JP2008062000A - Circuit mechanism of passage in dialysis treatment and temporary dialysate storage method in dialysis treatment - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a circuit mechanism of passage in dialysis treatment and a temporary dialysate storage method in dialysis treatment by which the blood staying in a blood circuit and a dialyzer can be safely and efficiently returned into a patient's body after dialysis treatment such as elimination of waste products in dialyzed blood, elimination of water, adjustment of electrolytes, adjustment of pH, etc. <P>SOLUTION: An artery side blood circuit tube, a vein side blood circuit tube, a dialyzate supply tube, and a dialyzate drain tube are attached to a dialyzer and a fluid replenishing circuit is provided in a state communicating with the artery side blood circuit tube. On the distal end of the fluid replenishing circuit, a fluid replenishing storage body configured so that the dialyzate in the artery side blood circuit tube is temporarily stored during a washing/priming process is installed. The dialyzate drain tube is configured so as to be capable of opening/closing the passage. Around the edge end parts of the artery side blood circuit tube and the vein side blood circuit tube, blood clamper to open/close the passages of both blood circuit tubes is installed. Around the connection part of the fluid replenishing circuit with the artery side blood circuit tube, a fluid replenishing clamper for opening/closing the passage of the fluid replenishing circuit is installed. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention is an artificial dialysis using a dialyzer, and after performing artificial dialysis such as removal of waste in dialysis blood, removal of water, adjustment of electrolyte, adjustment of blood pH, etc., blood BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a circuit mechanism of a flow path in artificial dialysis that can safely and efficiently return blood staying in a circuit and a dialyzer into a patient's body and a method for temporarily storing dialysate in artificial dialysis.

Conventionally, artificial dialysis using a dialyzer has been widely performed in the medical field, and the main operations in this artificial dialysis (hemodialysis) include operations such as washing / priming, dialysis, and blood return.
Here, washing and priming are blood circuits that allow the patient's blood to pass through in the stage of artificial dialysis (the arterial blood circuit from the arterial puncture needle connection to the dialyzer inlet, and the venous puncture needle from the dialyzer outlet. Is a process of cleaning the inside of the dialyzer and preparing to receive the blood to be dialyzed. Dialysis is the process of dialyzer and blood and dialysate. The semi-permeable membrane removes waste in the blood based on the diffusion action, removes excess electrolyte, compensates for the lack of electrolyte, or extra water based on the ultrafiltration action. The blood return is the process of normalizing the blood by removing the blood, etc., and returning blood after the dialysis is completed, the blood that has been guided from the patient's body to the blood circuit and dialyzer into the patient's body Is that the step of returning in the absence of Ri.

  The conventional washing and priming process involves injecting dialysate from the dialysate circuit supply side of the dialyzer (the drain side of the dialysate circuit is closed at this time), and passing this dialysate through the semipermeable membrane. The inside of the blood circuit and the dialyzer was washed by applying pressure so that it slips through and forcing the dialysate into the blood circuit and the dialyzer.

  In the conventional blood return process, the dialysate is pressurized and injected from the dialysate circuit supply side of the dialyzer (the dialysate circuit is closed at this time, so the dialysate is injected under pressure. In this manner, the dialysate is forcibly sent into the blood circuit, and the remaining blood in the blood circuit is pushed back with the dialysate.

Here, as means for feeding the dialysate into the blood circuit, a method using a dialysate pump (water removal pump) installed in the dialysate circuit of the dialyzer has been adopted.
In this method, the dialysate pump was rotated to apply pressure to the dialysate, and the dialysate forcibly passed through the semipermeable membrane in the dialyzer was sent into the blood circuit. It is used at any time during the washing, priming, and dialysis processes. Depending on each process, the dialysate may be drained from the dialysate circuit on the drainage side, so the dialysate pump repeats normal rotation or reverse rotation. Similarly, the drain side of the dialysate circuit has a complicated structure in which the flow path is repeatedly opened and closed.
Further, there is a method in which a physiological saline pack is set in the blood circuit, the physiological saline is naturally dropped, the blood in the blood circuit and the analyzer is replaced with physiological saline, and the blood is returned to the body.
Japanese Patent Application Laid-Open No. 6-14993

  In the above-described blood return method using the dialysate pump, residual blood in the blood circuit is forcibly returned to the patient's body by the pressurizing force of the dialysate pump, so there are bubbles in the blood circuit. In such a case, even if a bubble trap or a bubble sensor is provided, there is a risk that the bubbles are forcibly sent into the body. Furthermore, since a large amount of dialysate was sent out in the forward / reverse direction, the load was excessive and there was a high possibility of causing trouble.

