JPH09208420A - Cosmetic material for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic material for a skin, capable of manifesting and imparting an aging prevention effect and a skin beautifying effect and excellent in feeling in use thereof by simultaneously using a mevalonic acid with a specific compound obtained from a shell of a crab or a pawn. SOLUTION: This cosmetic material for a skin is obtained by blending (a) mevalonic acid or mevalonic lactone with (b) a mucopolysaccharide or salt thereof. The blending amount of the component (a) is 0.001-10wt.%, especially 0.01-2.0wt.% approximately and that of the component (b) is 0.001-3.0wt.%, and especially 0.01-1.0wt.% is preferable. Further, the mucopolysaccharide or salt thereof is preferably blended so as to attain 0.1-10wt.% based on mevalonic acid or lactone. Although there are two isomers of R(-)-mevalonic acid and S(+)-mevalonic acid in mevalonic acid of the component (a), easily available R(-)-mevalonic acid is preferable. As the mucopolysaccharide of the component (b), a chitin, a chitosan, a low molecular weight hyaluronic acid (10,000-100,000 molecular weight), etc., are cited.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a skin cosmetic, and more specifically, it exhibits and imparts an excellent anti-aging effect (rough skin improving effect, keratin improving effect, effect of accelerating turnover speed), beautiful skin effect and the like. The present invention relates to a skin cosmetic which is excellent in usability.

[0002]

2. Description of the Related Art Aged skin becomes rough and dry without smoothness, and keratinocyte exfoliation is observed. Aged skin has a slow turnover speed, and it is said that when the antiaging effect is developed and imparted to the skin, the turnover speed of the skin is increased. Heretofore, various cosmetics have been proposed which give an appropriate moist feeling and flexibility to the skin surface, and for example, JP-A-4-99707 proposes a skin cosmetic containing R-(-) mevalonic acid. However, although these skin cosmetics act on the epidermis of skin tissue, they rarely act on the dermis, which is the tissue below the epidermis, and none of them has a sufficient effect of preventing skin aging. In addition, mucopolysaccharides are present in connective tissue that fills the space between parenchymal cells of the living body and regulate the volume of extracellular fluid, migration of electrolytes, equilibrium and deposition of calcium in tissues, etc. It is a substance that plays an important role in relation to etc. Conventionally, it has been proposed to use mucopolysaccharide as a moisturizing agent in skin cosmetics, but it does not have a sufficient effect for preventing skin aging, and in particular, skin cosmetics containing a low-molecular mucopolysaccharide. When applying the product to the skin,
It had a sticky feeling and was inferior in usability.

[0003]

The object of the present invention is to develop and impart an anti-aging effect (rough skin improving effect, keratin improving effect, effect of accelerating turnover speed), and beautiful skin effect, and a feeling of use ( It is to provide a skin cosmetic excellent in (no stickiness).

[0004]

[Means for Solving the Problems] The above-mentioned object is achieved by a skin cosmetic containing (a) one or more selected from mevalonic acid and a mevalonic acid lactone and (b) one selected from mucopolysaccharide and a salt thereof. To be achieved.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The mevalonic acid used as the component (a) in the present invention is also referred to as pyroclastic acid (molecular formula: C ₆ H ₁₂ O ₄ ), and true fire bacterium (Lactobacillus) mixed in sake.
lulus homeochichi and L. et al. hetero
chichi), and lactic acid bacteria (L. a.
It is a substance discovered as a growth promoting factor of cidophillus) and is used as a biosynthetic precursor of isoprenoid compounds such as sterols, or as a raw material for chemical or enzymatic synthesis of various optically active substances. And to mevalonic acid, two kinds of isomers [R (-)-mevalonic acid, S
(+)-Mevalonic acid], and naturally-occurring R
Although (-)-mevalonic acid can be used in the present invention, R (-)-mevalonic acid, which is easily available, is preferable. R (−)-mevalonic acid is described in, for example, JP-A-63 / 1988.
-216184, JP-A-63-216485, JP-A-63-216486, and JP-A-63-216487. Or racemic mixture (isomer mixture) by chemical synthesis method
Alternatively, each isomer can be obtained separately. In addition, mevalonic acid lactone (molecular formula: C ₆ H ₁₀ O ₃ ) which is a derivative of mevalonic acid used as the other component (a) in the present invention is a compound having a property of being easily converted to mevalonic acid by hydrolysis. is there.

On the other hand, the mucopolysaccharides used as the component (b) in the present invention include, for example, chitin, chitosan, high molecular hyaluronic acid (molecular weight: several million), low molecular weight hyaluronic acid (molecular weight: 3,000 to 100,000). ), Or high molecular weight, low molecular weight chitin, chitosan, chondroitin 4 sulfate, chondroitin 6 sulfate, deltamatan sulfate, chondroitin 4, 6
Examples include shark cartilage extract and purified products containing boric acid, keratan sulfate, heparin, heparan sulfate, and mucopolysaccharides thereof, and bovine nasal cartilage mucin purified products. Among these mucopolysaccharides, low molecular weight hyaluronic acid (molecular weight 1,000 to 100,000)
However, it is preferable to achieve the object of the present invention. Also,
Examples of the salts include potassium and sodium salts of these mucopolysaccharides. Two or more kinds of these mucopolysaccharides and salts thereof may be blended in the skin cosmetic of the present invention.

