JPH0838597A - Method and apparatus for automatic priming treatment of hemocatharsis circuit - Google Patents

Abstract

PURPOSE:To improve priming effect by a method and an apparatus wherein a liq. discontinuance detector and a cramping means are installed in a priming liq. feeding system and a cramping means is disposed at a specified position in a circulation circuit and such treating processes as a cleaning and discharging process of the vein side are successively and properly combined and performed. CONSTITUTION:A hemocatharsis circuit (cleaning circuit) wherein a blood pump 14, an inlet side drip chamber 16, a hemocatharsis tool 18 and an outlet side drip chamber 20 are successively arranged from an arterial side blood sampling part 10 to a venous side blood returning part 12, is formed. A circulation circuit 24 is formed by connecting the cleaning circuit 22 with connectors 10a and 12a of the blood sampling part 10 and the blood returning part 12. A liq. discontinuance detector 50 to a storing container 26a is attached to a priming liq. feeding system 26 and is connected with the upstream venous side circuit 24a of the circulation circuit 24 by a cramping mans 52. A cramping means 54 is also attached on the downstream side of the circulation circuit of the outlet side drip chamber 20 and is connected with the connector 12a. The cramping means 52 and 54 are controlled by means of an operation controlling part 56.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for automatically priming a blood purification circuit (extracorporeal blood circulation circuit) including a blood purifier (dialyzer, plasma separator, blood purification adsorber, etc.). Related to the device.

[0002]

2. Description of the Related Art Generally, a blood purification circuit removes foreign matters and air in the circuit by priming treatment, that is, introducing and filling a priming solution (generally, physiological saline) into the circuit each time it is used. Processing is being carried out.

That is, in this kind of priming processing method and processing apparatus, for example, FIG.
No. 9076), basically, the blood pump 1 is sequentially transferred from the arterial blood collection unit 10 to the venous blood return unit 12.
4. A blood purification circuit 22 in which an inlet drip chamber 16, a blood purifier 18, and an outlet drip chamber 20 are arranged, and the blood collection and blood return portions 10, 12 (connectors 10a, 12a) are connected to a circulation circuit. 24 and the upstream venous circuit portion 24a of the blood pump 14.
Is connected to a priming liquid supply system 26 composed of a storage container 26a and a supply pipe 26b, and an overflow system 28 is connected to the outlet drip chamber 20. In this case, the priming liquid supply system 26 is provided with a liquid shortage detector 30 and a flow control valve 32 for the priming liquid in the storage container 26a,
Clamping means 34 is provided in the overflow system 28, and further clamping means 36 is provided downstream of the circulation circuit in the outlet side drip chamber 20. Then, the liquid shortage detector 30, both clamping means 34 and 36, and the blood pump 1
4 is controlled by the operation control unit 38 to perform a predetermined priming processing operation.

Accordingly, in such a processing method and / or processing apparatus (hereinafter, referred to as a prior art), when the blood pump 14 is driven with both clamp means 34 and 36 opened, the circulation circuit 24 A mixed liquid of the liquid retained in the circuit 24 and the priming liquid supplied from the priming liquid supply system 26 is circulated, and the mixed liquid corresponding to the supplied priming liquid is discharged from the overflow system 28. Therefore, according to the above-mentioned prior art, the cleaning (mixing) liquid circulating in the circulation circuit increases for a certain amount of the priming liquid. The increase amount of the cleaning liquid in this case can be arbitrarily adjusted by adjusting the priming liquid replenishment amount via the flow rate adjusting valve 32, so that the priming effect (removal efficiency of foreign matter and air in the circulation circuit) can be improved. Clearly, it can be improved. In this case, the priming process (step) is completed (stopped) when the detector 30 detects the lack of the priming liquid.

[0005]

However, the above-mentioned prior art still has drawbacks to be improved as described below.