This method also uses a dialysate pump to return blood, so new dialysate is replenished at any time, resulting in an increase in dialysate consumption and ultimately the cost of artificial dialysis. There was a fundamental problem that led to up.
On the other hand, according to the method of setting the physiological saline pack, a new physiological saline pack must be prepared every time the blood is returned, so that the amount of dialysate (saline) used similarly increases. was there.

  The present invention can automate the work in artificial dialysis without using a dialysate pump according to the procedure in accordance with the conventional dialysis operation manual, and is drained during the washing and priming process while using a general-purpose standardized blood circuit. The dialysis fluid (of course in a clean state) is temporarily stored in advance in the fluid replacement body in the fluid replacement circuit as dialysate for use in the washing / priming process, fluid replacement process, and blood return process. Thus, the present invention aims to provide a circuit mechanism for a flow path in artificial dialysis and a method for temporarily storing the dialysate in artificial dialysis, which can solve all of the above-mentioned problems by effectively using the dialysate.

  According to the first aspect of the present invention, the circuit mechanism of the flow path in the artificial dialysis and the method for temporarily storing the dialysate in the artificial dialysis is such that an arterial blood circuit tube is connected to one side of the dialyzer performing the artificial dialysis, A dialysis fluid that connects a venous blood circuit tube to the other side, constitutes a blood circuit with the arterial blood circuit tube and the venous blood circuit tube, and is partitioned from the blood passage part through a semipermeable membrane in the dialyzer A dialysate supply pipe for feeding dialysate into the chamber and a dialysate drain pipe for discharging dialysate from the dialysate chamber are attached to the dialyzer, and the dialysate supply pipe and dialysate drain pipe constitute a dialysate circuit. A replacement fluid circuit is provided in communication with the arterial blood circuit tube of the blood circuit, a replacement fluid storage body is attached to the tip of the replacement fluid circuit, and the replacement fluid storage body is dialyzed through the artery side blood circuit tube during the washing and priming process. Is temporarily stored, and the dialysate drain pipe of the dialysate circuit is configured to be able to open and close the flow path, and the arterial blood circuit tube and the venous blood circuit tube of the blood circuit A blood clamper capable of opening and closing the flow path of each blood circuit tube is provided in the vicinity of the edge of the replacement fluid circuit, and in the vicinity of the connection portion of the replacement fluid circuit with the arterial blood circuit tube, the flow path of the replacement fluid circuit is provided. A circuit mechanism in artificial dialysis characterized in that a replacement fluid clamper that can be opened and closed is provided.

  Further, according to claim 2, in each of the arterial blood circuit tube and the venous blood circuit tube, an air trap capable of trapping air bubbles in the flow path and discharging it out of the blood circuit is provided. Circuit mechanism.

  The circuit in artificial dialysis according to claim 1 or 2, further comprising a blood pump capable of feeding blood in the flow path of each blood circuit tube near the side wall of the artery side blood circuit tube. Mechanism.

  Furthermore, a circuit mechanism in artificial dialysis according to any one of claims 1 to 3, further comprising an anticoagulant circuit for injecting an anticoagulant into the arterial blood circuit tube.

  The circuit mechanism in artificial dialysis according to any one of claims 2 to 4, wherein a venous pressure circuit capable of measuring venous pressure is provided in an air trap provided in the venous blood circuit tube.

  A sixth aspect of the present invention is the circuit mechanism for artificial dialysis according to any one of the first to fifth aspects, comprising a bubble sensor for determining the presence or absence of bubbles in the blood circuit.

  The circuit mechanism in artificial dialysis according to any one of claims 1 to 6, further comprising a permeability sensor for determining whether a substance passing through the blood circuit is blood or dialysate.

