JPH08206488A - Liquid composition in which only component is solubilized - Google Patents

Abstract

PURPOSE: To provide a liquid composition, in which oily component is solubilized and water phase is combined with oil phase, and which is in a stable state at near room temperature even in a wide range of composition ratio and whose utilization range is not limited and safety is improved. CONSTITUTION: The liquid composition includes, as indispensable components, sucrose fatty acid monoester (a), 4-20C monohydric alcohol (b), oily component (c), and water (d), and the ratio between (a) and (b) is in the range of 0.1-0.7. By using this liquid composition, the purpose can be easily achieved.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a liquid composition in which an oily component is solubilized. Specifically, it relates to a liquid composition in which an oily component is solubilized, which is used in a wide range of fields such as cosmetics, pharmaceuticals and foods.

[0002]

2. Description of the Related Art A conventional liquid composition in which an oily component is solubilized, that is, a so-called microemulsion (hereinafter, a composition in which an oily component is solubilized may be referred to as "microemulsion"). There are roughly two manufacturing methods. That is, the first is a method using an oily component and an ordinary nonionic surfactant, and the second is
Is an oil component, an anionic (anionic) surfactant, and a lipophilic nonionic surfactant, and if necessary,
This is a method of using an electrolyte together.

The first method is to add a hydrocarbon (oil) such as cyclohexane or tetradecane (hereinafter referred to as "oil" or "oil component") to an aqueous solution of a nonionic surfactant such as polyethylene glycol alkyl ether. When the temperature of the liquid is increased, a region where the amount of solubilized hydrocarbons in the aqueous phase increases rapidly appears before the cloud point of the nonionic surfactant. It utilizes the nature of what is said. It is known that in the region from the solubilization limit temperature to the cloud point shown in the phase diagram, the solubility of oil in the aqueous phase sharply increases, forming a so-called microemulsion.

However, a microemulsion obtained by a nonionic surfactant-hydrocarbon (oil) system, which has been studied so far, in which the amount of oil solubilized in an aqueous phase is increased, is a hydrophilic property of the system. It can exist only in a very narrow temperature range (usually about -10 ° C) in which the hydrophobic balance (HLB) is maintained, and outside this temperature range, the system becomes cloudy immediately or with time, and eventually becomes an aqueous phase. It has the drawback of separating into an oil phase. This limits its application to cosmetics and pharmaceuticals.

The second method is disclosed in JP-A-58-128311.
JP-A-58-131127, etc., a lipophilic nonionic surfactant and a specific anionic surfactant, or a lipophilic nonionic surfactant In an aqueous solution that uses an ionic surfactant together,
An electrolyte is added to utilize a region in which the solubilization amount of hydrocarbon (oil) rapidly increases in a very narrow ratio range in which the HLB of the system is balanced from the composition. However, in the methods described in these publications, although stability with respect to temperature has been solved, microemulsions that can stably exist for a long period of time have a very limited mixed composition range, and thus the actual product The system limits the combination of formulations.

The nonionic surfactants used for preparing these conventional microemulsions are mainly
It is impossible to use a polyoxyethylene-based surfactant, which is used alone or in the form of a microemulsion with an ionic surfactant, for food applications because of safety and health restrictions. there were.

Further, in JP-A-63-126543 and JP-A-63-126544, a hydrophilic nonionic surfactant and an inorganic (organic conceptual diagram, Yoshio Koda, Sankyo Publishing) are used. , 1984.) Disclosed is a method for preparing a microemulsion from the above and oil having a limited carbon number in a specific range, and water. Since it is necessary to set the addition amount of the agent, the mixing ratio of oil and water, and the like within specific ranges, the range of use thereof is limited.

[0008]

Therefore, the use of the conventionally known microemulsion in the applications of cosmetics, pharmaceuticals, foods, etc. intended for use at ordinary temperatures is
The first method has a drawback in that the temperature stability, that is, the temperature range in which it can exist stably is narrow. There was a problem in terms of safety and health of the product as well as the drawback of being limited. Under such circumstances, it has been strongly desired to complete a microemulsion which has high temperature stability and is not limited in its use range and has high safety.

