JP3065814B2 - Chemical filling syringe - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a syringe filled with a drug solution. More specifically, the present invention relates to a syringe that is pre-filled with a drug solution and that can aseptically inject the drug solution for errands.

[0002]

2. Description of the Prior Art A cylindrical container having both ends open is filled with a drug solution, and both open ends thereof are respectively closed with rubber stoppers. A plunger for pushing out the drug solution from the syringe tube, a syringe outer tube, The combination of the means for communicating the inside of the cylinder with the injection needle is known as a so-called prefilled syringe. The drug-filled syringe of the present invention is a modified example of a prefilled syringe, which is composed of a combination of a drug solution container (also serving as a plunger) filled with a drug solution in advance and a syringe outer cylinder. Can be communicated with. Many proposals have already been made for such a drug-filled syringe (Japanese Patent Publication No. Sho 5).
0-8273, JP-B-52-8634, JP-A-59-120166, etc.).

The syringes disclosed in Japanese Patent Publication No. 50-8273 and Japanese Patent Publication No. 52-8634 are composed of a drug solution container whose open end is sealed with a rubber stopper and a syringe outer cylinder with a double-ended needle, and screwed into the syringe outer cylinder. Means are provided so that the rubber stopper of the drug solution container can be fixed by screwing means of the syringe outer cylinder, and the rubber stopper of the drug solution container is pierced with a double-ended needle. Japanese Patent Publication No. 50-8273 discloses a female screw formed on the inner wall of a cylindrical member provided concentrically with the outer cylinder or a female screw formed on the inner wall of the outer cylinder. And JP-B-52-86.
No. 34 discloses a female screw formed on the inner wall of a cup-shaped portion provided at the rear end of the hub of the double-ended needle.

A prefilled ampoule syringe disclosed in Japanese Patent Application Laid-Open No. Sho 59-120166 is composed of an ampoule having a neck portion tapered as compared with a main body, and a stopper device attached to the neck portion of the ampule. The stopper device has a needle top for attaching a needle and a central communication pipe, which is composed of an axial branch pipe and a radial branch pipe communicating with the branch pipe. Then, the stopper device is opened and closed by moving between the sealing position and the injection position, so that the injection needle mounting step top and the inside of the ampule communicate with each other at the injection position. Japanese Patent Publication No. 50-827
No. 3 discloses a structure similar to that described in Japanese Patent Application Laid-Open No. 3 (3). Is installed).

However, the syringes disclosed in Japanese Patent Publication Nos. 50-8273 and 52-8634 each use a hollow needle as a means for communicating a tip for mounting a needle with the inside of a drug solution container. When the hollow needle is pierced into the rubber stopper, the rubber stopper is scraped off by the hollow needle (so-called coring), which is a problem. Further, the prefilled ampoule syringe disclosed in FIGS. 12 to 16 of Japanese Patent Application Laid-Open No. 59-120166 avoids the problem of coring when connecting the top of the syringe needle mounting step and the inside of the ampoule. However, when the stopper moves to a position off the neck of the ampoule, the seal between the inner wall of the ampoule and the stopper becomes sweet, and there is a possibility that the chemical solution in the ampoule may leak,
It is a problem.

On the other hand, a prefilled syringe that does not cause such problems of coring and leakage of a chemical solution has already been proposed (Japanese Patent Publication No. 56-12140). This is a prefilled syringe of a type in which a syringe outer cylinder is filled with a drug solution, and has an orifice at the tip end for liquid ejection and a pipe-like fixed column coaxial with the orifice at the rear end. And a cylindrical housing whose front and rear openings are sealed with a piston valve seal and a plunger piston seal, respectively. An inner hole for the liquid passage is formed in the piston valve seal, and the inner hole is sealed with a plug seal which is dropped off by the fixing column when using a syringe.

However, the prefilled syringe disclosed in Japanese Patent Publication No. 56-12140 has a large contact area between a piston valve seal and a plug seal (usually a rubber stopper is used) and a chemical solution, so that the additive is eluted from the rubber stopper. However, there is a possibility that the inner hole is closed by the plug seal during use of the syringe.

