JPH0782012B2 - Blood-sink tube and method for producing water-filled porous synthetic resin body used therein - Google Patents
Blood-sink tube and method for producing water-filled porous synthetic resin body used thereinInfo
- Publication number
- JPH0782012B2 JPH0782012B2 JP1284230A JP28423089A JPH0782012B2 JP H0782012 B2 JPH0782012 B2 JP H0782012B2 JP 1284230 A JP1284230 A JP 1284230A JP 28423089 A JP28423089 A JP 28423089A JP H0782012 B2 JPH0782012 B2 JP H0782012B2
- Authority
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- Japan
- Prior art keywords
- synthetic resin
- blood
- porous
- tube
- resin body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は血沈管に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a blood tube.
従来の血沈管は、両端が開口し、長さ30cm、内径3mmの
ガラス管によって作られている。このガラス管は、これ
の一端開口から20cmにわたり1mm目盛りが付けられてい
る。そして、血沈検査は、このような従来の血沈管を使
用することにより次のように行なわれる。まず、血液に
血液抗凝固剤、例えば、３、８％クエン酸ナトリウムを
添加し、人が吸うことにより血沈管内を減圧して、血液
を血沈管の０点（基点）まで入れ、又は注射器等で血液
を血沈管の０点まで入れていた。次に、この血沈管を垂
直に静置し、時間ごとの赤血球の沈降した界面を測定す
る。血沈検査の終了後は、使用した血沈管を洗浄、滅
菌、乾燥等を行ない、血沈管を再生使用していた。しか
しながら、上述の従来の血沈管を使用して血沈検査を行
なうには、まず、人が口で吸ったり、注射器を使用して
血液を血沈管の０点まで入れる必要がある。この操作
は、単純ではあるが、熟練を要するものであり、且つ、
このような手作業は時間がかかり、多数検体を短時間で
処理することは困難である。又、上述のような作業過
程、若しくは、再生使用による洗浄、滅菌、乾燥などの
作業過程において、医療従事者が血液に由来する疾病、
例えば、ウィルス性肝炎、AIDS等の院内感染の可能性が
あり、しかも、再生使用に伴う作業も手間かがかかる。
更に、上述の血沈管を長期にわたり使用していると、壁
面に脂肪、蛋白質等が付着して、洗浄が不完全になりや
すく、得られたデータが不完全になる虞がある。A conventional blood tube is made of a glass tube with both ends open and a length of 30 cm and an inner diameter of 3 mm. The glass tube is graduated 1 mm from the opening at one end thereof for 20 cm. The blood sedimentation test is performed as follows by using such a conventional blood sedimentation tube. First, a blood anticoagulant, for example, 3,8% sodium citrate, is added to blood, and a person sucks the blood to reduce the pressure inside the blood sedimentation tube and put the blood to the zero point (base point) of the blood sedimentation tube, or a syringe or the like. Blood was filled up to 0 in the blood tube. Next, the blood tube is allowed to stand vertically, and the erythrocyte sedimentation interface is measured every hour. After the blood sedimentation test was completed, the blood sedimentation tube used was washed, sterilized, dried, etc., and the blood sedimentation tube was reused. However, in order to perform a blood sedimentation test using the above-described conventional blood sedimentation tube, first, it is necessary for a person to inhale with a mouth or use a syringe to put blood up to the zero point of the blood sedimentation tube. This operation is simple, but requires skill, and
Such manual work is time-consuming and it is difficult to process a large number of samples in a short time. In addition, in the above-mentioned work process, or in the work process such as cleaning, sterilization, and drying by recycling, the medical personnel may have diseases derived from blood,
For example, there is a possibility of nosocomial infections such as viral hepatitis and AIDS, and the work involved in recycling is time-consuming.
Furthermore, if the above-mentioned blood-condensing tube is used for a long period of time, fat, protein, etc. may adhere to the wall surface, and cleaning may easily become incomplete, resulting in incomplete data.
そこで、このような不都合な点を解消したものとして、
実願昭60−171843号及び本発明者による実願昭63−1373
53号等がある。これらの血沈管は、いずれも均一な内径
を有し且つ両端が開口している合成樹脂管内に気体は通
すが液体は通さない多抗性合成樹脂体（高吸水性高分子
を含有している）を挿着してなる。そして、使用時、採
血した血液中に血沈管の液体流入口側を入れ、血沈管の
他端から、血沈管内を減圧することにより、多孔性合成
樹脂体の挿着位置まで血液を直ちに、しかも多数同時に
導入することができるものである。Therefore, as a solution to these inconveniences,
Japanese Patent Application No. 60-171843 and Japanese Patent Application No. 63-1373 by the present inventor
There is No. 53, etc. All of these blood-precipitation tubes have a uniform inner diameter and both ends are open, and a multi-resistant synthetic resin body (containing a super absorbent polymer) that allows gas but does not allow liquid to pass through a synthetic resin tube. ) Is attached. Then, at the time of use, the liquid inflow port side of the blood sedimentation tube is put into the collected blood, and the blood is immediately depressurized from the other end of the blood sedimentation tube to the insertion position of the porous synthetic resin body, and Many can be introduced at the same time.
