JPH09225029A - Injector and its manufacture - Google Patents

Injector and its manufacture

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Publication number
JPH09225029A
JPH09225029A JP8063714A JP6371496A JPH09225029A JP H09225029 A JPH09225029 A JP H09225029A JP 8063714 A JP8063714 A JP 8063714A JP 6371496 A JP6371496 A JP 6371496A JP H09225029 A JPH09225029 A JP H09225029A
Authority
JP
Japan
Prior art keywords
gasket
outer cylinder
injection
syringe
inner diameter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8063714A
Other languages
Japanese (ja)
Inventor
Kazuya Araki
Keinosuke Isono
啓之介 磯野
和也 荒木
Original Assignee
Material Eng Tech Lab Inc
株式会社新素材総合研究所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Material Eng Tech Lab Inc, 株式会社新素材総合研究所 filed Critical Material Eng Tech Lab Inc
Priority to JP8063714A priority Critical patent/JPH09225029A/en
Publication of JPH09225029A publication Critical patent/JPH09225029A/en
Application status is Pending legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M2005/1787Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3129Syringe barrels
    • A61M2005/3132Syringe barrels having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3129Syringe barrels
    • A61M5/3134Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3129Syringe barrels
    • A61M5/3135Syringe barrels characterised by constructional features of the proximal end

Abstract

PROBLEM TO BE SOLVED: To enable previous mounting of an injection needle at an injection port without disturbing high pressure steam sterilization and filling of an injection agent into an outer cylinder with neary no mixed air by arranging the outer cylinder as a thermoplastic resin molded product with the inner diameter of a gasket insertion opening part larger than the inner diameter of a sliding part of the gasket.
SOLUTION: An insertion opening part 2C of a gasket 4 of an outer cylinder 2 has its inner diameter L larger than the inner diameter M of a sliding part 2B of the gasket 4. More concretely, the insertion opening part 2C of the gasket 4 is a thermoplastic resin molded product which is formed by expanding gradually. Gradually tapered expansion is not necessary as the shape of the opening part 2C. It suffices that air in the outer cylinder 2 can escape from a gap between the gasket 4 and the inner wall of the outer cylinder 2 when the injection agent 6 is housed and sealed by the gasket 4. A plug body 5 is arranged at a sliding part 2B of the outer cylinder 2 spaced at an interval from an injection port 2A avoiding a ridge rib 11 and the injection agent 6 undergoes a steam sterilization to be housed into the outer cylinder 5 between the gasket 4 and the plug body 5.
COPYRIGHT: (C)1997,JPO

Description

【発明の詳細な説明】 DETAILED DESCRIPTION OF THE INVENTION

【0001】 [0001]

【産業上の利用分野】本発明は、予め注射剤が充填された注射器に関するものであり、より詳細には、外筒への注射剤の充填に際して、殆どエアが混入せず、高圧蒸気滅菌に支障の生じない注射器及びその製造方法に関するものである。 BACKGROUND OF THE INVENTION The present invention relates to pre-injection syringe is filled, more particularly, when injection-filled in the outer tube, mostly air not mixed, the autoclaving it relates syringe and its manufacturing method does not cause trouble.

【0002】 [0002]

【従来の技術】最近、医療事故を未然に防止するために、また院内感染等を極力防止するために、予め滅菌又は無菌状態で外筒内に薬剤又は薬液等の注射剤が充填されたプレフィールドシリンジと一般に称される注射器が提案されている。 Recently, in order to prevent medical accidents and to prevent nosocomial infections such as much as possible, the pre-to injections of such drugs or drug solution into the barrel at a pre-sterilized or aseptically filled field syringe and commonly referred to as the syringe has been proposed. また、かかるプレフィールドシリンジには二医薬成分以上の注射剤がその注射時まで分離して充填されている多成分用注射器も提案されている。 It has also been proposed a syringe for a multi-component second medicament component or more injections are filled in isolation until its injection to such pre-field syringe.

【0003】従来、注射器には、外筒の射出口部に密閉キャップが装着され、外筒の基端挿入開口からはプランジャーのガスケットが挿入され、かかるガスケット内に注射剤が収容されている。 Conventionally, the syringe is sealed cap to the injection port of the outer cylinder is mounted, from the proximal end insertion opening of the outer cylinder is inserted a gasket of the plunger, injections are accommodated in such a gasket . そして、注射剤を外筒内に充填する場合は、先ずガスケットが外筒内に所定の位置まで挿入され、次に、外筒の射出口から注射剤が充填され、充填後に密閉キャップが射出口に装着される。 When filling the injection into the barrel, the first gasket is inserted to a predetermined position in the outer tube, then injection from the injection port of the outer cylinder is filled with sealing cap injection port after filling It is attached to. かかる状態で注射器が高圧蒸気滅菌にかけられる。 Syringe this state is subjected to high pressure steam sterilization. この場合、注射剤は外筒の射出口から充填するため、外筒内にエアが殆どない状態で充填することができる。 In this case, injections for filling from the injection port of the outer cylinder can be filled while the air little into the barrel.

【0004】 [0004]

【発明が解決しようとする課題】しかしながら、従来の注射器では、外筒の射出口に密閉キャップを備えているため、予め注射針を射出口に取り付けることができない。 [SUMMARY OF THE INVENTION However, in the conventional syringe, due to the provision of a sealing cap on the injection port of the outer cylinder, it is not possible to attach the pre-injection needle into the injection port. このため、注射器の使用時には病院での注射針の取付操作を要し、院内感染のおそれが生じる。 Therefore, it takes the mounting operation of the injection needle in the hospital during use of the syringe, the risk of nosocomial infections occur. また、二成分用注射器などでは、ガスケットと栓体との間に注射液を充填するため、ガスケットの挿入開口から注射液を充填するが、エアなどの外筒内に残存するという不都合があり、このようなエアの残存状態で注射器の高圧蒸気滅菌を行うと、外筒内にエアにより圧力差が生じ、熱可塑性樹脂外筒を変形させるという問題がある。 Also, in such two-component syringe, to fill the injection liquid between the gasket and the plug, filling the injectable solution from the insertion opening of the gasket, but there is a disadvantage that remains in the outer cylinder such as an air, Doing syringe autoclaved at residual state of this air, the pressure difference by the air is caused in the outer tube, there is a problem of deforming the thermoplastic resin outer tube.