That is, in the above-mentioned prior art, the circulation circuit 24
In contrast, the priming effect is improved by circulating a mixture of the staying liquid and the replenishing priming liquid in the circuit 24. However, in the circulation treatment step using the mixed solution, each circuit portion 24a,
The flow direction of the liquid in 24b, the priming liquid supply system 26, and the overflow system 28 is limited to one direction indicated by the arrow. Therefore, in the above-mentioned prior art, especially in the vein side circuit portion 24a between the outlet side drip chamber 20 and the connection point 40 of the priming liquid supply system 26, first, due to the long downward pipe between them, air bleeding is favorably performed. Foreign matter (dust, chemicals, etc.) that has not been performed and is present during this period is the artery side circuit portion 24b.
This easily adheres to the arterial circuit portion 24b and the blood purifier 18, so that the cleaning effect cannot be sufficiently exerted. In addition, regarding the washing, a method of overflowing a part of the priming solution contaminated during circulation with a limited amount of a new clean priming solution while replenishing the priming solution with a limited amount, not only the vein side circuit portion 24a but also the vein side circuit portion 24a. Full circulation circuit 2 including arterial side circuit portion 24b
In No. 4, the cleaning effect was limited. Further, in the above-mentioned conventional technique, two control clamp means 34,
Because of the necessity of 36, there is also a disadvantage that the configuration is relatively complicated and expensive.

Therefore, an object of the present invention is to provide an automatic priming processing method and apparatus for a blood purification circuit which can achieve a sufficient priming effect and can be constructed relatively easily.

[0008]

In order to achieve the above object, a method for automatically priming a blood purification circuit according to the present invention is a blood pump and an inlet drip in order from an arterial blood sampling unit to a venous blood returning unit. A blood purification circuit in which a chamber, a blood purifier and an outlet side drip chamber are arranged is connected to both the blood collecting and blood returning sections to form a circulation circuit, and a priming liquid supply system is provided on the upstream side of the blood pump. In the priming treatment method, which comprises connecting an overflow system to the outlet-side drip chamber,
A venous side washing / discharging step for flowing the priming liquid from the priming liquid supply system to the circulation circuit from the upstream venous circuit part of the blood pump to the overflow system by its own drop; and priming from the priming liquid supply system. An arterial side washing and discharging step of causing the liquid to flow from the downstream arterial side circuit portion of the blood pump to the overflow system by its own head and the discharge pressure of the blood pump,
An overall washing circulation step of circulating the staying liquid in the circulation circuit through the entire circuit by the discharge pressure of the blood pump.

In this case, the priming process is configured so that the venous side washing / discharging step, the arterial side washing / discharging step and the whole washing / circulating step are further performed, and the venous side washing / discharging step and / or the arterial side washing / discharging step are performed. be able to. Further, after the vein side washing and discharging step or the arterial side washing and discharging step, the whole washing circulation step may be further continued, and these steps may be repeated once or plural times. Furthermore, in the whole cleaning circulation step, the priming liquid can be partially replenished from the priming liquid supply system to the circulating retention liquid.

As an apparatus for carrying out the automatic priming treatment method for the blood purification circuit, a blood pump, an inlet side drip chamber, a blood purifier and an outlet side drip chamber are sequentially provided from the arterial blood collection unit to the venous blood return unit. With respect to the arranged blood purification circuit, a circulation circuit is formed by connecting both the blood sampling and blood returning sections, and a priming liquid supply system is connected to the upstream side of the blood pump and an overflow system is connected to the outlet side drip chamber. In the connected priming processing apparatus, a priming liquid supply system is provided with a liquid shortage detector and a clamp means, and a clamp means is provided downstream of the circulation circuit of the outlet side drip chamber. The priming liquid from the priming liquid supply system in the circulation circuit for the means and the blood pump. The washing and draining process on the venous side that causes the liquid to flow from the upstream venous circuit part of the blood pump to the overflow system by its own head, and the priming liquid from the priming liquid supply system by its own head and the discharge pressure of the blood pump. A process including an arterial side washing and discharging step of flowing from the downstream arterial side circuit portion of the blood pump to the overflow system, and a whole washing and circulating step of circulating the staying liquid in the circulation circuit through the entire circuit by the discharge pressure of the blood pump It is characterized in that a control means for performing a control operation for sequentially carrying out the steps is provided.

