JPH09225032A - Syringe - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a syringe previously filled with a liquid, which enables highly simplifying of the molding of an outer cylinder while sufficiently securing safety for handling, contamination and the like during injection along with safe operation. SOLUTION: An outer cylinder 2 is a molded product made of a thermoplastic resin and a plug body 5 is provided on the side of a gasket 4 spaced at an interval from an injection port 2A. A ridge rib 11 extending almost in the axial direction of the outer cylinder 2 is formed on an internal wall of the outer cylinder part between the plug body 5 and the injection port 2A. In the course of movement of the plug body to the injection port 2A, an outer circumferential wall of the plug body 5 is elastically deformed by the ridge rib 11 to form a clearance so that an injection agent 6 passes to the injection port. The ridge rib 11 formed at the position between the plug body 5 and the injection port 2A provides a space part at least with the width thereof exceeding 2mm during the formation of the clearance.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a syringe pre-filled with an injection agent. More specifically, the injection method of the outer cylinder is simple, and the injection agent is liquid-tightly filled in the outer cylinder. The present invention relates to a two-component syringe in which sterilization can be easily performed, different injection components are aseptically filled, and each injection component is sequentially and aseptically administered into the body upon injection.

[0002]

2. Description of the Related Art In recent years, in order to prevent medical accidents and to prevent hospital-acquired infections and the like as much as possible, sterile or aseptic pre-filled syringes have been filled with injections such as drugs or medicinal solutions. Syringes, commonly referred to as field syringes, have been proposed. In addition, a multi-component syringe in which an injection of two or more pharmaceutical ingredients is separately filled in the prefield syringe until the injection is also proposed.

Conventionally, in such an injector, in addition to an outer cylinder having an injection port to which an injection needle is attached at the tip and a plunger having a gasket, the syringe is disposed at the inner end of the tip in the outer cylinder. There is proposed a plug having a plug for closing the injection port, and an injection liquid is liquid-tightly filled between the plug and the gasket (Japanese Utility Model Publication No. 2-51560). In such a syringe, the outer cylinder can be liquid-tightly filled with a predetermined amount of the injection liquid almost completely (a state in which air or the like hardly enters the filling chamber). Further, steam sterilization and the like are extremely easy, and if the gasket can be slid to some extent during sterilization, a method such as smooth sterilization without pressure in the filling chamber can be adopted (JP-A-5-253296, JP-A-5
-305140).

For the above-mentioned purpose, the multi-component injector has a hollow inner wall surface between the stopper and the injection port, and the hollow is formed as a bypass passage for mixing the injection components. FIG. 13 is a sectional view of a conventional two-component syringe. As shown in FIG. 13, the syringe 70 includes a plunger 71 having a gasket and an outer cylinder 72, and the outer cylinder 72 is a glass or plastic molded product. A hollow portion 73 (or an expanded portion of the inner diameter) is formed on the inner wall surface of the outer cylinder 72 in the axial direction, and the hollow portion 73 is between the sliding plug body 74 and the injection port 75. In addition, an injectable drug 7 different from the first component and the second component 7
6 and 77 are aseptically filled with the stopper 74 as a boundary, and the injection port 75 is covered with a cap 78.

In the syringe 70 having such a structure,
When the plunger 71 is pushed in, the stopper 74 is moved and positioned in the recess 73. Therefore, the injection agent 77 on the proximal end side flows into the distal end portion side from the recessed portion 73 by the further pushing of the plunger 71 as shown in FIG. Therefore, the injections 76 and 77 are aseptically mixed in the outer cylinder 72 at the time of use and provided as required injections. In addition, when manufacturing a syringe,
Nos. 6 and 77 are subjected to high-pressure steam sterilization. In this case,
If the gasket can be slid to some extent during sterilization, it is possible to adopt a method that can be smoothly sterilized without applying pressure to the filling chamber (JP-A-5-253296 and JP-A-5-305140).