[0009]

Means for Solving the Problems Accordingly, the present inventors have:
In a liquid composition that combines an aqueous phase and an oil phase, even at a wide range of composition ratios, it is thermodynamically stable even at around room temperature, and the range of use is not limited, and an oily component with excellent safety is solubilized. As a result of extensive studies for the purpose of providing a liquid composition (microemulsion), a specific sucrose fatty acid monoester approved as an emulsifier for food and monohydric alcohols having 4 to 20 carbon atoms, It has been found that the above object can be achieved by using a composition having an oily component and water in a specific weight ratio, and has reached the present invention.

The invention according to claim 1 which has solved the above-mentioned problems is (a) sucrose fatty acid monoester {hereinafter referred to as (a) component. }, (B) Monovalent alcohol having 4 to 20 carbon atoms {hereinafter referred to as (b) component. }, (C) Oily component {hereinafter referred to as (c) component. }, And (d) water {hereinafter referred to as (d) component. } Is a liquid composition containing as an essential component, and the ratio of the component (b) to the total weight of the component (a) and the component (b) is in the range of 0.1 to 0.7. A liquid composition in which the components are solubilized is provided.

The present invention will be described in detail below. A liquid composition (microemulsion) in which an oily component according to the present invention is solubilized includes a sucrose fatty acid monoester as a component (a), a monohydric alcohol having 4 to 20 carbon atoms as a component (b), An oily component as component (c), and (d)
It contains four components of water as components as essential components. Hereinafter, each component will be described.

Component (a): The component (a) functions to solubilize the component (c) in the aqueous phase together with the component (b). Specific examples of the sucrose fatty acid monoester constituting the component (a) include sucrose caprylic acid monoester, sucrose capric acid monoester, sucrose laurate monoester, sucrose myristic acid monoester, and sucrose palmitic acid. Monoester, sucrose stearic acid monoester, sucrose oleic acid monoester, etc. are mentioned.
The sucrose fatty acid monoester preferably has an HLB value representing the degree of hydrophilicity / lipophilicity, in other words, having an HLB in the range of 10-18. Since sucrose fatty acid monoesters have a hydroxyl group, which is a hydrophilic group, in the molecule, they can be measured by ordinary measurement as compared with polyoxyethylene-based nonionic surfactants that have been mainly used for the preparation of microemulsion. At possible temperatures, the HLB rarely changes with temperature. Therefore, a microemulsion that is stable in a wide temperature range and has high practicality can be obtained without adding an ionic surfactant or the like. The component (a) may be one type or a mixture of two or more types.

Component (b): The component (b) functions to solubilize the component (c) in the aqueous phase together with the component (a). Specific examples of the alcohols constituting the component (b) are monohydric alcohols having 4 to 20 carbon atoms, specifically, 1-butanol, 1-pentanol, 1-hexanol, 1-heptanol, 1 -Octanol, 1-nonanol, 1-decanol, 1-undecanol, 1
-Dodecanol, 1-tridecanol, 1-tetradecanol, 1-pentadecanol, 1-hexadecanol, 1-heptadecanol, 1-octadecanol, 1
-Nonadecanol, 1-eicosanol and the like can be mentioned. Among them, 1-hexanol, 1-heptanol, 1
-Octanol, 1-nonanol, 1-decanol, 1
-Undecanol, 1-dodecanol, 1-tridecanol, 1-tetradecanol, 1-pentadecanol,
1-hexadecanol and the like are preferable. The component (b) is
It may be one kind or a mixture of two or more kinds.