[0008]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and has no risk of coring or leakage of a chemical solution, and is substantially free from a problem of elution. It is intended to provide a filling syringe.

[0009]

SUMMARY OF THE INVENTION In order to solve the above-mentioned problems, the present invention provides a syringe outer cylinder having a tip for attaching a syringe needle at a front end and a flange at a rear end, and a slide on the syringe outer cylinder. A syringe comprising a bottomed cylindrical drug solution container movably inserted therein, wherein the open end side of the drug solution container is closed by a rubber stopper slidably inserted on the inner wall of the container, and the rubber The stopper has a chemical solution passage penetrating the rubber stopper along the central axis,
The chemical solution passage is composed of an upper closed portion and a lower communicating portion,
The closing portion is closed by a closing body, and a groove is formed in the communication portion so that a chemical solution passage is opened when the closing body moves here. The syringe outer cylinder is formed by the syringe outer cylinder. And a pipe-shaped communicating means having a chemical liquid passage communicating with the inner cavity of the chip,
The communication means includes a rubber stopper insertion part for moving the closure from the closure part to the communication part at a tip end thereof, and a rubber stopper stopping means provided adjacent to the rubber stopper insertion part. The drug-filled syringe has been adopted.

[0010] Further, a syringe comprising a syringe outer cylinder having a tip for mounting a syringe needle at a front end and a flange at a rear end, and a cylindrical drug solution container assembly slidably inserted into the syringe outer cylinder. The chemical solution container assembly comprises a bottomed cylindrical adapter and a bottomed cylindrical chemical solution container held in the adapter, and the open end side of the chemical solution container is slidably inserted into the inner wall of the container. The rubber stopper has a chemical passage that penetrates the rubber stopper along the central axis, and the chemical passage includes an upper closed portion and a lower communication portion, and is closed. The part is closed by a closing body, a groove is formed in the communication part so that the chemical solution passage is opened when the closing body moves here, and the syringe outer cylinder is connected to the syringe outer cylinder. A pie having a chemical solution passage formed concentrically and communicating with the lumen of the chip Communication means, the communication means, at the tip thereof, a rubber plug insertion portion for moving the closing body from the closing portion to the communication portion, adjacent to the rubber plug insertion portion A drug-filled syringe equipped with a provided rubber stopper stopping means is employed.

[0011]

According to the above arrangement, when the index finger and the middle finger are put on the flange of the syringe outer cylinder and the chemical solution container is pressed with the thumb in the manner of using a normal syringe, the rubber plug insertion portion of the communication means is connected to the rubber solution of the rubber stopper. It is inserted through the passage. At this time, the closing body is pushed by the rubber stopper insertion portion and moved in the chemical solution passage from the closing portion to the communication portion, but the communication portion is formed with a groove for opening the chemical solution passage. The inside of the chemical solution container and the tip of the syringe outer cylinder are in a communicating state. When the chemical solution container is further pushed, the rubber stopper is prevented from moving by the rubber stopper means, while the chemical solution contained in the chemical solution container passes through the chemical solution passage and the groove of the rubber stopper, and passes through the chemical solution passage of the communication means. And the rubber stopper slides on the inner wall of the chemical solution container, so that the chemical solution container can be further advanced. Thus, the liquid medicine can be poured out until the rubber stopper reaches the bottom of the liquid medicine container. At this time, since the rubber stopper insertion portion is sealed by the rubber stopper, there is no possibility that the chemical solution leaks.

[0012]

Next, an embodiment of the present invention will be described with reference to the drawings. FIG. 1 is an axial sectional view of a drug-filled syringe according to an embodiment of the present invention, FIG. 2 is an enlarged sectional view taken along line AA of the drug-filled syringe shown in FIG. 1, and FIG. 3 is a rubber stopper shown in FIG. FIG. 4 is an enlarged cross-sectional view of the rubber wire shown in FIG. 3 along the line BB. 5 is a sectional view of another embodiment of the present invention, FIG. 6 is an enlarged sectional view showing another embodiment of the combination of the rubber stopper and the closing body, and FIG. 7 is a sectional view of the rubber stopper shown in FIG. It is a C-line enlarged sectional view.

