JP2002114631A - Oil-in-water type emulsified composition and method for producing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oil-in-water type emulsified composition with an oily phase comprising a solid fat and a liquid oil dispersed stably for a long period, thus useful as a cosmetic in particular. SOLUTION: This oil-in-water type emulsified composition comprises (A) a hydrophilic polyglycerol fatty acid ester, (B) a solid fat with a melting point of >=30 deg.C, (C) a liquid oil with a melting point of <30 deg.C and (D) an aqueous medium.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention relates to an oil-in-water emulsion composition which can be formulated into a stable oil-in-water emulsion together with a liquid oil, which is generally considered to be difficult to stably blend, and which is particularly useful as a cosmetic. About things.

[0002]

2. Description of the Related Art It is known that the melting point of an oily component greatly affects the texture of an emulsified composition containing the oily component, and the texture of an emulsion is adjusted by combining a solid fat and a liquid oil. Is possible. Particularly, in the field of cosmetics, the solid fat component is a material preferably used because of its good feel, and sphingolipids such as ceramides, pseudo-ceramides, and sphingosines;
Phospholipids such as lecithin; amphiphilic lipids such as sterols also have an excellent skin care effect when applied to the skin, and are excellent materials as cosmetic bases in terms of both feel and skin care effect. However, these solid fats have a problem that it is difficult to stably blend them into the aqueous composition, and the blending must be restricted.

Therefore, in order to stably blend an oily component containing a solid fat into an oil-in-water emulsion composition, various measures such as using a large amount of a surfactant or using an anionic surfactant in combination have been devised. However, when the amount of the surfactant is large, the amount of the cosmetic is limited because of a demand for suppressing the irritation to the skin, especially in the case of a cosmetic that is applied to the skin and not washed away. When an anionic surfactant is used in combination, the anionic surfactant tends to be difficult to function in an acidic region having a pH of 6 or less. On the other hand, Japanese Patent Application Laid-Open No. 2-78432 describes a method of adding a surfactant and an oil component to solid fat to obtain a transparent emulsion by strong shearing force in order to reduce the amount of the surfactant to be added. ing. Also, Japanese Patent Application Laid-Open No.
No. 3814 discloses that a stable composition is prepared by blending an amphipathic lipid using a nonionic surfactant and an ionic surfactant, making the amphipathic lipid finer and making the composition translucent. The method of obtaining is described.

[0004] Attempts have been made to stabilize specific solid fats using polyglycerol fatty acid esters, which are surfactants having excellent safety. For example, Japanese Unexamined Patent Publication No. 62-186
No. 936 discloses an emulsified or solubilized composition of sterine using a sucrose fatty acid ester and / or a polyglycerin fatty acid ester. Also, Japanese Patent Application Laid-Open No. 08-2567
No. 29 describes a ceramide-containing water-soluble composition using a polyglycerin fatty acid ester. However, these compositions are all those in which only solid fat is emulsified or solubilized, and do not stably emulsify a system combining solid fat and liquid oil, and in terms of effect and feel as a cosmetic. It was not satisfactory.

[0005]

SUMMARY OF THE INVENTION The present invention provides an oil-in-water emulsified composition comprising a solid fat which is difficult to stably blend together with a liquid oil, which is stable over time, has excellent safety and is particularly useful as a cosmetic. The purpose is to do.

[0006]

Means for Solving the Problems The present inventors have found that a stable and safe cosmetic can be obtained by emulsifying an oil containing a solid fat and a liquid oil with a hydrophilic polyglycerin fatty acid ester. It has been found that an oil-type emulsion composition can be obtained.

That is, the present invention provides the following component (A):
(B), (C) and (D): (A) hydrophilic polyglycerin fatty acid ester, (B) solid fat having a melting point of 30 ° C. or higher, (C) liquid oil having a melting point of less than 30 ° C., (D) aqueous An oil-in-water emulsion composition containing a medium is provided. Further, the component (B) is obtained by dissolving a solid fat having a melting point of 30 ° C. or higher in a liquid oil having a melting point of less than 30 ° C. and dissolving or dispersing the component (A) hydrophilic polyglycerin fatty acid ester therein. It is intended to provide a method for producing an oil-in-water emulsion composition in which the obtained oil phase and the aqueous medium of the component (D) are mixed at a temperature not lower than the melting point of the mixture of the components (B) and (C).

