JPH09291023A - Preparation for external use for skin - Google Patents
Preparation for external use for skinInfo
- Publication number
- JPH09291023A JPH09291023A JP9033211A JP3321197A JPH09291023A JP H09291023 A JPH09291023 A JP H09291023A JP 9033211 A JP9033211 A JP 9033211A JP 3321197 A JP3321197 A JP 3321197A JP H09291023 A JPH09291023 A JP H09291023A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- external preparation
- catalase
- substance
- action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、カタラーゼ作用を
示す物質とUV−A吸収剤及び/又はUV−A散乱剤と
を含有し、UV−A傷害防御に効果的な皮膚外用剤であ
り、さらには色素沈着抑制効果及び/又は老化防止効果
に優れたUV−A傷害防御に有効な皮膚外用剤に関する
ものである。TECHNICAL FIELD The present invention is an external preparation for skin which contains a substance exhibiting a catalase action and a UV-A absorber and / or a UV-A scatterer and is effective for protection against UV-A injury. Furthermore, the present invention relates to a skin external preparation which is excellent in pigmentation suppression effect and / or aging prevention effect and effective for UV-A injury protection.
【0002】[0002]
【従来の技術】紫外線の中でUV−Aと呼ばれる長波長
紫外線(320〜400nm)は、それより短波長の紫
外線であるUV−B(280〜320nm)と比べて、
炎症等の急性反応を生じず作用も緩和なことから、その
防御の必要性が従来ほとんど論じられなかった。2. Description of the Related Art Among the ultraviolet rays, long wavelength ultraviolet rays called UV-A (320 to 400 nm) are shorter than UV-B (280 to 320 nm) which is a shorter wavelength ultraviolet ray.
Since the acute reaction such as inflammation does not occur and the action is mild, the necessity of the protection has not been discussed so far.
【0003】これまでに知られているUV−Aの皮膚へ
の作用としては、即時黒化と呼ばれ照射直後から数時間
で消失する皮膚黒化現象や、数日間持続する遅延黒化と
呼ばれる色素沈着現象が知られている。又UV−Aは皮
膚の真皮にまで到達することから、皮膚老化に関与する
ことも報告されている。このようなUV−Aの遅延黒化
による色素沈着や真皮レベルでの老化に対しては、これ
までUV−A吸収剤及び/又はUV−A散乱剤を用いて
防御するという対応がなされていたが、UV−A吸収剤
及び/又はUV−A散乱剤を外用するだけではカタラー
ゼの失活を防ぐには十分ではなく、それ以外の効果的な
防御方法は考えられていなかった。A known action of UV-A on the skin has been called immediate blackening, which is a phenomenon of skin blackening that disappears within a few hours immediately after irradiation, or a delayed blackening that lasts for several days. The pigmentation phenomenon is known. Since UV-A reaches the dermis of the skin, it is also reported that it is involved in skin aging. Pigmentation due to such delayed blackening of UV-A and aging at the dermis level have been hitherto dealt with protection using a UV-A absorber and / or a UV-A scatterer. However, external application of a UV-A absorber and / or a UV-A scatterer is not sufficient to prevent the inactivation of catalase, and no other effective protection method has been considered.
【0004】一方カタラーゼは過酸化水素を消去する酵
素であり、皮膚内のあらゆる細胞(表皮細胞、線維芽細
胞、メラノサイト等)に存在し、紫外線により生じた活
性酸素傷害を防御していることが知られている。On the other hand, catalase is an enzyme that eliminates hydrogen peroxide, exists in every cell in the skin (epidermal cells, fibroblasts, melanocytes, etc.) and protects against active oxygen damage caused by ultraviolet rays. Are known.
【0005】最近このカタラーゼがUV−Aにより失活
することが、皮膚線維芽細胞を用いた実験により報告さ
れている(J.Invest.Dermatol.,V
ol.100,No.5P692〜698(199
3))。しかし、カタラーゼを単に皮膚上に外用するだ
けではUV−A障害を防御するには十分ではなかった。Recently, the inactivation of this catalase by UV-A has been reported by an experiment using skin fibroblasts (J. Invest. Dermatol., V.
ol. 100, No. 5P692 to 698 (199
3)). However, the simple topical application of catalase on the skin was not sufficient to protect against UV-A damage.
【0006】[0006]
【発明が解決しようとする課題】本発明はこのような現
状を鑑みてUV−A傷害を効果的に防御することにより
色素沈着抑制および老化防止効果を有する皮膚外用剤を
開発することを目的としてなされたものである。SUMMARY OF THE INVENTION In view of the above situation, the present invention aims to develop a skin external preparation having a pigmentation-suppressing and anti-aging effect by effectively protecting against UV-A injury. It was made.