Furthermore, claim 8 uses the circuit mechanism in the artificial dialysis according to claim 1,
As a first step, the dialysate supply pipe of the dialyzer is opened in a state where the blood clamper that opens and closes the arterial blood circuit tube is opened, and the replacement fluid clamper that opens and closes the replacement fluid circuit and the blood clamper that opens and closes the vein blood circuit tube are closed. The dialyzer is further circulated through the dialyzer to wash the dialyzer and the arterial blood circuit tube. As a second step, the blood clamper that opens and closes the arterial blood circuit tube and the blood clamper that opens and closes the venous blood circuit tube are closed. In a state where the replacement fluid clamper that opens and closes the replacement fluid circuit is opened, the dialysate is circulated into the dialyzer from the dialysate supply pipe of the dialyzer, and the dialysate is stored in the replacement fluid container. The dialysate supply tube is closed, the blood clamper that opens and closes the arterial blood circuit tube is closed, the replacement fluid clamper that opens and closes the replacement fluid circuit is opened, and the venous blood In a state where the blood clamper for opening and closing the circuit tube is opened, the dialysate and the venous blood circuit tube are circulated from the replacement fluid storage body through the replacement fluid circuit to the dialyzer and the venous blood circuit to wash the dialyzer and the venous blood circuit tube. It is the temporary storage method of the dialysate in the artificial dialysis characterized.

  According to the circuit mechanism of the flow path in the artificial dialysis and the temporary storage method of the dialysate in the artificial dialysis according to the present invention, using the new dialysate temporarily stored in the replacement fluid storage body during the washing / priming process, The dialyzer and blood circuit can be washed, and the dialysate can be used during the blood return process. Therefore, there is an excellent effect that an increase in the amount of dialysate used can be suppressed and effective and efficient artificial dialysis can be performed.

  Blood circuit and replacement fluid circuit, and further, the replacement circuit and the replacement fluid storage body are arranged in a state where the replacement fluid circuit and the replacement fluid storage body are connected and integrated, and each circuit is cleaned using dialysate supplied from the dialyzer. Temporary storage of dialysate in the storage body can be performed by a single operation.

  Accident that air is forcibly sent into the body because the blood remaining in the blood circuit after artificial dialysis without using a blood pump is naturally returned to the body by dialysate from the replacement fluid storage body due to natural fall Does not happen.

  In addition, the dialysate circulated in the blood circuit flows unnecessarily into the body by installing a permeability sensor and an open / close clamper for each circuit in the blood circuit of each artery and vein. There is no accident.

  In the present invention, since an artificial dialysis apparatus having a blood pump that rotates in the reverse direction is not required, the price of the artificial dialysis apparatus can be reduced.

Hereinafter, embodiments of a circuit mechanism of a flow path in artificial dialysis and a method for temporarily storing a dialysis fluid in artificial dialysis will be described with reference to the drawings.
1 to 7 are circuit diagrams for explaining the cleaning / priming process, FIGS. 8 to 12 are circuit diagrams for explaining the blood return process, FIG. 1 is a basic circuit diagram of the cleaning / priming process, and FIGS. FIG. 8 is a basic circuit diagram of the blood return process, and FIGS. 9 to 12 are work procedure diagrams.

First, each circuit arrangement according to the present invention will be described. An arterial blood circuit tube 2 is connected to one side of a dialyzer (dialyzer) 1 for performing artificial dialysis, and a venous blood circuit tube 3 is connected to the other side. The arterial blood circuit tube 2 and the venous blood circuit tube 3 constitute a blood circuit 5.
The structure of the dialyzer 1 is a known one, and a blood passage part and a dialysate chamber (both not shown) are provided inside through a semipermeable membrane (not shown).

  The dialyzer 1 includes a dialysate supply pipe 5 for feeding dialysate into the dialysate chamber in the dialyzer 1, and a dialysate drain pipe 6 for draining dialysate that is no longer necessary in the dialyzer to the outside. The dialysate supply pipe 5 and the dialysate drain pipe 6 constitute a dialysate circuit 7. Here, the dialysate drain pipe 6 is configured to be able to shut off the communication state with the dialyzer 1 as required by appropriate means, and is configured to be able to restore the communication state at any time due to a change in the situation.

  Next, a replacement fluid circuit 8 is connected to the arterial blood circuit tube 2 in a continuous manner, and a pack container having a capacity of, for example, about 1000 to 2000 ml, more preferably about 1500 to 2000 ml, is connected to the tip of the replacement fluid circuit 8. Alternatively, a replacement fluid storage body 9 composed of other appropriate containers is attached. In the replacement fluid storage body 9, the dialysate sent from the dialysate supply pipe 5 into the dialyzer 1 flows into the arterial blood circuit pipe 2 via the semipermeable membrane in the dialyzer 1 during the washing / priming process. The dialysate flows from the lower side of the replacement fluid circuit 8 toward the upper side.