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION As the component (A) hydrophilic polyglycerin fatty acid ester used in the present invention, a hydrophilic polyglycerin fatty acid ester having an HLB of 8 or more as defined by Griffin is preferable. In particular, a hydrophilic polyglycerin fatty acid ester whose 5% by weight (hereinafter simply referred to as%) aqueous solution becomes a liquid having fluidity at 25 ° C. is preferable.

The structure of the hydrophilic polyglycerol fatty acid ester of the present invention is such that the polyglycerin moiety is formed by condensation of 2 to 10 glycerins, while the fatty acid moiety has 8 carbon atoms.
Preferred are those composed of up to 24 saturated or unsaturated fatty acid residues. Specific examples of preferred polyglycerin moieties include diglycerin, triglycerin, tetraglycerin, pentaglycerin, hexaglycerin, decaglycerin and the like. The fatty acid residues include lauric acid, myristic acid, palmitic acid, stearic acid,
Residues such as behenic acid, isostearic acid, oleic acid, linoleic acid, ricinoleic acid and the like can be mentioned. These hydrophilic polyglycerin fatty acid esters are often obtained as a mixture, and are composed of components having different degrees of glycerin polymerization and esterification.

The component (A) hydrophilic polyglycerin fatty acid ester of the present invention is preferably a polyglycerin monofatty acid ester or a polyglycerin difatty acid in view of the stability of an oil-in-water emulsion and the use and effect as a cosmetic. ester,
Alternatively, a mixture thereof is preferable, and a polyglycerin monofatty acid ester is particularly preferable. Specifically, triglycerin, tetraglycerin, pentaglycerin,
Mono or diesters such as myristic acid such as hexaglycerin and decaglycerin, stearic acid, isostearic acid and oleic acid are preferred. Commercially available products include Sunsoft Q-18S (decaglyceryl monostearate, HLB12.0), Sunsoft Q-18F (hexaglyceryl monostearate, HLB10.5), Sunsoft Q-182S (decaglyceryl distearate,
HLB 11.0), Sunsoft Q-17S (decaglyceryl monooleate, HLB 14.5), Sunsoft A
-181E (pentaglyceryl monostearate, HL
B13.0), Sunsoft A-171C (triglyceryl monooleate, HLB 10.0), Sunsoft A-
141C (triglyceryl monomyristate, HLB1
2.0), (Sunsoft M-12J (polyglyceryl monolaurate, HLB16.0) (more than Taiyo Kagaku); SY Glister MSW-750 (decaglyceryl monostearate), SY Glister SS-500 (hexa sesquistearate) Glyceryl), S-face IS-
401 (tetraglyceryl monoisostearate), S
Faith M-1001 (decaglyceryl monomyristate), S-face O-1001 (decaglyceryl monooleate) (Sakamoto Yakuhin Kogyo) and the like.

In the present invention, the component (A) may be used in combination of two or more kinds, and is used in an amount of 0.1 to 20%, particularly 0.5 to 10% from the viewpoint of emulsion stability, feel and texture. Is preferred.

The melting point of the component (B) used in the present invention is 30 ° C.
The above solid fat is preferably an amphiphilic lipid or sphingolipid having a partial structure of an amide group or a phosphate group. Here, the amide group and the phosphate group may be present simultaneously.

Specific examples of component (B) solid fat having a melting point of 30 ° C. or higher include sphingolipids such as ceramides, pseudo-ceramides, sphingosines (including natural and synthetic products); alkyl phosphates and analogs thereof. Compounds; long-chain alkyl glyceryl ethers; phospholipids such as lecithin, phosphatidylcholine, and phosphatidylethanolamine; cholesterol, dehydrocholesterol, β-sitosterol, stearoyl cholesteryl ester, isostearyl cholesteryl ester, vegetable oil cholesteryl ester And sterols and analogs thereof; higher alcohols such as cetyl alcohol, stearyl alcohol, behenyl alcohol, butyl alcohol, and kimyl alcohol; and analogs thereof.

Ceramides and pseudo-ceramides include:
In addition to natural ceramides, sphingosine derivatives and the like, JP-A-62-228048, JP-A-63-216812,
JP-A-63-227513, JP-A-64-29347
JP-A-64-31752, JP-A-8-31926
Ceramide-like structural substances described in No. 3 and the like are exemplified.
Specifically, a substance selected from the following general formulas (1) and (2) is preferable.

