JPH0834725A - Bathing agent composition - Google Patents

Abstract

PURPOSE:To obtain a bathing agent composition which is excellent in the humectant effect on skin and inhibits skin dryness and roughness, moreover sustains moisture retention effect on skin after bathing. CONSTITUTION:This bathing agent composition comprises at least one of monoesters between cholesterol and a dicarboxylic acid of the formula (R<1> is a 2-20C straight or branched alkylene or alkenylene; R<2> is a residue after OH proton is removed from cholesterol), for example, cholesteryl hemimaleate or cholesteryl hemisuccinate in an amount of 0.01-50wt.%, particularly 0.1-10wt.%. When an antiinflammatory agent is incorporated into this composition, anti-itching effect becomes stronger than in the case of its single application after bathing. The antiinflammatory agent is preferably rice bran oil, german chamomile essence or dipotassium glycyrrhizinate, in the meaning of controlling skin itching. The amount of these antiinflammatory agents is particularly preferably 0.1-5wt.%. This composition may also contain other oil components than the monoester stated above and a dispersion emulsifier for these oil components.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bath agent composition which is excellent in the moisturizing effect and the effect of improving the bulkiness of the skin and which gives a moist feel to the skin after bathing.

[0002]

2. Description of the Related Art Bath agents have various effects such as cleansing the body, warming not only limbs but also the core, and relaxing mentally, and are an essential activity on a daily basis.

On the other hand, many people complain of the loss of oil content from the skin due to bathing, especially the roughness of the skin after bathing in the winter. Then, in order to suppress the bulkiness of the skin after bathing, such people usually use various skin care products such as lotions and creams after bathing.
However, when using a skin care product, labor is required for its application work, and it is difficult for an elderly person to apply the skin care product to every corner of his / her body.

Therefore, an oil or a moisturizer is added to the bath agent,
Attempts have been made to prevent the loss of oil from the skin due to bathing.For example, in order to enhance the moisturizing effect on skin and the effect of improving bulkiness, a bath agent containing a difatty acid glycerin ester or an intercellular lipid (special feature) is used. Kaihei 2-1151
No. 17) is proposed.

[0005]

However, the bath agent composition containing the difatty acid glycerin ester and the intercellular lipid has the effect of remarkably improving the keratin water content of the skin and preventing or treating the rough skin. Although it is possible to solve problems such as dryness of the skin and the like, but it is not yet satisfactory because the effect cannot be sufficiently exerted against a rash and severe itching caused by dry skin.

Therefore, there has been a demand for a bath preparation having an effect of suppressing rash and severe itching caused by dry skin.

[0007]

Under such circumstances, the present inventor has conducted diligent studies, and as a result, has found that a bath agent composition containing a monoester of cholesterols and dicarboxylic acid represented by the following formula (1). Has an excellent moisturizing effect on the skin and an effect of improving bulkiness and brings a moist feel,
Moreover, they have found that they have the effect of suppressing rash and severe itching caused by dry skin, and completed the present invention.

That is, the present invention provides the following general formula (1);

[0009]

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(In the formula, R ¹ represents a linear or branched alkylene group or alkenylene group having 2 to 20 carbon atoms, and R ²
Indicates a residue of cholesterols from which hydroxyl group protons have been removed. The present invention provides a bath agent composition comprising one or more monoesters of cholesterols and a dicarboxylic acid represented by the formula (1).

The monoester of cholesterol and dicarboxylic acid used in the present invention is represented by the above formula (1). Among the linear or branched alkylene or alkenylene groups having 2 to 20 carbon atoms represented by R ¹ , the linear alkylene or alkenylene group has 2 to 1 carbon atoms.
0 is preferable, specifically, ethylene, trimethylene, tetramethylene, pentamethylene, hexamethylene, heptamethylene, octamethylene, nonamethylene,
Examples thereof include decamethylene and vinylene groups, among which ethylene and trimethylene are particularly preferable.

The branched alkylene or alkenylene group has the following formula (2);

[0013]

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(Wherein R ³ represents a linear or branched alkyl group or alkenyl group having 1 to 18 carbon atoms) is preferable.

In the above formula (2), R ³ is methyl, ethyl, propyl, isopropyl, n-butyl, t.
tert-butyl, pentyl, hexyl, octyl, nonyl, decyl, dodecyl, undecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, propenyl, butenyl, pentenyl, hexenyl, heptenyl, octenyl, nonenyl,
Decenyl, dodecenyl, undecenyl, tridecenyl,
Tetradecenyl, pentadecenyl, hexadecenyl, heptadecenyl, octadecenyl groups and the like can be mentioned, and among these, decenyl, undecenyl, dodecenyl, tridecenyl, tetradecenyl, pentadecenyl, hexadecenyl, heptadecenyl and octadecenyl groups are particularly preferable.

Examples of cholesterols represented by R ² in the above formula (1) include cholesterol, β-sitosterol, lanosterol, ergosterol and the like, of which cholesterol is particularly preferable.

Examples of the monoester (1) include cholesteryl hemi-succinate, cholesteryl hemiglutarate, cholesteryl hemi-maleate and the like. These may be used alone or in combination of two or more.

