JP3175136B2 - Automatic syringe - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an automatic injector. More specifically, the present invention relates to a prefilled syringe-type automatic injector that is pre-filled with a drug solution and that can inject the drug solution aseptically and automatically when used.

[0002]

2. Description of the Related Art A so-called syringe outer cylinder in which a cylindrical container having both open ends is filled with a drug solution and both open ends thereof are closed with rubber stoppers, a plunger for pushing out the drug solution from the syringe outer tube, and a syringe outer tube. The combination of the means for communicating the inside of the cylinder with the injection needle is known as a so-called prefilled syringe, and many proposals have already been made (Japanese Patent Laid-Open No. 49-68586, Japanese Utility Model Publication No. 51-22560). Gazette, Japanese Utility Model Publication No. 52-19435).

In the prefilled syringe disclosed in Japanese Patent Application Laid-Open No. 49-68586, a diaphragm for closing the syringe is provided at a distal end opening of the syringe outer cylinder, and the diaphragm is pierced with a needle of a cap with a needle attached to the distal end opening. Thus, the inside of the syringe barrel communicates with the outside,
In the prefilled syringe disclosed in Japanese Utility Model Publication No. 51-22560, the distal end opening of a syringe outer cylinder is closed with a sealing packing crimped by a pressing member (cap) with a small diameter beak tube, and the sealing packing is fitted so as to be able to advance and retreat. The inside of the syringe outer cylinder is communicated with the outside by piercing with a syringe needle attached to the case provided with the attached mounting cylinder, and the prefilled syringe disclosed in Japanese Utility Model Publication No. 52-19435 is provided with the tip of the syringe outer cylinder. The opening is sealed with a rubber septum, and the rubber septum is pierced with a syringe needle held by a holder movably attached to the distal end of the syringe outer cylinder to move the inside of the syringe outer cylinder. It communicates with the outside world.

[0004] However, the above-mentioned prefilled syringes have a disadvantage that the size of the injection needle is limited because the injection needle of a specific shape is incorporated in advance, and also the prefilled syringe disclosed in Japanese Patent Application Laid-Open No. 49-68586. When the center of the diaphragm is made thicker, it is difficult to pierce with a needle.On the other hand, when the center of the diaphragm is made thinner, the airtightness is impaired. Have
Further, the prefilled syringe disclosed in Japanese Utility Model Publication No. 51-22560 is troublesome to assemble because it has a large number of parts, and in assembling, the case in which the injection needle is fitted is fitted into an appropriate position of the mounting cylinder. Has the disadvantage of being difficult. Further, in general, a prefilled syringe has a large sliding resistance of a gasket, and has a problem that a physical burden is large for a person who injects, such as a nurse.

[0005]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a prefilled syringe type automatic injector which is easy to assemble and can perform automatic injection. And Another object of the present invention is to provide a prefilled syringe-type automatic injector that can use a commercially available injection needle of any size. Still another object of the present invention is to provide a prefilled syringe-type automatic injector which can be connected to an infusion set or the like having a flow control means.

[0006]

SUMMARY OF THE INVENTION In order to solve the above-mentioned problems, according to the present invention, a cylindrical member having a distal end and a proximal end, which is open at both ends, is sealed with a rubber stopper and a proximal end. A syringe outer cylinder in which an inner cavity is sealed with a gasket slidably inserted from a proximal end opening, and a space between the sealing member and the gasket is filled with an injection solution, and a proximal end side of the syringe outer cylinder. A cap-like member having a through hole in the top surface, which is attached and fixed to, and a spring receiver is provided at one end thereof,
A cylindrical or rod-shaped spring compression member having the spring receiving side inserted into the syringe outer cylinder and the other end exposed to the outside of the syringe outer cylinder through a through hole of the cap-shaped member; and a spring receiver of the spring compression member. And a coil spring, which is accommodated between the top surface of the cap-shaped member in a contracted state and can be extended in the longitudinal axis direction, wherein the spring compression member is immovable in the axial direction of the syringe outer cylinder by locking means. When the lock means is removed and the rubber stopper of the syringe barrel is pierced with a communication needle, the coil spring is extended to slide the gasket toward the distal end of the syringe barrel. Has adopted.