[0011] In this case, it is preferable that the inlet side drip chamber and the blood purifier are arranged in the upward pipe portion of the circulation circuit.

[0012]

According to the present invention, a blood purification circuit is formed in a circulation circuit composed of a venous side and an arterial side circuit portion, and a priming treatment system in which a priming liquid supply system and an overflow system are connected to the circulation circuit is provided. The priming liquid supply system is provided with a liquid shortage detector and a clamp means, and by providing the clamp means at a predetermined position of the circulation circuit, that is, on the downstream side of the outlet side drip chamber,
For the circulation circuit, it is possible to sequentially and appropriately combine the treatment steps including the venous side washing / discharging step, the arterial side washing / discharging step, and the whole washing / circulating step.

Therefore, in the present invention, first, the venous side circuit portion passes the priming liquid from the priming liquid supply system through the venous side circuit portion by its own drop in the vein side washing and discharging process to the overflow system. It is clear that good deaeration and sufficient cleaning effect can be achieved by direct and upward flow. Next, the arterial side circuit portion directly flows the priming liquid from the priming liquid supply system through the arterial side circuit portion by its own head and the discharge pressure of the blood pump in the arterial side washing and discharging step, and directly to the overflow system. By letting
It is clear that a sufficient cleaning effect can be achieved. If air and foreign matter remain in both circuit parts on the venous and arterial sides, that is, in the entire circulating circuit, the liquid retained in the circulating circuit is removed by the discharge pressure of the blood pump in the entire washing and circulating step, and the entire circuit is circulated. And it can be integrated at a predetermined position in the circuit, that is, at the outlet drip chamber. Then, in the artery-side washing / discharging step to be performed next, the fluid can be smoothly discharged to the overflow system.

[0014]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, an automatic priming method for a blood purification circuit according to the present invention will be described in detail with reference to the accompanying drawings in relation to an apparatus for performing the method. For convenience of explanation, the same components as those of the conventional structure shown in FIG. 3 are designated by the same reference numerals, and detailed description thereof will be omitted.

In FIG. 1, first, the basic configuration of the automatic priming processing apparatus of the present invention is the same as that of the conventional processing apparatus (FIG. 3). Therefore, although they are duplicated, they will be briefly described again to facilitate understanding. That is, the arterial blood collection unit 1
0 to the venous blood return unit 12, blood collection and return to a blood purification circuit 22 in which a blood pump 14, an inlet drip chamber 16, a blood purifier (for example, a dialyzer) 18 and an outlet drip chamber 20 are arranged. The circulation parts 24 are formed by connecting the blood parts 10, 12 (connectors 10a, 12a). Next, in the upstream vein side circuit portion 24a of the blood pump 14, the storage container 26a and the supply pipe 2 are provided.
A priming liquid supply system 26 composed of 6b is connected, and an overflow system 28 is connected to the outlet drip chamber 20.

However, according to the present invention, in the above construction, the priming liquid supply system 26 has a storage container 26a.
A liquid dead detector 50 and a clamp means 52 for the priming liquid in the inside are provided, and a clamp means 54 is provided on the downstream side of the circulation circuit of the outlet side drip chamber 20. Then, the liquid out detector 50, both clamp means 52, 5
4 and the blood pump 14 are configured to perform a predetermined priming processing operation via the operation control unit 56, respectively. The inlet-side drip chamber 16 and the blood purifier 18 are respectively arranged in the upward pipe portion, and each stepped portion is formed to shorten the downward pipe portion as much as possible. This is to improve the priming effect by increasing the ability to discharge air and foreign substances, as described later.