  Next, blood clampers 10 and 11 that can open and close each flow path are provided in the vicinity of the edge portions of the arterial blood circuit tube 2 and the venous blood circuit tube 3 (near the connection port with the human body). Therefore, when this blood clamper 10 is opened, the arterial blood circuit tube 2 becomes open, and when it is closed, it becomes closed. Similarly, when the blood clamper 11 is opened, the venous blood circuit tube 3 is opened, and when it is closed, it is closed.

  Subsequently, in the vicinity of the connection port of the replacement fluid circuit 8 to the arterial blood circuit tube 2, a replacement fluid clamper 12 that can open and close the flow channel of the replacement fluid circuit is provided. The circuit 8 becomes open and closes when it is closed.

  In the circuit mechanism according to the present invention, the presence of bubbles in the flow path of the blood circuit 4 is checked at appropriate positions of the arterial blood circuit tube 2 and the venous blood circuit tube 3. , Air traps 13 and 14 are provided which can capture and discharge them outside the blood circuit 4. Here, the air trap 13 discharges bubbles in the artery side blood circuit tube 2, and the air trap 14 discharges bubbles in the vein side blood circuit tube 3.

  Further, when bubbles are present in the blood circuit 4, it is effective to install the bubble sensor 18 at an appropriate position in the blood circuit 4 so that the bubbles are not sent into the body as they are. The bubble sensor 18 is configured to send a signal for closing a necessary circuit flow path in conjunction with the blood clampers 10 and 11 when the presence of bubbles is checked.

  Reference numeral 20 in the figure denotes an access port installed at an appropriate position of the blood circuit 4, and an external circuit, a blood collection needle or the like for injecting a drug solution into the blood circuit 4 or collecting blood in the blood circuit 4 It is a part for connecting easily and reliably. Further, reference numeral 21 denotes a pump segment, which is opposed to the blood pump 15 to be described later and the arterial blood circuit tube 2 sandwiched between them. The function of the blood pump 15 is surely exhibited, or the blood pump 15 and the pump segment 21 are sandwiched. This is a part for closing or opening the flow path of the arterial blood circuit tube 2 portion.

  Next, in the circuit mechanism according to the present invention, a blood pump 15 capable of feeding blood in the flow path in each blood circuit tube 4 is provided near the side wall of the arterial blood circuit tube 2. The blood pump 15 is driven to guide blood from the artery into the arterial blood circuit tube 2, finish hemodialysis via the dialyzer 1, and allow the dialyzed clean blood to flow into the venous blood circuit tube 3. And make a flow of returning to the vein.

  In the circuit mechanism according to the present invention, the anticoagulant circuit 16 for injecting an anticoagulant for preventing blood from solidifying is provided in the arterial blood circuit tube 2 or the venous blood circuit tube 3. The air trap 14 can be provided with a venous pressure circuit 17 that can measure venous pressure, or a permeability sensor 19 that determines whether the substance passing through the blood circuit 4 is blood or dialysate. By providing this permeability sensor, when the substance passing through the venous blood circuit tube 3 returned from the blood circuit 4 to the body during the blood return process is changed from blood to dialysate, the situation is checked, It will be possible to prevent unnecessary dialysate from being sent into the body.

  As a cleaning / priming process (preparation work) before artificial dialysis, first, the blood clamper 10 of the arterial blood circuit tube is closed, and the replacement fluid clamper 12 and the blood clamper 11 of the venous blood circuit tube are also closed. Then, the dialysate is circulated from the dialysate supply pipe 5 to the dialyzer 1 to wash the dialyzer (at this time, the dialysate drain pipe 6 is connected to the dialyzer so that the dialysate is open). It is drained to the outside through the drain pipe 6).

  Second, the blood clamper 10 of the arterial blood circuit tube is opened, the replacement fluid clamper 12 and the blood clamper 11 of the venous blood circuit tube are closed, and the dialysate is circulated from the dialysate supply pipe 5 to the dialyzer 1. The arterial blood circuit tube 2 is washed (at this time, the dialysate drain tube 6 is closed with the dialyzer, so that the dialysate does not flow into the dialysate drain tube 6).