[0007]

According to the above construction, the inside of the syringe outer cylinder is communicated with the outside air by piercing the rubber stopper of the syringe outer cylinder with the puncture needle of the communication needle, and then the lock member of the spring compression member is removed.
The coil spring, which is arranged in a contracted state between the top surface of the cap-shaped member and the spring receiver of the spring compression member, can be extended in the distal direction of the syringe outer cylinder, and the gasket is moved by the biasing force of the coil spring to the distal end of the syringe outer cylinder. Can slide in any direction. Therefore, a communication needle is attached to the distal end of the syringe outer cylinder, and an infusion set having flow rate control means is connected to the connection part of the communication needle (directly inserting the introduction needle of the infusion set into the rubber stopper of the syringe outer cylinder. Then, pierce the rubber stopper of the syringe outer cylinder with a communication needle, discharge the air in the infusion set, and then insert the venous needle at the tip of the infusion set into a vein, etc., automatically for a long time. Infusion therapy can be performed. In addition, by adopting a configuration in which a flow path closing means is provided at a connection part of the communication needle, the injection needle is connected to the connection part, and the rubber stopper of the syringe outer cylinder is connected to the communication needle with the flow path closing means closed. If the injection needle is inserted into, for example, a vein after opening the flow path closing means to release the air after opening the flow path closing means, the injection treatment can be automatically performed by opening the flow path closing means.

[0008]

Next, an embodiment of the present invention will be described with reference to the drawings. 1 is a longitudinal sectional view of an automatic injector according to one embodiment of the present invention, FIG. 2 is an enlarged longitudinal sectional view of the communicating needle shown in FIG. 1, FIG. 3 is a longitudinal sectional view showing another embodiment of the communicating needle, FIG. 4 is a sectional view taken along line AA of FIG. FIG. 5 is a longitudinal sectional view showing another embodiment of the locking means of the automatic injector of the present invention, and FIG. 6 is a plan view showing still another embodiment of the locking means of the automatic injector of the present invention. FIG. 3 is a schematic diagram showing a state in which an infusion set provided with a flow control means is connected to the automatic injector of the present invention. As shown in FIG. 1, the automatic injector of the present invention comprises:
The mouth 11 and the proximal end bore 14 are sealed with a rubber stopper 12 and a gasket 15, respectively, and are covered with a syringe outer cylinder 1 filled with an injection solution (not shown) and a proximal end side of the syringe outer cylinder 1. The attached cap-shaped member 2, the spring compression member 3 inserted into the syringe outer cylinder 1, and a coil spring housed in a contracted state in the spring receiver 31 of the spring compression member 3 and the top surface 21 of the cap-shaped member 2. The spring compression member 3 is locked by locking means, for example, the nut member 51 of FIG. 1, the lock pin 55 of FIG. 5, the engagement protrusion 56 of FIG. 1 cannot move in the axial direction. If the rubber stopper 12 of the syringe outer cylinder 1 is pierced with the communication needle 6 to release the locking means so that the spring compression member 3 can move in the axial direction of the syringe outer cylinder 1, the coil spring 4 extends and the gasket 15 Slides toward the distal end of the syringe outer cylinder 1.

The syringe outer cylinder 1 is a cylindrical member made of glass or synthetic resin, for example, polypropylene or polyethylene, and having both ends having a front end and a base end. Sealed, the rubber stopper 12 is fixed by a cap-shaped caulking member 13 preferably made of aluminum or the like. The proximal end lumen 14 is slidably sealed by a gasket 15 inserted through an opening in the proximal end, and an injection solution (not shown) is provided in a space between the rubber stopper 12 and the gasket 15. Is filled.
The mouth 11, which is the distal end of the syringe barrel 1, is usually reduced in diameter. The communication needle 6 is preferably attached to the mouth 11, and the communication needle 6 is protected by the cap 7.
The top surface of the caulking member 13 attached so as to cover the rubber stopper 12 has a central portion capable of being peeled off. In the case of an automatic injector in which the communication needle 6 is attached to the syringe barrel 1 in advance, the caulking member 13 is used. The one having the through-holes 14 on the top surface from the beginning or the one having the through-holes 14 formed by peeling the top surface later is adopted. On the other hand, at the base end of the syringe outer cylinder 1, a base end of a spring compression member 3 described later, that is, a spring receiver 31 is disposed outside the gasket 15 at an appropriate distance from the gasket 15. Both ends are compressed between the spring receiver 31 of the spring compression member 3 and the top surface 21 of the cap-like member 2 described later, and are accommodated in a contracted state. An annular projection 16 is provided on the outer wall of the base end to engage with an annular groove 23 of the cap-like member 2 described later.