[0006]

However, in the conventional syringe, a double-ended pricking injection needle having a pricking portion at both ends is used in order to make the injection port and the filling chamber communicate with each other at the time of injection. Since such an injection needle punctures the stopper inside the outer cylinder once when the injection port is attached, there is a risk that the contamination resistance against handling of the injection needle may be lost. In addition, since it is necessary to attach the injection needle at the injection site, the safety against contamination during operation is reduced. Further, the outer cylinder used in the conventional syringe is an expensive glass outer cylinder, but unlike the outer cylinder made of plastic, it is not easy to mold and it takes time to dispose of it after use. There is a problem.

Further, the conventional two-component syringe has various problems. First, there is a problem in molding the outer cylinder. A hollow portion 73 is formed on the outer cylinder. The formation of the hollow portion is
Molding is difficult regardless of whether it is made of glass or plastic. In particular, with a plastic syringe that is convenient as a disposable syringe, it is difficult to perform die-cutting from the recessed portion 73, and therefore injection molding cannot be performed to obtain a sufficient yield.
Secondly, there is a problem in high-pressure steam sterilization of the injection agent 76 on the tip side of the outer cylinder. The sterilization of the injection agent 77 on the proximal side does not cause any problem if the gasket can be slid to some extent during sterilization, but the sterilization of the injection agent 76 on the distal end cannot place the stopper 74 slidably. For this reason, the inside of the tip portion of the outer cylinder has a high pressure during sterilization, and a weak mouth portion may be damaged in the glass outer cylinder, and plastic material may be expanded and plastically deformed by pressure and heat. In particular, in the conventional two-liquid component injector, since the injection agent 77 on the proximal end side is allowed to completely flow into the distal end side external cylinder before injection, a space is required in the distal end side external cylinder of the injection agent 76, Air in the air gaps promotes the above problems. Third, the conventional two-component syringe was designed on the premise that the injections are mixed with each other at the time of injection, but a new two-component syringe like the invention of the present application described later does not mix at the time of injection. What to inject in is desired. Therefore, in the conventional syringe 70, it is impossible to first inject the injection agent 76 on the distal end side into the body and then inject the injection agent 77 on the proximal end side. For example, when administering an injectable agent 77 with pain, the injectable agent 76 and the injectable agent 77 are mixed with each other. Therefore, a local anesthetic is used for the injectable agent 76 to relieve the local pain of the injection and then The accompanying injection 77 cannot be aseptically injected. In addition, the inventors of the present application have proposed various types of plugs that can be opened in the vicinity of the injection port of the outer cylinder. It has been found that in such a syringe, when the plug is opened during its operation, excessive pushing of the plunger occurs. Therefore, due to such excessive pushing, there is a problem that the injection agent in the outer cylinder jumps out from the injection port.

Therefore, it is an object of the present invention that the outer cylinder can be molded very easily, the safety against handling and contamination during injection is sufficiently ensured, and the operation is made safe by prefilling with liquid. To provide a syringe. The object of the present invention is also that the outer cylinder has extremely high heat distortion resistance against high-pressure steam sterilization, ensures sterilization of the two-component injection, and does not mix the two-component injection during injection. It is an object of the present invention to provide a pre-liquid-filled two-component syringe that can be sequentially and aseptically administered.

[0009]

SUMMARY OF THE INVENTION The present invention comprises an outer cylinder having an injection port to which an injection needle is attached at the tip, and a plunger attached with a gasket and inserted into the outer cylinder. In a syringe in which a plug is arranged in the inner part of the tip of the outer cylinder to close the injection port and the injection is liquid-tightly filled between the plug and the gasket, the outer cylinder is a molded product of a thermoplastic resin. The plug body is provided on the gasket side at a constant distance from the injection port, and the inner wall of the outer cylinder portion between the plug body and the injection port is provided in a substantially axial direction of the outer cylinder. An extended ridge rib is formed, and while the plug is moving to the injection port, the ridge rib elastically deforms the outer peripheral wall of the plug to form a space for the injection to flow into the injection port, Moreover, the position between the plug body and the injection port at the time of forming the void is small. By Kutomo width (S) to provide a syringe which is characterized in that the ridge ribs are formed so as to have a space of more than 2 mm, it is obtained by achieving the above object.

