JPH08505152A - ワクチン製剤 - Google Patents
ワクチン製剤Info
- Publication number
- JPH08505152A JPH08505152A JP6515529A JP51552994A JPH08505152A JP H08505152 A JPH08505152 A JP H08505152A JP 6515529 A JP6515529 A JP 6515529A JP 51552994 A JP51552994 A JP 51552994A JP H08505152 A JPH08505152 A JP H08505152A
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- immunogen
- vaccine formulation
- formulation
- adsorbed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.アルミニウム塩アジュバントに吸着された免疫原を含んでなる、安定な粒 状形の即時放出ワクチン製剤。 2.アルミニウム塩アジュバントが水酸化アルミニウム又はリン酸アルミニウ ムである、請求項1に記載のワクチン製剤。 3.タンパク質安定剤を更に含んだ、請求項1に記載のワクチン製剤。 4.安定剤が糖又は糖誘導体である、請求項3に記載のワクチン製剤。 5.安定剤がトレハロース、ラクトース、デキストロース及びグルコサミンか らなる群より選択される、請求項4に記載のワクチン製剤。 6.粒状形が易流動性粉末である、請求項1に記載のワクチン製剤。 7.アルミニウム塩吸着免疫原の水性懸濁液を形成し、その後上記懸濁液をス プレードライするステップを含む、請求項1に記載のワクチン製剤の製造方法。 8.粒子が別々の免疫原含有部分を含む生分解性ポリマーの連続マトリックス を含んでなる微小球粒子である、安定な粒状形の制御又は遅延放出ワクチン製剤 。 9.免疫原含有部分がアジュバントも含んでいる、請求項8に記載のワクチン 製剤。 10.免疫原含有部分がアルミニウム塩アジュバントに吸着された免疫原を含 んだ粒子を含有している、請求項8に記載のワクチン製剤。 11.生分解性ポリマーがポリ乳酸、ポリグリコール酸及びそれらのコポリマ ーからなる群より選択される、請求項8に記載のワクチン製剤。 12.生分解性ポリマーを溶解させた連続有機相中に免疫原と場合によりアジ ュバントを含む水性懸濁液のエマルジョンを形成し、その後油中水型エマルジョ ンをスプレードライして微小球粒子を形成するステップを含む、請求項8に記 載のワクチン製剤の製造方法。 13.エマルジョンが乳化剤を含有している、請求項12に記載の方法。 14.生分解性ポリマーを溶解させた連続有機相中に粒状免疫原含有物質と場 合によりアジュバントとの懸濁液を形成し、その後懸濁液をスプレードライして 微小球粒子を形成するステップを含む、請求項8に記載のワクチン製剤の製造方 法。 15.粒状免疫原含有物質がアルミニウム塩アジュバントに吸着された免疫原 を含んでいる、請求項14に記載の方法。 16.請求項1〜6のいずれか一項に記載の少くとも1種の即時放出ワクチン 製剤を医薬又は獣薬用に許容されるキャリア又は希釈剤と一緒に含んでなるワク チン組成物。 17.請求項8〜11のいずれか一項に記載の少くとも1種の制御又は遅延放 出ワクチン製剤を医薬又は獣薬用に許容されるキャリア又は希釈剤と一緒に含ん でなるワクチン組成物。 18.少くとも1種の即時放出ワクチン製剤を安定な粒状形で更に含んでいる 、請求項17に記載のワクチン組成物。 19.即時放出ワクチン製剤がアルミニウム塩アジュバントに吸着された免疫 原を含んでいる、請求項18に記載のワクチン組成物。 20.非経口投与用に適した形をした、請求項16〜19のいずれか一項に記 載のワクチン組成物。 21.キャリアが固体キャリアであり、ワクチン組成物が固体ペレット又はイ ンプラントの形をしている、請求項16〜20のいずれか一項に記載のワクチン 組成物。 22.請求項16〜21のいずれか一項に記載のワクチン組成物の患者への投 与からなる、ヒト又は他の動物患者の予防接種方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US248593A | 1993-01-08 | 1993-01-08 | |
US08/002,485 | 1993-01-08 | ||
PCT/AU1993/000677 WO1994015636A1 (en) | 1993-01-08 | 1993-12-24 | Vaccine preparations |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08505152A true JPH08505152A (ja) | 1996-06-04 |
JP3583128B2 JP3583128B2 (ja) | 2004-10-27 |
Family
ID=21701000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51552994A Expired - Lifetime JP3583128B2 (ja) | 1993-01-08 | 1993-12-24 | ワクチン製剤 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0678035B9 (ja) |
JP (1) | JP3583128B2 (ja) |
KR (1) | KR100291357B1 (ja) |
AT (1) | ATE218884T1 (ja) |
AU (1) | AU667003B2 (ja) |
CA (1) | CA2152949C (ja) |
DE (1) | DE69332031T2 (ja) |
NZ (1) | NZ259285A (ja) |
WO (1) | WO1994015636A1 (ja) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPM855194A0 (en) * | 1994-10-04 | 1994-10-27 | Csl Limited | Controlled-release pharmaceutical preparations |
US5958455A (en) * | 1996-02-09 | 1999-09-28 | Quadrant Holdings Cambridge Ltd | Oral solid dosage forms, methods of making same and compositions thereof |
EP1579851A3 (en) * | 1997-08-29 | 2009-09-02 | Corixa Corporation | Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of use thereof |
US6312731B1 (en) * | 1997-08-29 | 2001-11-06 | Southern Research Institute | Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof |
US7087236B1 (en) | 1998-09-01 | 2006-08-08 | Merrion Research I Limited | Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof |
ATE452651T1 (de) | 1998-09-01 | 2010-01-15 | Merrion Res Iii Ltd | Orale impfstoff-zusammensetzung |
US6498153B1 (en) | 1998-12-31 | 2002-12-24 | Akzo Nobel N.V. | Extended release growth promoting two component composition |
GB9906695D0 (en) * | 1999-03-24 | 1999-05-19 | Secr Defence | Vaccine composition |
ES2272447T3 (es) * | 2000-03-22 | 2007-05-01 | The Secretary Of State For Defence | Composicion farmaceutica para aplicar en superficies mucosas. |