The cap-shaped member 2 is made of, for example, polypropylene, polyethylene, polyester, polyvinyl chloride, AB
It is a cylindrical member composed of a top surface 21 and a skirt 22 formed of a synthetic resin such as S resin, and is attached to the syringe outer cylinder 1 from the rear end thereof. An annular groove 23 that engages with the annular projection 16 of the syringe outer cylinder 1 is provided on the inner wall of the tip of the skirt 22 of the cap-shaped member 2,
A cap-shaped member 2 is firmly fixed to a syringe outer cylinder 1. The top surface 21 of the cap-shaped member 2 has a through hole 2 substantially in the center.
The spring compression member 3 described below is exposed to the outside of the syringe outer cylinder 1 through the through hole 24. When a nut member 51 as shown in FIG. 1 is employed as a locking means for preventing the spring compression member 3 from moving in the axial direction of the syringe outer cylinder 1, a plurality of projections 25 are provided on the top surface 21, It is preferable to reduce the contact portion between the cap member 2 and the nut member 51 to reduce the frictional resistance.
Further, as a locking means, an engagement protrusion 56 as shown in FIG.
Is adopted, a groove or a slit-shaped notch 27 is provided in the through hole 24 of the top surface 21, and when the spring compression member 3 is rotated so that the engagement protrusion 56 comes to the position of the notch 27, the engagement protrusion 56 Through the notch 27, the cap-shaped member 1 and the spring compression member 3 are unlocked.

The spring compression member 3 is a cylindrical or rod-shaped member made of the same synthetic resin as the cap-shaped member 2, and has a base end accommodated in the syringe outer cylinder 1 and a transparent member of the cap-shaped member 2. It has a tip exposed to the outside through the hole 24, and a spring receiver 31 is provided on the outer periphery at the base end, and the coil spring 4 is provided between the spring receiver 31 and the top surface 21 of the cap-shaped member 2. It is arranged in a contracted state. When a nut member 51 as shown in FIG. 1 is employed as a locking means at the distal end of the spring compression member 3, a male screw 32 screwed with the female screw 52 of the nut member 51 is provided on the outer surface thereof. When a lock pin 55 as shown in FIG. 5 is employed as the lock means, a pin insertion hole 33 that engages with the lock pin 55 in a direction perpendicular to the shaft is provided. When an engaging projection as shown in FIG. 6 is employed as the locking means, a grip portion 34 may be provided at the distal end so that the spring compression member 3 can be easily rotated when the lock is released. it can.

When the nut member 51 is employed as the locking means, the spring compression member 3 is provided with a rotation preventing means (rotational means) as shown in FIG. 4 so that the spring compression member 3 does not rotate when the nut member 51 is turned. Stop) may be provided. In this case, an axial ridge 35 is provided on the outer wall of the spring compression member 3 (in this case, the male screw 32 is provided on the ridge 35), and the ridge 35 is formed on the top surface 21 of the cap-shaped member 2. The cross section of the spring compression member 3 and the cross section of the cross section of the cap-shaped member 2 formed by the through hole 24 and the cutout 26 are substantially similar in shape. Has become. Although not shown, a vertical groove in the axial direction may be provided in the spring compression member 3 and a projection may be provided in the cap-shaped member 2 so that the vertical groove engages with the projection.

The coil spring 4 housed in a compressed state between the top surface 21 of the cap-shaped member 2 and the spring receiver 31 of the spring compression member 3 is usually formed of stainless steel, but is particularly limited. Instead, any material having spring elasticity can be used. The strength of the spring elasticity of the coil spring 4 may be slightly larger than the sliding resistance of the gasket 15, for example, when an injection needle is directly connected and used in the same manner as a normal syringe, and may be used for an infusion set or the like. In the case of continuous infusion for a long time after connection, it may be decided according to the purpose of injection, such as making it slightly stronger. The spring receiver 31 is a member that efficiently transmits the urging force of the spring to the gasket 15. In FIG. 1, the spring receiver 31 is formed separately from the spring compression member 3, but is formed integrally with the spring compression member 3. Is also good.

As described above, the automatic injector according to the present invention has a basic configuration including the syringe outer cylinder 1, the cap-like member 2, the spring compressing member 3, and the coil spring 4, and is used in this basic configuration. The mouth 1 of the syringe barrel 1
The rubber stopper 12 may be exposed by removing the peeled portion of the top surface from the caulking member 13, and an introduction needle such as an infusion set or a catheter may be pierced through the rubber stopper 12. 6 may be attached.

