellyl oxyacetaldehyde, citral dimethyl acetal, citral diethyl acetal, phenylacetaldehyde dimethyl acetal, methyl-n-amyl ketone, ethyl-n-
Amyl ketone, methyl-n-hexyl ketone, methyl-
n-nonyl ketone, methylheptene, diacetyl, l-
Carvone, d-carvone, menthone, d-pulegone, piperine, camphor, methylcedrine, acetophenone, p-methylacetophenone, p-methoxyacetophenone, benzophenone, benzylideneacetone, methylnaphthylketone, yonone, damascon, damacenone,
Methylyonone, Iron, Maltol, Ethylmaltol, Hydroxyfuran, Nerone, Hydroxyphenylbutanone, Anisylacetone, Jasmon, Hydrojasmon, Nootkatone, Muscon, Dibeton, Cyclopentadecane, Cyclohexadecenone, Cyclopentadecanolide, Ambretlide, Cyclohexe Sadecanolide, ethylene brushlate, ethylene dodecanedioate, 12
-Oxahexadecanolide, 11-oxahexadecanolide, 10-oxahexadecanolide, musk xylol, musk ketone, musk ambrette, musk
Tibetan, Mosken, Phantolide, Celestride, Traseolide, Berthalide, Tonalide, Galaxolid,
Rose oxide, oxide ketone, 3,3,6-trimethyl-6-vinyltetrahydropyran, dihydromethylpentenylpyran, linalool oxide, cineol, bicyclodihydrohomofarnesyl oxide,
Phenylethyl isoamyl ether, geranyl formate, benzyl formate, phenyl formate, ethyl acetate, isoamyl acetate, citronellyl acetate, geranyl acetate, linalyl acetate,
Menthyl acetate, bornyl acetate, isobornyl acetate, terpinyl acetate, benzyl acetate, phenylethyl acetate, methylphenylcarbinyl acetate, cinnamyl acetate, anisyl acetate, paracresyl acetate, isoeugenol acetate, myrcenyl acetate, tertiary butylcyclohexyl acetate dihydrotel acetate Pinyl, ethyl propionate, isoamyl propionate, citronellyl propionate, linalyl propionate, geranyl propionate, terpinyl propionate, benzyl propionate, cinnamyl propionate,
Ethyl butyrate, isoamyl butyrate, geranyl butyrate, linalyl butyrate, linalyl isobutyrate, citronellyl butyrate, citronellyl isobutyrate, benzyl isobutyrate, n-propyl isovalerate, isoamyl isovalerate, geranyl isovalerate, benzyl isovalerate, iso Cinnamyl valerate, methyl heptine carboxylate, isoamyl heptine carboxylate, ethyl heptine carboxylate, isoamyl pyruvate, methyl octine carboxylate, ethyl acetoacetate, ethyl levulinate, methyl β-methylmercaptopropionate, ethyl benzoate , Methyl benzoate, isobutyl benzoate, isoamyl benzoate, geranyl benzoate, linalyl benzoate, benzyl benzoate, methyl phenylacetate, ethyl phenylacetate, isobutyl phenylacetate, isoamyl phenylacetate, phenyl acetate Geranyl acetate, benzyl phenylacetate, ethyl cinnamate, benzyl cinnamate, cinnamyl cinnamate, dimethyl phthalate, diethyl phthalate, methyl salicylate, ethyl salicylate, isobutyl salicylate, isoamyl salicylate, allyl salicylate, benzyl salicylate, phenylethyl salicylate, anise Methyl acid,
Ethyl anisate, methyl anthranilate, methyl methyl anthranilate, ethyl anthranilate, methyl dihydrojasmonate, methyl jasmonate, synthetic oak moss, benzoic acid, cinnamic acid, phenylacetic acid, hydrocinnamic acid,
Coumarin, indole, skatole, 2-methyltetrahydroquinoline, 6-methylquinoline, 6-methyltetrahydroquinoline, 7-methylquinoline, isobutylquinoline, 6-isopropylquinoline, tetramethylpyrazine, acetylpyrrole, geranyltolyl, bromsteel, acetic acid Examples include trichloromethylphenylcarbinyl and furfuryl mercaptan. Further, one kind or two or more kinds selected from the exemplified synthetic flavors can be used.

The pesticide is an agricultural chemical,
It repels or kills animals, insects, mites, nematodes, microorganisms, etc. There are fungicides, insecticides, acaricides and nematicides.

The bactericidal agent is an agent capable of killing various bacteria and fungi such as plant pathogens. As specific bactericides, dithiocarbamate agents (Manzeb, Manneb, polycarbamate, etc.), organic sulfur agents (Captan, Captafol, Forvet, etc.),
Organic phosphorus agents (O, O-diisopropyl-S-benzylthiophosphate, O-ethyl-S, S-diphenyldithiophosphate, etc.), organic chlorine agents (pentachlorophenol, chlorothronyl, etc.), organic arsenic agents (methyl Arsenic Dimethyl Carbamate, Dodecyl Sulfate), Aliphatic Halogen (Methyl Bromide, Chlorpicrin, etc.), Benomyl, Oxycarboxyne, Phenazine Oxide, Anilazine, Oxyquinoline Sulfate, Triphenyltin Hydroxide, Hydroxyisoxazole , Pinapacryl,
Butiobate, inorganic sulfur agents (sulfur, polysulfide lime, etc.), copper agents (Bordeaux solution), antibiotics (streptomycin, novobiocin, chloramphenicol, blasticidin S, kasugamycin, validamycin A, polyoxin, cycloheximide, etc.), other plants Derived bactericidal components (humulon, lupu
lon), allicin, allyl isothiocyanate (ally)
l isotiocyanate)), chlorogenic acid,
Examples thereof include solanine, tangeritin, berberine, hinokitiol, iodine and the like. Further, one kind or two or more kinds selected from the exemplified bactericides can be used.