しかしながら、上述の合成樹脂管内に気体は通すが液体
は通さない多孔性合成樹脂体を挿着した血沈管では、多
孔性合成樹脂体が浸水性のため、使用時、多孔性合成樹
脂体に不注意にわずかでも水滴や血液をたらした場合、
瞬間的に通気性がなくなり、血沈管を使用することがで
きなくなってしまう。However, in a blood sedimentation tube in which a porous synthetic resin body that allows gas but not liquid to pass through is inserted into the synthetic resin tube described above, since the porous synthetic resin body is submerged, the porous synthetic resin body may not be used during use. If a small amount of water or blood is dropped on the caution,
For a moment, it loses breathability, and it becomes impossible to use the blood tube.
また、多孔性合成樹脂体が浸水性であるため、多孔性合
成樹脂体の孔径を小さく、しかもその長さを長くしない
と血液を止めることができない。この結果、血沈管内の
吸引圧を高める必要があり、液体と高吸水性高分子、例
えば、キセロゲル状態のコーンスターチとが接触した
時、多孔性合成樹脂体の表面にあるキセロゲル状態のコ
ーンスターチが通常のゲルとなり、このゲルが血沈管内
に流れ出てしまい、赤血球の沈降に影響を与える。Further, since the porous synthetic resin body is water-immersive, blood cannot be stopped unless the pore diameter of the porous synthetic resin body is small and the length is long. As a result, it is necessary to increase the suction pressure in the blood sedimentation tube, when the liquid and the superabsorbent polymer, for example, cornstarch in the xerogel state, when the cornstarch in the xerogel state on the surface of the porous synthetic resin body is normal. It becomes a gel, and this gel flows out into the blood tube, affecting the sedimentation of red blood cells.
そこで、本発明は上記事情に鑑みてなされたもので、不
注意に水、血液等の液体をたらしても通気性がなくなり
使用できなくなったりせず、しかも吸引圧を高くした
り、高吸水性高分子が血液中に流れ出たりすることのな
い血沈管を提供することを目的とする。Therefore, the present invention has been made in view of the above circumstances, and even if carelessly pouring a liquid such as water or blood, it cannot be used because it has no air permeability, and the suction pressure is high or the water absorption is high. It is an object of the present invention to provide a blood sedimentation tube in which a functional polymer does not flow out into blood.
〔課題を解決するための手段〕 上記課題を解決するため、本発明の血沈管は、均一な内
径を有し且つ両端が開口している合成樹脂管のいずれか
一方の開口から所定位置に、気体は通過するが液体は通
過させない特性を有する多孔性合成樹脂体を挿着し、い
ずれか他方の開口を液体流入口とする血沈管において、
前記合成樹脂管を揆水性とし、かつ前記多孔性合成樹脂
体を揆水性多孔体にて構成すると共に該揆水性多孔体内
にこれの総重量に対してキセロゲル状の高吸水性高分子
を0.5〜10.0重量％含有させてなるものである。[Means for Solving the Problems] In order to solve the above problems, the blood tube according to the present invention has a uniform inner diameter and a predetermined position from either one of the openings of the synthetic resin tube whose both ends are open, In a blood condensing tube in which a porous synthetic resin body having a property of passing a gas but not a liquid is inserted, and one of the other openings serves as a liquid inlet,
The synthetic resin pipe is made water repellent, and the porous synthetic resin body is constituted by a water repellent porous body and a xerogel-like highly water-absorbing polymer is contained in the water repellent porous body in an amount of 0.5 to 5%. The content is 10.0% by weight.
また、多孔性合成樹脂体は着色されているのが良い。The porous synthetic resin body is preferably colored.
更に、液体流入口側から合成樹脂管に目盛を付け、多孔
性合成樹脂体の一橋面が前記目盛の基点となるように、
前記合成樹脂管内に前記多孔性合成樹脂体を挿着してる
のが良い。Furthermore, a scale is attached to the synthetic resin pipe from the liquid inlet side so that the bridge surface of the porous synthetic resin body serves as the base point of the scale.