[0015]

Embedded image

Wherein R ^1b represents a hydrocarbon group having 10 to 26 carbon atoms, R ^2b represents a hydrocarbon group having 9 to 25 carbon atoms, and X represents
-(CH ₂ ) _n- (where n represents an integer of 2 to 6). ]

[0017]

Embedded image

(Wherein, R ¹ and R ² are the same or different and each represent a hydrocarbon group having 1 to 40 carbon atoms which may be hydroxylated, and R ³ represents an alkylene group having 1 to 6 carbon atoms or a single bond. And R ⁴ represents a hydrogen atom, an alkoxy group having 1 to 12 carbon atoms or a 2,3-dihydroxypropyloxy group. However, when R ³ is a single bond, R ⁴ is a hydrogen atom.)

In the above formulas (1) and (2), the hydrocarbon group is preferably an alkyl group or an alkenyl group.

These components (B) can be used in combination of two or more, and the content in the oil-in-water emulsion composition is 0 considering the use, dosage form, texture, skin care effect and the like. .1-20%, especially 0.5-10%
Is preferred. It is desirable that the component (B) is dissolved or dispersed in the component (C) and blended in order to effectively exert the effect.

In the present invention, preferably, the component (A)
The hydrophilic polyglycerin fatty acid ester, the component (B) solid fat having a melting point of 30 ° C. or higher, and the component (D) aqueous medium described later form a thickening structure. here,
"Thickening structure" refers to one that exhibits viscous behavior,
A hydrophilic polyglycerin fatty acid ester and a solid fat are associated with each other in an aqueous medium to form an aggregated structure having optical anisotropy. Typical examples include a liquid crystal and an α-gel structure.

Since the thickened structure of the present invention has optical anisotropy, it can be confirmed with a polarizing microscope or the like. In addition, it can be confirmed by the following inversion method. Inversion method Approximately 20 mL of a predetermined amount of hydrophilic polyglycerin fatty acid ester and solid fat
The vial is weighed and an aqueous medium is added to prepare a sample so that the total amount becomes 10 g. After heating and stirring in a 90 ° C water bath to obtain a uniform sample, the mixture is cooled to 25 ° C. After standing for a certain period of time, observe the sample in the vial. When the thickening structure is formed, the sample in the vial has low or no fluidity, and the liquid level does not follow even when the vial is tilted. When the thickening structure is not formed, the liquid level follows when the vial is tilted.

From the viewpoint of forming the thickened structure, 0.1
% To 20% of the component (A) may be added in an amount of 0.1% to 20%, particularly 0.5 to 10% of the component (A). % Of component (B) is preferably added.

As the solid fat forming the thickening structure, one containing an amphipathic lipid or a sphingolipid having a partial structure of an amide or a phosphate group inside the structure is preferable. Particularly preferred solid fats of component (B) are sphingolipids such as ceramides, pseudo-ceramides and sphingosines; alkyl phosphates and analogs thereof; phospholipids such as lecithin, phosphatidylcholine and phosphatidylethanolamine. And the like.

Component (C) The liquid oil having a melting point of 30 ° C. or lower includes horse oil, mink oil, egg yolk oil, lanolin, liver oil,
Animal and vegetable fats and oils such as squalene, squalane, soybean oil, olive oil, sunflower oil, safflower oil, jojoba oil, camellia oil, perilla oil, perilla oil and derivatives thereof; essential oils such as lavender oil, chamomile oil, eucalyptus oil; Glyceryl di- or tri-oleate, mono,
Glyceryl di- or tri-2-ethylhexanoate, mono,
Mono-acyl glycerin such as di- or tri-glyceryl isostearate, diacyl glycerin, triacyl glycerin and their derivatives; fatty acids such as isotridecyl isononanoate, isopropyl isostearate, octyl dodecyl myristate, neopentyl glycol dicaprate, and alcohols Ester oil; ester oil comprising an organic acid such as diisostearyl malate and octyldodecyl lactate and a long-chain alcohol; cetyl-1,3
Ether oils such as dimethyl butyl ether, cetyl-2-ethylhexyl ether; hydrocarbon oils, petrolatum,
Mineral oils such as liquid paraffin; silicone oils such as dimethicone, cyclomethicone, alkyl-modified silicone and ethylene oxide-modified silicone; and fluorine oils such as fomblin. These components (C) can be used in combination of two or more, and considering the use, dosage form, texture, and the like, the content in the oil-in-water emulsion composition is 0.05 to 50%, particularly 0.1-30% is preferred.