The insecticide is a drug capable of killing sanitary pests such as cockroaches, mosquitoes, fleas, mites and agricultural pests. Specific examples of the insecticide include organic phosphorus insecticides (dichlorvos, sinophos, O-ethyl-
O-phenylphosphothionate, marathon, parathion, etc.), carbamate insecticides (1-naphthyl-N-methylcarbamate, isoprocarb, etc.), organohalogen insecticides (Dediti, benzahexachloride, erdrine, aldrin) , Dieldrin, etc.), nicotine (nicotine, nornicotine, etc.), fluoroacetamide, pyrethroid (pyresulin, allethrin, etc.),
Examples include plant-derived essential oils (cineole, dill oil, Japanese peppermint oil, eucalyptus oil, turpentine oil, etc.) and boric acid. Further, one or two or more selected from the exemplified insecticides can be used.

The acaricide is a drug capable of killing mites such as mites and mites. Specific miticides include quelsen, proclonol, chlorvedilate, chlorpropylate, phenisobromolate, and chlorfenson.
on), tetradiphone, propargite (proparg)
ito), pinapacryl, tricyclohexyltin hydroxide, fenbutatin oxide, quinothiomate, amitraz, benzomate, polynactiones (polynac)
ions), lavender oil, melissa oil, peppermint oil, salvia oil, rosemary oil and the like. Further, one kind or two or more kinds selected from the exemplified acaricides can be used.

The nematicidal agent is a drug capable of killing pine wood nematodes, root-knot nematodes, and nematodes nematodes. Specific examples of nematicides include mesulfenphos, morantel tartrate, chloropicrin, a mixture of 2,3-dichloropropane and 1,3-dichloropropene, 1,2-dibromomethane, methylisocyanate and the like. Further, one kind or two or more kinds selected from the exemplified nematicides can be used.

As the antibacterial agent, unlike the bactericidal agent,
It is a drug that can suppress the growth of bacteria and fungi without killing them. Specific antibacterial agents include methylparaben, ethylparaben, propylparaben, vanillin, cinnamic aldehyde, p-hydroxybenzoic acid ester, d-limonene, ethyl alcohol, camphor, phenyl oxide, p-dichlorobenzene, dimethyl fumarate. Rate, hiba oil, asunaro oil, taiwan cypress oil, cassia oil, dill oil, lemon oil, citronella oil, clove oil, thyme oil, linalool, trans-pinocalveol, p-
Examples include isopropylcyclohexanol, camferenic aldehyde, γ-decalactone, γ-undecalactone, and the like. Further, one kind or two or more kinds selected from the exemplified antibacterial agents can be used.

The repellent is a drug capable of preventing animals, sanitary pests, agricultural pests or insects from approaching or adhering to a specific place. Specific repellents include lemon grass oil, lemon grass, synthetic musk, cinnamic aldehyde, pine oil, eugenol, terpineol, wood vinegar, vanillin, acetoxyphenyl butane, hexanal, geranyl formate,
α, β-pinene, limonene, safrole, anethole,
Anisaldehyde, γ-lactone, 1,8-cineole, naphthalene, angelica, cyclic terpene alcohol, menthol, N, N-diethyl-m-toluamide,
Ethyl thiomethone, isothionate, cresol, spices (pepper, capsicum, peppermint, perilla, clove, etc.), vanilla, nonyl lactone, citryl, linalool, 2-butoxyethanol, bisether, cyclohexanone, isophorone, spearmint oil, green leaf alcohol, cinnamon alcohol, Examples thereof include methylnonylketone, methylphenylketone, camphor, citral, eucalyptol, allylisotianate, capsaicin, cycloheximide and the like. Further, one kind or two or more kinds selected from the exemplified repellents can be used.

The deodorant is one which eliminates the cause of the unpleasant odor by aromatizing, masking or neutralizing it. Specific examples of such deodorants include aromatic oil deodorants such as rose oil, lily of the valley oil, linseed oil,
Fragrances such as jasmine oil, lemon oil, gardenia oil, mint oil and violet oil can be used. Among the above-mentioned fragrances, cinnamic aldehyde, vanillin, heliotropin, coumarin, carvone, canafer, boneool and the like can be exemplified as masking agents. Examples of the deodorant that further neutralizes and deodorizes include turpentine oil, clove oil, cinnamon oil, cedar oil, orange oil, lemon oil, orange peel oil, and the like. In addition, flavonoids and the like can also be used. Further, one kind or two or more kinds selected from the exemplified deodorants can also be used.

As the plant extract, there are those having various medicinal effects, and examples thereof include aloe extract, chamomile extract, orange extract, seaweed extract, Dutch mustard extract, sardine extract, Hypericum perforatum extract, oriental extract, apricot extract, apricot extract. Examples of the extract include a raspberry extract, a raspberry extract, a kuki extract, a gardenia extract, a mulberry extract, a ginger ginger extract, a burdock extract, a mixed fruit extract, a mixed plant extract, a comfrey extract, and a peony extract. Further, one kind or two or more kinds selected from the exemplified plant extract agents can be used.