These monohydric alcohols form an aggregate together with the above-mentioned sucrose fatty acid monoester molecule by monodisperse dissolving in the aqueous phase. Affect.
For example, when the difference between the fatty acid chain length of sucrose fatty acid monoester and the chain length of alcohol is small, the association between the two increases and the solubilizing ability of the oily component increases, but on the other hand, it becomes easier to form liquid crystals. . Conversely, if the difference in chain length between the two is large,
Sucrose palmitic acid monoester, which easily forms liquid crystals,
Even when stearic acid monoester is used, the microemulsion phase can be expanded by adding monohydric alcohols. Almost all monohydric alcohols having less than 4 carbon atoms are monodispersed and dissolved in the aqueous phase, so that the ability to form the above-mentioned association with the hydrophilic group portion of the surfactant is very small, and the same effect is obtained. A considerable amount of addition is required to obtain.

The ratio when the components (a) and (b) are combined is the ratio of the component (b) to the total weight of the components (a) and (b), that is, [{(b) component}. /
It is necessary to set {(a) component + (b) component}] to 0.1 to 0.7. When the ratio of the component (b) is less than 0.1, a microemulsion is not formed, and when it exceeds 0.7, the liquid composition is likely to undergo two-phase separation, which is not preferable.

The total weight of the components (a) and (b) is preferably 20% by weight or more based on the total weight of the solubilizing composition. The total amount of the components (a) and (b) is 20
If it is less than wt%, the microemulsion becomes unstable and the two phases may separate due to temperature change. A particularly preferable range of the total weight of the components (a) and (b) is 30% by weight or more based on the total weight of the solubilized composition.

Component (c): Specific examples of the oily component constituting the component (c) include n-heptane, n-octane and n.
Hydrocarbons such as decane, cyclohexane, squalene, squalane, ethers such as diheptyl ether, diethers such as ethylene glycol dibutyl ether, long chain amino alcohols such as sphingosine,
Examples include long-chain aldehydes, long-chain ketones, terpenoids, steroids, carotenoids, waxes, acylglycerols, ether glycerides, ceramides, phospholipids, glycolipids, phosphoglycolipids, sulfurized lipids and amino acid lipids. It may be a mixture of liquid paraffin, petrolatum, animal oils and fats such as fish oils, vegetable oils and fats such as soybean oils, mineral oils and the like, and is selected depending on the use of the liquid composition. The component (c) is
It may be one kind or a mixture of two or more kinds.

In the liquid composition according to the present invention, (c)
The ratio of the component to the component (d) is arbitrary, but according to the experiments conducted by the present inventor, from the viewpoint of the stability of the microemulsion against temperature changes, ((c) component and (d) component relative to the total weight of c) component weight fraction, that is, [{(c)
Component} / {(c) component + (d) component}] is 0.05 to
It has been found that a range of 0.95 is preferable.
A particularly preferable range of the total weight of the components (c) and (d) is less than 70% by weight based on the total weight of the solubilized composition.

In order to prepare the liquid composition in which the oily component of the present invention is solubilized, the essential components may be weighed, mixed and dispersed. Mixing at this time is preferably performed with a mixer capable of uniformly mixing and dispersing the above-mentioned four essential components.
Examples of such a mixer include known shear-type mixers such as an emulsifying machine and a high-pressure homogenizer that give a strong shearing force to a mixing system containing the essential four components.

Further, according to a method of mixing a mixing system containing the four essential components with gentle stirring, once raising the temperature of the system to a temperature above the solubilization limit temperature of the system and then cooling it. It is not necessary to use a special shear-type mixer, and a simple stirrer or shaker and a constant temperature bath for temperature control can easily prepare a liquid composition in which the oil component is solubilized. The latter method is advantageous over the former because it has an advantage that a more stable system can be obtained easily without using a special mixer, and at the same time, the manufacturing process can be labor-saving.

In addition to the components (a) and (c), the liquid composition according to the present invention may optionally contain an ionic surfactant, a glycoside, a salt, or the like, depending on the use of the liquid composition. An amphipathic substance or the like can be added.