【0007】[0007]
【課題を解決するための手段】本発明者らはカタラーゼ
作用を示す物質とUV−A吸収剤及び/又はUV−A散
乱剤とを組み合わせ、皮膚上のカタラーゼ活性を補い且
つ元凶であるUV−Aの皮膚への到達を遮断することに
より、色素沈着抑制及び/又は老化防止効果を有するU
V−A傷害防御に効果的な皮膚外用剤を得ることができ
るという知見を得た。The present inventors have combined a substance having a catalase action with a UV-A absorber and / or a UV-A scatterer to supplement the catalase activity on the skin and cause UV- By blocking the access of A to the skin, U having a pigmentation suppressing and / or antiaging effect
It was found that a skin external preparation effective for VA injury protection can be obtained.
【0008】[0008]
【発明の実施の形態】カタラーゼ作用を示す物質は、非
常に多くのものに存在することが知られている。本発明
において必須成分であるカタラーゼ作用を示す物質の起
源については、動物由来、植物由来、微生物由来、合成
品のいずれでも良く特に限定はされないが、例えば、ウ
マ、ウシ、イヌ、ネズミ等の肝臓や赤血球、あるいは鶏
冠等の動物由来の抽出物、ホウレンソウ、西洋ワサビ、
大豆、イチジク、落花生、クロロプラスト、アカメガシ
ワ、ヤシャジツ、ヤコウトウ、カイドウヒ、トマト、メ
ロン、リンゴ、ナシ、バナナ等の植物由来の抽出物及び
/又は圧搾物、ミクロコッカス リソディクティカス
(Micrococcus lysodeikticu
s)、アスペルギルス ニガー(Aspergillu
s niger)等の微生物由来の抽出物が挙げられ
る。天然起源の場合はその抽出方法、精製処理方法等に
ついては適宜選択すれば良く特に何ら限定されない。BEST MODE FOR CARRYING OUT THE INVENTION It is known that a great number of substances exhibit catalase action exist. The origin of the substance showing a catalase action which is an essential component in the present invention is not particularly limited, and may be animal-derived, plant-derived, microbial-derived, or synthetic, for example, the liver of horses, cattle, dogs, mice, etc. , Red blood cells, or animal-derived extracts such as chicken caps, spinach, horseradish,
Extracts and / or squeezed products derived from plants such as soybeans, figs, peanuts, chloroplasts, red wrinkles, yashajitsu, yam sprout, cauliflower, tomato, melon, apple, pear, and banana, Micrococcus lysodeikticu
s), Aspergillus niger
s niger) and the like derived from microorganisms. In the case of natural origin, the extraction method, purification treatment method, etc. may be appropriately selected without any particular limitation.
【0009】又本発明の皮膚外用剤におけるカタラーゼ
作用を示す物質の含有量は、カタラーゼ換算量として製
品100g中に101〜107Unitであればよく、よ
り好ましくは104〜106Unitである。The content of the substance showing a catalase action in the external preparation for skin of the present invention may be 10 1 to 10 7 Units per 100 g of the product as a catalase conversion amount, and more preferably 10 4 to 10 6 Units. is there.
【0010】本発明においてもう一つの必須成分である
UV−A吸収剤及び/又はUV−A散乱剤に関しては、
化粧料や医薬品で一般に使用されるものであれば特に限
定されないが、UV−A吸収剤の場合、例えばパラメト
キシケイ皮酸2−エチルエステル、2−ヒドロキシ−4
−メトキシベンゾフェノン、4−t−ブチル−4’−メ
トキシジベンゾイルメタン、2−ヒドロキシ−4−メト
キシベンゾフェノン−5−スルフォン酸ナトリウム、ジ
メトキシベンジリデンジオキソイミダゾリジンプロピオ
ン酸2−エチルヘキシル等が挙げられる。このうち特に
4−t−ブチル−4’−メトキシジベンゾイルメタン、
2−ヒドロキシ−4−メトキシベンゾフェノン−5−ス
ルフォン酸ナトリウム、ジメトキシベンジリデンジオキ
ソイミダゾリジンプロピオン酸2−エチルヘキシルが好
ましい。又UV−A散乱剤としては、酸化亜鉛、酸化チ
タン、微細亜鉛華、微粒子酸化チタン等が挙げられ、特
に微細亜鉛華、微粒子酸化チタンが好ましい。Regarding the UV-A absorber and / or the UV-A scattering agent, which is another essential component in the present invention,
There is no particular limitation as long as it is one commonly used in cosmetics and pharmaceuticals, but in the case of a UV-A absorber, for example, para-methoxycinnamic acid 2-ethyl ester, 2-hydroxy-4.
-Methoxybenzophenone, 4-t-butyl-4'-methoxydibenzoylmethane, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dimethoxybenzylidene dioxoimidazolidine propionate 2-ethylhexyl and the like can be mentioned. Of these, especially 4-t-butyl-4′-methoxydibenzoylmethane,
Sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate and 2-ethylhexyl dimethoxybenzylidenedioxoimidazolidinepropionate are preferred. Examples of the UV-A scattering agent include zinc oxide, titanium oxide, fine zinc white, fine particle titanium oxide, and the like, and fine zinc white and fine particle titanium oxide are particularly preferable.