The ultraviolet shielding agent is from 200 to 40
It is used for the purpose of absorbing ultraviolet rays with a wavelength of 0 nm to prevent harmful effects on the human body and cosmetics, and also to prevent the occurrence of phenomena such as sunburn of the skin and deterioration of cosmetics due to its shielding agent. is there. As a specific example, 2-
Hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-2'-carboxybenzophenone, 5-chloro-2-hydroxybenzophenone, 2,
Examples thereof include benzophenone compounds such as 4-hydroxybenzophenone and 2-oxy-5-methoxyacetophenone. Examples thereof include benzoic acid ester systems such as ethyl-p-glucosylimide benzoate, glucosyl-p-aminobenzoate, salicylate ester, p-octylphenyl salicylate and phenyl salicyate. Further, one kind or two or more kinds selected from the exemplified UV shielding agents can also be used.

The antioxidant is a drug that prevents the substance from being oxidatively deteriorated by oxygen. Specific examples of the antioxidant include nordihydroguaiaretic acid,
Examples include guaiac fat, propyl gallate, butylhydroxyanisole, dibutylhydroxytoluene, α-tocopherol (vitamin E) and the like. Also, sodium sulfite, ascorbic acid, sodium pyrosulfite, isoascorbic acid, thiosorbitol, cysteine hydrochloride,
Water-soluble antioxidants such as thioglycolic acid and sodium thiosulfate can be exemplified. Further, one kind or two or more kinds selected from the exemplified antioxidants can be used.

The antipruritic agent is one which prevents pruritus by local anesthesia and a refreshing stimulating action, and specific examples thereof include camphor, thymol, menthol, polyoxyethylene lauryl ether, antihistamine, ethyl aminobenzoate and the like. Can be illustrated. Further, one or two or more selected from the exemplified antipruritics can be used.

The hair-growth-promoting agent is one which penetrates well into the root of the hair, promotes blood flow in the hair papilla, promotes division of hair mother cells, and promotes hair growth. As a thing, cantaris tincture, capsicum tincture, ginger tincture, cepharanthin, lecithin, hinokitiol, photosensitizer No. 301, estrogen, pantothenic acid,
Examples include assembly extract and glycyrrhizin. Further, one kind or two or more kinds selected from the exemplified hair growth-promoting agents can be used.

As the vitamin agent, a vitamin which is supplied to the human body as nutrition, and a water-soluble or fat-soluble vitamin can be used. Specific examples of the vitamin include water-soluble vitamins such as vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , and vitamin B _{12 in} the vitamin B group and vitamin C. Furthermore, examples of fat-soluble vitamins include vitamin A, vitamin E, and vitamin D. Further, one kind or two or more kinds selected from the exemplified vitamin preparations can be used.

The antiperspirant has an action of suppressing perspiration, and specific examples thereof include aluminum chloride, allantoin, chlorohydroxyaluminum, aluminum sulfate, alum and aluminum chlorohydroxide. Further, one kind or two or more kinds selected from the exemplified vitamin preparations can be used.

The sunscreen agent is for preventing sunburn of the human body, and is a mixture of the above-mentioned UV absorber and UV scatterer. Specific examples of the ultraviolet scattering agent include zinc oxide and titanium oxide. Further, one kind or two or more kinds selected from the exemplified ultraviolet scattering agents can also be used.

The antiseptic agent is used for the purpose of suppressing the growth of microorganisms and preserving it without deteriorating the quality of medicines, and specifically, benzoic acid, salicylic acid, dehydroacetic acid, sorbic acid. , Boric acid, chlorxylenol, resorcin, paraoxybenzoic acid ester, phenoxyethanol, thymol, hinokitiol, thioxolone, benzalkonium chloride, benzotonium chloride, lauryldi (aminoethyl) glycine, chlorhexidine gluconate, chlorobutanol and the like. And
One kind or two or more kinds selected from the exemplified preservatives can be used.

The moisturizer has a function of moisturizing the skin and keeping moisture, and specific examples thereof include glycerin, propylene glycol, sorbit, 1,3-butylene glycol and dl-pyrrolidone carboxylic acid. Examples thereof include acids and sodium lactate. Further, one kind or two or more kinds selected from the exemplified moisturizers can be used.

The astringent is used for cosmetics and the like to tighten the skin, and specifically, citric acid,
Tartaric acid, lactic acid, aluminum chloride, aluminum sulfate,
Potassium sulphate, allantoin chlorohydroxyaluminum, allantoin chlorodihydroxyaluminum,
Examples thereof include aluminum phenol sulfonic acid, paraphenol sulfone zinc, zinc sulfate, and aluminum chlorohydroxide. Further, one kind or two or more kinds selected from the exemplified astringents can be used.

As the oily agent, in cosmetics and the like, various effects such as flexibility, cleaning, friction effect, moisturizing effect, and gloss effect are given to the skin. It includes fats and oils, waxes, higher fatty acids, hydrocarbons and the like, and specifically, almond oil, olive oil, camellia oil, castor oil, mokurou, coconut oil, lanolin, cetanol, liquid lanolin, paraffin, vaseline, Squalane, oleic acid, hexyl laurate, isopropyl myristate,
Examples include isopropyl palmitate and octyldodecyl myristate. Further, one kind or two or more kinds selected from the exemplified astringents can be used.