IL153241A0 (en) * | 2000-06-08 | 2003-07-06 | Powderject Vaccines Inc | Powder compositions |
FR2814957B1 (fr) * | 2000-10-06 | 2002-12-20 | Aventis Pasteur | Composition vaccinale et procede de stabilisation |
FR2825276B1 (fr) * | 2001-05-31 | 2004-11-26 | Seppic Sa | Adujvant d'immunite sous forme solide et vaccin le contenant |
FR2873386B1 (fr) | 2004-07-22 | 2011-01-14 | Agence Francaise De Securite Sanitaire Des Aliments Afssa | Composition vaccinale contre le rhodococcus equi |
EP2068834A2 (en) * | 2006-09-08 | 2009-06-17 | Becton, Dickinson & Company | Stable powder formulations of aluma-dsorbed vaccines |
AU2008231072B2 (en) * | 2007-03-22 | 2013-08-01 | The Regents Of The University Of Colorado | Method of preparing an immunologically-active adjuvant-bound dried vaccine composition |
PT2079456E (pt) | 2007-04-04 | 2013-03-13 | Sigmoid Pharma Ltd | Composições farmacêuticas de ciclosporina |
BRPI1012196B1 (pt) | 2009-05-18 | 2021-11-30 | Sublimity Therapeutics Limited | Composição compreendendo gotas de óleo |
GB2485327A (en) * | 2009-08-12 | 2012-05-09 | Sigmoid Pharma Ltd | Immunomodulatory compositions comprising a polymer matrix and an oil phase |
WO2012038801A1 (en) * | 2010-09-21 | 2012-03-29 | National Institute Of Immunology | A spray dried powder formulation for vaccines entrapping alum and the antigen in biodegradable polymer particles |
GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
FR2977800B1 (fr) * | 2011-07-13 | 2014-03-14 | Sanofi Pasteur | Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium |
GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
CN107106644B (zh) | 2014-11-07 | 2022-04-15 | 卓越治疗有限公司 | 包含环孢菌素的组合物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH645270A5 (en) * | 1979-10-11 | 1984-09-28 | Schweiz Serum & Impfinst | Vaccine against coli bacillosis of piglets and process for its preparation |
HU188847B (en) * | 1983-02-22 | 1986-05-28 | Human Oltoanyagtermeloe Es Kutato Intezet,Hu | Process for producing liophylized combined vaccines |
JPS60193925A (ja) * | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
AU620149B2 (en) * | 1988-08-18 | 1992-02-13 | Vaxine Pty Ltd | Gamma inulin compositions |
US5242686A (en) * | 1990-11-07 | 1993-09-07 | American Home Products Corporation | Feline vaccine compositions and method for preventing chlamydia infections or diseases using the same |
CA2097830C (en) * | 1990-12-04 | 2000-02-01 | Stephen G. Newman | Spray-dried antigenic products and method of preparation |
CA2126685C (en) * | 1992-10-26 | 2002-07-23 | Bruno Gander | Process for the production of microcapsules |
-
1993
- 1993-12-24 AU AU58053/94A patent/AU667003B2/en not_active Expired
- 1993-12-24 NZ NZ259285A patent/NZ259285A/en not_active IP Right Cessation
- 1993-12-24 AT AT94903697T patent/ATE218884T1/de not_active IP Right Cessation
- 1993-12-24 CA CA002152949A patent/CA2152949C/en not_active Expired - Lifetime
- 1993-12-24 DE DE69332031T patent/DE69332031T2/de not_active Expired - Lifetime
- 1993-12-24 EP EP94903697A patent/EP0678035B9/en not_active Expired - Lifetime
- 1993-12-24 WO PCT/AU1993/000677 patent/WO1994015636A1/en active IP Right Grant
- 1993-12-24 KR KR1019950702817A patent/KR100291357B1/ko not_active IP Right Cessation
- 1993-12-24 JP JP51552994A patent/JP3583128B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE218884T1 (de) | 2002-06-15 |
EP0678035A4 (en) | 1997-02-26 |
EP0678035A1 (en) | 1995-10-25 |
DE69332031T2 (de) | 2002-12-19 |
CA2152949A1 (en) | 1994-07-21 |
NZ259285A (en) | 1996-07-26 |
KR100291357B1 (ko) | 2001-09-17 |
AU667003B2 (en) | 1996-02-29 |
EP0678035B1 (en) | 2002-06-12 |
EP0678035B9 (en) | 2006-12-13 |
AU5805394A (en) | 1994-08-15 |
DE69332031D1 (de) | 2002-07-18 |
WO1994015636A1 (en) | 1994-07-21 |
KR960700070A (ko) | 1996-01-19 |
JP3583128B2 (ja) | 2004-10-27 |
CA2152949C (en) | 2009-02-24 |
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