JPH08150201A - Body fluid treating device and priming method for body fluid treating device - Google Patents
Body fluid treating device and priming method for body fluid treating deviceInfo
- Publication number
- JPH08150201A JPH08150201A JP6321761A JP32176194A JPH08150201A JP H08150201 A JPH08150201 A JP H08150201A JP 6321761 A JP6321761 A JP 6321761A JP 32176194 A JP32176194 A JP 32176194A JP H08150201 A JPH08150201 A JP H08150201A
- Authority
- JP
- Japan
- Prior art keywords
- dialysate
- blood
- side circuit
- chamber
- dialysis solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001124 body fluid Anatomy 0.000 title claims abstract description 15
- 239000010839 body fluid Substances 0.000 title claims abstract description 15
- 230000037452 priming Effects 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 title claims description 5
- 239000008280 blood Substances 0.000 claims abstract description 46
- 210000004369 blood Anatomy 0.000 claims abstract description 46
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 18
- 210000003462 vein Anatomy 0.000 claims abstract description 13
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 239000012528 membrane Substances 0.000 claims description 16
- 238000000502 dialysis Methods 0.000 claims description 8
- 238000011144 upstream manufacturing Methods 0.000 claims description 6
- 239000000385 dialysis solution Substances 0.000 abstract description 10
- 210000001367 artery Anatomy 0.000 abstract description 9
- 239000002504 physiological saline solution Substances 0.000 abstract description 6
- 238000001631 haemodialysis Methods 0.000 abstract description 3
- 230000000322 hemodialysis Effects 0.000 abstract description 3
- 238000007599 discharging Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000000694 effects Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
- A61M1/3649—Mode of operation using dialysate as priming or rinsing liquid
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は血液透析治療時に、プラ
イミングと返血の際に使用する生理食塩水の代わりに透
析液を使用することのできる体液処理装置と体液処理装
置のプライミング方法に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a body fluid treatment device and a method for priming a body fluid treatment device in which a dialysate can be used in place of a physiological saline solution used for priming and blood return during hemodialysis treatment.
【０００２】[0002]
【従来の技術及び発明が解決しようとする課題】現在、
血液透析治療は透析器の中に透析膜を配置して、血液室
と透析室に区画し、血液室の中に血液、透析液室の中に
透析液を向流により還流させて、血液中の不要物質を透
析液中に移動させることにより実施されている。しかし
ながら、透析器とこれに接続される動静脈側回路に、治
療開始前に生理食塩液をプライミングし、さらに透析器
と動静脈側回路内に導出した血液を返血する際にも生理
食塩液を流し続けるので、多量の生理食塩水を消費しな
ければならなかった。そこで本発明者は、生理食塩水を
使用せずに血液透析器治療を行うことのできる体液処理
装置を鋭意検討した結果次の発明に到達した。2. Description of the Related Art
In hemodialysis treatment, a dialysis membrane is placed in a dialyzer to divide it into a blood chamber and a dialysis chamber, and blood in the blood chamber and dialysate in the dialysate chamber are circulated by countercurrent flow to the blood chamber. It is carried out by moving the unnecessary substances of 1. into the dialysate. However, when the dialyzer and the arteriovenous circuit connected to it are primed with physiological saline before the start of treatment, and when the blood drawn into the dialyzer and arteriovenous circuit is returned, the saline solution is also used. Since it was kept flowing, a large amount of physiological saline had to be consumed. Therefore, the present inventor has earnestly studied a body fluid treatment device capable of performing hemodialyzer treatment without using physiological saline, and has arrived at the following invention.