The following are used as the inorganic porous fine particles for impregnating or carrying such chemicals as pesticides, fragrances and repellents. The inorganic porous fine particles are porous ones formed of an inorganic compound, and as the shape, various shapes such as an amorphous shape can be used, but a substantially spherical shape is particularly preferable. It is desirable to use. As the inorganic compound, carbonates, silicates, phosphates, sulfates and metal oxides of alkaline earth metals, metal hydroxides, other metal silicates, and other metal carbonates can be used. . Specifically, the carbonates of alkaline earth metals include calcium carbonate, barium carbonate, and magnesium carbonate, and the silicates of alkaline earth metals include calcium silicate, barium silicate, magnesium silicate, and the like. Examples of the phosphates include calcium phosphate, barium phosphate, magnesium phosphate, and the like, and alkaline earth metal sulfates include calcium sulfate, barium sulfate, magnesium sulfate, and the like. Further, as the metal oxide, silica, titanium oxide, iron oxide, cobalt oxide, zinc oxide, nickel oxide,
Examples of the metal hydroxide include manganese oxide and aluminum oxide, and examples of the metal hydroxide include iron hydroxide, nickel hydroxide, aluminum hydroxide, calcium hydroxide, and chromium hydroxide. And as other metal silicates, zinc silicate,
Examples of the other metal carbonates include aluminum silicate and zinc carbonate, aluminum carbonate, copper carbonate and the like.

As the inorganic porous fine particles, it is possible to use, in particular, those using an inorganic material obtained by the interfacial reaction method, and for example, inorganic porous particles such as calcium silicate can be used. . And in particular, Japanese Patent Publication Sho 57
The spherical inorganic porous fine particles obtained by the interfacial reaction method described in JP-A-55454 can be preferably used. Specifically, spherical inorganic porous fine particles (trade name: Gottball, manufactured by Suzuki Yushi Kogyo Co., Ltd.) that have already been commercialized can be used.

That is, when silica is used as the inorganic compound, as an example, a water glass solution is first emulsified with a liquid paraffin solution of a mixture of sorbitan monostearate and polyoxyethylene sorbitan monooleate to form a water-in-oil emulsion. Is prepared, further added to an ammonium sulfate solution to cause a reaction, and the mixture is allowed to stand. Then, filtration, washing and drying are performed to obtain hollow porous fine particles whose wall substance is silicic acid anhydride.

Then, under the equipment structure as shown in FIG. 1, the drug 3 was introduced into the voids 2 of the inorganic porous fine particles 1 shown in FIG. In this device, a vacuum chamber 6 provided with an exhaust valve 4 and a leak valve 5 and a tank 7 containing a solution of a drug 3 are connected via an introduction valve 8, and the inorganic material in the vacuum chamber 6 is By depressurizing the porous fine particles 1, the solution of the drug 3 under normal pressure was introduced into the void 2 by utilizing the pressure difference. An example of the schematic process is shown below.

First, the inorganic porous fine particles 1 are set in the vacuum chamber 6, the exhaust valve 4 is opened while the leak valve 5 and the introduction valve 8 are closed, and the vacuum chamber 6 is depressurized to 10 to 10 ^-3 torr. To do. Next, the exhaust valve 4 is closed to end the exhaust of the vacuum chamber 6, and the introduction valve 8 is opened. At this time, since the inside of the tank 7 containing the solution of the drug 3 is at atmospheric pressure, the drug 3 is introduced into the vacuum chamber 6 due to the pressure difference. Since the voids 2 of the inorganic porous fine particles 1 are also depressurized by the exhaust in the vacuum chamber 6, the drug 3 introduced into the vacuum chamber 6 permeates the voids 2 inside the inorganic porous fine particles 1 and carries them.
Subsequently, the leak valve 5 is opened to return the vacuum chamber 6 to the atmospheric pressure, and then the excess solution of the drug 3 is separated by filtration or the like to obtain inorganic porous fine particles carrying the drug 3. The inorganic porous fine particles 1 used here are
For example, the particle size is 0.1 to 300 μm, and the wall thickness is 0.05 to 1
50 μm, pore diameter of 2 nm to 2 μm, and bulk density of 0.1 to 5 cc / g. The amount of the drug 3 supported on the inorganic porous fine particles is desirably about 1 to 500% by weight, preferably 10 to 130% by weight.
It is good to That is, if it is less than 1% by weight, the sustainability of the drug is short, and if it is more than 500% by weight, it becomes excessive and flows out from the inorganic porous fine particles.

A schematic sectional structure of the inorganic porous fine particles 1 carrying the drug 3 in this manner is shown in FIG. In the example shown in the figure, the drug 3 is carried in the non-hollow inorganic porous fine particles 1 whose wall substance is silicic acid, and the drug 3 is supported by the innumerable voids 2 present on the wall surface. It gradually evaporates, and the antibacterial and antifungal effects of the drug can be maintained for a long time. The drug 3 can be supported in the hollow portion 9 of the hollow inorganic porous fine particle 1 as shown in FIG.

The inorganic porous fine particles carrying the drug can be contained in the drug dispersion in an amount of 0.01 to 60% by weight, preferably 1 to 30% by weight. That is, if it is less than 0.01% by weight, the sustainability of the drug is short, and if it is 60% by weight or more, the fluidity of the dispersion liquid is impaired.

