JPH09504428A - 流体サンプルの移送装置及び方法 - Google Patents
流体サンプルの移送装置及び方法Info
- Publication number
- JPH09504428A JPH09504428A JP7511849A JP51184995A JPH09504428A JP H09504428 A JPH09504428 A JP H09504428A JP 7511849 A JP7511849 A JP 7511849A JP 51184995 A JP51184995 A JP 51184995A JP H09504428 A JPH09504428 A JP H09504428A
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- block
- chamber
- propellant
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00366—Several different temperatures used
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00376—Conductive heating, e.g. heated plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00742—Type of codes
- G01N2035/00752—Type of codes bar codes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.デバイス内の反応チャンバーと検出チャンバーの間で流体サンプルを移送す る方法であって、 a)反応チャンバーと検出チャンバーをもつデバイスを準備し、反応チャンバー と検出チャンバーをこれらのチャンバーの間の流体連通手段によって相互に連結 し、前記反応チャンバー内に反応サンプルを配置し、推進剤とサンプルが混合す るように又はサンプルが推進剤と流体連通手段の間に位置するように前記反応チ ャンバー内に推進剤も配置され、更に前記推進剤が膨張するように誘導可能であ る段階と、 b)推進剤を膨張するように誘導してより大きい容積を占有させ、サンプルを流 体連通手段を介して検出チャンバーに圧入する段階とを含む前記方法。 2.前記反応チャンバーが細長形チャンバーであり、前記誘導する段階が前記推 進剤に熱を加える段階を含む請求項1に記載の方法。 3.前記熱が前記細長形反応チャンバーの推進剤を含む局在領域に加えられる請 求項2に記載の方法。 4.前記推進剤が前記反応サンプルと混合するように前記反応チャンバー内に配 置される請求項3に記載の方法。 5.前記推進剤は該推進剤と流体連通手段の間にサンプルが位置するように前記 反応チャンバー内に配置される請求項3に記載の方法。 6.前記反応チャンバーが核酸増幅用熱サイクリングチャンバーであり、前記誘 導する段階が熱サイクリング反応の完了後に実施される請求項1に記載の方法。 7.前記反応チャンバーが核酸増幅用細長形熱サイクリングチャンバーであり、 前記誘導する段階が前記推進剤を加熱する段階を含む する段階が前記推進剤を加熱する段階を含む請求項1に記載の方法。 8.前記推進剤が前記反応サンプルと混合するように前記反応チャンバー内に配 置される請求項7に記載の方法。 9.前記推進剤は該推進剤と流体連通手段の間にサンプルが位置するように前記 反応チャンバー内に配置される請求項7に記載の方法。 10.前記推進剤が蒸発可能な流体である請求項1に記載の方法。 11.前記推進剤が蒸発可能な流体である請求項7に記載の方法。 12.前記蒸発可能な流体が反応サンプル自体である請求項1に記載の方法。 13.前記蒸発可能な流体が反応サンプル自体である請求項8に記載の方法。 14.前記推進剤が空気である請求項1に記載の方法。 15.前記推進剤が空気である請求項9に記載の方法。 16.前記誘導する段階が非機械的手段によって実施される請求項1に記載の方 法。 17.前記誘導する段階が非機械的手段によって実施される請求項6に記載の方 法。 18.前記誘導する段階が前記推進剤を蒸発させることによって実施され、前記 蒸発が前記推進剤中で核形成部位を使用することによって局在化される請求項1 0に記載の方法。 19.前記核形成部位が微粒状物質を含む請求項18に記載の方法。 20.前記核形成部位がガラス又はプラスチックマイクロビーズを含む請求項1 8に記載の方法。 21.前記反応チャンバーが少なくとも二つの異なる長手方向セグメントをもつ 細長形チャンバーであり、更に、 a)第1の長手方向セグメントを断続的に加 熱して前記熱サイクリング反応を実施する段階と、 b)別の長手方向セグメントを加熱して前記推進剤の膨張を誘導し、前記反応サ ンプルを前記検出チャンバーに移送する段階とを含む請求項6に記載の方法。 22.前記反応チャンバーが長手方向セグメントをもつ細長形チャンバーであり 、更に、 a)前記長手方向セグメントに第1の最大量の熱を断続的に加えて前記熱サイク リング反応を実施する段階と、 b)前記長手方向セグメントに前記第1の最大量を上回る熱を加えて前記推進剤 の膨張を誘導し、前記反応サンプルを前記検出チャンバーに移送する段階とを含 む請求項6に記載の方法。 23.前記熱サイクリング反応がリガーゼ連鎖反応又はポリメラーゼ連鎖反応を 含む請求項6に記載の方法。 24.前記熱サイクリング反応がリガーゼ連鎖反応又はポリメラーゼ連鎖反応を 含む請求項7に記載の方法。 25.標的核酸を含む疑いのあるサンプルと複数のプライマー又はプローブを反 応チャンバー内で反応させて前記標的核酸を増幅する段階と、前記サンプルを前 記反応チャンバーと別個の検出領域に移送し、増幅標的の存在又は量を検出する 段階とを含むところの標的核酸の増幅及び検出方法において、前記サンプルを前 記反応チャンバーから前記検出領域に推進するために熱を使用することによって 前記サンプルを検出領域に移送する段階を含む改良。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14073093A | 1993-10-21 | 1993-10-21 | |
US08/140,730 | 1993-10-21 | ||
PCT/US1994/011016 WO1995011437A1 (en) | 1993-10-21 | 1994-09-28 | Apparatus and method for transfer of a fluid sample |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09504428A true JPH09504428A (ja) | 1997-05-06 |
JP3741439B2 JP3741439B2 (ja) | 2006-02-01 |
Family
ID=22492549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51184995A Expired - Fee Related JP3741439B2 (ja) | 1993-10-21 | 1994-09-28 | 流体サンプルの移送装置及び方法 |