The communication needle 6 attached to the mouth 11 of the syringe outer cylinder 1 is usually formed of a synthetic resin such as polypropylene, polyethylene or ABS resin, and has a liquid passage 67 as shown in FIG. A hub 63 is provided at the center of the hollow member, and a connecting portion 61 and a puncture needle 62 are formed on both sides of the hub 63 and coaxially with the liquid passage 67. The hub 63 has skirts 64 and 65 formed on the connection portion 61 side and the puncture needle 62 side, respectively. The skirt 64 on the connection portion 61 side has a female screw 68 formed on the inner wall thereof. 7 and the connection end 101 of the infusion set 10 as shown in FIG. On the other hand, the skirt 6 on the side of the puncture needle 62
5 is slidable along the mouth 11 of the syringe barrel 1, a plurality of vertical ribs 66 are formed on the inner wall thereof, and the communication needle 6 is slid to remove the rubber stopper 12 of the syringe barrel 1. When penetrated by the puncture needle 62, it is engaged with the caulking member 13. Incidentally, the coupling means formed on the skirt 64 on the connection portion 61 side is not limited to the female screw 68 as the screwing means, and it may be possible to enable luer lock.

As shown in FIG. 3 , the communication needle 6 may be provided with a flow path closing means 60 such as a cock at a connection portion 61 thereof, and the liquid passage 67 may be formed narrow. Flow
By providing the passage closing means 60 or forming the liquid passage 67 to be narrow, a normal injection needle can be connected to the connecting portion 61 and used like a normal syringe. in this case,
A skirt 64 may not be provided on the connecting portion 61 side. If the connecting portion 61 is formed in the shape of a tip of a syringe, an injection needle can be directly connected to the connecting portion 61. In this case, a rubber cap or a plastic cap (not shown) attached to an ordinary injection needle may be used as the cap 7 for protecting the connection portion 61.

The connecting needle 61 of the communication needle 6 is usually protected by the cap 7. The cap 7 shown in FIG.
A skirt 73 is formed outside the fitting portion 72 to fit the U-shaped
3 has an external thread 7 screwed with the internal thread 68 of the communication needle 6.
1 is formed. As the material for forming the cap 7, a natural rubber or a synthetic rubber (for example, isoprene rubber, butadiene rubber, butyl rubber, or the like), a rubber-like elastic material such as a thermoplastic elastomer, or a thermoplastic resin such as polypropylene or polyethylene is preferably used. Is done.

Next, the use of the automatic injector of the present invention will be described. The automatic injector shown in FIG. 1 is suitable for use in combination with an infusion set 10 having a flow control means 102 as shown in FIG. 7, A is an automatic injector, 10 is an infusion set, 101 is a connection end with the automatic injector A, 102 is a clamp, 103 is a flow control means, 104
Is a winged needle. First, the cap 7 is removed from the communication needle 6 of the automatic injector A, and the infusion set 10 with the clamp 102 closed is connected to the connection portion 61. Next, the communication needle 6 is slid in the direction of the syringe barrel 1, and the puncture needle 62 pierces the rubber stopper 12 of the syringe barrel 1. In this state, the liquid passage between the inside of the syringe outer cylinder 1 and immediately before the clamp 102 of the infusion set 10 is the liquid passage of the communication needle 6.
Fluid communication is via 67 . Next, the nut member 51 of the automatic injector A is turned in a direction in which the spring compression member 3 is disengaged from the nut member 51, for example, clockwise to release the threaded state between the spring compression member 3 and the nut member 51. Then, the spring compression member 3 moves toward the gasket 15 by the urging force of the coil spring 4, collides with the gasket 15 and stops. next,
After the clamp 102 is opened and the air in the infusion set 10 is exhausted, the clamp 102 is closed again, the winged needle 104 is inserted into a vein of a patient, for example, and then the clamp 102 is opened. Is injected into a patient's vein at a flow rate controlled by the flow control means 103.

In the case of an automatic injector not provided with the communication needle 6, the introduction needle of the infusion set may be pierced directly into the rubber stopper and used in the same manner as described above. When the connecting needle 61 is provided with the flow path closing means 60 or the liquid passage 67 is made narrower as the communicating needle 6, a normal injection needle is directly connected to the connecting part 61. It can also be used as a normal syringe. In this case, in the case where the flow path closing means 60 is provided, the cap 7 is removed from the communication needle 6, and the injection needle is connected to the connection portion 61 of the communication needle 6 in which the flow path closing means 60 is closed. Next, the nut member 51 is turned to rotate the spring compression member 3 and the nut member 51.
Is released, the puncture needle 62 pierces the rubber stopper 12 of the syringe barrel 1, and after removing air, the injection needle is inserted into, for example, a vein of the patient to close the closed flow. When the road closing means 60 is opened, the drug solution is automatically injected into the vein of the patient. In the case of a device having a narrow liquid passage 67 , if air is removed and an injection needle is inserted into a patient's vein as it is, the medicinal solution is automatically injected into the patient's vein.