As shown in FIGS. 1 to 4, the liquid medicine filling syringe of the present invention comprises a syringe outer cylinder 1 and a liquid medicine container 2 slidably inserted into the syringe outer cylinder 1. The inner wall of the container 2 is closed by a rubber stopper 3 slidable. The rubber stopper 3 is provided with a chemical solution passage 31 formed of an upper closing portion 32 and a lower communicating portion 33 along a central axis. The chemical solution passage 31 has a closing portion 32 having a cylindrical shape. Closed at 4. Further, the syringe outer cylinder 1 is provided with communication means 6 having a chemical solution passage 61 which communicates with the inner cavity 13 of the tip 11, and the communication means 6 has a rubber stopper insertion portion 62 at the tip end thereof, and is adjacent to this. In addition, a rubber stopper stopping means 63 is provided. If the outer diameter of the chemical solution container 2 is small, an adapter 9 as shown in FIG. 4 may be provided to accommodate and hold the chemical solution container 2.

The syringe barrel 1 is a cylindrical container usually made of glass or a transparent synthetic resin, for example, polypropylene, polyester, polycarbonate, polystyrene, polymethylpentene, etc., and has a tip 11 for attaching a syringe needle at the tip. And a flange 14 for hanging a finger on the rear end. Unlike a normal syringe outer cylinder, a chemical solution passage 61 communicating concentrically with the inner cavity 13 of the tip 11 is provided inside the syringe outer cylinder. Communication means 6 is provided. This communication means 6 has a tip portion which is connected to the chemical passage 31 of the rubber stopper 3.
A rubber plug insertion portion 62 for moving the closing body 4 in the closing portion 32 of the chemical solution passage 31 to the communication portion 33 when the rubber plug 3 is inserted into the chemical liquid passage 31. A rubber stopper stopping means 63 for stopping the movement is provided. If the rubber stopper 3 is prevented from moving by the rubber stopper 3, the rubber stopper 3 slides relatively on the inner wall of the liquid container 2 when the liquid container 2 is advanced. still,
The shape of the rubber stopper 63 may be a cross-shaped one as shown in FIG. 2 or a flange-shaped one.

The tip 11 is formed in the shape of a pipe having a gentle taper, and an injection needle (not shown) may be directly fitted to the tip 11, but may be concentric with the outside as shown in FIG. For example, a female coupling means 12 having a female screw 121 may be used, and an injection needle may be coupled to the female coupling means 12. In addition, an annular rib 15 is provided on the inner wall of the syringe outer cylinder 1, and an open end 21 of the chemical solution container 2 described later is formed in an outwardly thickened shape as shown in FIG. 1, cooperating with the annular rib 15 and the open end 21. Inadvertent advancement of the drug solution container 2 and dropping from the syringe barrel 1 may be prevented, and a seal member such as an O-ring 5 may be attached to the inner wall of the flange 14 for example, so that the inside of the syringe barrel 1 and The rubber stopper 3 may be prevented from being contaminated by the outside air. Further, the tip of the chip 11 may be protected by a seal member 8 such as a synthetic resin film or a protector (not shown).

The chemical liquid container 2 is a cylindrical container made of the same material as the syringe outer cylinder 1, and has an open end 21 and a bottom 22.
The inside of which is filled with a chemical solution 7 and has an open end 2
On one side, a rubber stopper 3 for closing the chemical solution container 2 is preferably inserted at an appropriate distance from the open end 21 thereof so as to make it easier to push the chemical solution container 2. A chemical solution passage 31 is formed in the rubber stopper 3 along the center axis thereof. The chemical solution passage 31 is a closed body 4 in which an upper closed portion 32 is made of glass or a synthetic resin having chemical resistance. It is closed. The inner wall of the lower portion of the chemical liquid passage 31 is provided with a liquid passage as shown in FIG. 3 so that the chemical liquid passage is opened when the closing body 4 is moved by the communication means 6 of the syringe outer cylinder 1.
As shown in FIG. 3, one or a plurality of grooves 34 running longitudinally in the axial direction for securing the chemical solution passage 31 are formed (four grooves 34 in FIG. 3). In addition, chemical solution passage 3
The diameter of 1 is smaller than the outer diameter of the rubber plug insertion part 62 of the communication means 6, and when the rubber plug insertion part 62 is inserted into the chemical liquid passage 31, the rubber plug insertion part 62 is firmly fixed on the inner wall of the chemical liquid passage 31. Sealed. Incidentally, the open end 21 of the chemical solution container 2 is
Is formed in a shape which is thickened to the outside as shown in FIG. 1 and cooperates with an annular rib 15 provided on the inner wall of the syringe outer cylinder 1 to prevent the chemical solution container 2 from being inadvertently advanced and falling off from the syringe outer cylinder 1. You may.