【0005】従って、本発明の目的は、外筒への注射剤の充填に際して、殆どエアが混入せず、高圧蒸気滅菌に支障の生じない、しかも予め射出口に注射針を取り付けて置くことのできる注射器及びその製造方法を提供することにある。 It is therefore an object of the present invention, when injection-filled in the outer tube, hardly air contamination, does not cause trouble in the high-pressure steam sterilization, yet of placing the injection needle attached to a previously injection port to provide a syringe and a manufacturing method thereof.

【0006】 [0006]

【課題を解決するための手段】本発明は、予め外筒内に注射剤が収容される注射器において、上記外筒は、ガスケットの挿入開口部の内径(L)が該ガスケットの摺動部の内径(M)より大径に形成された熱可塑性樹脂成形物であることを特徴とする注射器を提供することにより、上記目的を達成したものである。 The present invention SUMMARY OF THE INVENTION, in advance syringe injections into the outer cylinder is housed, the outer tube has an inner diameter of the insertion opening of the gasket (L) of the sliding portion of the gasket by providing a syringe, which is a thermoplastic resin molded product formed in the larger diameter than the inner diameter (M), in which to achieve the above objects. 本発明はまた、上記注射器において、上記注射剤を上記ガスケットの挿入開口から上記外筒内に充填し、且つ上記挿入開口部の内径(L)の形成位置より上位の液位まで満たし、次に、 The present invention also provides, in the syringe, filled with the injection from the insertion opening of the gasket is filled in the outer tube, until and upper liquid level than the formation position of the inner diameter of the insertion opening (L), then ,
上記ガスケットを上記開口の上方から挿入して上記注射剤を液密に上記外筒内に充填し、その後、上記外筒と共に注射剤を高圧蒸気滅菌することを特徴とする注射器の製造方法を提供することにより、上記目的を達成したものである。 The gasket is inserted from above the opening is filled in the outer tube in a liquid-tight manner the injections, then, provides a method for producing a syringe which is characterized in that the high-pressure steam sterilization injections with the outer tube by, in which to achieve the above objects.

【0007】 [0007]

【作用】上記注射器の外筒では、例えば図3に示す状態で外筒内に注射剤を充填し、上方からガスケットを挿入していくと、図4に示す如く、外筒内のエアは末広がりの開口の側壁から逃げ出ることができ、注射剤を末広がりの開始位置より多少高い位値に液位があれば、注射剤はガスケットから微量はみ出した状態で外筒内に液密に充填され、この結果、殆どのエアが外筒内から除かれることなる。 [Action] In the barrel of the syringe, for example by filling an injection into the barrel in the state shown in FIG. 3, when we insert the gasket from above, as shown in FIG. 4, the air in the outer tube flared can of escape from the side wall of the opening, if any liquid level injections somewhat higher position value than divergent starting position, injection is filled in a liquid tight manner to the outer cylinder in a state of protruding traces from the gasket, as a result, that most of the air is removed from the outer cylinder. また、このようなガスケットの挿入開口を介して注射剤を充填する方法では、図1に示す如く射出口に密閉キャップを設ける必要はなく、外筒内に開放可能な栓体を配して射出口等に予め注射針を取り付けることができる。 In the method of filling the injection through the insertion opening of such a gasket, it is not necessary to provide a closure cap on the injection port, as shown in FIG. 1, morphism by arranging an openable stopper into the barrel it can be attached in advance injection needle outlet and the like.

【0008】 [0008]

【実施例】以下、本発明に係る注射器の好ましい実施例を添付図面を参照しながら詳述する。 EXAMPLES The following will be described in detail with reference to the accompanying drawings a preferred embodiment of the injector according to the present invention. 図1は本発明の注射器の第一実施例の側断面図、図2は図1のI−I線に沿った注射器の断面図、図3(A)及び(B)は図1の注射器の組立途中の側断面図、図4は図1の注射器の組立途中の側断面図、図5及び図6は第一実施例における注射器の使用時の側断面図である。 Figure 1 is a side sectional view of a first embodiment of the syringe of the present invention, FIG 2 is the syringe sectional view taken along line I-I in FIG. 1, FIG. 3 (A) and (B) is in Fig. 1 syringe sectional side view of the middle assembly, and FIG. 4 is a syringe assembly during the side sectional view of FIG. 1, FIGS. 5 and 6 are a side sectional view of when use of the syringe in the first embodiment.

【0009】図1〜図6に示す第一実施例の注射器1 [0009] The syringe 1 of the first embodiment shown in FIGS. 1 to 6
は、予め外筒内に注射剤が収容される注射器であり、外筒2は、ガスケット4の挿入開口部2Cの内径(L)がガスケット4の摺動部2Bの内径(M)より大径に形成された熱可塑性樹脂成形物である。 In advance a syringe injection is accommodated in the outer cylinder, the outer cylinder 2, larger diameter than the inner diameter (M) of the sliding portion 2B inner diameter (L) of the gasket 4 in the insertion opening 2C of the gasket 4 a thermoplastic resin molded product formed. 即ち、本実施例のガスケット4の挿入開口部2Cは末広がりに形成されている。 That is, the insertion opening 2C of the gasket 4 in this embodiment is formed diverging.