As the aqueous medium of the component (D), water such as pure water, ion-exchanged water, alkaline ionized water, deep water, wave water and natural water; ethyl alcohol, propyl alcohol,
Lower alcohols such as isopropyl alcohol; polyhydric alcohols such as glycerin, 1,3-butylene glycol, isoprene glycol, dipropylene glycol and the like. Especially in terms of economy, safety and feel,
Preferably, water is used. The content of the component (D) is preferably 30% or more in consideration of the dosage form, the amount of other components, and the like.

[0027] The oil-in-water emulsion composition of the present invention may further contain component (E) an organic acid or a salt thereof. Specific examples include glycolic acid, lactic acid, malic acid,
Hydroxycarboxylic acids such as tartaric acid and citric acid; and polyvalent carboxylic acids such as oxalic acid, malonic acid, succinic acid, adipic acid, glutaric acid, maleic acid, fumaric acid, citraconic acid, aconitic acid, and the like. It can be used in any form of a mold, a neutralized salt, and a mixture thereof. The content of the oil-in-water emulsion composition of these organic acids or salts thereof is appropriately determined according to the product characteristics. 0.005% or more is desirable. The upper limit is
Considering precipitation of crystals, irritation to the skin when used as a cosmetic, and the like, the acid type is desirably 5% or less.

When used as a cosmetic, the pH of the composition of the present invention is from 2 to 7 from the viewpoint of non-irritation to the skin.
Is preferred.

The composition of the present invention may contain components such as alcohols, polyhydric alcohols, medicinal agents, antioxidants, preservatives, salts, amino acids, and sugars used in ordinary cosmetics. it can.

The oil-in-water emulsion composition of the present invention is disclosed in
It is characterized by an oil-in-water type rather than a water-in-oil type emulsifying system as shown in JP-178315, and in order to form a stable oil-in-water type emulsifying system, the components must be melted at a melting temperature. (B) An oil phase obtained by dissolving a solid fat having a melting point of 30 ° C. or higher in a component (C) liquid oil having a melting point of less than 30 ° C. and dissolving or dispersing the component (A) a hydrophilic polyglycerin fatty acid ester therein. And the aqueous medium of the component (D) are preferably mixed at a temperature equal to or higher than the melting point of the mixture of the components (B) and (C).

The oil-in-water emulsified composition of the present invention thus obtained is a form in which solid fat and liquid oil are stably dispersed in an aqueous phase (aqueous medium), so that the skin care effect of the solid fat is effective. It is excellent in use feeling, especially refreshing feeling, moist feeling, spreading, conformity, etc., and is useful as a cosmetic, especially as a skin care cosmetic. When used as a cosmetic, it is preferable to use it as an emulsion or cream.

[0032]

EXAMPLES Examples 1 and 2 and Comparative Examples 1 and 2 Oil-in-water emulsion compositions shown in Table 1 were prepared, and their storage stability was evaluated.

[0033]

[Table 1]

(Preparation method) After uniformly dissolving 10, 11, and 14,
12 was added to adjust the pH to 4.5. After the temperature was raised to 80 ° C., 13 was uniformly dissolved to obtain an aqueous phase. 1 to 8 were uniformly dissolved and dispersed at 80 ° C. to obtain an oil phase. The oil phase and the aqueous phase were mixed at 80 ° C., 9 was added, and emulsification was performed using a homogenizer while maintaining the temperature at 80 ° C. The system was cooled to 25 ° C. with stirring to complete the process.

(Evaluation Method) The properties and physical properties of the sample when stored at 5 ° C. and 40 ° C. for one month were evaluated according to the following criteria. The results are shown in Table 1.

(Evaluation Criteria) ○ No change is observed △ Slight change is observed × Clear change is observed (level with a problem in product characteristics)

The emulsions of Examples 1 and 2 were prepared at 5 ° C. and 40 ° C.
Even after storage for one month at ℃, the change in properties and physical properties was small, and there was no particular precipitation of crystalline substances and the stability was excellent.

Example 3 Skin Care Emulsion 1 (Composition) (% by Weight) 1. Ceramide analog (manufactured by Kao, Softcare Ceramide SL-E) 3.0 Cholesterol 0.53. Isostearyl cholesteryl ester 0.54. Bacyl alcohol 0.55. Squalane 1.5 6. 6. Isostearyl myristyl glycerin 1.0 (Exepearl DG-MI, manufactured by Kao) Olive oil (Cropure OL, manufactured by Croda) 2.0 8. 8. Pentaglyceryl stearate 4.0 (manufactured by Taiyo Kagaku Co., Ltd., Sunsoft A-181E) Silicone KF-96A (6cs, Shin-Etsu Chemical Co., Ltd.) 2.010. Eucalyptus extract 2.0 (Falco Rex Eucalyptus, manufactured by Ichimaru Falcos) 11.1,3-butylene glycol 3.0 12. Succinic acid 0.1 13. Sodium hydroxide (adjusted to pH 4.5) qs. Methyl paraben 0.2 15. Purified water balance