The mucopolysaccharide and salts thereof contained in the skin cosmetic of the present invention may be of any quality suitable for incorporation into the skin cosmetic, and no special one is required. When mucopolysaccharides are prepared from animal tissues and used, the animal tissues containing mucopolysaccharides (eg, crab and shrimp shells, chicken cobs, shark skin, animal cartilage, animal organs, etc.) are degreased and then watered. After extraction, the extract is subjected to treatments such as desalting, deproteinization and nucleic acid removal, and then purified by an ethanol precipitation method or the like. If necessary, it is further subjected to gel filtration, purification using ion exchange cellulose, ion exchange Sephadex, etc. before use.

The skin cosmetic of the present invention can be obtained by using (a) one or more selected from mevalonic acid and mevalonic acid lactone and (b) one or more selected from mucopolysaccharide and a salt thereof. By the synergy of
An excellent anti-aging effect of skin is exhibited. Further, when a skin cosmetic containing only mucopolysaccharide is applied to the skin, there is a sticky defect, but as in the present invention, by using mucopolysaccharide, mevalonic acid, and mevalonic acid lactone in combination,
A skin cosmetic having an improved stickiness and an excellent feeling in use can be obtained.

In the skin cosmetic of the present invention, the compounding amount of one or more of (a) component mevalonic acid and mevalonic acid lactone is preferably 0.001 to 10% by weight based on the total amount of the skin cosmetic. Hereinafter, it is abbreviated as wt%), and particularly preferably 0.01 to 2.0 wt%. Further, the blending amount of one or more of the component (b), mucopolysaccharide, and a salt thereof is preferably 0.001 to 3.0 wt%, and particularly preferably 0.01 to 1.0 wt%.
Furthermore, it is desirable to mix the mucopolysaccharide and its salt in an amount (weight) of 0.1 to 10 times that of mevalonic acid or mevalonic acid lactone.

The dosage form of the skin cosmetic of the present invention is not particularly limited, and a usual skin cosmetic dosage form such as cream, emulsion, lotion, ointment, powder, etc. is applied. be able to. The skin cosmetics of the present invention appropriately contain, as other components, an emulsifier, an oily substance, a moisturizer, a thickener, a fragrance, an antiseptic, an antioxidant, a colorant and the like within a range to achieve the object of the present invention. You can

[0011]

The present invention will be described below in detail based on examples and comparative examples. In the Examples, (1) the method for measuring the turnover speed of the stratum corneum, (2) the method for measuring the effect of improving rough skin, (3) the method for measuring the effect of improving stratum corneum, and (4) the sensory test are as follows. .

(1) Method for measuring turnover rate of stratum corneum 5 wt% of dansyl chloride as a fluorescent dye in white petrolatum
% Ointment was prepared and occluded and applied to the skin of the forearm of 20 subjects for 24 hours, and dansyl chloride was osmotically bonded to the stratum corneum. Thereafter, the test sample was applied to the same site twice a day (morning and evening), and the fluorescence of dansyl chloride was examined every day.
The number of days until the fluorescence disappeared was defined as the skin stratum corneum turnover speed. The measurement results were shown as an average of the number of days for each subject. The normal skin stratum corneum turnover is 1
4-16 days, but extends around 18 days in aged skin. On the other hand, when the anti-aging effect appears, 12
It is shortened to around days.

(2) Method for measuring the effect of improving rough skin The effect of continuous application for 4 weeks was investigated for 20 middle-aged and elderly subjects who have rough skin on their lower legs. That is, a test sample is applied to the left lower leg test site of the subject twice a day (morning and evening),
The skin condition before and after the test was evaluated according to the criteria shown in Table 1 below. The lower leg on the right side was used as a control without applying the test sample.

[0014]

[Table 1]

Then, the judgment results of the test site before and after the test and the control site are compared, and when the skin dryness is improved by two stages or more (for example: + → −, ++ → ±), it is “effective” and improved by one stage. When the result is "slightly valid", when there is no change, it is considered "invalid". The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

(3) Method for measuring the effect of improving keratin (increasing anti-peeling property of keratinocytes) Scotch tape (Nichiban Mending Tape) was adhered to the skin of the test area before and after the start of and the end of the rough skin improvement measurement test. When this is peeled off, the state of keratinocytes attached to the tape is examined in detail by a scanning electron microscope,
The stratum corneum exfoliating property was classified according to the criteria shown in Table 2 below, and the effect of improving the keratin was determined.