【0010】本実施例の注射器1を更に説明すると、本実施例の注射器1の外筒2は、熱可塑性樹脂の成形物で、射出成形により成形される。 [0010] Further describing the injector 1 of this embodiment, the outer cylinder 2 of the syringe 1 of this embodiment is a molded product of a thermoplastic resin is molded by injection molding. 外筒2には予め注射針7がセットされるため、外筒2の奥部には栓体5が配され、栓体5に開放機能を持たせるため後述する凸条リブ11が形成されている。 Since the pre-injection needle 7 in the outer tube 2 is set, the inner part of the outer cylinder 2 is arranged, the plug 5, are formed ridge ribs 11 to be described later for imparting release function to plug 5 there. 熱可塑性樹脂成形物としては、 The thermoplastic resin molded product,
例えば、低密度或は高密度ポリエチレン、ポリプロピレン、ポリブタジエン−1等のポリオレフィン類、ポリ塩化ビニル、ポリ塩化ビニリデン、塩化ビニリデン共重合体、ポリメタクリル酸メチル、ポリビニルアルコール、 For example, low-density or high density polyethylene, polypropylene, polyolefins such as polybutadiene -1, polyvinyl chloride, polyvinylidene chloride, vinylidene chloride copolymer, polymethyl methacrylate, polyvinyl alcohol,
エチレン−ビニルアルコール共重合体、アクリロニトリル共重合体、ポリエチレンテレフタレート等を挙げることができる。 Ethylene - vinyl alcohol copolymer, acrylonitrile copolymer, and polyethylene terephthalate. 特に、ポリオレフィン類は汎用性及び薬剤に影響を与えない点で好ましく、更には非晶質の環状のオレフィンコポリマー等の高いガラス転移温度を有し比重が1.0〜1.1のものが望ましい。 Especially, polyolefins preferably in that it does not affect the versatility and drug, even gravity has a glass transition temperature higher, such as olefin copolymers amorphous annular desirable ones 1.0-1.1 . 具体的には、光デイスク基板、光学レンズなどの材料として最近用いられている商標名ゼオネックス(日本ゼオン株式会社)、 Specifically, the optical disc substrate, tradename ZEONEX, which is currently used as a material for optical lens (Nippon Zeon Co., Ltd.),
商標名アペル(三井石油化学工業株式会社)等のポリオレフィン系樹脂である。 Trade name APEL is a polyolefin-based resin (Mitsui Petrochemical Industries Co., Ltd.), and the like.

【0011】栓体5は、射出口2Aから一定間隔あけてガスケット4側に設けられ、栓体5と射出口2Aとの間の外筒2部分の内側壁には、外筒2の軸方向に延びる凸条リブ11、11・・・が形成され、栓体5が射出口2 [0011] stopper 5 is provided in the gasket 4 side spaced a predetermined distance from the exit opening 2A, on an inner wall of the outer tube 2 the portion between the exit 2A and stopper 5, the outer cylinder 2 axially ridge ribs 11, 11 extending ... are formed, the plug 5 is injection port 2
Aに達する際に、凸条リブ11、11・・・により栓体5の外周壁が弾性変形して注射剤6が射出口2Aに流通する空隙が形成される。 When reaching the A, injections 6 gap flowing into the injection port 2A is formed an outer peripheral wall of the plug 5 by ridges ribs 11, 11, ... are elastically deformed. ガスケット4及び栓体5は外筒2の内壁と液密を保つ程度の弾性体を有するものであれば良い。 Gasket 4 and the plug 5 may be one having an elastic body to the extent to maintain the liquid-tight and the outer tube 2 inside wall. 具体的にはゴム製のガスケット及びゴム栓が用いられる。 Specifically rubber gasket and rubber stopper is used.

【0012】栓体5と射出口2Aとの間の外筒2の内壁面における複数の凸条リブ11は、外筒2の軸方向に向かって形成される。 [0012] stopper 5 and the injection opening 2A with a plurality of ridges ribs 11 on the inner wall surface of the outer cylinder 2 between are formed toward the axial direction of the outer cylinder 2. 即ち、凸条リブ11は外筒2の成形時の型抜き方向とほぼ同一の方向に向けて形成される。 That is, ridges ribs 11 are formed toward the substantially same direction as the die cutting direction at the time of the outer tube 2 forming.
また、凸条リブ11の数は、1以上、好ましくは3以上、更に好ましく5以上である。 The number of ridges ribs 11, 1 or more, preferably 3 or more, more preferably 5 or more. また凸条リブ11が複数形成される場合は、点対称の配置がなされても良いし、また外筒の一部の内壁面に偏らせて形成しても良い。 In the case where the ridge ribs 11 are plurally formed, to the arrangement of the point symmetry may be made, or may be formed to bias a portion of the inner wall surface of the outer cylinder. また凸条リブ11は外筒2の先端奥部に向かって徐々に隆起したテーパ頂部11Aとなっている。 The ridges rib 11 has a tapered top portion 11A that protrudes gradually toward the tip inner portion of the outer tube 2. テーパは必ずしも必要ではない。 Taper is not always necessary. しかし、かかるテーパ頂部11 However, such a tapered top 11
Aの形成は、成形の型抜き時に型などの影響を受けず、 Formation of A is not affected by such mold when demolding the molded,
スムースに型を抜くことができ、また、注射器1の使用時に栓体5が外筒2の奥深くスムースに挿入することができる。 Smoothly can be pulled out of the mold, also, it is the plug 5 when using the syringe 1 can be inserted deep smooth the outer tube 2.