In the syringe according to the present invention, the width (S) of the space is less than or equal to the total width of the gasket and the plug. In the syringe according to the present invention, a partition plug body is provided between the gasket and the plug body in the outer cylinder, and the partition plug body is filled with injection agents of different components, and the width of the space portion. (S) achieves the second object by providing a syringe characterized by having a total width of the gasket, the stopper and the partition stopper which is equal to or less than the total width.

[0011]

In the syringe, as shown in FIG. 1, for example, a plug is arranged near the injection port of the outer cylinder, and the injection is aseptically contained between the plug and the gasket of the plunger. Further, a convex rib is formed on the inner wall surface of the outer cylinder between the plug body and the injection port. Therefore, when the plunger is pushed in at the time of the operation, the plug body is pushed toward the ejection port side in conjunction with this. The convex rib bites into the outer peripheral wall of the pushed plug body, and the outer peripheral wall of the plug body is deformed. Due to the deformation of the outer peripheral wall of the stopper, a gap is formed between the outer peripheral wall of the stopper and the inner wall of the outer cylinder, and the injection agent between the stopper and the gasket flows into the injection port side through the gap. When the plunger slides, it receives the dynamic friction resistance of the gasket and the plug body and the riding resistance of the convex rib, and when a gap is formed between the outer peripheral wall of the plug body and the inner wall of the outer cylinder, the dynamic friction resistance of the plug body. Also, the riding resistance of the convex rib is eliminated. Therefore, at the moment when a gap is created between the outer peripheral wall of the stopper and the inner wall of the outer cylinder, in operation of the plunger,
Excessive indentation occurs. Therefore, due to such excessive pushing, the injection agent between the gasket and the stopper may suddenly flow into the injection port side through the gap, and the injection agent may fly out from the attached needle tip. However, in the above syringe, when a gap is formed between the outer peripheral wall of the stopper and the inner wall of the outer cylinder, at least the width (s) is 2 mm or more at the position between the stopper and the injection port. Since the convex rib is formed so as to have the space portion, the injectable agent that rapidly flows in is stocked in the space portion, and there is no fear that the injectable agent will fly out from the attached needle tip.

The outer cylinder of the syringe is easily injection-molded at the time of manufacture. That is, when the outer cylinder, which is a resin molded product, is injection-molded, the ribs formed on the inner wall at the tip of the outer cylinder can be easily formed. Since the ribs are formed in the axial direction and extend toward the inner part of the distal end of the outer cylinder, the mold can be easily removed during injection molding. Furthermore, when the convex ribs are formed so that the tops gradually rise toward the inner part of the tip and are formed in a taper shape, the outer cylinder molded product is less susceptible to distortion and the like at the time of mold release.
When assembling the above-mentioned syringe, the stopper is first inserted into the outer cylinder, the injection is filled, and the gasket is fitted to perform high-pressure steam sterilization. A general injection needle is used and may be attached to the injection port of the outer cylinder in advance for steam sterilization. Therefore, high-pressure steam sterilization of the injection is easily performed, and unlike the case where a double-ended stick type injection needle or the like is attached, a normal injection needle can be already sterilized and attached to the outer cylinder.

[0013]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of a syringe according to the present invention will be described below in detail with reference to the accompanying drawings. FIG. 1 is a side sectional view of a first embodiment of the syringe of the present invention, FIG. 2 is a sectional view of the syringe taken along the line I-I of FIG. 1, and FIG. 3 is a partially pushed plunger of the syringe of FIG. FIG. 4 is a side sectional view showing a state, FIG. 4 is a sectional view of the syringe taken along line II-II of FIG. 3, FIG. 5 is a side view of a stopper used in the syringe of the first embodiment, and FIG. 6 is FIG. Fig. 7 is a side sectional view of the stopper body portion, Fig. 7 is a side sectional view of the first embodiment when the plunger is completely pushed in, and Fig. 8 is a shoulder inner wall surface of the tip of the outer cylinder of the syringe in the first embodiment. FIG.