【0011】又本発明の皮膚外用剤におけるUV−A吸
収剤及び/又はUV−A散乱剤の含量は0.01〜10
重量%(以下単に「%」で示す)であり、より好ましく
は0.05〜5%である。The content of the UV-A absorber and / or the UV-A scattering agent in the external preparation for skin of the present invention is 0.01-10.
% (Hereinafter, simply indicated as "%"), and more preferably 0.05 to 5%.
【0012】本発明の皮膚外用剤は、カタラーゼ作用を
示す物質とUV−A吸収剤及び/又はUV−A散乱剤と
を公知の皮膚外用剤用の基剤と常法に従って組み合わせ
ることにより製造される。The external preparation for skin of the present invention is produced by combining a substance exhibiting a catalase action and a UV-A absorber and / or a UV-A scattering agent with a known base for external preparation for skin according to a conventional method. It
【0013】皮膚外用剤の形態の例としては特に限定さ
れず、例えば乳液、クリーム、ファンデーション、化粧
水、ボディーローション、口紅等の化粧品や、軟膏、外
用液、クリーム剤等の医薬品等にすることができ、外用
剤の基剤としてはこれらの外用剤の形態に応じた基剤、
例えば、精製水、低級アルコール、多価アルコール、油
脂、界面活性剤、粉体、美容成分、UV−B吸収剤、U
V−B散乱剤、増粘剤、色素、防腐剤、香料等を用いる
ことができる。The form of the external preparation for skin is not particularly limited, and may be cosmetics such as milky lotion, cream, foundation, lotion, body lotion, lipstick, and pharmaceuticals such as ointment, external preparation, cream and the like. As a base for external preparations, a base depending on the form of these external preparations,
For example, purified water, lower alcohols, polyhydric alcohols, oils and fats, surfactants, powders, cosmetic ingredients, UV-B absorbers, U
VB scattering agents, thickeners, pigments, preservatives, perfumes and the like can be used.
【0014】[0014]
【実施例】次に製造例、試験例及び実施例を挙げ本発明
を更に詳しく説明するが、本発明はこれに何ら限定され
ない。EXAMPLES The present invention will be described in more detail with reference to Production Examples, Test Examples and Examples, but the present invention is not limited thereto.
【0015】製造例1 メロン抽出物の製造 メロン果肉50gに精製水150mlを添加し、ホモジ
ナイズした後濾過し、メロン抽出液を得た。Production Example 1 Production of Melon Extract To 50 g of melon pulp, 150 ml of purified water was added, homogenized and filtered to obtain a melon extract.
【0016】製造例2 鶏冠抽出物の製造 ニワトリの鶏冠50gを水洗後細切し、0.01%蛋白
分解酵素(アクチナーゼE、1×106PU/g、科研
製薬社製)を含む精製水を150ml添加し、60℃に
て8時間加温した後濾過し、鶏冠抽出物を得た。Production Example 2 Production of Chicken Cob Extract 50 g of chicken cob was washed with water and then chopped, and purified water containing 0.01% proteolytic enzyme (Actinase E, 1 × 10 6 PU / g, manufactured by Kaken Pharmaceutical Co., Ltd.) (150 ml) was added, and the mixture was heated at 60 ° C. for 8 hours and then filtered to obtain a chicken cob extract.
【0017】製造例3 ヤシャジツ抽出物の製造 ヤシャジツの実10gを細切し、50%エチルアルコー
ル100mlを加え、室温で時々攪拌しながら3日間抽
出した後濾過し、ヤシャジツ抽出物を得た。Production Example 3 Production of Yashajitsu Extract 10 g of yashajitsu fruit was finely chopped, 100 ml of 50% ethyl alcohol was added, and the mixture was extracted at room temperature for 3 days with occasional stirring and then filtered to obtain a yashajitsu extract.