【0013】図2に示す如く本実施例では外筒2の凸条リブ頂部11Aの最大高さ(w)は1mmである。 [0013] In this embodiment, as shown in FIG. 2 the maximum height of the outer tube 2 ridge rib apex 11A (w) is 1 mm. 凸条リブ頂部11Aの最大高さ(w)は、外筒の内径(M) The maximum height of the ridge rib apex 11A (w) has an inner diameter of the outer cylinder (M)
によって好ましい範囲が決定され、凸条リブ頂部11A The preferred range is determined by, ridge rib apex 11A
の最大高さ(w)が外筒の内径(M)の1/50〜1/ The maximum height of the (w) is the inner diameter of the outer cylinder (M) 1 / 50~1 /
5倍であることが好ましい。 A is preferably 5 times. 凸条リブ頂部11Aの最大高さ(w)が上記範囲を下回ると、外筒2の外周壁と栓体5の内周壁との間に充分な空隙12ができないおそれがあり、上記範囲を上回ると、栓体5の摺動性が悪くなる。 When the maximum height of the ridge rib apex 11A (w) is less than the above range, there may not be sufficient gap 12 between the outer wall and the inner peripheral wall of the plug body 5 of the outer cylinder 2, exceeds the above range and, sliding properties of the plug 5 is poor. また、本実施例の外筒2の射出口2Aが形成される肩部13の内壁には、複数の突起部14が形成され、突起部14により、外筒2の内側壁と栓体5の外周壁との空隙12を流れる注射剤6を射出口2Aに導くための通路が突起部14間に形成される。 Further, the inner wall of the shoulder portion 13 of the exit opening 2A of the outer cylinder 2 is formed in this embodiment, a plurality of projections 14 are formed by protrusions 14, the outer cylinder 2 of the inner wall and the plug 5 passage for guiding the injection 6 flowing gap 12 between the outer wall to the injection port 2A is formed between the projecting portion 14. かかる通路は、必ずしも必要はないが、栓体5が完全に肩部13の内周面に密着して注射剤6の流出通路が塞がれるのを防止している。 Such passages, not necessarily, but to prevent the outflow passage of the injection 6 is closed stopper 5 is in close contact with the inner peripheral surface of the complete shoulder 13. 従って、突起部14を形成する代わりに、肩部13 Thus, instead of forming the projections 14, the shoulder 13
の内壁面に溝状部を形成して射出口2Aまでの通路を確保しても良い。 Passage of the inner wall surface to an exit port 2A to form a groove-like portion of the may also be ensured.

【0014】外筒2のガスケット4の挿入開口部2C [0014] insertion opening 2C of the outer cylinder 2 of the gasket 4
は、その内径(L)がガスケット4の摺動部2Bの内径(M)より大径に形成されている。 Has its inner diameter (L) is formed larger in diameter than the inner diameter (M) of the sliding portion 2B of the gasket 4. 本実施例では具体的に、ガスケット4の挿入開口部2Cは末広がりに形成されている。 Specifically, in this embodiment, the insertion opening 2C of the gasket 4 is formed in a flared. 開口部2Cの形状はテーパ状の末広がりである必要はなく、ガスケット4で注射剤6を密封収容する際に、外筒2内のエアがガスケット4と外筒2内壁との間から逃げ出すようになっていればよい。 The shape of the opening 2C need not be divergent tapered, when the sealing housing the injection 6 with a gasket 4, as the air in the outer tube 2 escapes from between the gasket 4 and the outer tube 2 inside wall it is sufficient that. 従って、内径(L)と内径(M)との間にエアが逃げ出す差がある限り段差形成されたものでも良い。 Accordingly, the inner diameter (L) and inner diameter (M) also may be one which is stepped form as long as there is a difference of air escapes between. 栓体5は凸条リブ11 Plug 5 ridge rib 11
を避けて、射出口2Aから一定間隔あけてガスケット4 The avoiding, gasket 4 spaced a predetermined distance from the exit port 2A
側に配せられ、ガスケット4は最終的に外筒2の摺動部2Bに配されている。 Is Haise on the side, the gasket 4 is finally disposed on the sliding portion 2B of the outer tube 2. ガスケット4と栓体5との間の外筒2内には注射剤6が蒸気滅菌されて収容されている。 The outer cylinder 2 between the gasket 4 and the plug 5 injections 6 is accommodated are steam sterilized.

【0015】次に、上記注射器1の製造方法を説明すると、先ず、射出成形により外筒2に末広がりの挿入開口部2C、凸条リブ11、及び突起部14を正確に形成する。 [0015] Next, explaining the manufacturing method of the syringe 1, first, flared insertion opening 2C the outer tube 2 by injection molding, ridge ribs 11, and to accurately form a protruding portion 14. この場合、挿入開口部2Cが末広がりであり、且つ凸条リブ11が外筒2の軸方向でしかもテーパ状に形成されるため、外筒2を歪ませることなく正確に型抜き成形でき、特に、上述の非晶質のポリオレフィンにおいて正確な成形ができる。 In this case, an insertion opening 2C is divergent, and since the ridges ribs 11 are formed on the outer cylinder Moreover tapered two axial, accurately stamped without distorting the outer tube 2, in particular It can accurately molded in the amorphous polyolefins described above. 図3(A)に示す如く、成形外筒2の先端に注射針7を取付け、外筒2に栓体5を挿入する。 As shown in FIG. 3 (A), fitted with a needle 7 on the tip of the forming barrel 2, to insert the stopper 5 into the outer tube 2. 栓体5は形成凸条リブ11から約栓体5幅分を空けて配する。 Plug 5 is coordinating the forming ridges ribs 11 spaced about the plug body 5 width of. 図3(B)に示す如く、注射剤6をガスケット4の挿入開口2Cから外筒2内に充填し、且つ上記挿入開口部の大径な内径(L)の形成位置Sより上位の液位Hまで満たす。 As shown in FIG. 3 (B), injection 6 was filled into the barrel 2 through the insertion opening 2C of the gasket 4 and the insertion opening larger diameter inner diameter (L) of the forming position higher liquid level than S of meet until H.