The syringe 1 of the first embodiment shown in FIGS.
Is composed of an outer cylinder 2 having an injection port 2A to which an injection needle 7 is attached at the tip, and a plunger 3 fitted with a gasket 4 and fitted into the outer cylinder 2. The injection body 6 is liquid-tightly filled between the plug body 5 and the gasket 4 by disposing the plug body 5 in the portion to close the injection port 2A. The outer cylinder 2 of the syringe 1 is a molded product of thermoplastic resin, and has a plug 5
Is provided on the gasket 4 side at a constant distance from the injection port 2A, and on the inner wall of the outer cylinder 2 portion between the plug body 5 and the injection port 2A, a ridge rib 11 extending in the axial direction of the outer cylinder 2 is provided. , 11 ...
··························································································································································································································································································· [ Is formed. Further, at least a width (S) of 2 mm or more is provided at a position between the plug body 5 and the injection port 2A when forming the gap, and the gasket 4 is provided.
The ribs 11, 11 ... Are formed so as to have a space 99 that is less than or equal to the total width of the plug 5.

To further explain the syringe 1 of this embodiment, the outer cylinder 2 of the syringe 1 of this embodiment is a molded product of a thermoplastic resin and is formed by injection molding. Convex ribs 11 on the outer cylinder 2
Such a plastic cylinder is preferable for forming Examples of the plastic material used include low density or high density polyethylene, polypropylene,
Polyolefins such as polybutadiene-1, polyvinyl chloride, polyvinylidene chloride, vinylidene chloride copolymer,
Examples thereof include polymethyl methacrylate, polyvinyl alcohol, ethylene-vinyl alcohol copolymer, acrylonitrile copolymer and polyethylene terephthalate. In particular, polyolefins are preferable from the viewpoint of versatility and chemicals, and those having a high glass transition temperature such as an amorphous cyclic olefin copolymer and a specific gravity of 1.0 to 1.1 are desirable. . Specifically, it is a polyolefin resin such as a trade name Zeonex (Nippon Zeon Co., Ltd.) and a trade name Apel (Mitsui Petrochemical Industry Co., Ltd.), which are recently used as materials for optical disk substrates, optical lenses and the like.

The gasket 4 and the plug 5 may be any as long as they have an elastic body that maintains liquid tightness with the inner wall of the outer cylinder 2. Specifically, a rubber gasket and a rubber stopper are used.
As shown in FIGS. 1 and 2, the plug body 5 is provided on the gasket 4 side with a certain distance from the injection port 2A, and the injection agent 6 is sterilized in the outer cylinder 2 between the gasket 4 and the plug body 5. Filled with. High-pressure steam sterilization is performed for sterilization, and aseptic filling can be performed in addition to this, but high-pressure steam sterilization is desirable to ensure sterilization.

A plurality of convex ribs 11 are formed on the inner wall surface of the outer cylinder 2 between the stopper 5 and the injection port 2A in the axial direction of the outer cylinder 2. That is, the ribs 11 are formed in a direction substantially the same as the die cutting direction when the outer cylinder 2 is molded. The number of the ribs 11 is 1 or more, preferably 3 or more,
It is more preferably 5 or more. When a plurality of convex ribs 11 are formed, they may be arranged symmetrically with respect to each other, or may be formed so as to be biased to a part of the inner wall surface of the outer cylinder 2. Further, the convex rib 11 is a tapered top portion 11A that gradually rises toward the inner end of the outer cylinder 2. The taper is not always necessary. However, the formation of the tapered top portion 11A allows the die to be smoothly removed without being affected by the die or the like during the die removal of the molding, and the plug body 5 can be smoothly inserted deep into the outer cylinder 2 when the syringe 1 is used. Can be inserted.