【０００３】[0003]
［１］本発明は内部に限外ロ過膜を配置して血液室と透
析液室に区画し、前記血液室の上流側に血液入口を形成
するとともに下流側に血液出口を形成し、前記透析室の
上流側に透析液出口を形成するとともに下流側に透析液
入口を形成した、透析器と、前記血液入口に接続される
動脈側回路と、前記血液出口に接続される静脈側回路
と、前記透析液入口に接続される透析液導入チューブ
と、前記透析液出口に接続される透析液排出チューブ
と、前記動脈側回路の途中に分岐チューブを介して接続
される透析液貯留バッグ、とから構成される体液処理装
置を提供する。 ［２］本発明は次の各工程よりなる［１］記載の体液処
理装置のプライミング方法を提供する。 （１）透析液導入チューブと透析液排出チューブの端部
を透析装置に接続し、透析液を透析装置より、透析液導
入チューブを経て透析液室へプライミングする工程、
（２）透析液を限外ロ過膜により逆ロ過して、限外ロ過
膜を洗浄する工程、（３）透析液を限外ロ過膜により逆
ロ過して動脈側回路、分岐チューブを経て透析液貯留バ
ッグに充填する工程、（４）透析液貯留バッグ中の透析
液を動脈側回路を経て血液室、静脈側回路へプライミン
グする工程、[1] In the present invention, an ultrafiltration membrane is placed inside to divide into a blood chamber and a dialysate chamber, a blood inlet is formed on the upstream side of the blood chamber, and a blood outlet is formed on the downstream side. A dialyzer in which a dialysate outlet is formed on the upstream side of the dialysis chamber and a dialysate inlet is formed on the downstream side, an arterial circuit connected to the blood inlet, and a vein circuit connected to the blood outlet. A dialysate introduction tube connected to the dialysate inlet, a dialysate discharge tube connected to the dialysate outlet, and a dialysate storage bag connected via a branch tube in the middle of the arterial circuit. A body fluid treatment device comprising: [2] The present invention provides a method for priming a body fluid treatment device according to [1], which comprises the following steps. (1) a step of connecting the ends of the dialysate introduction tube and the dialysate discharge tube to a dialyzer, and priming the dialysate from the dialyzer to the dialysate chamber via the dialysate introduction tube;
(2) Reverse filtration of dialysate with ultrafiltration membrane to wash ultrafiltration membrane, (3) Reverse filtration of dialysate with ultrafiltration membrane, arterial circuit, branch Filling the dialysate storage bag via a tube, (4) priming the dialysate in the dialysate storage bag to the blood chamber and vein side circuit via the arterial side circuit,
【０００４】[0004]
【実施例】図１は本発明の体液処理装置１の概略図を示
す。体液処理装置１は透析器２と、これに接続される動
脈側回路４及び静脈側回路５により構成される。透析器
２はハウジング２ａの内部に限外ロ過膜３を配置して、
血液室１３と透析液室１４に区画されている。前記血液
室１３の上流側には血液入口１５が形成されるとともに
下流側に血液出口１６が形成されている。また前記透析
液室１４の上流側には透析液出口１８が形成されるとと
もに下流側に透析液入口１７が形成されている。前記血
液入口１５には動脈側回路４が接続され、前記血液出口
１６には静脈側回路５が接続されている。動脈側回路４
の途中にはチャンバー１０を配置するとともに分岐チュ
ーブ７を介して透析液貯留バッグ６が接続されている。
また静脈側回路５の途中にもチャンバー１１が配置され
ている。前記透析液入口１７には透析液導入チューブ８
が接続され、前記透析液出口１８には透析液排出チュー
ブ９が接続されている。透析液導入チューブ８と透析液
排出チューブ９の他方の端部は透析装置１２に接続され
る。1 shows a schematic view of a body fluid treatment device 1 of the present invention. The body fluid treatment device 1 includes a dialyzer 2 and an arterial side circuit 4 and a vein side circuit 5 connected to the dialyzer 2. The dialyzer 2 has an ultrafiltration membrane 3 arranged inside a housing 2a,
It is divided into a blood chamber 13 and a dialysate chamber 14. A blood inlet 15 is formed on the upstream side of the blood chamber 13 and a blood outlet 16 is formed on the downstream side. A dialysate outlet 18 is formed on the upstream side of the dialysate chamber 14 and a dialysate inlet 17 is formed on the downstream side. The blood inlet 15 is connected to the artery side circuit 4, and the blood outlet 16 is connected to the vein side circuit 5. Arterial circuit 4
A chamber 10 is arranged in the middle of, and a dialysate storage bag 6 is connected via a branch tube 7.