The dispersion liquid of the present invention is a liquid in which a drug can be dispersed, and it is desirable that it is in a liquid state in an environment of 0 to 50 ° C., depending on the application, water or an organic solvent, and further The mixture can also be used. As the organic solvent, alcohols, ethers, ketones, aldehydes and the like can be preferably used. And specifically, methyl alcohol, ethyl alcohol, propyl alcohol, isopropyl alcohol, butyl alcohol, etc. can be illustrated. Furthermore, examples of ethers include petroleum ether and diether ether. Examples of ketones include acetone and methyl ether ketone. Examples of aldehydes include formaldehyde and acetaldehyde. It is preferable to use alcohols, particularly preferably 1 to 1 carbon atoms.
Methyl alcohol, ethyl alcohol, propyl alcohol, isopropyl alcohol, etc. of 3 can be used. In addition, as a particularly preferable use form of the dispersion liquid,
It is desirable to use a mixture of alcohols and water because it is used for the human body, and it is preferable that the content of the alcohols is 75 to 95% by weight, and the drug can be more uniformly dispersed. .

Next, the acrylic acid polymer, which is also called polyacrylic acid, is obtained by polymerizing two or more acrylic acids, and in particular, a cross-linking type acrylic acid polymer can be used. Specific examples of the acrylic acid polymer are Junron PW-110 and Junron PW- manufactured by Nippon Pure Chemical Industries, Ltd.
150, Carbopol 907, Carbopol 910, Carbopol 934, Carbopol 9 manufactured by Showa Denko KK
34P, Carbopol 940, Carbopol 941, Akpek HV-505 manufactured by Iron and Steel Chemical Co., Ltd., Hibiswako 103, Hibiswako 1 manufactured by Wako Pure Chemical Industries, Ltd.
04, Hibisu Wako 105, Hibisu Wako 204,
Hibiswako 304 and the like can be exemplified. The content of the acrylic acid polymer in the drug dispersion is 0.0001.
It is desirable to set the content to ˜6% by weight, preferably 0.01 to 0.5% by weight. That is, if it is less than 0.0001% by weight, the viscosity is too low to disperse uniformly, and if it is more than 6% by weight, the viscosity is too high to disperse uniformly. Is desirable.

The above-mentioned alkaline agent is necessary for neutralizing the acrylic acid polymer and is a water-insoluble or poorly water-soluble agent which is mixed with the acrylic acid polymer to increase its viscosity. Specific examples of the alkaline agent include polyoxyethylene oleyl amine, polyoxyethylene stearyl amine, polyoxyethylene propylene diamine, polyoxyethylene tallow amine, polyoxyethylene coco amine, dibutyl amine, tri- (2-ethyl) hexyl amine. , Tributylamine, N, N-dibutyl-2-
Ethylhexylamine, diisobutylamine, diallylamine, di-sec-isobutylamine, triallylamine, N, N-dimethylbutylamine, N, N-dimethylallylamine, 1,2-dimethylpropylamine, N
-Methyldiallylamine, N-ethyl-1,2-dimethylpropylamine, N, N-diisopropylethylamine, hexylamine, dibenzylamine, N-methylhexylamine, dimethylbenzylamine, di-n-octylamine, 2-ethylhexyl Oxypropylamine, tri-n-octylamine, dibutylaminopropylamine, N-methyl-di-n-octylamine, 2-
Examples thereof include ethylhexylamine and di- (2-ethyl) hexylamine. And, as the content of the alkali salt, it is necessary to neutralize the acrylic acid polymer, and depending on the content of the cross-linked acrylic acid polymer, 0.00001 to 20% by weight, Preferably 0.01
It is desirable to set the content to ˜0.5% by weight. That is, 0.000
When it is less than 01% by weight, neutralization is insufficient and uniform dispersion cannot be achieved, and when it is more than 20% by weight, it becomes excessive.

Further, in the present invention, a surfactant can be added depending on the application. As the surfactant, it is possible to use an anionic surfactant, a cationic surfactant, an amphoteric surfactant, a nonionic surfactant, and the like,
Especially for use in the human body, those described in the standard of cosmetic raw materials are desirable. Further, the surfactant has an HLB value of 1 to 2
It is possible to use one of 0 and particularly preferably 5
The use of the compounds of No. 15 to 15 enables more uniform dispersion of the drug and the inorganic porous fine particles. The amount of the surfactant is preferably 0.01 to 5% by weight,
If it is less than 0.01% by weight, it becomes difficult to disperse the drug.
If it is more than wt%, the amount will be in excess, so it is desirable to set it in the above range. Specific examples of the surfactant include the following. Examples of the anionic surfactant include zinc laurate, zinc myristate, magnesium myristate, zinc palmitate, magnesium stearate, zinc stearate, aluminum stearate, calcium stearate, sodium lauryl sulfate, triethanolamine laurate, cetyl. Sodium sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether phosphoric acid, sodium polyoxyethylene lauryl ether phosphate, polyoxyethylene thiether ether phosphate, sodium polyoxyethylene thicel ether phosphate , Polyoxyethylene stearyl ether phosphoric acid, polyoxyethylene oleyl ether phosphoric acid, polyoxyethylene ester Yl ether sodium phosphate, polyoxyethylene alkyl phenyl ether phosphate, polyoxyethylene alkyl phenyl ether phosphate triethanolamine, sodium polyoxyethylene alkylphenyl ether phosphate, sodium lauroyl sarcosinate, soybean phospholipid and the like.