【0018】試験例 カタラーゼ活性測定 下記方法により、製造例1、2及び3において製造した
各抽出物のカタラーゼ活性を測定した。即ち、0.05
Mリン酸緩衝液(pH7.0)を用いて、製造例1、2
及び3において製造した抽出物をn(2×104〜2×
107)倍に希釈し、試験液とした。更に、30%過酸
化水素溶液0.1mlを0.05Mリン酸緩衝液(pH
7.0)50mlに添加した溶液を基質とし、本基質溶
液2.9mlに試験液0.1mlを添加した。次いで、
20℃において、240nmの吸光度変化を測定し、吸
光度が0.450から0.400まで低下する、即ち、
過酸化水素が3.45μmol分解する時間(T分)を
測定し、下記の式(1)に従ってカタラーゼ活性を算出
した。測定結果を表1に示した。尚、カタラーゼ活性
は、1分間に分解された過酸化水素のμmol数を示
す。Test Example Catalase activity measurement The catalase activity of each extract produced in Production Examples 1, 2 and 3 was measured by the following method. That is, 0.05
Production examples 1 and 2 using M phosphate buffer (pH 7.0)
And n (2 × 10 4 to 2 ×
It was diluted 10 7 ) times to obtain a test solution. Furthermore, 0.1 ml of 30% hydrogen peroxide solution is added to 0.05M phosphate buffer (pH
7.0) A solution added to 50 ml was used as a substrate, and 0.1 ml of a test solution was added to 2.9 ml of this substrate solution. Then
At 20 ° C., the change in absorbance at 240 nm is measured and the absorbance drops from 0.450 to 0.400, ie
The time (T minute) at which hydrogen peroxide decomposed by 3.45 μmol was measured, and the catalase activity was calculated according to the following formula (1). The measurement results are shown in Table 1. The catalase activity indicates the number of μmol of hydrogen peroxide decomposed in 1 minute.
【0019】[0019]
【数1】 [Equation 1]
【0020】[0020]
【表1】 [Table 1]
【0021】表1から明らかなごとく、メロン抽出物、
鶏冠抽出物並びにヤシャジツ抽出物には高いカタラーゼ
様活性があることが示された。As is clear from Table 1, the melon extract,
It was shown that the chicken cob extract and the yashajitsu extract had high catalase-like activity.
【0022】実施例1〜3及び比較例1〜4 ファ
ンデーション 表2に示す組成及び下記製法でファンデーションを作成
し、その色素沈着抑制効果を調べた。その結果を表3に
示す。Examples 1 to 3 and Comparative Examples 1 to 4 Foundation A foundation was prepared by the composition shown in Table 2 and the following production method, and its pigmentation inhibiting effect was examined. Table 3 shows the results.
【0023】[0023]
【表2】 [Table 2]
【0024】(製法) A.成分(1)〜(7)を混合する。 B.成分(8)〜(11)を加熱混合し、75℃に保
つ。 C.AにB及び成分(12)、(13)を添加し、混
合、粉砕し均質にする。 D.Cをプレスし、ファンデーションを得る。(Production Method) A. Mix components (1)-(7). B. The components (8) to (11) are mixed by heating and kept at 75 ° C. C. Add B and components (12) and (13) to A, mix and grind to homogenize. D. Press C to obtain foundation.
【0025】(試験方法)25〜45才の28名の男性
をパネルとし、実施例1〜3及び比較例1〜4のファン
デーション7品について色素沈着抑制効果を測定した。
すなわち、背部に各試料を2mg/cm2塗布した後
(1名につき3品、1品につき12名)、UV−Aを4
0J/cm2照射し、1週間後の黒化度合いを以下の基
準により評価した。結果を表3に示す。(Test method) 28 males aged 25 to 45 years were used as a panel, and the pigmentation suppressing effect was measured for 7 foundation products of Examples 1 to 3 and Comparative Examples 1 to 4.
That is, after applying 2 mg / cm 2 of each sample on the back (3 items per person, 12 items per item), UV-A was applied to 4 parts.
The degree of blackening one week after irradiation with 0 J / cm 2 was evaluated according to the following criteria. The results are shown in Table 3.
【0026】(評価基準) 評価 状態 有効 黒化が認められない やや有効 わずかな黒化が認められる 無効 強い黒化が観察される(Evaluation Criteria) Evaluation state Effective blackening is not recognized Slightly effective Blackening is recognized Ineffective Strong blackening is observed
【0027】[0027]
【表3】 [Table 3]
【0028】表3の結果に示される様に本発明品はUV
−A照射による色素沈着を効果的に抑制することが明ら
かとなった。As shown in the results of Table 3, the product of the present invention is UV
It became clear that pigmentation by -A irradiation was effectively suppressed.
【0029】実施例4〜6及び比較例5〜8 乳液 表4に示す組成及び下記製法で乳液を作成し、その光加
齢防止効果を調べた。その結果を表5に示す。Examples 4 to 6 and Comparative Examples 5 to 8 Emulsion An emulsion was prepared with the composition shown in Table 4 and the following production method, and its photoaging resistance effect was examined. The results are shown in Table 5.
【0030】[0030]
【表4】 [Table 4]
【0031】(製法) A.成分(6)を成分(14)の一部に分散させる。 B.成分(7)〜(10)、(13)及び(14)の残
量を加熱混合し70℃に保つ。 C.成分(1)〜(5)及び成分(11)を加熱混合
し、70℃に保つ。 D.CにBを加えて均一に混和した後、成分(12)及
びAを加えて均一に乳化し、30℃まで冷却して乳液を
得る。(Production method) A. Ingredient (6) is dispersed in a portion of ingredient (14). B. The remaining amounts of the components (7) to (10), (13) and (14) are mixed by heating and kept at 70 ° C. C. The components (1) to (5) and the component (11) are mixed by heating and kept at 70 ° C. D. After adding B to C and mixing uniformly, the components (12) and A are added to uniformly emulsify, and the mixture is cooled to 30 ° C. to obtain an emulsion.