The content of the monoester (1) is not particularly limited, but is 0.01 to 50% by weight (hereinafter simply referred to as%) in the present composition, particularly 0.01 to 20%, more preferably 0.1 to 20%. 1
It is preferably 0%.

Further, when an anti-inflammatory agent is added to the bath agent composition of the present invention, the effect of suppressing itching of the skin after bathing is improved as compared with the case where the anti-inflammatory agent is used alone. In the present invention, in the general formula (1), R ¹ is the general formula (2),
It is particularly preferable to use a compound in which R ² is cholesterol and an anti-inflammatory agent in combination.

Among the anti-inflammatory agents used in the present invention, herbs such as chamomile, rice germ oil, fennel, ginkgo biloba, oleander, cinnamon, safflower, peony drug, ginger, pearl oyster, linseed, ginger, chinpi, oleander, linden, juniperia japonica. , Spruce, peppermint, butterbur, carrot and the like. Further, as the compound having an anti-inflammatory action, there are compounds such as general steroidal corticosteroids and non-steroidal compounds, but non-steroidal compounds are preferable in consideration of side effects and the like. Examples include antihistamines such as diphenhydramine, triperenamine, chloropheniramine, and anti-inflammatory compounds such as sodium salicylate, phenylbutazone, flufenamic acid, indomethacin, glycyrrhetinic acid, and allantoin. These may be used alone or in combination of two or more. In the present invention, rice germ oil, chamomile extract, and dipotassium glycyrrhizinate are particularly preferable from the viewpoint of the effect of suppressing itching of the skin.

The amount of the anti-inflammatory agent to be added to the bath agent composition of the present invention is not particularly limited, but is 0.01 to 30 of the total composition.
%, Particularly 0.01 to 10%, more preferably 0.1 to 5%.

If desired, the bath agent composition of the present invention may contain an oil component other than the above monoester (1). Examples of such oily components include difatty acid glycerin esters. As the difatty acid glycerin ester, those having a melting point of 30 ° C. or higher are preferably used, and among them, one of fatty acids having 8 to 20 carbon atoms such as 2-ethylhexanoic acid, myristic acid, oleic acid and isostearic acid, or Two diglycerin esters are preferred.

Further, as other oily components, fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols,
Esters, silicone oils, etc. can also be blended. Examples of the oils and fats include natural oils and fats such as soybean oil, bran oil, jojoba oil, avocado oil, almond oil, olive oil, cacao butter, sesame oil, persic oil, castor oil, coconut oil, mink oil, beef tallow, and pork fat. Hydrogenated natural fats and oils, hydrogenated hard oils, synthetic triglycerides such as myristic acid triglyceride and 2-ethylhexanoic acid triglyceride. Examples of waxes include carnauba wax, whale wax, beeswax, and lanolin. Examples of the hydrocarbons include liquid paraffin, petrolatum, paraffin microcrystalline wax, ceresin, squalane, blistane and the like. The higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid,
Examples thereof include oleic acid, linoleic acid, linolenic acid, lanolinic acid and isostearic acid. Examples of higher alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, 2-hexyldecanol and the like. Examples of the esters include myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate and the like. These oily components described above can be used alone or in combination of two or more.

The content of the oily component other than these monoesters (1) in the bath agent composition can be appropriately selected according to the type and formulation (form) of the bath agent, and usually 1 to
It can be 90%.

If desired, the above-mentioned oily component dispersion / emulsifier may be added to the bath agent composition of the present invention. The dispersant / emulsifier acts to prevent the oily components in the bath agent from rising to the surface of the water when the bath agent is poured into the bath water, and also makes the bath water cloudy, creating a high-class image like a milk bath. You can also Examples of such dispersion / emulsifiers include water-soluble polymer compounds and surfactants. Among them, water-soluble polymer compounds include sodium alginate, propylene glycol alginate, gum arabic, xanthan gum, pectin, tragacanth, sodium carboxymethyl cellulose, methyl cellulose, carboxyvinyl polymer, polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, milk protein, soy protein. , Gelatin, egg protein, sodium caseinate, whey protein and the like. Among them, gum agents such as gum arabic and xanthan gum and water-soluble proteins such as casein sodium and whey protein are preferable.

As the above-mentioned surfactant, any of anionic, cationic, nonionic, natural and synthetic surfactants can be used. In particular, two or more kinds of nonionic surfactants having different HLB are combined. It is preferable to use. Examples of such nonionic surfactants include:
Glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene alkyl ether, Examples thereof include polyethylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, and polyglycerin fatty acid ester.

The content of the dispersion of these oily components and the content of the emulsifier is 0.1 to 50%, especially 1 in the bath agent composition of the present invention.
-30%, and more preferably 5-20%.