A chamber 11 is also arranged in the middle of the vein side circuit 5. A dialysate inlet tube 8 is provided at the dialysate inlet 17.
And the dialysate outlet tube 9 is connected to the dialysate outlet 18. The other ends of the dialysate introduction tube 8 and the dialysate discharge tube 9 are connected to the dialyzer 12.
【０００５】本発明においては、透析液を限外ロ過膜３
を介して逆ロ過し、動脈側回路４、分岐チューブ７を経
て透析液貯留バッグ６に充填するため、透析器２はでき
るだけ高い限外ロ過能を有するように工夫するのが良
い。（例えばハウジングの形状、構造、限外ロ過膜３の
選択等。） また透析液貯留バッグ６は組み立て時に動脈側回路４に
一体に接続しても良いし、使用時に動脈側回路４に接続
しても良い。透析液貯留バッグ６の容量は５００−ｍｌ
（ミリリットル）から２−ｌ（リットル）に設定され、
治療目的に応じて自由に設定することができる。In the present invention, the dialysate is used as an ultrafiltration membrane 3.
The dialyzer 2 is filled with the dialysate storage bag 6 via the artery side circuit 4 and the branch tube 7 via the arterial side circuit 4, so that the dialyzer 2 may be devised so as to have an ultrafiltration capacity as high as possible. (For example, the shape and structure of the housing, selection of the ultrafiltration membrane 3, etc.) Further, the dialysate storage bag 6 may be integrally connected to the arterial circuit 4 at the time of assembly, or may be connected to the arterial circuit 4 at the time of use. You may. The capacity of the dialysate storage bag 6 is 500-ml.
It is set from (milliliter) to 2-l (liter),
It can be freely set according to the purpose of treatment.
【０００６】次に体液処理装置１を用いた透析液のプラ
イミング方法の一例について説明する。最初に透析装置
１２より透析液を透析液導入チューブ８を経て、透析室
１４へプライミングする。続いて透析液出口１８及び血
液入口１５を封止するかあるいは透析液排出チュ−ブ９
及び動脈側回路４（血液入口１５の近く）の途中をクラ
ンプした後、透析液を限外ロ過膜３により逆ロ過して、
限外ロ過膜３を洗浄する。洗浄に使用した透析液は血液
出口１６、静脈側回路５を経て排出する。次に、血液出
口１６を封止するかあるいは静脈側回路５（血液出口１
６の近く）をクランプし、血液入口１５あるいは静脈側
回路４（血液入口１５の近く）を開放した後、透析液を
限外ロ過膜３により逆ロ過して、動脈側回路４、分岐チ
ューブ７を経て透析液貯留バッグ６に充填する。透析液
貯留バッグ６中の透析液を動脈側回路４を経て、血液室
１３、静脈側回路５にプライミングする。透析器２と各
回路４、５内に患者から導出した血液を返血する際にも
透析液貯留バッグ６中の透析液を透析器２と各回路４、
５中に流して使用することができる。Next, an example of a dialysis fluid priming method using the body fluid treatment device 1 will be described. First, the dialysate is primed from the dialyzer 12 to the dialyzer 14 through the dialysate introducing tube 8. The dialysate outlet 18 and blood inlet 15 are then sealed or the dialysate drain tube 9
And after clamping the middle of the arterial circuit 4 (near the blood inlet 15), the dialysate is reverse-filtered by the ultrafiltration membrane 3,
The ultrafiltration membrane 3 is washed. The dialysate used for washing is discharged through the blood outlet 16 and the vein side circuit 5. Next, the blood outlet 16 is sealed or the venous circuit 5 (blood outlet 1
6) is clamped to open the blood inlet 15 or the vein side circuit 4 (near the blood inlet 15), and then the dialysate is reversely filtered by the ultrafiltration membrane 3 to branch the artery side circuit 4 and branch. The dialysate storage bag 6 is filled via the tube 7. The dialysate in the dialysate storage bag 6 is primed to the blood chamber 13 and the vein side circuit 5 via the artery side circuit 4. When returning the blood drawn from the patient to the dialyzer 2 and the circuits 4 and 5, the dialysate in the dialysate storage bag 6 is returned to the dialyzer 2 and the circuits 4 and 5.