【0032】(試験方法)6週齢のヘアレスマウスにU
V−Aを照射して作成する光加齢モデルマウスに対する
効果を測定した。すなわち42J/cm2のUV−Aを
週5回の頻度で連続20週間照射し、試料はマウス背部
に0.1ml/匹を塗布した。各群6匹ずつとし、しわ
形成及び光加齢の特徴的な現象であるエラスチン沈着に
ついて以下の基準によりスコア評価を行った。しわ形成
については皮膚外観の観察により行い、エラスチン沈着
については背部皮膚を採取後に組織切片を作成しそれを
フォンタナマッソン染色したものを光顕観察によりそれ
ぞれスコア評価した。各スコアは1匹ずつ付けたのち1
群6匹のスコア値を平均して結果とした。結果を表5に
示す。(Test method) U was applied to 6-week-old hairless mice.
The effect on the photo-aging model mouse produced by irradiating VA was measured. That is, 42 J / cm 2 of UV-A was irradiated 5 times a week for 20 consecutive weeks, and 0.1 ml / mouse was applied to the back of the mouse as a sample. Six animals were used in each group, and scored for elastin deposition, which is a characteristic phenomenon of wrinkle formation and photoaging, according to the following criteria. Wrinkle formation was observed by observing the appearance of the skin, and elastin deposition was evaluated by observing the tissue sections of the dorsal skin and then staining them with Fontana Masson by light microscopy. 1 for each score
The scores of 6 animals in the group were averaged to obtain the result. Table 5 shows the results.
【0033】(評価基準) <しわ形成スコア> スコア 状態 0 しわがない 1 細かいしわがある 2 粗いしわがある <エラスチン沈着スコア> スコア 状態 0 エラスチン沈着なし 1 エラスチン沈着わずかにあり 2 エラスチン沈着あり(Evaluation Criteria) <Wrinkle formation score> Score State 0 No wrinkles 1 Fine wrinkles 2 Coarse wrinkles <Elastin deposition score> Score state 0 No elastin deposition 1 Slight elastin deposition 2 Elastin deposition
【0034】[0034]
【表5】 [Table 5]
【0035】表5の結果に示される様に本発明品はしわ
形成およびエラスチン沈着を抑制することによりUV−
Aによる光加齢を効果的に抑制することが明らかとなっ
た。As shown in the results of Table 5, the product of the present invention suppresses wrinkle formation and elastin deposition, and thus UV-
It was revealed that the photoaging due to A was effectively suppressed.
【0036】実施例7〜9及び比較例9〜12 ク
リーム 表6に示す組成及び下記製法でクリームを作成し、その
美肌効果を調べた。その結果を表7に示す。Creams of Examples 7 to 9 and Comparative Examples 9 to 12 Creams having the compositions shown in Table 6 and the following production method were prepared, and the skin beautifying effect was examined. Table 7 shows the results.
【0037】[0037]
【表6】 [Table 6]
【0038】(製法) A.成分(13)の一部で成分(8)を分散させる。 B.成分(1)〜(7)及び成分(10)〜(12)を
加熱混合により均質とし、70℃に保つ。 C.成分(9)及び成分(13)の残量を加熱混合し、
70℃に保つ。 D.CにBを加えて乳化した後、Aを添加混合し、30
℃まで冷却してクリームを得る。(Production Method) A. The component (8) is dispersed in a part of the component (13). B. The components (1) to (7) and the components (10) to (12) are homogenized by heating and mixed, and kept at 70 ° C. C. The remaining amounts of the component (9) and the component (13) are heated and mixed,
Keep at 70 ° C. D. After adding B to C and emulsifying, add A and mix,
Cool to ℃ to obtain a cream.
【0039】(試験方法)被験クリーム1品につき27
〜54才の女性15名をパネルとし、毎日朝夕2回12
週間被験クリームを適量塗布し、くすみときめの改善効
果を評価することで本発明品の美肌効果を評価した。(Test method) 27 per cream of test
~ 15 women aged 54 years old will be on the panel, and twice a day every morning 12
The test cream was applied in an appropriate amount for a week, and the effect of improving the skin tone of the present invention was evaluated by evaluating the effect of improving dullness and texture.
【0040】(評価基準) <くすみ評価> 評価 状態 有効 くすみが目立たなくなった やや有効 くすみがあまり目立たなくなった 無効 使用前と変化なし <きめ評価> 評価 状態 有効 きめがよく整った やや有効 きめがわずかに整った 無効 使用前と変化なし(Evaluation Criteria) <Dullness evaluation> Evaluation state Effective Dullness is less noticeable Effective Dullness is less noticeable Invalid Before use and no change <Texture evaluation> Evaluation state Effective Good texture and slightly effective Texture is slight Aligned to invalid before use and unchanged
【0041】[0041]
【表7】 [Table 7]
【0042】表7の結果に示される様に本発明品は連続
使用によりくすみを目立たなくし、且つきめを整える効
果を持つことから美肌効果を示すことが明らかとなっ
た。As shown in the results in Table 7, the product of the present invention has the effect of making dullness inconspicuous and adjusting the texture by continuous use.