[0017]

[Table 2]

The judgment is “effective” when the difference between the evaluation points of the test site and the control site after continuous application for 4 weeks is 2 or more, “effective”, 1 or more is “slightly effective”, and 0 is 0. "Invalid" The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

(4) Sensory test (Beautiful skin effect and usability test) Female subjects (35-35) who complain of rough skin, fine wrinkles, dry skin, etc.
Test sample twice a day (morning, evening) for 20 persons 3
The coating was applied for 1 month, and the effect after 1, 2 and 3 months was evaluated.
The test results are "wet skin,""smoothskin,""tension on skin,""application" for each item of wettability, smoothness, and elasticity of skin. There is no sticky feeling afterwards. "

Examples 1 to 4 and Comparative Examples 1 to 7 (skin cream) One or more kinds selected from mevalonic acid and mevalonic acid lactone (a), and one kind selected from mucopolysaccharides and salts thereof (b). And were blended as described in Table 4, each skin cream was prepared with the composition of Table 3, and the above-mentioned various experiments were carried out.

(1) Composition

[Table 3]

(2) Preparation method The components (A) and (B) are uniformly heated and dissolved to bring the temperature to 80 ° C., and then the component (A) is poured into the component (B) and mixed by stirring. Then, the temperature was cooled to 30 ° C. with stirring to prepare a skin cream. It is considered that the R (-)-mevalonic acid lactone blended in the skin cream coexists with R (-)-mevalonic acid by hydrolysis.

(3) Properties Tables 4 and 5 show the results of various tests performed on each skin cream.

[0024]

[Table 4]

[0025]

[Table 5]

As shown in Tables 4 and 5, the skin creams of Comparative Examples 1 to 7 without (a) component mevalonic acid or mevalonic acid lactone, or (b) component hyaluronic acid or chitosan were blended alone or alone. Although sufficient effects cannot be obtained in various characteristics, (a) of Examples 1 to 4 of the present invention
A skin cream that uses mevalonic acid or mevalonic acid lactone in combination with (b) component hyaluronic acid or chitosan is effective in improving rough skin, improving keratin, and increasing turnover speed, that is, the effect of preventing skin aging. In addition to the wettability, smoothness and elasticity were obtained after 2 months of application in a sensory test, and a non-sticky feeling was obtained as a feeling of use.

Example 5, Comparative Examples 8 to 10 (Skin Lotion) Each skin lotion was prepared according to the composition shown in Table 6 below, and various tests were carried out.

(1) Composition

[Table 6]

(2) Preparation Method The ingredients in Table 6 above were stirred and uniformly dissolved to prepare a skin lotion.

(3) Characteristics Table 7 shows the results of the sensory test of each skin lotion.

[0031]

[Table 7]

As is apparent from Table 7 above, the skin lotion of Example 5 provided a good skin-beautifying effect two months after application. Also, the effect of preventing skin aging (effect of improving rough skin, effect of improving keratin, effect of accelerating turnover speed) was confirmed. Furthermore, Example 5 was less sticky than Comparative Example 10, and was excellent in usability.

Example 6 (Skin Cream) A skin cream having the composition shown in Table 8 below was prepared.

[Table 8]

(2) Preparation method The components (A) and (B) shown in Table 8 were uniformly heated and dissolved to bring the temperature to 80 ° C. Then, after injecting and emulsifying the component (B) into the component (A) A, the mixture is stirred at 30 ° C.
Cooled down.

Example 7 (makeup base) A makeup base having the composition shown in Table 9 below was prepared. (1) Composition

[Table 9]

(2) Preparation method The components (A) and (B) shown in Table 9 were uniformly heated and dissolved to bring the temperature to 80 ° C. Next, the component (A) was injected and emulsified while stirring the component (B) with a homomixer, and then cooled to 30 ° C.

Example 8 (Skin milk) Skin milk having the composition shown in Table 10 below was prepared. (1) Composition

[Table 10]

(2) Preparation method The components (A) and (B) shown in Table 10 were uniformly heated and dissolved to bring the temperature to 80 ° C. Then, after injecting and emulsifying the component (B) in the component (A), the mixture is stirred at 30 ° C.
Cooled down.

The above-mentioned Examples 6 to 8 showed an excellent skin beautifying effect, a skin aging preventing effect (rough skin improving effect, keratin improving effect, effect of accelerating turnover speed) and feeling of use (no sticky feeling).

[0040]

EFFECTS OF THE INVENTION As described above, the present invention is excellent in the effect of preventing skin aging (effect of improving rough skin, effect of improving keratin, effect of increasing turnover speed), beautiful skin effect, and feeling of use (no sticky feeling). It is clear that it provides a useful skin cosmetic.

Claims (1)

[Claims] 1. A skin cosmetic comprising (a) one or more selected from mevalonic acid and a lactone of mevalonic acid, and (b) one or more selected from mucopolysaccharide and a salt thereof.