Country Status (8)
Country | Link |
---|---|
US (1) | US6068978A (ja) |
EP (1) | EP0724717B1 (ja) |
JP (1) | JP3741439B2 (ja) |
AT (1) | ATE170001T1 (ja) |
AU (1) | AU8073294A (ja) |
DE (1) | DE69412632T2 (ja) |
ES (1) | ES2123162T3 (ja) |
WO (1) | WO1995011437A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002513936A (ja) * | 1998-05-01 | 2002-05-14 | ジェン−プロウブ インコーポレイテッド | 自動化診断用分析器および方法 |
JP2010500009A (ja) * | 2006-08-11 | 2010-01-07 | ユースター バイオテクノロジーズ(ハンツォウ) | 標的核酸増幅産物高速検査方法、および完全密封式標的核酸増幅物高速検査装置 |
JP2010502930A (ja) * | 2006-09-08 | 2010-01-28 | フィンザイムズ・インストゥルーメンツ・オサケユキテュア | サーマルサイクリングに関する機器及び方法 |
US9046507B2 (en) | 2010-07-29 | 2015-06-02 | Gen-Probe Incorporated | Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure |
US9726607B2 (en) | 2005-03-10 | 2017-08-08 | Gen-Probe Incorporated | Systems and methods for detecting multiple optical signals |
US9915613B2 (en) | 2011-02-24 | 2018-03-13 | Gen-Probe Incorporated | Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector |
WO2018181268A1 (ja) * | 2017-03-28 | 2018-10-04 | 日本電気株式会社 | マイクロチューブ |
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US7040653B1 (en) * | 2004-10-27 | 2006-05-09 | Automotive Technologies International, Inc. | Steering wheel assemblies for vehicles |
GB9719673D0 (en) * | 1997-09-17 | 1997-11-19 | Glaxo Group Ltd | Novel apparatus |
US8337753B2 (en) | 1998-05-01 | 2012-12-25 | Gen-Probe Incorporated | Temperature-controlled incubator having a receptacle mixing mechanism |
JP4045475B2 (ja) * | 1999-09-06 | 2008-02-13 | 東洋紡績株式会社 | 核酸・蛋白質精製装置 |
US6620625B2 (en) * | 2000-01-06 | 2003-09-16 | Caliper Technologies Corp. | Ultra high throughput sampling and analysis systems and methods |
US20020031836A1 (en) * | 2000-09-11 | 2002-03-14 | Feldstein Mark J. | Fluidics system |
US7402282B2 (en) | 2001-07-20 | 2008-07-22 | Ortho-Clinical Diagnostics, Inc. | Auxiliary sample supply for a clinical analyzer |
US6637476B2 (en) | 2002-04-01 | 2003-10-28 | Protedyne Corporation | Robotically manipulable sample handling tool |
EP1546386A4 (en) * | 2002-09-17 | 2006-05-10 | Pharmacia Corp | RNA CONSERVATION AND REVERSE TRANSCRIPTASE DURING AUTOMATED LIQUID TREATMENT |
US7249529B2 (en) * | 2003-03-28 | 2007-07-31 | Protedyne Corporation | Robotically manipulable sample handling tool |
DE102005028897A1 (de) * | 2005-06-17 | 2006-12-28 | Eckert & Ziegler Eurotope Gmbh | Anordnung und Verfahren zur Verarbeitung von chemischen Stoffen, Computerprogramm zur Steuerung einer solchen Anordnung sowie ein entsprechendes computerlesbares Speichermedium |
EP2752671A3 (en) | 2010-07-23 | 2016-08-24 | Beckman Coulter, Inc. | System or method of including analytical units |
US9266110B2 (en) * | 2010-10-14 | 2016-02-23 | Genereach Biotechnology Corp. | Reaction tube for performing isothermal polymerase chain reaction therein |
GB2493981A (en) * | 2011-08-26 | 2013-02-27 | Isis Innovation | Temperature controlled analyte transferring device |
BR112014010955A2 (pt) | 2011-11-07 | 2017-06-06 | Beckman Coulter Inc | sistema e método para processar amostras |