The inner diameter (L) of the outer cylinder 2 is 12 mm, and the plug 5 slides in the outer cylinder 2 in a liquid-tight manner as shown in FIG.
The diameters of the peripheral elastic rib portions 5A, 5A of the plug body 5 are formed to be slightly thicker than the inner diameter of the inner wall outer cylinder 2. Twelve convex ribs 11 are formed at regular intervals. Further, the maximum height (w) of the convex rib top portion 11A is 1 mm. A preferable range of the maximum height (w) of the convex rib tops 11A is determined by the inner diameter (L) of the outer cylinder, and the maximum height (w) of the convex rib tops 11A is 1 of the inner diameter (L) of the outer cylinder. It is preferably / 50 to 1/5 times. When the maximum height (w) of the convex rib top portion 11A is less than the above range, the outer peripheral wall of the outer cylinder 2 and the plug body 5 are separated.
There is a possibility that a sufficient space 12 cannot be formed between the inner peripheral wall of the plug and the inner wall of the plug.

The position where the ribs 11 are formed is determined by the position where the plug 5 is elastically deformed and a gap is formed between the outer peripheral wall of the plug 5 and the inner wall of the outer cylinder 2. That is, as shown in FIG. 3, a gap is formed during the movement of the plug body 5 to the ejection port 2A, and a space portion having a width (S) of at least 2 mm or more between the plug body and the ejection port when the gap is formed. The ridge rib 11 is formed so that 99 exists. The width (S) of the void 99 is 2
It is desirable that the width is not less than mm, particularly not less than 4 mm and not more than the total width of the gasket 3 and the plug 5. If the width (S) of the void 99 is less than the above range, the excessive inflow of the injection cannot be stored. If the amount exceeds the above range, liquid leakage from the gasket 4 may occur due to the ribs 11 in the state of FIG. 7.

As shown in FIG. 8, a plurality of protrusions 14 are formed on the inner wall of the shoulder 13 in which the injection port 2A of the outer cylinder 2 of this embodiment is formed. Passages 15, 15 are formed for guiding the injection 6 flowing through the space 12 between the inner wall and the outer wall of the plug 5 to the injection port 2A. The passage 15 is not necessarily required, but prevents the plug 5 from completely adhering to the inner peripheral surface of the shoulder 13 and blocking the outflow passage of the injection 6. Therefore, instead of forming the projecting portion 14, a groove-like portion is formed on the inner wall surface of the shoulder portion 13 to form the injection port 2
You may secure the passage to A.

Next, a method of manufacturing the above-mentioned syringe 1 will be described. First, the ribs 11, the ribs 11, and the outer tube 2 are formed by injection molding.
And the protrusion 14 is accurately formed. In this case, since the ribs 11 are formed in a taper shape in the axial direction of the outer cylinder 2, the outer cylinder 2 can be accurately die-molded without being distorted.
In particular, accurate molding can be performed with the above-mentioned amorphous polyolefin. The injection 6 is filled in the outer cylinder 2, and after the filling, the gasket 4 is attached to the outer cylinder 2. Plunger 3
Is attached to the gasket 4, and the injection needle 7 is attached to the injection port 2A. Then, in this state, the syringe 1 is sterilized by high-pressure steam to sterilize the injection 6. The plunger 3 and the injection needle 7 may be aseptically attached after high-pressure steam sterilization.