  Thirdly, in the state where the blood clamper 10 of the arterial blood circuit tube and the blood clamper 11 of the venous blood circuit tube are closed and the replacement fluid clamper 12 is opened, the dialyzer 1 and the arterial blood circuit tube 2 are dialyzed. And the dialysate is stored in the replacement fluid storage body 9 via the replacement fluid circuit 8.

Fourth, in a state where the blood clamper 10 of the arterial blood circuit tube is closed, the replacement fluid clamper 12 and the blood clamper 11 of the venous blood circuit tube are opened, and the air trap 14 installed in the venous blood circuit is closed. The blood pump 15 installed in the arterial blood circuit tube 2 is rotated, and a part of the dialysate stored in the replacement fluid storage body 9 is circulated so that the arterial blood circuit tube 2, the dialyzer 1 and the venous blood circuit are circulated. Tube 3 is washed.
At this time, it is necessary to leave at least about 500 ml of the dialysate in the replacement fluid storage body 9 as the amount to be used in the blood return step described later without using all of the dialysate.

  Next, blood return work after artificial dialysis will be described. First, in a state where the blood clamper 10 and the replacement fluid clamper 12 of the arterial blood circuit tube are opened, and the blood clamper 11 of the venous blood circuit tube is closed. The blood remaining in the arterial blood circuit 2 extending from the replacement fluid circuit 8 and the connecting portion of the arterial puncture needle is spontaneously dropped from the replacement fluid storage body 9 without operating the blood pump 15 after completion of the artificial dialysis. It returns to the body due to the action of dialysate. At this time, the pump segment 21 at the position facing the blood pump 15 is brought into contact with the blood pump 15, and the flow path of the arterial blood circuit tube 2 portion sandwiched between the blood pump 15 and the pump segment 21 is closed. In this case, a part of the blood on the connection side of the arterial puncture needle remaining in the blood circuit 4 is returned.

  Second, the dialysate is circulated through the arterial blood circuit tube 2 between the fluid replacement clamper 12 and the blood clamper 10 of the arterial blood circuit tube by the permeability sensor 19 installed in the arterial blood circuit tube 2. Is determined (that is, when the blood in that portion is returned), the blood clamper 10 of the arterial blood circuit tube is closed to prevent the dialysate from flowing into the body.

  Third, the blood clamper 10 of the arterial blood circuit tube is closed, the replacement fluid clamper 12 and the blood clamper 11 of the venous blood circuit tube are opened, and the remaining arterial blood circuit tube 2 and venous blood circuit are left. The blood return in the tube 3 is sent back into the body by the action of dialysate that naturally falls from the replacement fluid storage body 9 in the direction of the venous puncture needle as described above. At this time, the pump segment 21 at the position facing the blood pump 15 is separated from the blood pump 15, and the flow path of the artery side blood circuit tube 2 portion sandwiched between the blood pump 15 and the pump segment 21 is opened. .

Fourth, when it is determined that the dialysate is circulating in the venous blood circuit tube 3 by the permeability sensor 19 installed in the venous blood circuit tube 3 (that is, when the blood in that portion is returned). In this case, the blood clamper 11 of the venous blood circuit tube is closed to prevent the dialysate from flowing into the body.
After the blood return process for all the blood in the blood circuit 4 is completed as described above, the arterial puncture needle and the vein puncture needle are removed from the patient's body to complete the blood return process.

  INDUSTRIAL APPLICABILITY According to the present invention, it can be used in the medical field where artificial dialysis is performed.

It is a basic circuit diagram of a cleaning and priming process. It is work procedure figure 1 of a washing | cleaning and priming process. It is work procedure figure 2 of a washing | cleaning and priming process. FIG. 3 is a work procedure diagram of a cleaning / priming process. FIG. 4 is a work procedure diagram of a cleaning / priming process. FIG. 5 is a work procedure diagram of a cleaning / priming process. FIG. 6 is a work procedure diagram of a cleaning / priming process. It is a basic circuit diagram of a blood return process. FIG. 1 is a work procedure of the blood return process. It is work procedure figure 2 of a blood return process. FIG. 3 is a work procedure diagram 3 of a blood return process. FIG. 4 is a work procedure diagram of a blood return process.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Dialyzer 2 Arterial side blood circuit tube 3 Vein side blood circuit tube 4 Blood circuit 5 Dialysate supply pipe 6 Dialysate drain pipe 7 Dialysate circuit 8 Replacement fluid circuit 9 Replacement fluid storage body 10 Blood clamper 11 of artery side blood circuit tube Vein side Blood circuit tube blood clamper 12 Fluid replacement clamper 13 Arterial blood circuit tube air trap 14 Venous blood circuit tube air trap 15 Blood pump 16 Anticoagulant circuit 17 Venous pressure circuit 18 Bubble sensor 19 Permeability sensor 20 Access port 21 Pump segment