【0043】実施例10 軟膏: (成分) (%) (1)ステアリン酸 18.0 (2)セタノール 4.0 (3)トリエタノールアミン 2.0 (4)グリセリン 5.0 (5)メロン抽出物 *1 1.0 (6)ジメトキシベンジリデンジオキソイミダゾリジン プロピオン酸2−エチルヘキシル *2 0.1 (7)精製水 残量Example 10 Ointment: (Component) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Melon extraction Substance * 1 1.0 (6) Dimethoxybenzylidene dioxoimidazolidine 2-ethylhexyl propionate * 2 0.1 (7) Purified water Remaining amount
【0044】*1製造例1で製造したもの *2味の素社製* 1 Manufactured in Manufacturing Example 1 * 2 Manufactured by Ajinomoto Co., Inc.
【0045】(製法) A.成分(3)、(4)、(6)及び(7)の一部を加
熱混合し、75℃に保つ。 B.成分(1)及び(2)を加熱混合し、75℃に保
つ。 C.AをBに徐々に加える。 D.Cを冷却しながら(7)の残部で溶解した(5)を
加え、軟膏を得た。(Production Method) A. A part of the components (3), (4), (6) and (7) is mixed by heating and kept at 75 ° C. B. Heat mix components (1) and (2) and maintain at 75 ° C. C. Add A slowly to B. D. While cooling C, (5) dissolved in the rest of (7) was added to obtain an ointment.
【0046】実施例10の軟膏はシワの形成及びエラス
チン沈着を抑制し、UV−Aによる光加齢を効果的に抑
制するものであった。The ointment of Example 10 suppressed the formation of wrinkles and the deposition of elastin, and effectively suppressed the photoaging due to UV-A.
【0047】実施例11 パック: (成分) (%) (1)ポリビニルアルコール 20.0 (2)エチルアルコール 20.0 (3)グリセリン 5.0 (4)カオリン 6.0 (5)鶏冠抽出物 *1 1.0 (6)微細亜鉛華 *2 3.0 (7)防腐剤 適量 (8)香料 適量 (9)精製水 残量Example 11 Pack: (Component) (%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Chicken comb extract * 1 1.0 (6) Fine zinc white * 2 3.0 (7) Preservative proper amount (8) Perfume proper amount (9) Purified water remaining amount
【0048】*1製造例2で製造したもの *2堺化学社製* 1 manufactured in Production Example 2 * 2 manufactured by Sakai Chemical Co., Ltd.
【0049】(製法) A.成分(1)、(3)、(4)及び(9)を混合し、
70℃に加熱し、攪拌する。 B.成分(2)、(7)及び(8)を混合する。 C.上記Bを先のAに加え、混合した後、冷却して
(5)、(6)を均一に分散してパックを得た。(Production method) Mixing components (1), (3), (4) and (9),
Heat to 70 ° C. and stir. B. Mix components (2), (7) and (8). C. The above B was added to the above A, mixed, cooled, and (5) and (6) were uniformly dispersed to obtain a pack.
【0050】実施例11のパックはUV−A照射による
色素沈着を効果的に抑制し、透明感のある肌とするもの
であった。The pack of Example 11 effectively suppressed pigmentation due to UV-A irradiation and gave a transparent skin.
【0051】実施例12 化粧水: (成分) (%) (1)グリセリン 2.0 (2)1,3−ブチレングリコール 2.5 (3)ポリオキシエチレン(20E.O.) ソルビタンモノラウレート 1.2 (4)エチルアルコール 8.0 (5)ヤシャジツ抽出物 *1 1.0 (6)2−ヒドロキシ−4−メトキシベンゾフェノン− 5−スルフォン酸ナトリウム *2 0.5 (7)防腐剤 適量 (8)香料 適量 (9)精製水 残量Example 12 Lotion: (Component) (%) (1) Glycerin 2.0 (2) 1,3-butylene glycol 2.5 (3) Polyoxyethylene (20EO) sorbitan monolaurate 1.2 (4) Ethyl alcohol 8.0 (5) Yashajitsu extract * 1 1.0 (6) 2-Hydroxy-4-methoxybenzophenone-5-sulphonate sodium * 2 0.5 (7) Preservative Suitable amount (8) Perfume proper amount (9) Purified water remaining amount
【0052】*1製造例3で製造したもの *2湘南化学工業社製* 1 Manufactured in Manufacturing Example 3 * 2 Manufactured by Shonan Chemical Industry Co., Ltd.