Therefore, according to the present invention, in the above configuration, the venous washing and discharging step (first type processing step), the arterial washing and discharging step (second type processing step) and the entire washing and circulation are performed on the circulation circuit 24. Each processing step including a step (third type processing step) is performed sequentially and appropriately in combination. That is, referring also to FIG. 2, first, the standby treatment step is performed in step 0, the first type treatment step is performed in step 1, and the second type treatment step is performed in step 2.
Thereafter, a third type processing step is performed in step 3, a second type processing step is performed again in step 4, and if necessary, the processing step (third type) is performed again in step 5.
(Seed-second kind) or the repetition thereof, and finally a completion (stop) processing step is performed in Step 6.

In this case, step 0 (standby processing step)
Is activated by inputting a standby switch (not shown) of the operation control unit 56. In this state, in FIG.
As shown in (5), the other components are kept inactive (open or stopped) except for the operation (close) of the clamp means 52 of the priming liquid supply system 26. And there is no liquid flow in each part. Thereafter, in the above state, by inputting (manually or automatically) a priming switch (not shown) of the operation control unit 56, each of the subsequent steps 1 described above is performed.
To 6 are sequentially and automatically performed.

That is, when step 1 (venous side washing / discharging step) is activated, the priming liquid from the priming liquid supply system 26 itself is opened by opening the clamping means 52 of the priming liquid supply system 26. At the head of
The fluid is discharged from the connection point 40 through the vein side circuit portion 24a (and the connectors 10a and 12a and the outlet side drip chamber 20 therebetween) to the overflow system 28. However, at this time, the priming liquid flows in the vein side circuit portion 24a directly and upward (illustrated by a mark *), so that the air removal and cleaning of the vein side circuit portion 24a can be satisfactorily and sufficiently achieved. it is obvious.

Next, after a predetermined time has elapsed, when step 2 (the artery-side washing and discharging step) is activated, the vein-side circuit portion 24 is activated.
a when the clamping means 54 of FIG.
4 is operated in a predetermined state, and the priming liquid from the priming liquid supply system 26 is moved from the connection point 40 to the arterial circuit portion 2 by its own head and the discharge pressure of the blood pump 14.
4b (and the inlet side drip chamber 16 and the blood purifier 18 therebetween), and is discharged to the overflow system 28. However, at this time, the priming fluid flows directly in the arterial circuit portion 24b,
Since the drip chamber 16 and the blood purifier 18 are arranged in the upwardly-facing pipe step as short as possible, the ability to discharge air and foreign substances is increased as described above. Therefore, it is clear that air bleeding and cleaning of the arterial circuit portion 24b can be satisfactorily and sufficiently achieved.

As described above, in the present invention, the priming process in the steps 1 and 2 can be almost completely achieved, but the following processing steps can be performed to further improve the effect. That is, after that, step 3
When the (entire washing and circulating step) is activated, the clamping means 54 of the venous circuit portion 24a is opened, and the clamping means 52 of the priming liquid supply system 26 is closed, so that the priming stays in the circulation circuit 24. The liquid circulates in this circuit 24 at the discharge pressure of the blood pump 14. Thus, if air and debris still remain in the circuit 24, these residues will eventually collect in the outlet drip chamber 20. At this time, the blood pump 14
When the high speed / stop operation is repeatedly performed, the accumulation effect can be enhanced. In this step 3,
By simultaneously opening the clamping means 52 of the priming liquid supply system 26 together with the clamping means 54 of the vein side circuit portion 24a, a fresh priming liquid for the staying priming liquid is partially removed from the priming liquid supply system 26. It can also be configured to replenish.