Further, the bath agent composition of the present invention may further contain known bath agent raw materials which are generally used in bath agents, such as sodium chloride, sodium hydrogen carbonate, borax, sodium sulfate, Inorganic salts such as sodium sulfide, sodium sesquicarbonate, sodium nitrate, sodium polyphosphate, sodium metaphosphate, sodium phosphate, calcium oxide, magnesium oxide, calcium carbonate, magnesium carbonate, potassium chloride, potassium sulfide; boric acid, metasilicic acid, Inorganic acids such as anhydrous silicic acid; Organic acids such as succinic acid, fumaric acid, malic acid, tartaric acid, citric acid, benzoic acid; Yellow No. 4, Blue No. 1, Yellow No. (1), etc. Table I of selected tar dyes
And II pigments, chlorophyll, riboflavin, crocin, safflower, anthraquinone, and other natural pigments recognized as food additives; vitamins A, vitamin C, vitamin D, vitamin E, and other vitamins; flavors, sulfur Examples include, but are not limited to, hot spring water, mica powder, neutral clay, fungicides, and other components necessary for formulation.

When the bath agent composition of the present invention prepared as described above is in a liquid state, an appropriate amount of water is added within the range of 0.01 to 90% to increase the stability of the preparation, The formulation can also be in an emulsified form. Needless to say, the bath agent composition of the present invention can be made into various dosage forms (forms) such as powders, granules, tablets, and liquids in the same manner as known bath agents.

[0030]

The bath agent composition of the present invention is excellent in the moisturizing effect on the skin and the effect of improving bulkiness, provides a moist feel, and has the effect of calming the rash and severe itching caused by the dryness of the skin. Is.

[0031]

The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

Examples 1 to 8 and Comparative Examples 1 and 2 Bath compositions were prepared according to the formulations shown in Table 1. Table 1 specifies the reference single-use amount for 150 liters of bath water.

[0033]

[Table 1]

<Test Example 1> In order to see the effect of the bath agent composition of the present invention, a questionnaire of use of each sample for 3 days was taken from 10 panelists for the bath agent composition of Table 1, and after bathing, The "moist feeling of skin" and "dry feeling of skin" were examined. The results are shown in Tables 2 and 3.

[0035]

[Table 2]

[0036]

[Table 3]

From the above results, it can be seen that the bath agent compositions of the examples of the present invention have excellent performance in giving a moist feeling to the skin after bathing.

<Test Example 2> In order to see the effect of the bath agent composition of the present invention, the bath agent composition shown in Example 1 of Table 1 and the bath agent composition shown in Comparative Example 1 were used. A 10-day use questionnaire was taken from a famous panelist, and the feeling of the skin during bathing, the moist feeling of the skin after bathing, and the dryness were examined. The results are shown in Table 4.

[0039]

[Table 4]

As is clear from the results shown in Table 4, it was recognized that the bath preparation composition of Example 1 had a high moisturizing effect even in the actual bathing.

<Test Example 3> (Anti-inflammatory test) A group of 10 Wistar male rats weighing about 130 g was used to carry out a hindlimb carrageenin edema inhibition test according to a conventional method. That is, after carrageenin was intradermally injected into a rat foot pad, Examples 1 and 2 of Comparative Examples 2 and 6 and Comparative Example 2
Equivalent concentration for single use (150 times the reference use amount shown in Table 1)
Equivalent to the concentration dissolved in liters (temperature of 40 degrees)
The bath volume was measured for 20 minutes and the bath volume was measured 3 and 6 hours after bathing, and the foot volume before the injection of carrageenin was set to 100, and the result was compared with the case of sara hot water. The results are shown in Table 5. The numerical values in Table 5 are average values.

[0042]

[Table 5]

<Test Example 4> In order to see the effect of the bath agent composition of the present invention, the bath agent compositions shown in Examples 2 and 6 of Table 1 were itched on the skin after bathing by 20 persons each. A 10-day use questionnaire was taken by a panelist who complained about the effect on skin feeling during bathing, moist feeling after bathing, and effect on itching. The results are shown in Table 6.

[0044]

[Table 6]

As is clear from the results shown in Table 6, it was recognized that the bath preparation composition of Example 2 had a high effect of suppressing itch even in actual bathing.

Examples 9 to 10 According to the formulation shown in Table 7, an anti-inflammatory agent was added to the monoester of cholesterols and dicarboxylic acid represented by the above formula (1), and tablets or granules for bath were prepared according to a conventional method. An agent composition was prepared.

[0047]

[Table 7]

Continuation of front page (51) Int.Cl. ⁶ Identification number Office reference number FI technical display location A61K 35/78 ABE T 8217-4C

Claims (4)

[Claims] 1. The following general formula (1): (Wherein R ¹ represents a linear or branched alkylene group or alkenylene group having 2 to 20 carbon atoms, and R ² represents a residue obtained by removing a hydroxyl group proton of cholesterols). A bath agent composition comprising one or more monoesters of dicarboxylic acids. 2. The bath agent composition according to claim 1, further comprising an anti-inflammatory agent. 3. One or two anti-inflammatory agents selected from chamomile extract, dipotassium glycyrrhizinate and rice germ oil.
The bath agent composition according to claim 2, which comprises one or more species. 4. The bath agent composition according to claim 1, further comprising an oily component other than the monoester and a dispersion emulsifier of the oily component.