【0016】次に、図4に示す如くガスケット4を開口部2Cの上方から挿入して注射剤6を液密に外筒2内に充填する。 Next, filled into the outer cylinder 2 liquid-tightly injections 6 gasket 4 is inserted from above the opening 2C, as shown in FIG. この場合、注射剤6液位表面のエアは、ガスケット4の降下と共に、ガスケット4の外壁と外筒2の内壁の隙間を通って逃げ出し、エアが残存しない状態で注射剤6が充填される。 In this case, air injection 6 liquid level surface, with drops of the gasket 4, escape through the gap of the outer wall and the outer tube 2 the inner wall of the gasket 4, injections 6 is filled in a state where the air does not remain. これは、挿入開口部2Cの大径な内径(L)と摺動部2Bの内径(M)の差により達成されるものである。 This is achieved by the difference in inner diameter of the large-diameter inner diameter (L) and the sliding portion 2B of the insertion opening 2C (M). このようなエアの残留状態で注射剤6が収容されると、高圧蒸気滅菌時等の外部と内部とに差圧が生じる場合でも、外筒2内はエアによる膨縮変化が殆ど見られないので、熱可塑性樹脂の外筒2を熱変形させてしまう虞がない。 When injections 6 residual state of this air is contained, even when the pressure difference outside and inside such high-pressure steam sterilization occurs, the outer cylinder 2 is seen little expansion and contraction change by the air since the outer cylinder 2 of thermoplastic resin there is no fear that by thermally deformed. このため、使用時にガスケット4の摺動性に問題が生じない。 Therefore, it does not occur a problem in slidability of the gasket 4 in use. ガスケット4を図1に示す如く摺動部2Bまで押し下げた後、外筒2と共に注射剤6を高圧蒸気滅菌する。 After depressing the gasket 4 to the sliding portion 2B as shown in FIG. 1, the injection 6 to the high-pressure steam sterilization with the outer tube 2. 尚、高圧蒸気滅菌に際してはガスケット4にプランジャー3を取付ておいても良い。 Incidentally, the plunger 3 to the gasket 4 may be previously attached. Before autoclaving.
高圧蒸気滅菌は、105℃〜140℃、特に好ましくは105℃〜125℃の範囲で蒸気滅菌することが望ましい。 High-pressure steam sterilization, 105 ° C. to 140 ° C., particularly preferably it is desirable to steam sterilization in the range of 105 ° C. to 125 ° C.. かかる範囲であれば、滅菌が確実になされる一方、 With such a range, while sterilization is performed reliably,
外筒2などの熱変形のおそれが少なくなる。 Fear is reduced thermal deformation such as the outer tube 2.

【0017】次に図1、図5及び図6に従って本実施例の注射器1の使用を説明すると、図1の注射器の状態から図5に示す状態までプランジャー3を押し込む。 [0017] Next Fig. 1, describing the use of the syringe 1 of the present embodiment in accordance with FIGS. 5 and 6, pushed the plunger 3 to the state shown in FIG. 5 from the syringe in the state of FIG. この場合、プランジャー3の押し込みにより栓体5が連動し射出口2A側に押し込まれ、栓体5の外周壁には凸状リブ11が食い込む。 In this case, by pushing the plunger 3 interlockingly plug 5 is pushed into the injection port 2A side, convex ribs 11 bites on the outer wall of the plug body 5. これにより、栓体5の外周壁が変形し、栓体5の外周壁と外筒2の内壁との間に空隙が生じ、栓体5とガスケット4との間の注射剤6が空隙を介して射出口2A側に流入可能となる。 Thus, the deformed outer peripheral wall of the plug body 5, the gap occurs between the outer peripheral wall and the outer cylinder 2 of the inner wall of the plug body 5, through the injection 6 is the air gap between the stopper 5 and the gasket 4 It allows flow into the injection port 2A side Te. かかる状態でプランジャー3の押し込みをコントロールしながら外筒2内の全てのエアを押し出したのち、注射針7を患者に刺通する。 After extrusion of all air in the outer cylinder 2 while controlling the pushing of the plunger 3 in such a state, Togedorisuru needle 7 into the patient. 図6に示す如くプランジャー3を完全に押し込み、患者への注射剤6の投与が完了する。 Fully into the plunger 3 as shown in FIG. 6, completing the administration of injections 6 to the patient. このようなガスケットの挿入開口を介して注射剤を充填する方法では、図1に示す如く射出口に密閉キャップを設ける必要はなく、外筒2内に開放可能な栓体5を配して射出口等に予め注射針7を取り付けることができる。 The method of filling an injection through the insertion opening of such a gasket, it is not necessary to provide a closure cap on the injection port, as shown in FIG. 1, morphism by disposing the stopper 5 can be opened to the outer cylinder 2 it can be attached in advance needle 7 to the outlet or the like.