JP6190380B2 (ja) | 2011-11-07 | 2017-08-30 | ベックマン コールター, インコーポレイテッド | 等分機システムおよびワークフロー |
JP2014532881A (ja) | 2011-11-07 | 2014-12-08 | ベックマン コールター, インコーポレイテッド | 標本輸送システムのための磁気制動 |
EP2776843B1 (en) | 2011-11-07 | 2019-03-27 | Beckman Coulter, Inc. | Centrifuge system and workflow |
EP2776844B1 (en) | 2011-11-07 | 2020-09-30 | Beckman Coulter, Inc. | Specimen container detection |
CN104040352B (zh) | 2011-11-07 | 2016-09-07 | 贝克曼考尔特公司 | 机械臂 |
AU2013202808B2 (en) | 2012-07-31 | 2014-11-13 | Gen-Probe Incorporated | System and method for performing multiplex thermal melt analysis |
US10001497B2 (en) | 2013-03-15 | 2018-06-19 | Abbott Laboratories | Diagnostic analyzers with pretreatment carousels and related methods |
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-
1994
- 1994-09-28 ES ES94931783T patent/ES2123162T3/es not_active Expired - Lifetime
- 1994-09-28 AT AT94931783T patent/ATE170001T1/de not_active IP Right Cessation
- 1994-09-28 AU AU80732/94A patent/AU8073294A/en not_active Abandoned
- 1994-09-28 WO PCT/US1994/011016 patent/WO1995011437A1/en active IP Right Grant
- 1994-09-28 DE DE69412632T patent/DE69412632T2/de not_active Expired - Fee Related
- 1994-09-28 EP EP94931783A patent/EP0724717B1/en not_active Expired - Lifetime
- 1994-09-28 JP JP51184995A patent/JP3741439B2/ja not_active Expired - Fee Related
-
1997
- 1997-05-20 US US08/859,552 patent/US6068978A/en not_active Expired - Fee Related
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JP2002513936A (ja) * | 1998-05-01 | 2002-05-14 | ジェン−プロウブ インコーポレイテッド | 自動化診断用分析器および方法 |
US10006862B2 (en) | 2005-03-10 | 2018-06-26 | Gen-Probe Incorporated | Continuous process for performing multiple nucleic acid amplification assays |
US9726607B2 (en) | 2005-03-10 | 2017-08-08 | Gen-Probe Incorporated | Systems and methods for detecting multiple optical signals |
JP2010500009A (ja) * | 2006-08-11 | 2010-01-07 | ユースター バイオテクノロジーズ(ハンツォウ) | 標的核酸増幅産物高速検査方法、および完全密封式標的核酸増幅物高速検査装置 |
JP2010502930A (ja) * | 2006-09-08 | 2010-01-28 | フィンザイムズ・インストゥルーメンツ・オサケユキテュア | サーマルサイクリングに関する機器及び方法 |
US9046507B2 (en) | 2010-07-29 | 2015-06-02 | Gen-Probe Incorporated | Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure |
US9915613B2 (en) | 2011-02-24 | 2018-03-13 | Gen-Probe Incorporated | Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector |
US10641707B2 (en) | 2011-02-24 | 2020-05-05 | Gen-Probe Incorporated | Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector |
WO2018181268A1 (ja) * | 2017-03-28 | 2018-10-04 | 日本電気株式会社 | マイクロチューブ |
JPWO2018181268A1 (ja) * | 2017-03-28 | 2020-02-06 | 日本電気株式会社 | マイクロチューブ |
US11199527B2 (en) | 2017-03-28 | 2021-12-14 | Nec Corporation | Microtube |
Also Published As
Publication number | Publication date |
---|---|
ATE170001T1 (de) | 1998-09-15 |
DE69412632T2 (de) | 1999-01-14 |
AU8073294A (en) | 1995-05-08 |
US6068978A (en) | 2000-05-30 |
EP0724717B1 (en) | 1998-08-19 |
JP3741439B2 (ja) | 2006-02-01 |
WO1995011437A1 (en) | 1995-04-27 |
EP0724717A1 (en) | 1996-08-07 |
DE69412632D1 (de) | 1998-09-24 |
ES2123162T3 (es) | 1999-01-01 |
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