[0020]

As is apparent from the above description, the automatic injector of the present invention is a pre-filled syringe type automatic injector which is easy to assemble and has a small number of parts so that injection can be performed automatically. It can be provided at low cost. By attaching a communication needle provided with a flow path closing means or a communication needle provided with a narrow liquid passage,
It is convenient because a commercially available injection needle of any size can be used. By connecting to a transfusion set or the like provided with a flow control means, a medical solution can be continuously administered for a long time, so that a continuous medical solution injector can be provided at a lower cost than conventional ones. It is convenient because it can be used on mobile phones. It has advantages such as.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional view of an automatic injector according to one embodiment of the present invention.

FIG. 2 is an enlarged vertical sectional view of the communication needle shown in FIG.

FIG. 3 is a longitudinal sectional view showing another embodiment of the communication needle.

FIG. 4 is a sectional view taken along line AA of FIG. 1;

FIG. 5 is a longitudinal sectional view showing another embodiment of the locking means of the automatic injector according to the present invention.

FIG. 6 is a plan view showing still another embodiment of the locking means of the automatic injector according to the present invention.

FIG. 7 is a schematic diagram showing a state in which an infusion set including a flow rate control means is connected to the automatic injector shown in FIG. 1;

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Syringe outer cylinder 12 Rubber stopper 15 Gasket 2 Cap-shaped member 21 Top surface 24 Through hole 26 Notch 27 Notch 3 Spring compression member 31 Spring receiver 33 Pin insertion hole 35 Ridge 4 Coil spring 51 Nut member 55 Lock pin 56 Engagement protrusion 6 communication needle 61 connection part 62 puncture needle 7 cap

Claims (8)

(57) [Claims] 1. A gasket having a cylindrical member having a distal end and a proximal end which is open at both ends, the distal end opening of which is sealed with a rubber stopper, and a proximal end side bore slidably inserted from the proximal end opening. A syringe outer cylinder filled with an injection solution in a space between the sealing member and the gasket, and a cap-shaped member attached to the proximal end of the syringe outer cylinder and having a through hole in a top surface. And a spring receiver is provided at one end thereof, the spring receiving side is inserted into the syringe outer cylinder, and the other end is exposed to the outside of the syringe outer cylinder through a through hole of the cap-shaped member. And a coil spring which is accommodated in a contracted state between the spring receiver of the spring compression member and the top surface of the cap-shaped member and is extendable in the longitudinal axis direction, wherein the spring compression member is a lock. Means that the syringe barrel cannot move in the axial direction. When the lock means is removed and the rubber stopper of the syringe outer cylinder is pierced with a communication needle, the coil spring extends to slide the gasket toward the distal end of the syringe outer cylinder. Automatic syringe. 2. The locking means is a nut member, and a male screw is formed on an outer surface of a portion of the spring compression member exposed to the outside of the syringe outer cylinder, and the male screw and the female screw of the nut member are engaged. 2. The automatic injector according to claim 1, wherein the automatic injector is adapted to match. 3. The automatic injector according to claim 2, wherein the spring compression member is provided with a rotation preventing means so that the spring compression member does not rotate when the nut member is rotated. 4. The lock means is a lock pin, and a pin insertion hole is provided in a portion of the spring compression member exposed to the outside of the syringe outer cylinder so that the insertion hole and the lock pin engage. Item 6. The automatic injector according to Item 1. 5. The locking means is an engaging projection provided at a direction perpendicular to the axis at an end of a portion of the spring compression member exposed to the outside of the syringe outer cylinder, and a notch is provided in a through hole of the cap-shaped member. 2. The automatic injector according to claim 1, wherein the locking means is released when the engaging projection comes to the notch by rotating the spring compression member. 6. A syringe needle according to claim 1, wherein a communication needle having a connection portion and a puncture needle at both ends thereof is attached to a distal end portion of the syringe outer cylinder so that the puncture needle side comes to the syringe outer cylinder side. The automatic injector as described. 7. The automatic injector according to claim 6, wherein a connection portion of the communication needle is protected by a cap. 8. The automatic injector according to claim 6, wherein a passage closing means is provided at a connection portion of the communication needle.