5 can be used by pouring.
【０００７】[0007]
【発明の作用効果】透析治療開始前に動脈側回路の途中
に設けた透析液貯留バッグ６内に透析液を限外ロ過３に
より逆ロ過して貯留しておくことができるので、これを
従来の生理食塩水の代わりにプライミングと返血時に使
用することができる。このため従来の様に多量の生理食
塩水を消費しなくても良いので安価な透析治療が可能と
なる。[Advantageous Effects of the Invention] Since the dialysate can be reversely filtered and stored by the ultrafiltration 3 in the dialysate storage bag 6 provided in the middle of the arterial circuit before the dialysis treatment is started. Can be used in place of conventional saline for priming and blood return. Therefore, unlike the conventional case, it is not necessary to consume a large amount of physiological saline, so that inexpensive dialysis treatment can be performed.
【図１】本発明の体液処理装置の概略図。FIG. 1 is a schematic view of a body fluid treatment device of the present invention.
１ 体液処理装置 ２ 透析器 ２ａ ハウジング ３ 限外ロ過膜 ４ 動脈側回路 ５ 静脈側回路 ６ 透析液貯留バッグ ７ 分岐チューブ ８ 透析液導入チューブ ９ 透析液排出チューブ １０、１１ チャンバー １２ 透析装置 １３ 血液室 １４ 透析液室 １５ 血液入口 １６ 血液出口 １７ 透析液入口 １８ 透析液出口 1 Body fluid treatment device 2 Dialysis machine 2a Housing 3 Ultrafiltration membrane 4 Arterial side circuit 5 Vein side circuit 6 Dialysate storage bag 7 Branch tube 8 Dialysate introduction tube 9 Dialysate discharge tube 10, 11 Chamber 12 Dialysis machine 13 Blood Chamber 14 dialysate chamber 15 blood inlet 16 blood outlet 17 dialysate inlet 18 dialysate outlet
Claims (2)
液室に区画し、前記血液室の上流側に血液入口を形成す
るとともに下流側に血液出口を形成し、前記透析室の上
流側に透析液出口を形成するとともに下流側に透析液入
口を形成した、透析器と、 前記血液入口に接続される動脈側回路と、 前記血液出口に接続される静脈側回路と、 前記透析液入口に接続される透析液導入チューブと、 前記透析液出口に接続される透析液排出チューブと、 前記動脈側回路の途中に分岐チューブを介して接続され
る透析液貯留バッグ、とから構成されることを特徴とす
る体液処理装置。1. An ultrafiltration membrane is disposed inside to divide into a blood chamber and a dialysate chamber, a blood inlet is formed on the upstream side of the blood chamber and a blood outlet is formed on the downstream side, and the dialysis is performed. Forming a dialysate outlet on the upstream side of the chamber and forming a dialysate inlet on the downstream side, a dialyzer, an arterial circuit connected to the blood inlet, a vein side circuit connected to the blood outlet, From a dialysate introduction tube connected to the dialysate inlet, a dialysate discharge tube connected to the dialysate outlet, and a dialysate storage bag connected via a branch tube in the middle of the arterial circuit. A body fluid treatment device characterized by being configured.