Next, in the case of injecting using the syringe 1 of this embodiment, when the plunger 3 is pushed in from the state of the syringe of FIG. 1 as shown in FIG. 3, the plug 5 is fired in conjunction with this. It is pushed to the exit 2A side. As shown in FIGS. 4 and 6, the convex ribs 11 bite into the outer peripheral wall of the plug 5 to deform the outer peripheral wall of the plug 5. Due to the deformation of the outer peripheral wall of the stopper 5,
A space 12 is formed between the outer peripheral wall of the outer cylinder and the inner wall of the outer cylinder 2,
The injection agent 7 between the stopper 5 and the gasket 4 flows into the injection port 2A side through the space 12. When the plunger 3 receives the dynamic frictional resistance of the gasket 4 and the plug 5 and the riding resistance of the convex rib during sliding, a gap 12 is formed between the outer peripheral wall of the plug 5 and the inner wall of the outer cylinder 2. The stopper 5 stops, and the dynamic frictional resistance of the stopper 5 and the riding resistance of the convex rib 11 disappear. Therefore, at the moment when the gap 12 is formed between the outer peripheral wall of the plug body 5 and the inner wall of the outer cylinder 2, excessive pushing occurs due to the operation of the plunger 3. Therefore, due to such excessive pushing, the injection 6 between the gasket 4 and the stopper 5 may suddenly flow into the injection port 2A side through the gap 12, and the injection 6 may fly out from the attached needle tip 7. Occurs.

However, in the syringe 1, when the gap 12 is formed between the outer peripheral wall of the stopper 5 and the inner wall of the outer tube 2, at least the width () is provided at a position between the stopper 5 and the injection port 2A. Since the convex rib 11 is formed so that s) has the space 99 of 2 mm or more, the injectable solution 6 that rapidly flows in is stocked in the space 99 and the injection 6 is injected from the tip of the attached needle 7. There is no fear of jumping out. Next, in this state, the air in the outer cylinder 2, the ejection port 2A and the injection needle 7 is expelled, and then the injection needle is punctured into the patient. Then, the plunger 3 is further pushed in and the stopper 5 is slid completely into the outer cylinder 2 to complete the injection process as shown in FIG. Therefore,
The syringe 1 is extremely easy to be sterilized, and since the double-ended needle is not used for the syringe 1, it is possible to attach the injection needle to the syringe 1 in advance, and it is possible to reduce contamination accidents at the work site. it can. In the above embodiment,
Although the plug 5 has two liquid-tight circumferential elastic ribs 5A, such a circumferential elastic rib 5A may not be provided as long as the liquid-tightness is maintained.

Next, a syringe according to a second embodiment of the present invention will be described with reference to FIGS. FIG. 8 is a side sectional view of the second embodiment of the syringe of the present invention. 10 to 12 are sectional views showing steps of using the syringe of the second embodiment. The two-component syringe 21 of the second embodiment shown in FIGS. 9 to 12 has an injection port 2A to which the injection needle 7 is attached at the tip.
And an outer cylinder 2 having a gasket 4 attached thereto and fitted into the outer cylinder 2.
The plug 5 is arranged in the inner part of the tip end to close the ejection port 2A and the plug 5
Since the injection agents 6A and 6B are liquid-tightly filled between the gasket 4 and the gasket 4, the members and the structure are substantially the same as those of the syringe 1 of the first embodiment. The same reference numerals are given and detailed description thereof is omitted. Further, the outer cylinder 2 of the syringe 21 is a molded product of a thermoplastic resin, and the plug body 5 is provided on the gasket 4 side with a certain distance from the injection port 2A, and is provided outside the space between the plug body 5 and the injection port 2A. Since the ribs 11, 11, ... That extend in the axial direction of the outer cylinder 2 are formed on the inner wall of the cylinder 2 portion, the members and the structure are substantially the same as the syringe 1 of the first embodiment. Such members are given the same reference numerals as those of the syringe 1 of the first embodiment, and detailed description thereof will be omitted.

The syringe 21 differs from the syringe 1 in that the partition plug 22 is provided between the gasket 4 and the plug 5 in the outer cylinder 2.
Is provided and filled with the injectables 6A and 6B having different components at the partition plug body 22 as a boundary, and the width (S) of the space portion is not less than the widths of the plug body 5 and the partition plug body 22, the gasket 4 and the plug body 5. And the total width of the partition plug body 22 or less.