Thereafter, when the step 4 is activated, the clamping means 54 of the vein side circuit portion 24a is closed and the clamping means 52 of the priming liquid supply system 26 is opened, so that the processing step is performed again on the artery side. The process returns to the cleaning / discharging step (step 2).
Not only the residue (chemicals such as dust and glycerin) accumulated in the inside, but also the residue contained in the entire circuit to be cleaned is discharged from the overflow system 28. Further, if necessary, in step 5, the above-mentioned processing step (third type) or its repetition (second type to third type)
It is clear that the priming effect can be further improved by implementing (seeds). In addition, this is
Metaphorically speaking, squeezing and rinsing rather than rinsing during washing is the same as increasing the washing efficiency per unit wash water.

In step 4, the process is returned to step 1 (venous side washing / discharging step). Then, if necessary, in step 5, the above-described processing steps (third type or second type to second type) are performed again. 3 types) or its repetition (1st type ~
It is clear that the priming effect can be improved by implementing the third type or the first to second types to the third type).

Finally, step 6 (completion stop step)
Is activated, and when the liquid shortage detector 50 detects the liquid shortage of the priming liquid in the storage container 26a, the venous circuit portion 2
The clamp means 54 of 4a is opened and the clamp means 52 of the priming liquid supply system 26 is closed, so that the processing step returns to the overall cleaning circulation step (step 3), and in this state, the priming processing is performed. Complete (stop).

When the priming process is completed (stopped), the flow rate of the priming solution is calculated and integrated based on, for example, an operation signal of the blood pump 14 without using the liquid shortage detector 50. However, when a predetermined amount of the priming solution is supplied, the priming process may be completed (stopped) in the same manner as described above.

As described above, according to the present invention, the entire circulation circuit (blood purification circuit), particularly the venous circuit portion thereof, can exhibit good air bleeding and cleaning functions.
A sufficient priming effect can be achieved. Furthermore, in the present invention, the overflow system does not require a clamp means, and the clamp for the vein side circuit portion can use the air bubble detector interlocking clamp normally provided in the blood purification apparatus as it is. This has the advantage that it can be constructed relatively simply and inexpensively.

The preferred embodiment of the present invention has been described above. However, the present invention is not limited to the above-described embodiment, and many design changes can be made without departing from the spirit of the present invention.

[0028]

As described above, the method and apparatus for automatically priming the blood purification circuit according to the present invention form the blood purification circuit in the circulation circuit composed of the venous side and the arterial side circuit parts, In contrast to the priming treatment device in which the priming liquid supply system and the overflow system are connected to the circuit, the priming liquid supply system is provided with a liquid shortage detector and clamp means, and at a predetermined position of the circulation circuit, that is, on the downstream side of the outlet side drip chamber. By providing the clamp means, with respect to the circulation circuit,
The venous circuit part is configured so that it can be sequentially and appropriately combined with the treatment steps including the venous side washing and discharging step, the arterial side washing and discharging step, and the whole washing circulation step, so that the venous side circuit portion can be treated with the priming liquid in the venous side washing and discharging step. The priming liquid from the supply system can flow directly and upwardly through this vein side circuit portion to the overflow system by its own drop, and thus good air removal and sufficient cleaning effect can be achieved. In the arterial side washing and discharging process, the priming solution from the priming solution supply system is caused to flow directly through the arterial side circuit section to the overflow system due to its own head and the discharge pressure of the blood pump, thereby providing a sufficient cleaning effect. Can be achieved. Note that if air and foreign matter remain in the circulation circuit, they will be generated in the entire washing circulation step and the venous side washing and discharging step and / or the arterial side washing and discharging step that continue to this.
It can be discharged to the overflow system.

Therefore, according to the present invention, a sufficient priming effect can be achieved for the entire circulation circuit (blood purification circuit), particularly for the vein side circuit portion thereof. Further, according to the present invention, the overflow system does not require any clamp means, and the clamp for the vein side circuit portion can use the air bubble detector interlocking clamp usually provided in the blood purification apparatus as it is. Therefore, there is an advantage that the configuration can be made relatively easily and inexpensively.