項１記載の体液処理装置のプライミング方法。 （１）透析液導入チューブと透析液排出チューブの端部
を透析装置に接続し、透析液を透析装置より、透析液導
入チューブを経て透析液室へプライミングする工程、
（２）透析液を限外ロ過膜により逆ロ過して、限外ロ過
膜を洗浄する工程、（３）透析液を限外ロ過膜により逆
ロ過して動脈側回路、分岐チューブを経て透析液貯留バ
ッグに充填する工程、（４）透析液貯留バッグ中の透析
液を動脈側回路を経て血液室、静脈側回路へプライミン
グする工程、2. The method for priming a body fluid treatment device according to claim 1, which comprises the following steps. (1) a step of connecting the ends of the dialysate introduction tube and the dialysate discharge tube to a dialyzer, and priming the dialysate from the dialyzer to the dialysate chamber via the dialysate introduction tube;
(2) Reverse filtration of dialysate with ultrafiltration membrane to wash ultrafiltration membrane, (3) Reverse filtration of dialysate with ultrafiltration membrane, arterial circuit, branch Filling the dialysate storage bag via a tube, (4) priming the dialysate in the dialysate storage bag to the blood chamber and vein side circuit via the arterial side circuit,
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32176194A JP3302520B2 (en) | 1994-11-30 | 1994-11-30 | Body fluid treatment device and priming method for body fluid treatment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32176194A JP3302520B2 (en) | 1994-11-30 | 1994-11-30 | Body fluid treatment device and priming method for body fluid treatment device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08150201A true JPH08150201A (en) | 1996-06-11 |
| JP3302520B2 JP3302520B2 (en) | 2002-07-15 |
Family
ID=18136155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP32176194A Expired - Lifetime JP3302520B2 (en) | 1994-11-30 | 1994-11-30 | Body fluid treatment device and priming method for body fluid treatment device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3302520B2 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0992255A2 (en) | 1998-10-07 | 2000-04-12 | Nissho Corporation | Dialysis system and cleaning and priming method thereof |
| EP0992254A2 (en) | 1998-10-07 | 2000-04-12 | Nissho Corporation | Dialysis system and cleaning and priming method thereof |
| US7186342B2 (en) | 2001-06-05 | 2007-03-06 | Gambro Lundia Ab | Method for filling and washing a filter for a dialysis machine |
| JP2011182992A (en) * | 2010-03-09 | 2011-09-22 | Kawasumi Lab Inc | Priming method and dialyzer of dialysis system |
| JP2011239866A (en) * | 2010-05-17 | 2011-12-01 | Nipro Corp | Blood purifying apparatus |
| JP2019115715A (en) * | 2003-11-05 | 2019-07-18 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | High convection home hemodialysis/hemofiltration and sorbent system |
-
1994
- 1994-11-30 JP JP32176194A patent/JP3302520B2/en not_active Expired - Lifetime
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0992255A2 (en) | 1998-10-07 | 2000-04-12 | Nissho Corporation | Dialysis system and cleaning and priming method thereof |
| EP0992254A2 (en) | 1998-10-07 | 2000-04-12 | Nissho Corporation | Dialysis system and cleaning and priming method thereof |
| US6274034B1 (en) | 1998-10-07 | 2001-08-14 | Nipro Corporation | Dialysis system and cleaning and priming method thereof |
| US6277272B1 (en) | 1998-10-07 | 2001-08-21 | Nipro Corporation | Dialysis system and cleaning and priming method thereof |
| US6551513B2 (en) | 1998-10-07 | 2003-04-22 | Nipro Corporation | Cleaning and priming method for dialysis system |
| US6582604B2 (en) | 1998-10-07 | 2003-06-24 | Nipro Corporation | Method of cleaning and priming dialysis system |
| US7186342B2 (en) | 2001-06-05 | 2007-03-06 | Gambro Lundia Ab | Method for filling and washing a filter for a dialysis machine |
| JP2019115715A (en) * | 2003-11-05 | 2019-07-18 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | High convection home hemodialysis/hemofiltration and sorbent system |
| JP2011182992A (en) * | 2010-03-09 | 2011-09-22 | Kawasumi Lab Inc | Priming method and dialyzer of dialysis system |
| JP2011239866A (en) * | 2010-05-17 | 2011-12-01 | Nipro Corp | Blood purifying apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3302520B2 (en) | 2002-07-15 |
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