The two-component syringe 21 of this embodiment will be further described. The outer cylinder 2 of the syringe 21 is formed longer than before. As with the gasket 4 and the plug 5, the partition plug 22 may be elastic enough to maintain liquid tightness with the inner wall of the outer cylinder 2. Specifically, the same material as the rubber gasket and the rubber stopper is used. An injection agent 6A is accommodated between the stopper body 5 and the partition stopper body 22, and an injection agent 6B is accommodated between the partition stopper body 22 and the gasket 4. For example, in this embodiment, the injection 6A is a local anesthetic, etc.
B is a painful injection. High-pressure steam sterilization is performed for sterilization of the injections 6A and 6B, and aseptic filling can be performed in addition to this, but high-pressure steam sterilization is desirable to ensure sterilization. High-pressure steam sterilization has a temperature of 105 ° C to 14 ° C.
The temperature is in the range of 0 ° C, but especially when the temperature is 105 ° C to 125 ° C.
Is desirably within the range. Within such a range, the outer cylinder 2 is unlikely to be deformed by heat and pressure.

On the inner wall surface of the outer tube 2 between the plug 5 and the injection port 2A, a plurality of elongated ribs 11 having a length similar to that of the syringe 1 of the first embodiment are directed in the axial direction of the outer tube 2. Is formed. The formation position or the length of the convex rib 11 is determined by the position where the plug 5 is elastically deformed and a gap is formed between the outer peripheral wall of the plug 5 and the inner wall of the outer cylinder 2. That is, FIG.
As shown in FIG. 5, a gap is formed during the movement of the plug 5 to the ejection port 2A, and a space 99 exists at least between the width of the plug 5 and the ejection port 2A when the gap is formed and at least the width of the plug 5 or more. Thus, the ribs 11 are formed. The width (S) of the space 99 is preferably less than or equal to the total width of the gasket 3, the plug body 5, and the partition plug body 22. If it exceeds the above range, there is a possibility that the convex rib 11 causes liquid leakage from the gasket 4 in the state shown in FIG.

Next, a method of manufacturing the above-mentioned syringe 1 will be described. First, the ridge rib 11 together with the outer cylinder 2 by injection molding,
And the protrusion 14 is accurately formed. The plug 5 is inserted into the outer cylinder 2 to a predetermined depth, and the injection 6A is filled in the outer cylinder 2. After the injection agent 6A is filled, the partition plug body 22 is attached to the outer cylinder 2
It is inserted to a specified depth with no air inside.
Next, the injection 6B is filled in the outer cylinder 2, and after the filling, the gasket 4 is inserted in the outer cylinder 2 in a state where no air enters. Then, the plunger 4 is attached to the gasket 4, and the injection needle 7 with a protector is attached to the injection port 2A. In this state, the syringe 21 is sterilized by high-pressure steam to sterilize the injections 6A and 6B.

Next, for injection using the two-component syringe 21 of this embodiment, the plunger 3 is pushed in from the state of FIG. 9 and the stopper 5 and the partition stopper are inserted through the injections 6A and 6B. The body 22 is pushed to the position shown in FIG. When pushed to the position shown in FIG. 10, a gap is formed between the outer peripheral wall of the plug 5 and the inner wall of the outer cylinder 2, and the plug 5 stops moving even if the plunger 3 is pushed. Therefore, injection 6
Although A rapidly flows into the space 99 once, it does not leak because it does not reach the needle tip 7. After the air in the space 99 is expelled, the injection 6A is injected and administered to the patient. When the partition plug body 22 is pushed to the position shown in FIG. 11 by the plunger 3, a gap is formed between the outer peripheral wall of the partition plug body 22 and the inner wall of the outer cylinder 2, and the partition plug body 22 is pushed in by the plunger 3. The movement stops even if there is. And
The injection 6B flows into the injection port 2A side, and the plunger 3
Is further pushed and injected into the patient's body. With such administration, the plug body 5 is moved to the portion of the ribs 11, and a gap 12 is formed between the outer peripheral wall of the plug body 5 and the inner peripheral wall of the outer cylinder 2 from the state of FIG. 3 as shown in FIG. It Therefore, the local anesthetic is first administered to the patient, and the painful injection 6B can be administered while the pain is paralyzed.