【0053】(製法) A.成分(3)、(4)、(7)及び(8)を混合溶解
する。 B.成分(1)、(2)、(5)、(6)及び(9)を
混合溶解する。 C.AとBを混合して均一にし、化粧水を得た。(Production Method) A. Components (3), (4), (7) and (8) are mixed and dissolved. B. Components (1), (2), (5), (6) and (9) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.
【0054】実施例13の化粧水はUV−A照射による
シワの形成を効果的に抑制し、キメの整った美しい肌と
するものであった。The lotion of Example 13 effectively suppressed the formation of wrinkles due to UV-A irradiation, and made the skin smooth and beautiful.
【0055】[0055]
【発明の効果】本発明の皮膚外用剤はカタラーゼ作用を
示す物質とUV−A吸収剤及び/又はUV−A散乱剤と
を含有することにより、UV−Aによるダメージを効果
的に防ぐことが出来、更には色素沈着抑制効果及び/又
は老化防止効果に優れたものである。INDUSTRIAL APPLICABILITY The external preparation for skin of the present invention contains a substance showing a catalase action and a UV-A absorber and / or a UV-A scatterer to effectively prevent damage by UV-A. It is excellent in pigmentation suppressing effect and / or aging preventing effect.
フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 FI 技術表示箇所 A61K 7/02 A61K 7/02 Z 7/42 7/42 35/12 AED 35/12 AED 35/18 35/18 35/407 ADA 35/407 ADA 35/70 35/70 35/74 35/74 D 35/78 35/78 C J 38/44 ADS C09K 3/00 104 C09K 3/00 104 A61K 37/50 ADS Continuation of front page (51) Int.Cl. 6 Identification number Office reference number FI Technical display location A61K 7/02 A61K 7/02 Z 7/42 7/42 35/12 AED 35/12 AED 35/18 35 / 18 35/407 ADA 35/407 ADA 35/70 35/70 35/74 35/74 D 35/78 35/78 C J 38/44 ADS C09K 3/00 104 C09K 3/00 104 A61K 37/50 ADS
Claims (9)
収剤及び/又はUV−A散乱剤とを含有することを特徴
とする皮膚外用剤。1. An external preparation for skin comprising a substance exhibiting a catalase action and a UV-A absorber and / or a UV-A scatterer.
であることを特徴とする請求項1記載の皮膚外用剤。2. The external preparation for skin according to claim 1, wherein the substance exhibiting a catalase action is catalase.
質であることを特徴とする請求項1記載の皮膚外用剤。3. The external preparation for skin according to claim 1, wherein the substance having a catalase action is an animal-derived substance.
ミの肝臓抽出物、ウシ、ウマ、イヌ、ネズミの赤血球抽
出物、鶏冠抽出物から選ばれる一種又は二種以上である
ことを特徴とする請求項3記載の皮膚外用剤。4. The animal-derived substance is one or more selected from bovine, equine, canine, and murine liver extracts, bovine, equine, canine, and murine red blood cell extracts, and chicken cob extracts. The external preparation for skin according to claim 3.
質であることを特徴とする請求項1記載の皮膚外用剤。5. The external preparation for skin according to claim 1, wherein the substance exhibiting a catalase action is a plant-derived substance.
ビ、大豆、イチジク、落花生、クロロプラスト、アカメ
ガシワ、ヤシャジツ、ヤコウトウ、カイドウヒ、トマ
ト、メロン、リンゴ、ナシ、バナナの抽出物及び/又は
圧搾物から選ばれる一種又は二種以上であることを特徴
とする請求項5記載の皮膚外用剤。6. The plant-derived substance is selected from spinach, horseradish, soybean, fig, peanut, chloroplast, red sprout, yashajitsu, yakkouto, kaidouhi, tomato, melon, apple, pear, banana extract and / or pressed product. The external preparation for skin according to claim 5, wherein the external preparation is one kind or two or more kinds.
物質であることを特徴とする請求項1記載の皮膚外用
剤。7. The external preparation for skin according to claim 1, wherein the substance exhibiting a catalase action is a substance derived from a microorganism.
ディクティカス(Micrococcus lysod
eikticus)、アスペルギルス ニガー(Asp
ergillus niger)の抽出物から選ばれる
一種又は二種以上であることを特徴とする請求項7記載
の皮膚外用剤。8. The microorganism-derived substance is Micrococcus lysod.
eikticus), Aspergillus niger (Asp
The external preparation for skin according to claim 7, which is one kind or two or more kinds selected from the extract of Ergillus niger).