The ionic surfactant is selected from conventionally known ones according to the application of the liquid composition. Glycosides include monohydric alcohols having 1 to 3 carbon atoms, sugars such as glucose and oligosaccharides, linear polyols such as glycerol, sorbitol and ethylene glycol, sugar alcohols such as maltitol and reduced oligosaccharides, and proteins. , Peptides, amino acids, mucopolysaccharides such as chondroitin sulfate and hyaluronic acid, and saponins. The amphipathic substance is a substance having a property of being compatible with polar and nonpolar solvents such as the components (a) to (d) at the same time, and specifically, sodium dodecylsulfate, triton, phosphatidylserine, phosphatiadyl. Examples include choline.

The product to which the liquid composition in which the oily component according to the present invention is solubilized is applied, if necessary, a fragrance, a dye, an antiseptic, a drug, a thickener, a chelating agent, an ultraviolet absorbing agent. Agents and the like can be added as appropriate.

The liquid composition according to the present invention is a detergent, shampoo, conditioner, hair tonic, hair oil, hair lotion, aftershave lotion, body lotion, emollient oil, makeup lotion, cleansing oil, aerosol product, deodorant, aromatic,
It can be used for liquid products such as deodorants, liquid medicines, and bath salts. Furthermore, a stable oil-in-water (o / w) emulsion can be prepared by diluting the composition with water. These emulsions include cleansing cream, massage cream, emollient cream,
In addition to cream emulsions such as hair cream, it can be used for liquid products such as foods and pharmaceuticals.

[0025]

The liquid composition in which the oily component according to the present invention is solubilized has the following advantageous effects and its industrial utility value is extremely large. 1. The conventional microemulsion has a drawback that the temperature range in which it can stably exist is narrow, but the liquid composition according to the present invention, which requires four components, is stable in a wide temperature range of 0 to 90 ° C. Very stable. 2. The liquid composition according to the present invention is extremely safe because the oily component is solubilized by a combination of a surfactant and an alcohol which are widely used as food additives. 3. The liquid composition according to the present invention essentially comprises four components, but is easy to prepare and has a wide temperature range in which it can be used.

[0026]

EXAMPLES Next, the present invention will be described in more detail by way of examples, but the present invention is not limited to the following examples as long as the gist thereof is not exceeded. In the following examples, the "stable temperature range (° C)" of the liquid composition was measured by the method described below. The liquid compositions prepared in Examples and Comparative Examples were enclosed in a glass tube having a diameter of 10 mm, the glass tube was shaken to uniformly mix the liquid composition in the tube, and then immersed in a constant temperature bath set to a predetermined temperature. Then, it is allowed to stand for several minutes to 1 hour, and the presence or absence of separation of the liquid composition in the tube is visually observed. While changing the temperature of the constant temperature bath, repeat the above operation according to the temperature, check the temperature range where the liquid composition does not separate into two phases, and set the upper and lower temperature ranges as the "stable temperature range (° C)". Indicated. The wider the upper and lower temperature ranges, the better the temperature stability.

[Examples 1 to 3] Sucrose monolaurate (SM-1200, Mitsubishi Chemical Foods Co., Ltd.) as the component (a), hexanol (special grade, Tokyo Chemical Industry Co., Ltd.) as the component (b). }, Decane as component (c) {special grade, Tokyo Kasei Kogyo Co., Ltd.}, distilled water as component (d) are weighed in the proportions shown in Table 1, respectively, placed in a container and heated to 95 ° C. While shaking, the mixture was cooled to room temperature to obtain a transparent liquid composition. With respect to the obtained transparent liquid composition, the stable temperature range (° C) was measured by the method described above. The results are shown in Table-1.

[Example 4] Sucrose monolaurate (same as Example 1) as the component (a), hexanol (same as Example 1) as the component (b), and hexadecane as the component (c) { Special grade, Tokyo Chemical Industry Co., Ltd.},
Distilled water as the component (d) was weighed in the proportions shown in Table 1, placed in a container, shaken while being heated to 95 ° C., and then cooled to room temperature to obtain a transparent liquid composition. With respect to the obtained transparent liquid composition, the stable temperature range (° C) was measured by the method described above. The results are shown in Table-1.