[0030]

As described above, in the syringe of the present invention, the outer cylinder is a molded product of a thermoplastic resin, and the plug body is provided on the gasket side with a certain distance from the injection port. A ridge rib extending substantially in the axial direction of the outer cylinder is formed on the inner wall of the outer cylinder portion between the plug and the injection port, and the ridge rib is formed while the plug is moving to the injection port. The ribs elastically deform the outer peripheral wall of the plug to form a void for allowing the injection to flow into the injection port, and at least the width (position of between the plug and the injection port at the time of forming the void ( Since the convex ribs are formed so that S) has a space of 2 mm or more, the outer cylinder can be molded very easily, and the safety for handling during injection and contamination is sufficiently ensured. And the operation is done safely. Further, in the injector of the present invention, a partition plug is provided between the gasket and the plug in the outer cylinder, and an injectable agent having different components is filled with the partition plug as a boundary, and the width of the space portion. Since (S) is less than the total width of the gasket, stopper and partition stopper, the outer cylinder has extremely high heat distortion resistance against high pressure steam sterilization, and sterilization of the two-component injection is ensured. That is, the two components can be sequentially and aseptically administered without being mixed at the time of injection.

[Brief description of drawings]

FIG. 1 is a side sectional view of a first embodiment of a syringe according to the present invention.

FIG. 2 is a cross-sectional view taken along line I-I in FIG.

FIG. 3 is a cross-sectional view showing a state where the plunger of the syringe of the first embodiment is pushed in halfway.

4 is a sectional view taken along the line II-II in FIG.

FIG. 5 is a side view of a stopper used in the syringe of the first embodiment.

FIG. 6 is a cross-sectional view showing a state in which the plug body of FIG. 5 is pushed into a ridge rib inside the outer cylinder.

FIG. 7 is a sectional view showing a state where the plunger of the syringe of the first embodiment is completely pushed in.

FIG. 8 is a perspective view of the inner surface of the shoulder portion of the syringe of the first embodiment.

FIG. 9 is a side sectional view of the syringe of the second embodiment.

FIG. 10 is a cross-sectional view showing a state where the plunger of the syringe of the second embodiment is pushed in halfway.

FIG. 11 is a cross-sectional view showing a state where the plunger of the syringe of the second embodiment is pushed in halfway.

FIG. 12 is a sectional view showing a state where the plunger of the syringe in the second embodiment is completely pushed in.

13A and 13B are side sectional views of a conventional syringe.

[Explanation of symbols]

 1, 21 Syringe 2 Outer cylinder 2A Outlet of outer cylinder 3 Plunger 4 Gasket 5 Stopper 6 Injection 7 Injection needle 11 Convex rib 22 Partition stopper

Claims (3)

[Claims] 1. An outer cylinder having an injection port to which an injection needle is attached at the tip, and a plunger attached to the outer cylinder with a gasket attached, and at the inner part of the tip inside the outer cylinder. In a syringe in which a plug is arranged to close the injection port and an injection is liquid-tightly filled between the plug and a gasket, the outer cylinder is a molded product of a thermoplastic resin, and the plug is Provided on the gasket side with a certain distance from the injection port, a ridge rib extending substantially in the axial direction of the outer cylinder is formed on the inner wall of the outer cylinder portion between the plug and the injection port, During the movement of the stopper to the injection port, the outer circumferential wall of the stopper is elastically deformed by the convex ribs to form a space for the injection to flow into the injection port, and the plug at the time of forming the space is formed. At least the width (S) is located between the body and the outlet.
The above-mentioned convex rib is formed so as to have a space of 2 mm or more. 2. The width (S) of the space is less than or equal to the total width of the gasket and the plug body.
The syringe as described. 3. A partition plug body is provided between the gasket and the plug body in the outer cylinder, and injecting agents of different components are filled with the partition plug body as a boundary, and the width of the space (S ) Is less than or equal to the total width of the gasket, stopper and partition stopper, the syringe according to claim 1.