The chemical solution container 2 is compared with the inner diameter of the syringe outer cylinder.
When the outer diameter of the liquid medicine container 2 is small, instead of reducing the outer diameter of the liquid medicine container 2, a liquid medicine container assembly composed of a combination of the adapter 9 and the liquid medicine container 2 as shown in FIG. 5 may be adopted.
The adapter 9 is a cylindrical container having an outer diameter that can be slidably inserted into the syringe outer cylinder 1 and an inner diameter that can accommodate and hold the liquid medicine container 2, and is usually made of ABS resin, polyvinyl chloride resin, or the like. It is formed of a synthetic resin such as polypropylene, polyethylene, polyester, polycarbonate, and polystyrene. When the liquid medicine container 2 is advanced to a position where the liquid medicine 7 is completely poured, if the distance between the flange 14 of the syringe outer cylinder 1 and the bottom 92 of the adapter 9 is too close,
Since it is difficult to press the chemical solution container 2, the bottom 92 of the adapter 9
When the chemical solution container 2 is advanced to a position where the chemical solution 7 is completely poured, a thickened portion 93 as shown in FIG. 5 is provided so that an appropriate distance is provided between the flange 14 and the bottom portion 92 of the adapter 9. For example, it may be formed on the raised bottom. In addition, the open end 91 of the adapter 9 is formed to have an outwardly thickened shape as shown in FIG. 5, and inadvertent advancement of the drug solution container 2 in cooperation with the annular rib 15 provided on the inner wall of the syringe outer cylinder 1. Also, it may be possible to prevent the syringe from dropping from the outer cylinder 1.

The closing body 4 may be spherical or cylindrical in shape, that is, the chemical solution passage 31 can be closed by the closing portion 32 and the communication portion 33 can be closed.
Although any shape may be used as long as it can be opened in the above, it is preferable to form the column as shown in FIG. In addition, the cylindrical body 41 may be formed with an annular projection 41 as shown in FIG. Can be prevented from dropping from the rubber stopper 3. In this case, the closing portion 32 of the chemical liquid passage 31
6 and 7 respectively have annular grooves 35 and 36 adapted to the shape of the annular projection 41 as shown in FIGS.
It is better to form

Next, the use of the drug-filled syringe of the present invention will be described with reference to FIG. First, the sealing member 8 is removed from the tip 11 of the syringe barrel 1, and a syringe needle is attached to the tip 11. Next, the flange 14 of the syringe barrel 1
When the index finger and the middle finger are hung on and the drug solution container 2 is pressed with the thumb,
The rubber plug insertion portion 62 of the communication means 6 is used to
The closure 4 is moved from the closed path 31 to the communication section 33 through the first closure 32. In this state, the lumen 13 of the tip 11 and the inside of the chemical solution container 2
1, since it is communicated through the groove 34 and the drug solution passage 61, the drug solution may be injected into the patient in the same manner as in a normal syringe.

[0020]

As apparent from the above description, the following effects can be obtained by employing the liquid medicine-filled syringe of the present invention. There is no risk of coring or leakage of the drug solution, and there is substantially no problem of elution, so that the drug solution can be administered safely. Since the medicinal solution can be administered aseptically, there is no risk of infection. Since the number of parts is small and the structure is simple, an inexpensive drug-filled syringe can be provided.