収剤及び/又はUV−A散乱剤とを含有することを特徴
とする色素沈着抑制効果及び/又は老化防止効果を有す
るUV−A傷害防御用の皮膚外用剤。9. A UV-A injury defense having a pigmentation-inhibiting effect and / or an aging-preventing effect, which comprises a substance exhibiting a catalase action and a UV-A absorber and / or a UV-A scattering agent. External preparation for skin.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9033211A JPH09291023A (en) | 1996-03-01 | 1997-01-31 | Preparation for external use for skin |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7117896 | 1996-03-01 | ||
JP8-71178 | 1996-03-01 | ||
JP9033211A JPH09291023A (en) | 1996-03-01 | 1997-01-31 | Preparation for external use for skin |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH09291023A true JPH09291023A (en) | 1997-11-11 |
Family
ID=26371871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9033211A Pending JPH09291023A (en) | 1996-03-01 | 1997-01-31 | Preparation for external use for skin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH09291023A (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999047006A1 (en) * | 1998-03-19 | 1999-09-23 | Sunstar Inc. | Foods, medical treatments and method relating to effects of promoting the growth of lactobacillus bifidus, preventing allergy and lowering human cholesterol level |
JP2000128728A (en) * | 1998-10-20 | 2000-05-09 | Ichimaru Pharcos Co Ltd | Cosmetic composition |
WO2001019331A1 (en) * | 1999-09-10 | 2001-03-22 | Henkel Kommanditgesellschaft Auf Aktien | Skin care product containing a catalase |
JP2001114634A (en) * | 1999-10-12 | 2001-04-24 | Pola Chem Ind Inc | Catalase protecting agent and antiager cosmetic including the same |
US6426080B1 (en) | 1998-06-24 | 2002-07-30 | Coty, B.V. | Cosmetic preparation of active substances with high protection factor against free radicals |
WO2004030645A1 (en) * | 2002-10-02 | 2004-04-15 | Societe D'extraction Des Primcipes Actifs (Vincience) | Use of a pear must extract as active principle in a cosmetic and/or pharmaceutical composition |
JP2004189663A (en) * | 2002-12-11 | 2004-07-08 | Ichimaru Pharcos Co Ltd | Maillard reaction inhibitor |
JP2012031133A (en) * | 2010-06-30 | 2012-02-16 | Fancl Corp | Proteasome activator |
JP2017088545A (en) * | 2015-11-11 | 2017-05-25 | 株式会社らいむ | Ultraviolet hazard alleviating composition, method for producing ultraviolet hazard alleviating composition, additive for culture medium, additive for microorganism diluent, culture medium, microorganism diluent, external preparation and cosmetics |
JP6173543B1 (en) * | 2016-08-17 | 2017-08-02 | マイスターバイオ株式会社 | External composition containing pterostilbene glycoside |
CN108938515A (en) * | 2018-07-04 | 2018-12-07 | 广西香蕉谷科技有限公司 | A kind of Banana facial mask preparation method and Banana facial mask obtained by this method |
-
1997
- 1997-01-31 JP JP9033211A patent/JPH09291023A/en active Pending
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999047006A1 (en) * | 1998-03-19 | 1999-09-23 | Sunstar Inc. | Foods, medical treatments and method relating to effects of promoting the growth of lactobacillus bifidus, preventing allergy and lowering human cholesterol level |
US6426080B1 (en) | 1998-06-24 | 2002-07-30 | Coty, B.V. | Cosmetic preparation of active substances with high protection factor against free radicals |
JP2000128728A (en) * | 1998-10-20 | 2000-05-09 | Ichimaru Pharcos Co Ltd | Cosmetic composition |
WO2001019331A1 (en) * | 1999-09-10 | 2001-03-22 | Henkel Kommanditgesellschaft Auf Aktien | Skin care product containing a catalase |
JP2001114634A (en) * | 1999-10-12 | 2001-04-24 | Pola Chem Ind Inc | Catalase protecting agent and antiager cosmetic including the same |
WO2004030645A1 (en) * | 2002-10-02 | 2004-04-15 | Societe D'extraction Des Primcipes Actifs (Vincience) | Use of a pear must extract as active principle in a cosmetic and/or pharmaceutical composition |
JP2004189663A (en) * | 2002-12-11 | 2004-07-08 | Ichimaru Pharcos Co Ltd | Maillard reaction inhibitor |
JP2012031133A (en) * | 2010-06-30 | 2012-02-16 | Fancl Corp | Proteasome activator |
JP2017088545A (en) * | 2015-11-11 | 2017-05-25 | 株式会社らいむ | Ultraviolet hazard alleviating composition, method for producing ultraviolet hazard alleviating composition, additive for culture medium, additive for microorganism diluent, culture medium, microorganism diluent, external preparation and cosmetics |
JP6173543B1 (en) * | 2016-08-17 | 2017-08-02 | マイスターバイオ株式会社 | External composition containing pterostilbene glycoside |
JP2018027906A (en) * | 2016-08-17 | 2018-02-22 | マイスターバイオ株式会社 | External composition containing pterostilbene glucoside |
CN108938515A (en) * | 2018-07-04 | 2018-12-07 | 广西香蕉谷科技有限公司 | A kind of Banana facial mask preparation method and Banana facial mask obtained by this method |
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