Examples of the cationic surfactant include stearyltrimethylammonium chloride, distearyldimethylammonium chloride, benzalkonium chloride, benzethonium chloride, stearyldimethylbenzylammonium chloride, cetylpyridinium chloride, alkylisoquinolinium bromide and odor. Domifene chloride and the like can be exemplified.

Examples of the amphoteric surfactant include sodium β-laurylaminopropionate, betaine lauryldimethylaminoacetate, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.

As the nonionic surfactant, self-emulsifying glyceryl monostearate, lipophilic glyceryl monostearate, lipophilic monoglyceride monooleate, ethylene glycol monostearate, propylene glycol monostearate, propylene dioleate. Glycol, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate, sucrose fatty acid ester, undecylenic acid monoethanolamide, lauric acid diethanolamide, coconut fat and oil Diethanolamide, polyethylene glycol monolaurate, polyethylene glycol monostearate, polyethylene glycol monooleate, myristyl lactate Thicel lactate, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, polyoxyethylene octylphenyl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene stearic acid amide, monostearin Acid polyoxyethylene glycerin,
Polyoxyethylene sorbitate monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene monostearate, polyoxyethylene sorbitan hexastearate, polyoxymonooleate Ethylene sorbitan, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbit tetraoleate,
Examples thereof include polyoxyethylene sorbit beeswax, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, and polyoxyethylene lanolin.

Then, in the method for producing a drug dispersion of the present invention, an acrylic acid polymer and an alkali salt are added to the dispersion to thicken it to give a viscous dispersion, and a drug is further supported. Inorganic porous fine particles are added and dispersed. And, in the manufacturing method of the present invention, particularly 10
It is desirable to carry out at room temperature of ˜35 ° C., and the acrylic acid polymer is added with stirring to uniformly disperse. And
Viscosity can be imparted to the dispersion by adding an alkali salt to neutralize the dispersion. The viscosity value measured by a viscometer such as a B-type viscometer is 10 to 3000.
It is desirable to adjust it to 00 cps, preferably 400 to 1000 cps. That is, if the viscosity value is out of the above range, the particles cannot be dispersed uniformly, so that the above range is preferable. Then, the drug dispersion liquid is obtained by adding the inorganic porous fine particles carrying the drug to the viscous dispersion liquid, and stirring and dispersing them uniformly. As a means for uniformly dispersing the particles, it is desirable to use a homogenizer to homogenize by high-speed stirring at a rotation speed of 10 to 13000 rpm / minute, preferably 5000 to 8000 rpm / minute. That is, 10r
If it is less than pm / min, the drug cannot be uniformly dispersed, and if the rotation speed is higher than 13000 rpm / min, the acrylic acid polymer is sheared and the drug cannot be dispersed. It is desirable to do.

Further, the operation of the present invention is as follows. According to the drug dispersion of the present invention, the inorganic porous fine particles carrying the drug are uniformly dispersed in the dispersion due to the thickening action formed by the acrylic acid polymer and the alkali salt. When volatilized, a film of acrylic acid polymer can be formed on the surface of the inorganic porous fine particles. The chemical dispersion liquid of the present invention in which at least one of water and alcohols is used as the dispersion liquid can quickly volatilize the dispersion liquid. The alcohol has 1 to 3 carbon atoms
When it is one, the dispersion liquid can be volatilized more efficiently. When the drug is a repellent, the repellent can be sustainedly released. When the inorganic porous fine particles are obtained by an interfacial reaction method, they can be dispersed more uniformly, and a more excellent sustained release effect can be obtained.
A drug dispersion liquid containing 0.01 to 60% by weight of the inorganic porous fine particles can be more uniformly dispersed. When the inorganic porous fine particles carry 1 to 500% by weight of the drug, the drug can be efficiently loaded.

[0046]

The details of the present invention will be described with reference to the drawings. (Example 1) In Example 1, a drug dispersion was prepared by using peppermint oil, which is a natural fragrance, as a drug and blending as shown in Table 1 below. That is, ethyl alcohol (trade name: ethyl alcohol special grade, manufactured by Wako Pure Chemical Industries, Ltd.)
Acrylic acid polymer (trade name: Carbopol, manufactured by Showa Denko KK) was added and mixed, and polyoxyethylene palmamine (trade name: Esomin-4 was added in order to further increase the viscosity.
5, manufactured by Lion Corporation) was added to prepare a mixed solution. Then, peppermint oil was added to and mixed with inorganic porous fine particles (trade name: Godball E-16C, manufactured by Suzuki Yushi Kogyo Co., Ltd.) to be supported. The inorganic porous fine particles carrying the paper mint oil were added to the mixed solution, and the mixture was heated at room temperature with a homogenizer to give 6000 rp / min.
Homogenization was carried out for 5 minutes at a rotation speed of m to prepare a drug dispersion containing peppermint oil.

(Example 2) In Example 2, N, N-diethyl-m, which is a repellent for the drug, was formulated by the formulation shown in Table 1.
A drug dispersion was prepared in the same manner as in Example 1, except that toluamide was used.

Example 3 As Example 3, the same procedure as in Example 1 was carried out except that the insecticide Allethrin (Sumitomo Chemical Co., Ltd.) was used in the formulation shown in Table 1 to disperse the drug. A liquid was prepared.