【0018】次に、図7乃至図10に従って本発明の第二実施例の注射器について説明する。 Next, description will be given syringe of the second embodiment of the present invention in accordance with FIGS. 7-10. 図7は本発明の注射器の第二実施例の側断面図である。 Figure 7 is a side sectional view of the syringe of the second embodiment of the present invention. 図8〜図10は第二実施例の注射器のプランジャーを押し込ませた状態を示す側断面図である。 8 to 10 are side sectional views showing a state in which force the plunger of the syringe of the second embodiment. 図7〜図10に示す第一実施例の二液成分用注射器21は、先端部に注射針7が取り付けられる射出口2Aを有した外筒2と、ガスケット4が取り付けられて外筒2に嵌入されるプランジャー3とからなり、また外筒2内の先端奥部に栓体5を配して射出口2Aを塞ぎ栓体5とガスケット4との間に注射剤6 Two component-component syringe of the first embodiment shown in FIGS. 7 to 10 21, an outer tube 2 having an injection port 2A which needle 7 is attached to the distal end, the outer tube 2 and the gasket 4 is mounted consists plunger 3 which is fitted, also injection between the plug body 5 and the gasket 4 closes the exit opening 2A by arranging a plug 5 in the distal inner end of the outer cylinder 2 6
A、6Bが液密充填されている点で、第一実施例の注射器1とほぼ同様な部材及び構造なので、かかる部材については第一実施例の注射器1と同一の符号を賦してその詳しい説明を省略する。 A, in that 6B is liquid-tightly filled, so substantially the same members and structures and the syringe 1 of the first embodiment, for such members and detailed by vehicle by the same reference numerals as the syringe 1 of the first embodiment description thereof will be omitted. また、注射器21の外筒2は熱可塑性樹脂の成形物であり、栓体5は、射出口2Aから一定間隔あけてガスケット4側に設けられ、栓体5と射出口2Aとの間の外筒2部分の内側壁には、外筒2の軸方向に延びる凸条リブ11、11・・・が形成されている点でも、第一実施例の注射器1とほぼ同様な部材及び構造なので、かかる部材については第一実施例の注射器1と同一の符号を賦してその詳しい説明を省略する。 Further, the outer cylinder 2 of the syringe 21 is molded of thermoplastic resin, the plug 5 is provided in the gasket 4 side spaced a predetermined distance from the exit opening 2A, outside between the injection ports 2A and the plug 5 the inner side wall of the cylinder 2 parts, in terms of ridge ribs 11, 11, ... extending in the axial direction of the outer cylinder 2 is formed, so substantially the same members and structures and the syringe 1 of the first embodiment, for such members will be omitted and the detailed description to vehicle by the same reference numerals as the syringe 1 of the first embodiment.

【0019】図7に示す如く注射器21が注射器1と異なる点は、外筒2の挿入開口部2Cが肉薄に形成され、 [0019] The syringe 21 as shown in FIG. 7 is the syringe 1 is different from the insertion opening 2C of the outer tube 2 is formed thin,
摺動部2Bの内径(M)より大径な内径(L)に形成されている。 Than the inner diameter (M) of the sliding portion 2B has a larger diameter inner diameter (L). また挿入開口部2Cの大径部の形成開始位置はテーパ面23で形成され、ガスケット4が摺動部2B The formation starting position of the large diameter portion of the insertion opening 2C is formed with a tapered surface 23, the gasket 4 is sliding portion 2B
に挿入案内されやすくなっている。 Which is likely to be the insertion guide to. また外筒2内のガスケット4及び栓体5との間に仕切り栓体22が設けられ、仕切り栓体22を境にそれぞれ異なる成分の注射剤6A、6Bが充填されている。 The partition stopper 22 is provided between the gasket 4 and the plug 5 of the outer cylinder 2, injections 6A of different components of the partition stopper 22 as a boundary, 6B are filled. 栓体5と射出口2Aとの間の外筒2の内壁面には、第一実施例の注射器1と同様な長めの複数の凸条リブ11が外筒2の軸方向に向かって形成されている。 The inner wall surface of the outer tube 2 between the plug 5 and the injection port 2A, the syringe 1 and similar long plurality of ridges ribs 11 of the first embodiment is formed toward the axial direction of the outer cylinder 2 ing. また凸条リブ11の形成位置またはその長さは、栓体5が弾性変形して栓体5又は仕切り栓体22の外周壁と外筒2の内壁とに空隙が形成される位置により決定される。 The formation position or length of the ridge ribs 11 is determined by the position stopper 5 which is a gap and the outer peripheral wall and the outer tube 2 the inner wall of the plug body 5, or the partition stopper 22 is elastically deformed is formed that.

【0020】注射器21の外筒2は、従来より長く成形される。 The outer cylinder 2 of the syringe 21 is molded conventionally long. 仕切り栓体22はガスケット4及び栓体5と同様に外筒2の内壁と液密を保つ程度の弾性を有するものであれば良い。 The partition plug 22 may be one having a degree of elasticity to keep the liquid-tight and the outer tube 2 an inner wall like the gasket 4 and the plug 5. 具体的にはゴム製のガスケット及びゴム栓と同様なものが用いられる。 Specifically those similar to the rubber gasket and rubber stopper is used. 栓体5と仕切り栓体22 Plug 5 and the partition plug 22
の間には注射剤6Aが収容され、仕切り栓体22とガスケット4の間には注射剤6Bが収容されている。 Between the accommodated injection 6A, injections 6B is accommodated between the partition plug 22 and the gasket 4. 例えば本実施例では注射剤6Aは局部麻酔剤等であり、注射剤6Bは痛みを伴う注射剤である。 For example injection 6A in this embodiment is a local anesthetic, etc., injections 6B are injection painful. 注射剤6A、6Bの滅菌は高圧蒸気滅菌がなされており、これ以外にも無菌充填などが可能であるが、滅菌を確実にするには高圧蒸気滅菌が望ましい。 Injections 6A, sterilization 6B are made autoclave sterilization is susceptible to such also aseptic filling in addition to this, to ensure sterilization autoclave sterilization is desired. 高圧蒸気滅菌は、温度が105℃〜1 High-pressure steam sterilization temperature of 105 ° C. to 1
40℃の範囲であるが、特に、温度が105℃〜125 Is in the range of 40 ° C., in particular at a temperature of 105 ° C. to 125
℃の範囲であることが望ましい。 It is preferably in the range of ° C.. かかる範囲であれば、 With such a range,
外筒2に熱・圧による変形が生じ難い。 Deformation due to heat and pressure hardly occurs in the outer tube 2.