[Comparative Examples 1 and 2] Sucrose monolaurate as the component (a) (same as Example 1), hexanol as the component (b) (same as Example 1), and as the component (c). Decane (same as in Example 1) and distilled water as the component (d) were weighed in the proportions shown in Table 1, respectively, placed in a container, shaken while heating to 95 ° C., and then cooled to room temperature to obtain a liquid form. A composition was obtained. The stable temperature range (° C) of the obtained liquid composition was measured by the method described above.
The results are shown in Table-1.

[Comparative Examples 3 to 4] Octaethylene glycol dodecyl ether {NIKKOL BL-8SY, HLB value 1 as a polyethylene glycol type surfactant.
3, Nikko Chemicals Co., Ltd. {not applicable to component (a)}, hexanol as component (b) (same as Example 1), decane as component (c) (same as Example 1),
Distilled water as the component (d) was weighed in the proportions shown in Table 1, placed in a container, shaken while being heated to 95 ° C., and then cooled to room temperature to obtain a liquid composition. For the obtained liquid composition, the stable temperature range (° C) is measured by the method described above.
Was measured. The results are shown in Table-1.

[Comparative Examples 5-6] Tetraethylene glycol dodecyl ether {NIKKOL BL-4SY, HLB value 9. as a polyethylene glycol type surfactant.
5, Nikko Chemicals Co., Ltd., and octaethylene glycol dodecyl ether {NIKKOL BL-8S
Y, HLB value 13, Nikko Chemicals Co., Ltd.} (none correspond to component (a)}, heptane {special grade, Tokyo Chemical Industry Co., Ltd.} {not correspond to component (b)}, as component (d) The distilled water in Example 1 was weighed at the ratio shown in Table 1, put in a container, shaken while being heated to 95 ° C., and then cooled to room temperature to obtain a liquid composition. The stable temperature range (° C) of the obtained liquid composition was measured by the method described above. The results are shown in Table-1.

[0032]

[Table 1]

The following matters are clarified from Table-1. 1. The liquid composition according to the present invention is not only transparent at room temperature but also stable in a wide temperature range without causing two-phase separation (Examples 1 to 4). 2. On the other hand, although four components of (a) component to (d) component are contained, [{(b) component} / {(a) component +
(B) component}] is outside the range of 0.1 to 0.7, in any case, in any case, in the temperature range of 0 to 90 ° C., the aqueous phase and the reverse micelle solution ( It is separated into two phases (oil phase) and a transparent liquid composition cannot be obtained. 3. Further, in Comparative Examples 3 to 4 not containing the component (a), the temperature range in which the liquid composition shows a transparent state is narrow, and the object of the present invention is not achieved. 4. Furthermore, in Comparative Examples 5 and 6 which do not contain the component (a) and also do not contain the component (c), the temperature range showing the transparent state is higher than room temperature and the range is narrow, and the object of the present invention is not achieved.

Continuation of the front page (51) Int.Cl. ⁶ Identification code Office reference number FI technical display area C11D 1/68 3/16

Claims (3)

[Claims] 1. A sucrose fatty acid monoester (a) {hereinafter referred to as a component (a). }, (B) Monovalent alcohol having 4 to 20 carbon atoms {hereinafter referred to as (b) component. }, (C) Oily component {hereinafter referred to as (c) component. }, And (d) water {hereinafter referred to as (d) component. } Is contained as an essential component, and the ratio of the component (b) to the total weight of the component (a) and the component (b) is in the range of 0.1 to 0.7. A liquid composition in which an oily component is solubilized. 2. The liquid composition according to claim 1, wherein the total amount of the components (a) and (b) is 20% by weight or more based on the total weight of the liquid composition. 3. The liquid composition according to claim 1, which has a uniform appearance in the temperature range of 0 to 90 ° C.