(Example 4) As Example 4, as the formulation shown in Table 1, Hiba oil (trade name: antibacterial agent) was used as a drug.
A drug dispersion was prepared in the same manner as in Example 1 except that Hiba oil, manufactured by Narita Forestry Co., Ltd. was used.

(Example 5) In Example 5, except that Kasugamycin (trade name: Kasugamycin hydrochloride monohydrate, manufactured by Wako Pure Chemical Industries, Ltd.), which is a bactericidal agent, was used as a drug in the composition shown in Table 1. The same procedure as in Example 1 was performed to prepare a drug dispersion.

(Comparative Example 1) As Comparative Example 1, a drug dispersion was prepared by dissolving peppermint oil which is a natural flavoring agent in ethyl alcohol according to the formulation shown in Table 1.

(Comparative Example 2) As Comparative Example 2, N, N-diethyl-m, which is a repellent for the drug, was prepared by the formulation shown in Table 1.
-A procedure similar to Comparative Example 1 was carried out except that toluamide was used to prepare a drug dispersion.

(Comparative Example 3) In Comparative Example 3, the same procedure as in Comparative Example 1 was carried out except that Allethrin (manufactured by Sumitomo Chemical Co., Ltd.), which was an insecticide, was used in the formulation shown in Table 1. A dispersion was prepared.

(Comparative Example 4) As Comparative Example 4, the same procedure as in Comparative Example 1 was carried out except that the same Hiba oil as in Example 1, which was an antibacterial agent, was used as the drug in the formulation shown in Table 1. Was produced.

(Comparative Example 5) As Comparative Example 5, except that the composition shown in Table 1 was used for the chemical agent Kasugamycin (trade name: Kasugamycin hydrochloride monohydrate, manufactured by Wako Pure Chemical Industries, Ltd.). In the same manner as in Comparative Example 1, a drug dispersion was prepared.

[0056]

[Table 1]

Comparative tests were carried out in Example 1 and Comparative Example 1, Example 2 and Comparative Example 2, Example 3 and Comparative Example 3, Example 4 and Comparative Example 4, and Example 5 and Comparative Example 5, respectively. I went about. The details will be described below. (Comparative Test of Example 1 and Comparative Example 1) Using a natural fragrance,
The persistence of the fragrance was confirmed. That is, 5 g of Example 1
Also, Comparative Example 1 was prepared by quantitative filter paper having a diameter of 110 mm (trade name:
NO. Advantech Toyo Co., Ltd.), and the filter paper has a humidity of 70% Rh and a temperature of 3
The fragrance was volatilized in a constant temperature and humidity bath at 0 ° C. And 20
The scent of spearmint oil was confirmed by human panelists, and it was examined whether or not the scent was perceived. The number of people who perceive the scent is shown in Table 2.

[0058]

[Table 2]

As a result, as is clear from Table 2, many people in Example 1 felt the scent of spearmint over a long period of time.

(Comparative Test of Example 2 and Comparative Example 2) When a repellent was used, its residual effect was evaluated. The method was confirmed using adult female Culex pipiens. As for the method, 5 g of Example 2 and Comparative Example 2 were adsorbed on a quantitative filter paper (trade name: NO.3, manufactured by Advantech Toyo Co., Ltd.) having a diameter of 110 mm, and the filter paper was stored at a chamber temperature of 2.
It was placed in a constant temperature bath at 5 ° C and a sustained release test was conducted. And
The filter paper in the sustained release test was put in one of the breeding cases of 30 × 30 × 30 cm designed so that the mosquitoes could pass through the central part obtained by dividing the inside into two, and the repellent effect against the mosquitoes was confirmed. The confirmation method was as follows. In one of the breeding cases in which the filter paper during the sustained-release test was set, one squid was put in one of the breeding cases, and the number of squid migrating to the one without the filter paper was observed every day, and the number was calculated in Table 3. It was shown to.

[0061]

[Table 3]

As is clear from Table 3, Example 2 is
Compared to Comparative Example 2, it had a repellent effect on Culex pipiens for a long period of time.

(Comparative Test of Example 3 and Comparative Example 3) When Example 3 and Comparative Example 3 were used, the residual effect of the repellent was performed. The method was confirmed using German cockroaches. The method is as follows: 5 g of Example 3 and Comparative Example 3 are adsorbed on a quantitative filter paper (trade name: NO.3, manufactured by Advantech Toyo Co., Ltd.) having a diameter of 100 mm, and the filter paper is further kept in a thermostatic chamber at a temperature of 25 ° C. The sustained release test was conducted at. The repellent effect of the filter paper that was subjected to the sustained release test was confirmed against German cockroaches. As for the confirmation method, the filter paper subjected to the sustained release test was put in a petri dish having a diameter of 90 mm and a thickness of 20 mm, and one German cockroach was further put into the petri dish and it was confirmed daily whether or not it would die. The results are shown in Table 4.

[0064]

[Table 4]

As is clear from Table 4, Example 3 had insecticidal activity over a long period of time.