[Brief description of the drawings]

FIG. 1 is an axial sectional view of a syringe filled with a drug solution according to one embodiment of the present invention.

FIG. 2 is an enlarged cross-sectional view taken along line AA of the medical-solution-filled syringe shown in FIG.

FIG. 3 is an enlarged sectional view showing a relationship between a rubber stopper and a closing body shown in FIG.

FIG. 4 is an enlarged sectional view of the rubber wire shown in FIG. 3, taken along line BB.

FIG. 5 is a sectional view of another embodiment of the present invention.

FIG. 6 is an enlarged sectional view showing another embodiment of the combination of the rubber stopper and the closure.

FIG. 7 is an enlarged cross-sectional view of the rubber plug shown in FIG. 6 taken along line CC.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Syringe outer cylinder 11 Tip 12 Female coupling means 14 Flange 2 Chemical liquid container 3 Rubber stopper 31 Chemical liquid passage 32 Closed part 33 Communication part 34 Groove 4 Closure body 5 O-ring 6 Communication means 61 Chemical liquid passage 62 Rubber plug insertion part 63 Rubber stopper Stopping means 7 Chemical solution 8 Seal member 9 Adapter 93 Thickened part

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-59-120166 (JP, A) JP-A-59-155264 (JP, A) JP-A-64-70070 (JP, A) 502086 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61M 5/178 A61M 5/28 A61M 5/30

Claims (7)

(57) [Claims] 1. A syringe comprising a syringe outer cylinder having a tip for attaching a syringe needle at a front end and a flange at a rear end, and a bottomed cylindrical drug solution container slidably inserted into the syringe outer cylinder. Wherein the open end side of the drug solution container is closed with a rubber stopper slidably inserted on the inner wall of the container, and the rubber stopper is
It has a chemical solution passage penetrating the rubber stopper along the central axis, the chemical solution passage is composed of an upper closed part and a lower communicating part, and the closed part is closed by a closed body, and the communicating part is here. A groove is formed so that a chemical solution passage is opened when the closing body moves, and the syringe outer cylinder is formed concentrically with the syringe outer cylinder and communicates with a lumen of the tip. A pipe-shaped communication means having a rubber stopper insertion part for moving the closing body from the closing part to the communication part at a tip end thereof, and a rubber stopper insertion part for the rubber stopper insertion part A drug-filled syringe comprising a rubber stopper stopping means provided adjacently. 2. A syringe filled with a drug solution according to claim 1, wherein a female coupling means is provided concentrically with the outside of the tip, and the tip thereof is sealed with a film. 3. The syringe filled with a drug solution according to claim 1, wherein the closing body is formed in a cylindrical shape. 4. A syringe comprising a syringe outer cylinder having a tip for mounting a syringe needle at a front end and a flange at a rear end, and a cylindrical drug solution container assembly slidably inserted into the syringe outer cylinder. The chemical solution container assembly comprises a bottomed cylindrical adapter and a bottomed cylindrical chemical solution container held in the adapter, and the open end side of the chemical solution container is slidably inserted into the inner wall of the container. The rubber stopper has a chemical passage that penetrates the rubber stopper along the central axis, and the chemical passage includes an upper closed portion and a lower communication portion, and is closed. The part is closed by a closing body, a groove is formed in the communication part so that a liquid passage is opened when the closing body moves here, and the syringe outer cylinder is connected to the syringe outer cylinder. A pipe-shaped member formed concentrically and having a drug solution passage communicating with the lumen of the chip. A communication means is provided, and the communication means is provided at a distal end thereof adjacent to the rubber stopper insertion part for moving the closing body from the closing part to the communication part and the rubber stopper insertion part. A liquid medicine-filled syringe provided with a rubber stopper stopping means. 5. The liquid medicine-filled syringe according to claim 4, wherein a female coupling means is provided concentrically with the outside of the tip, and the tip is sealed with a film. 6. The syringe filled with a drug solution according to claim 4, wherein the closing body is formed in a cylindrical shape. 7. The adapter according to claim 4, wherein the adapter is formed on the raised bottom.
7. The drug-filled syringe according to any one of 6.