【0021】次に、上記注射器21の製造方法を説明すると、先ず、射出成形により挿入開口部2Cと共に凸条リブ11、及び突起部14を外筒2に正確に形成する。 [0021] Next, explaining the manufacturing method of the syringe 21, firstly, to precisely form projections ribs 11 with the insertion opening 2C by injection molding, and the protruding portion 14 to the outer tube 2.
外筒2に栓体5を所定の深さまで挿入し、注射剤6Aを液位が開口部2Cの大径内径部に達するまで充填する。 The outer tube 2 by inserting the plug body 5 to a predetermined depth, filling the injection 6A until the liquid level reaches the large diameter inner diameter portion of the opening 2C.
注射剤6Aの充填後、仕切り栓体22を上部から外筒2 The outer tube 2 after filling of the injection 6A, the partition stopper 22 from the top
内にエアが残留しない状態で所定の深さまで挿入する。 Air inserted to a predetermined depth with no remaining within.
これにより、栓体5も同時に一定の深さまで移動する。 Thereby, the stopper 5 is also moved at the same time to the predetermined depth.
次に注射剤6Bを外筒2内に充填し、注射剤6Bを液位が開口部2Cの大径内径部に達するまで充填する。 Then filling the injection 6B the outer cylinder 2, to fill the injection 6B until the liquid level reaches the large diameter inner diameter portion of the opening 2C. その充填後、ガスケット4を外筒2内にエアが残留しない状態で挿入する。 After the filling, air gasket 4 into the outer cylinder 2 is inserted in a state where no residual. そして、ガスケット4にプランジャー4 Then, the plunger 4 to the gasket 4
を取付け、射出口2Aにプロテクター付の注射針7を取付ける。 Mounting, attaching the injection needle 7 dated protector exit 2A. かかる状態で、注射器21を高圧蒸気滅菌して注射剤6A、6Bを滅菌する。 In this state, the syringe 21 and the high-pressure steam sterilization is sterile injectable solutions 6A, the 6B.

【0022】次に、本実施例の二液成分用注射器21を用いて注射するには、図7の状態からプランジャー3が押し込まれ、注射剤6A、6Bを介して栓体5及び仕切り栓体22が図8の位置まで押し込まれる。 Next, the injected using a two-liquid component syringe 21 of this embodiment, is pressed plunger 3 from the state of FIG. 7, injections 6A, the plug body 5 and the partition stopper through the 6B body 22 is pushed to the position of FIG. 図8の位置まで押し込まれると、栓体5の外周壁と外筒2の内壁との間に空隙が形成され、栓体5はプランジャー3の押し込みがあっても移動が停止する。 When pushed to the position of FIG. 8, a gap is formed between the outer circumferential wall and the outer cylinder 2 of the inner wall of the plug body 5, the stopper 5 is moved to stop even if the pushing of the plunger 3. 従って、注射剤6Aが一旦急激に空間部99に流入されるが、針先7まで達することがないため漏れでない。 Therefore, although injection 6A is once abruptly flows into the space 99, it does not leak because it is not possible to reach the needle tip 7. 空間部99のエアを追い出した後、注射剤6Aが患者に注射投与される。 After purging the air in the space 99, injection 6A is administered by injection to a patient. 図9の位置まで仕切り栓体22がプランジャー3により押し込まれると、仕切り栓体22の外周壁と外筒2の内壁との間に空隙が形成され、仕切り栓体22はプランジャー3 When the position to the partition stopper 22 in FIG. 9 is pushed by a plunger 3, a gap is formed between the outer circumferential wall and the outer cylinder 2 of the internal wall of the partition stopper 22, the partition stopper 22 is plunger 3
の押し込みがあっても移動が停止する。 Movement is stopped even if there is a push. そして、注射剤6Bが射出口2A側に流入され、プランジャー3が更に押し込まれ、患者の体内に注射投与される。 The injections 6B are flow into the injection port 2A side, the plunger 3 is further pushed, administered by injection into the patient's body. 従って、先に局部麻酔剤が患者に投与され、痛みを麻痺させた状態で、痛みを伴う注射剤6Bを投与することができる。 Therefore, previously the local anesthetic is administered to the patient, while being paralyzed pain can be administered an injection 6B painful.

【0023】 [0023]

【発明の効果】以上説明したように本発明の注射器において、上記外筒は、ガスケットの挿入開口部の内径(L)が該ガスケットの摺動部の内径(M)より大径に形成された熱可塑性樹脂成形物であるので、また上記注射剤を上記ガスケットの挿入開口から上記外筒内に充填し、且つ上記挿入開口部の内径(L)の形成位置より上位の液位まで満たし、次に、上記ガスケットを上記開口の上方から挿入して上記注射剤を液密に上記外筒内に充填し、その後、上記外筒と共に注射剤を高圧蒸気滅菌するので、外筒への注射剤の充填に際して、殆どエアが混入せず、高圧蒸気滅菌に支障の生じない、しかも予め射出口に注射針を取り付けて置くことのできる。 According to the present invention as described above in the injector of the present invention, the outer tube has an inner diameter of the insertion opening of the gasket (L) has a larger diameter than the inner diameter (M) of the sliding portion of the gasket since a thermoplastic resin molded product, also satisfies the above injections from the insertion opening of the gasket is filled in the outer tube, until and upper liquid level than the formation position of the inner diameter of the insertion opening (L), following in, the gasket is inserted from above the opening is filled in the outer tube in a liquid-tight manner the injections, then, since the high-pressure steam sterilization injections with the outer tube, the injections into the outer tube upon filling, most air without contamination, does not cause trouble in the high-pressure steam sterilization, yet capable of placing a needle attached to a previously injection port.