(Comparative Test of Example 4 and Comparative Example 4) First,
5 g of Example 4 in a sterile room where the room temperature was adjusted to 25 ° C.
Further, Comparative Example 4 was evenly spread in a petri dish having a diameter of 90 mm and a height of 20 mm, and a sustained release test was conducted under aseptic conditions while irradiating with ultraviolet rays. Escherichia coli (Escherichia coli) adjusted to a bacterial count of 1 × 10 ⁵ cells / ml was added to the petri dish that had been subjected to the further sustained release test.
After suspending and washing a culture solution of richia coli) or Bacillus subtilis with physiological saline (saline content is 0.85%), 1 ml of the physiological saline was added, and further 5
g of sterilized standard agar medium (trade name: standard agar medium, manufactured by Nissui Pharmaceutical Co., Ltd.) was added to prepare an agar medium by the pour-in method and then cultured in a constant temperature bath at 37 ° C. for 24 hours to grow. After confirming the situation, the number of colonies is shown in Table 5.

[0067]

[Table 5]

As is clear from Table 5, Example 4 had a smaller number of colonies and had an antibacterial activity for a long period of time.

(Comparative Test of Example 5 and Comparative Example 5) First,
5 g of Example 5 in a sterile room where the room temperature was adjusted to 25 ° C.
Further, Comparative Example 5 was uniformly spread in a petri dish having a diameter of 90 mm and a height of 20 mm, and a sustained release test was conducted under aseptic conditions while irradiating with ultraviolet rays. Then, the petri dish that was subjected to the sustained release test showed that Escherichia coli or Bacillus subti
In order to confirm the bactericidal effect against lis), the same operation as in the comparative tests of Example 4 and Example 4 was performed, the growth status was confirmed, and the number of colonies is shown in Table 6.

[0070]

[Table 6]

As is clear from Table 6, Example 5 had a smaller number of colonies and had a bactericidal activity for a long period of time.

[0072]

EFFECTS OF THE INVENTION According to the drug dispersion of the present invention, the inorganic porous fine particles are made to uniformly support the drug by the thickening effect formed by the acrylic acid polymer and the alkali salt, and the inorganic porous fine particles are further dispersed in the dispersion. When the dispersion liquid volatilizes, a film of the acrylic acid polymer is formed on the surface of the inorganic porous fine particles, so that the effect of the drug can be maintained for a long period of time. Further, the drug dispersion of the present invention in which at least one of water and alcohols is used as the dispersion can volatilize the dispersion promptly, so that after coating or spraying, the drug is efficiently and uniformly vaporized. be able to. Furthermore, when water is used, the cost is also reduced. When the alcohol has 1 to 3 carbon atoms, the dispersion liquid can be volatilized more efficiently, so that the drug can be more evenly volatilized more efficiently after coating or spraying. When a repellent is used as the drug, the repellent can be released slowly, and thus sanitary pests, agricultural pests, and animals can be repelled over a long period of time. When the inorganic porous fine particles are obtained by an interfacial reaction method, they can be more uniformly dispersed to obtain a more excellent sustained release effect, and therefore, the sustained release effect can be obtained over a long period of time. it can. A drug dispersion liquid containing 0.01 to 60% by weight of the inorganic porous fine particles can be more uniformly dispersed, and thus can have an excellent sustained release effect. When the inorganic porous fine particles support the drug in an amount of 1 to 500% by weight, the drug can be efficiently loaded, so that a sustained release effect can be obtained over a long period of time. As described above, the drug dispersion of the present invention makes it possible to disperse drugs such as repellents, fragrances and pesticides in the dispersion, and also has an excellent sustained release function, so its faint scent, repellent, insecticide The bactericidal, acaricidal, nematicidal and acaricidal effect can be maintained over a long period of time.

Further, according to the production method of the present invention, the inorganic porous fine particles carrying the drug are prepared by adding an acrylic acid polymer and an alkali salt to the dispersion liquid to increase the viscosity.
Since it can be dispersed, an emulsifying agent and a surfactant have been conventionally required, but a step such as an emulsifying step is not necessary, and it is possible to disperse easily without any trouble and cost can be reduced.

[Brief description of drawings]

FIG. 1 is an explanatory view of a method for injecting a drug into inorganic porous fine particles of the present invention.

FIG. 2 is an explanatory view of solid inorganic porous fine particles used in the present invention.

FIG. 3 is an explanatory view of hollow inorganic porous fine particles used in the present invention.

[Explanation of symbols]

 1. Inorganic porous fine particles 2. Void 3. Drug 4. Exhaust valve 5. Leak valve 6. Vacuum chamber 7. Tank 8. Introduction valve 9. Hollow

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display area C08J 3/02 C08J 3/02 C08L 33/02 LHR C08L 33/02 LHR // B01J 13/02 B01J 13/02 L

Claims (8)

[Claims] 1. A drug dispersion liquid comprising inorganic porous fine particles carrying a drug, a dispersion liquid, an acrylic acid polymer, and an alkali salt. 2. The drug dispersion according to claim 1, wherein the dispersion is at least one of water and alcohols. 3. The drug dispersion according to claim 2, wherein the alcohol has 1 to 3 carbon atoms. 4. The drug dispersion according to claim 1, 2 or 3, wherein the drug is a repellent. 5. The drug dispersion according to claim 1, 2, 3 or 4, wherein the inorganic porous fine particles are obtained by an interfacial reaction method. 6. The drug dispersion liquid according to claim 1, which contains 0.01 to 60% by weight of the inorganic porous fine particles. 7. The inorganic porous fine particles carry a drug in an amount of 1 to 500% by weight.
The drug dispersion according to 4, 5, or 6. 8. A method for producing a drug dispersion, wherein an acrylic acid polymer and an alkali salt are added to the dispersion to increase its viscosity, and further inorganic porous fine particles carrying a drug are added and dispersed.