Claims (8)

An arterial blood circuit tube is connected to one side of the dialyzer for artificial dialysis, a venous blood circuit tube is connected to the other side of the dialyzer, and a blood circuit is constituted by the arterial blood circuit tube and the venous blood circuit tube. ,
A dialysate supply pipe for sending dialysate to a dialysate chamber partitioned from a blood passage part through a semipermeable membrane in the dialyzer, and a dialysate drain pipe for discharging dialysate from the dialysate chamber are attached to the dialyzer. The dialysate supply pipe and the dialysate drain pipe constitute a dialysate circuit,
A replacement fluid circuit is provided in communication with the arterial blood circuit tube of the blood circuit, a replacement fluid storage body is attached to the tip of the replacement fluid circuit, and the replacement fluid storage body is a dialysate that flows through the artery side blood circuit tube during the washing and priming process. Is temporarily stored,
The dialysate drain pipe of the dialysate circuit is configured to be able to open and close its flow path,
A blood clamper capable of opening and closing the flow path of each blood circuit tube is provided in the vicinity of the edge portion of the arterial blood circuit tube and the venous blood circuit tube of the blood circuit,
A circuit mechanism in artificial dialysis, wherein a replacement fluid clamper capable of opening and closing a flow path of the replacement fluid circuit is provided in the vicinity of a connection portion between the replacement fluid circuit and the arterial blood circuit tube.   2. The circuit mechanism in artificial dialysis according to claim 1, wherein each of the arterial blood circuit tube and the venous blood circuit tube is provided with an air trap capable of trapping air bubbles in the flow path and discharging them out of the blood circuit.   The circuit mechanism in artificial dialysis according to claim 1 or 2, further comprising a blood pump capable of feeding blood in the flow path of each blood circuit tube in the vicinity of the side wall of the artery side blood circuit tube.   The circuit mechanism in artificial dialysis according to any one of claims 1 to 3, further comprising an anticoagulant circuit for injecting an anticoagulant into the arterial blood circuit tube.   The circuit mechanism in artificial dialysis according to any one of claims 2 to 4, wherein a venous pressure circuit capable of measuring venous pressure is provided in an air trap provided in the venous blood circuit tube.   The circuit mechanism in artificial dialysis according to any one of claims 1 to 5, further comprising a bubble sensor for determining the presence or absence of bubbles in the blood circuit.   The circuit mechanism in artificial dialysis according to any one of claims 1 to 6, further comprising a permeability sensor that determines whether a substance passing through the blood circuit is blood or dialysate. Using the circuit mechanism in artificial dialysis according to claim 1,
As a first step, the dialysate supply pipe of the dialyzer is opened in a state where the blood clamper that opens and closes the arterial blood circuit tube is opened, and the replacement fluid clamper that opens and closes the replacement fluid circuit and the blood clamper that opens and closes the vein blood circuit tube are closed. Circulate dialysate more in the dialyzer, wash the dialyzer and the arterial blood circuit tube,
As a second step, the dialysate supply pipe of the dialyzer is closed with the blood clamper for opening and closing the arterial blood circuit tube and the blood clamper for opening and closing the venous blood circuit tube closed and the replacement fluid clamper for opening and closing the replacement fluid circuit opened. The dialysate is circulated through the dialyzer, and the dialysate is stored in the replacement fluid container.
As a third step, the dialysate supply pipe of the dialyzer is closed, the blood clamper that opens and closes the arterial blood circuit tube is closed, the replacement fluid clamper that opens and closes the replacement fluid circuit is opened, and the blood clamper that opens and closes the venous blood circuit tube Dialysis in artificial dialysis, wherein the dialyzer and the venous blood circuit tube are washed by circulating dialysate from the replacement fluid storage body through the replacement fluid circuit to the dialyzer and the venous blood circuit in the open state. Temporary storage method of liquid.

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