[Brief description of drawings]

FIG. 1 is a system diagram showing an embodiment of an automatic priming processing device for a blood purification circuit according to the present invention.

FIG. 2 is a process explanatory view showing an automatic priming processing operation in the processing apparatus shown in FIG.

FIG. 3 is a system diagram showing a conventional automatic priming device for a blood purification circuit.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 10 Arterial side blood collection part 12 Static artery side blood collection part 10a Blood collection side connector 12a Blood return side connector 14 Blood pump 16 Inlet drip chamber 18 Blood purifier 20 Outlet drip chamber 22 Blood purification circuit 24 Circulation circuit 24a Vein side circuit part 24b Arterial-side circuit part 26 Priming liquid supply system 26a Storage container 26b Supply pipe 28 Overflow system 40 Connection point 50 Liquid out detector 52 Supply pipe clamp means 54 Venous circuit part clamp means 56 Operation control unit

Claims (6)

[Claims] 1. A blood purification circuit in which a blood pump, an inlet side drip chamber, a blood purifier, and an outlet side drip chamber are sequentially arranged from an arterial blood collection unit to a venous blood return unit, and both the blood collection and blood return units are provided. A priming liquid supply system is connected to the upstream side of the blood pump and an overflow system is connected to the outlet side drip chamber. The venous side washing and discharging step of flowing the priming liquid from the liquid supply system to the overflow system from the upstream venous circuit part of the blood pump by its own head, and the priming liquid from the priming liquid supply system to its own head and Due to the discharge pressure of the blood pump, the overflow system from the downstream arterial circuit part of the blood pump And the artery side cleaning discharge step of flowing a,
An automatic priming treatment method for a blood purification circuit, comprising: an entire washing circulation step of circulating the staying liquid in the circulation circuit through the entire circuit by the discharge pressure of the blood pump. 2. The priming treatment is sequentially configured to perform a vein side washing and discharging step, an arterial side washing and discharging step and a whole washing circulation step, and further a vein side washing and discharging step and / or an arterial side washing and discharging step. The method for automatically priming a blood purification circuit according to claim 1, wherein 3. The blood purification circuit according to claim 2, wherein after the arterial side washing / discharging step or the vein side washing / discharging step, the whole washing / circulating step is further continued and these steps are repeated once or plural times, respectively. Automatic priming method. 4. The automatic priming treatment method for a blood purification circuit according to claim 1, wherein a part of the priming liquid is replenished from the priming liquid supply system to the circulating retention liquid in the whole washing circulation process. 5. A blood purification circuit in which a blood pump, an inlet side drip chamber, a blood purifier and an outlet side drip chamber are sequentially arranged from an arterial side blood collecting part to a venous side returning part, and both the blood collecting and blood returning parts are arranged. A priming solution supply system is connected to the upstream side of the blood pump, and an overflow system is connected to the outlet drip chamber. A detector and a clamp means are provided, and a clamp means is provided on the downstream side of the circulation circuit of the outlet side drip chamber. Further, a priming liquid supply system is provided in the circulation circuit for the liquid dead detector, both clamp means and the blood pump. The priming fluid from the And the venous side washing and discharging step for flowing into the overflow system, and the arterial side for flowing the priming solution from the priming solution supply system from the downstream arterial circuit part of the blood pump to the overflow system due to its own head and the discharge pressure of the blood pump. A control means is provided for performing a control operation for sequentially carrying out a processing step including a cleaning / discharging step and an overall cleaning / circulating step in which the accumulated liquid in the circulation circuit is circulated in the entire circuit by the discharge pressure of the blood pump. Automatic priming processing device for blood purification circuit. 6. An inlet-side drip chamber and a blood purifier are arranged in an upward pipe portion of a circulation circuit.
An automatic priming treatment device for the blood purification circuit described.