【図面の簡単な説明】 BRIEF DESCRIPTION OF THE DRAWINGS

【図1】本発明の注射器の第一実施例の側断面図である。 1 is a side sectional view of a first embodiment of the syringe of the present invention.

【図2】図1のI−I線に沿った注射器の断面図である。 2 is a cross-sectional view of the syringe taken along the line I-I of FIG.

【図3】(A)及び(B)は図1の注射器の組立途中の側断面図である。 3 (A) and (B) is a side sectional view of the middle assembly of the syringe of Figure 1.

【図4】図1の注射器の組立途中の側断面図である。 4 is a side sectional view of the middle assembly of the syringe of Figure 1.

【図5】第一実施例における注射器の使用時の側断面図である。 5 is a side sectional view of when use of the syringe in the first embodiment.

【図6】第一実施例における注射器の使用時の側断面図である。 6 is a side sectional view of when use of the syringe in the first embodiment.

【図7】本発明の注射器の第二実施例の側断面図である。 7 is a side sectional view of a second embodiment of the syringe of the present invention.

【図8】第二実施例の注射器のプランジャーを押し込ませた状態を示す側断面図である。 8 is a side sectional view showing a state in which force the syringe plunger second embodiment.

【図9】第二実施例の注射器のプランジャーを押し込ませた状態を示す側断面図である。 9 is a side sectional view showing a state in which force the syringe plunger second embodiment.

【図10】第二実施例の注射器のプランジャーを押し込ませた状態を示す側断面図である。 10 is a side sectional view showing a state in which force the syringe plunger second embodiment.

【符号の説明】 DESCRIPTION OF SYMBOLS

1、21 注射器 2 外筒 2A 外筒の射出口 2C 挿入開口部 3 プランジャー 4 ガスケット 5 栓体 6 注射液 7 注射針 11 凸条リブ 13 外筒の肩部 14 突起部 1, 21 syringes 2 exit 2C insertion opening of the outer cylinder 2A outer tube 3 plunger 4 gasket 5 plug 6 shoulder 14 projecting portions of injectables 7 needle 11 ridges ribs 13 outer tube

Claims (2)

    【特許請求の範囲】 [The claims]
  1. 【請求項1】 予め外筒内に注射剤が収容される注射器において、上記外筒は、ガスケットの挿入開口部の内径(L)が該ガスケットの摺動部の内径(M)より大径に形成された熱可塑性樹脂成形物であることを特徴とする注射器。 1. A pre-syringe injections into the outer cylinder is housed, the outer tube is larger in diameter than the inner diameter (M) of the inner diameter of the insertion opening of the gasket (L) is a sliding portion of the gasket syringe, characterized in that formed is a thermoplastic resin molded product.
  2. 【請求項2】 上記請求項1記載の注射器において、上記注射剤を上記ガスケットの挿入開口から上記外筒内に充填し、且つ上記挿入開口部の大径な内径(L)の形成位置より上位の液位まで満たし、 次に、上記ガスケットを上記開口の上方から挿入して上記注射剤を液密に上記外筒内に充填し、その後、上記外筒と共に注射剤を高圧蒸気滅菌することを特徴とする注射器の製造方法。 2. A syringe according to the first aspect, higher than the formation position of the injection was filled in the outer tube from the insertion opening of the gasket, and large-diameter inner diameter of the insertion opening (L) the filled to the liquid level, then, the gasket is inserted from above the opening is filled in the outer tube in a liquid-tight manner the injections, then, that the high-pressure steam sterilization injections with the outer tube method of manufacturing a syringe according to claim.
JP8063714A 1996-02-26 1996-02-26 Injector and its manufacture Pending JPH09225029A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8063714A JPH09225029A (en) 1996-02-26 1996-02-26 Injector and its manufacture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8063714A JPH09225029A (en) 1996-02-26 1996-02-26 Injector and its manufacture

Publications (1)

Publication Number Publication Date
JPH09225029A true JPH09225029A (en) 1997-09-02

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Family Applications (1)

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JP8063714A Pending JPH09225029A (en) 1996-02-26 1996-02-26 Injector and its manufacture

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Country Link
JP (1) JPH09225029A (en)

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US9675757B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9895493B2 (en) 2004-05-28 2018-02-20 Cilag Gmbh International Injection device
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JP2006271665A (en) * 2005-03-29 2006-10-12 Terumo Corp Outer cylinder for syringe, syringe, injection molding mold for outer cylinder for syringe, and manufacturing method of outer cylinder for syringe
US9649441B2 (en) 2005-04-06 2017-05-16 Cilag Gmbh International Injection device (bayonet cap removal)
US9731080B2 (en) 2005-04-06 2017-08-15 Cilag Gmbh International Injection device
US8968236B2 (en) 2005-04-06 2015-03-03 Cilag Gmbh International Injection device
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US9770558B2 (en) 2005-09-27 2017-09-26 Cilag Gmbh International Auto-injection device with needle protecting cap having outer and inner sleeves
WO2007099870A1 (en) * 2006-02-28 2007-09-07 Hisamitsu Pharmaceutical Co., Inc. Syringe cylinder
EP2000163A2 (en) * 2006-02-28 2008-12-10 Hisamitsu Pharmaceutical Co. Inc. Syringe cylinder
JPWO2007099870A1 (en) * 2006-02-28 2009-07-16 久光製薬株式会社 Syringe
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US9757520B2 (en) 2006-06-01 2017-09-12 Cilag Gmbh International Injection device
US9072833B2 (en) 2006-06-01 2015-07-07 Cilag Gmbh International Injection device
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