(Preparation method) 11, 12, and 15 were mixed and uniformly dissolved, and then 13 was added to adjust the pH to 4.5. After the temperature was raised to 80 ° C., 14 was uniformly dissolved to obtain an aqueous phase. After uniformly dissolving 1 to 7, 9 at 80 ° C, 8 was dispersed to obtain an oil phase. The oil phase and the aqueous phase were mixed at 80 ° C. and emulsified using a homogenizer while maintaining the temperature at 75 ° C. The mixture was cooled to 40 ° C. with stirring, 10 was added thereto, and the mixture was further cooled to 25 ° C. to complete the process.

Example 4 Skin Care Emulsion 2 (Composition) (% by Weight) Ceramide analog (manufactured by Kao, Softcare Ceramide SL-E) 2.0 2. Cholesterol 1.0 3. Cetanol 1.0 4. Squalane 1.5 5. 5. Sunflower oil 3.0 (Florasun 90, manufactured by Floratech) δ-tocopherol (E mix D, manufactured by Eisai) 0.17. Cedrol 0.2 8. 8. Polyglyceryl stearate 2.0 (manufactured by Taiyo Kagaku, Sunsoft A-18E) 9. Polyglyceryl stearate 0.5 (manufactured by Taiyo Chemical, Sunsoft Q-182S) Dimethyl polysiloxane 1.0 (silicone KF-96A (6cs) manufactured by Shin-Etsu Chemical Co., Ltd.) 11.1,3-butylene glycol 2.0 12. Citric acid 0.15 13. 13. Disodium phosphate 0.05 Sodium hydroxide (adjusted to pH 5.5) qs. Modified alcohol (Governed by the government) 3.5 16. Methyl paraben 0.2 17. Purified water balance

After mixing and dissolving 11 to 13 and 17, 14 was added to adjust the pH to 5.5. After the temperature was raised to 75 ° C., 16 was dissolved to form an aqueous phase. After dissolving 1 to 5 at 75 ° C, 8, 9 were dispersed, and 6, 7 were uniformly dissolved therein to obtain an oil phase. The oil phase and the aqueous phase were mixed at 70 ° C., and 10 was added, and emulsification was performed using a homogenizer while maintaining the temperature at 70 ° C. The mixture was cooled to 40 ° C. with stirring, 15 was added thereto, and further cooled to 25 ° C. to complete the process. This skin care cream is 5 ℃ and 40 ℃
-Even after storage for one month, changes in properties and physical properties were small, and the stability was excellent.

[0042]

Industrial Applicability The composition of the present invention has an oil phase containing a solid fat and a liquid oil dispersed stably as an oil-in-water emulsion for a long period of time, and is particularly useful as a cosmetic.

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Claims (7)

[Claims] 1. The following components (A), (B), (C) and (D): (A) a hydrophilic polyglycerin fatty acid ester, (B) a solid fat having a melting point of 30 ° C. or higher, and (C) a melting point. An oil-in-water emulsion composition containing a liquid oil having a temperature of less than 30 ° C. and (D) an aqueous medium. 2. The oil-in-water emulsion composition according to claim 1, wherein the component (A) is a polyglycerin monofatty acid ester. 3. Component (A), component (B) and component (D)
The oil-in-water emulsion composition according to claim 1 or 2, wherein the oil-forming composition forms a thickened structure. 4. The oil-in-water emulsion composition according to claim 1, wherein the component (B) is an amphipathic lipid or a sphingolipid having an amide or phosphate group partial structure. 5. The oil-in-water emulsion according to claim 1, wherein the component (B) contains ceramides, pseudo-ceramides, sphingosines, sterols, alkyl phosphates or phospholipids. Composition. 6. The oil-in-water emulsion composition according to claim 1, further comprising (E) an organic acid or a salt thereof. 7. A component (B) solid fat having a melting point of 30 ° C. or higher is dissolved in a component (C) liquid oil having a melting point of less than 30 ° C. A component (A) hydrophilic polyglycerin fatty acid ester is dissolved or dispersed therein. A method for producing an oil-in-water emulsion composition, wherein the oil phase obtained by the above is added to the aqueous medium of the component (D) at a temperature not lower than the melting point of the mixture of the components (B) and (C).