It is preferable that the porous synthetic resin body is inserted into the synthetic resin tube.
そして、揆水多孔性合成樹脂体は、熱可塑性樹脂の粉粒
体を半融成形して多孔体とし、該多孔体を所定形状に形
成してシリコン油に浸漬し、温度60℃、10〜20分間乾燥
させて作る。Then, the water-refined porous synthetic resin body is formed by semi-melt-molding a thermoplastic resin powder into a porous body, and the porous body is formed into a predetermined shape and immersed in silicon oil, at a temperature of 60 ° C., 10 to Let it dry for 20 minutes.
上記構成になる血沈管によれば、不注意で血沈管に若干
量の水や血液が多孔性合成樹脂体に接触しても、血沈管
における合成樹脂管及び多孔性合成樹脂体がいずれも揆
水性を有するから、水や血液をはじき、水や血液が高吸
水性高分子に到達しにくく、高吸水性高分子は作用しな
い。また、多孔性合成樹脂体は揆水性多孔体であるか
ら、浸水性のものに比して孔径が大きく且つ長手方向に
短くても血液を止めることができ、吸引圧力が低くても
血液を吸引することができ、水や血液が高吸水性高分子
に接触した後水や血液は直ちに封止され、更に浸水性で
ないから高吸水性高分子が血液側に流れにくい。According to the blood sedimentation tube having the above-mentioned configuration, even if some amount of water or blood is inadvertently contacted with the porous synthetic resin body, the synthetic resin tube and the porous synthetic resin body in the blood sedimentation tube are agitated. Since it is water-based, it repels water and blood, and it is difficult for water and blood to reach the superabsorbent polymer, and the superabsorbent polymer does not act. Further, since the porous synthetic resin body is a water repellent porous body, it can stop blood even if it has a large pore size and is short in the longitudinal direction as compared with a water-immersible one, and it can suck blood even if the suction pressure is low. The water and blood are immediately sealed after contact with the superabsorbent polymer, and since the superabsorbent polymer is not submerged, the superabsorbent polymer hardly flows to the blood side.
また、多孔性合成樹脂体が着色されていると、目盛の基
点が一見してわかる。Also, if the porous synthetic resin body is colored, the base point of the scale can be seen at a glance.
更に、流体流入口側から目盛を付け、その目盛の基点と
なる位置に多孔性合成樹脂体の一端面が位置するように
したもので、開口側から吸引すれば血液等の液体は目盛
の基点まで直ちに流入し、多孔性合成樹脂体によりそれ
以上流入しない。Furthermore, a scale is attached from the fluid inlet side, and one end surface of the porous synthetic resin body is positioned at the position that is the base point of the scale.If suction is applied from the opening side, liquid such as blood will be the base point of the scale. Immediately, and no further inflow due to the porous synthetic resin body.
以下、本発明の実施例を添付図面に基づいて詳述する。 Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.
図面は本発明の血沈管の斜視図である。同図において、
１は血沈管を示し、該血沈管１は、例えば、ポリエチレ
ン、ポリスチレン、ポリプロピレンなどの揆水性を有す
る合成樹脂管２から作られている。なお、この合成樹脂
管２は、揆水性のない素材から作られても良く、この場
合に揆水処理を施す必要がある。この合成樹脂管２は内
径が均一に形成され且つ両端が開口している。この合成
樹脂管２の一端は、血液等の液体を流入させる液体流入
口３となっている。この合成樹脂管２の他端はテーパ状
に形成され、このテーパ状開口４は、合成樹脂管２内の
所定位置に多孔性合成樹脂体５を挿着させ易いように設
けられたものである。The drawing is a perspective view of a blood tube according to the present invention. In the figure,
Reference numeral 1 denotes a blood sedimentation tube, and the blood sedimentation tube 1 is made of a synthetic resin tube 2 having a water repellent property such as polyethylene, polystyrene and polypropylene. The synthetic resin tube 2 may be made of a material having no water repellent property, and in this case, it is necessary to perform water repellent treatment. The synthetic resin pipe 2 has a uniform inner diameter and is open at both ends. One end of the synthetic resin tube 2 serves as a liquid inlet 3 into which a liquid such as blood flows. The other end of the synthetic resin pipe 2 is formed in a tapered shape, and the tapered opening 4 is provided so that the porous synthetic resin body 5 can be easily inserted at a predetermined position in the synthetic resin pipe 2. .
この多孔性合成樹脂体５は、気体は通過するが液体は通
過させない特性を有している。そして、この多孔性合成
樹脂体５は着色されている。この着色は通常３原色の色
素が使用される。この着色は、合成樹脂管２内に挿着さ
れた多孔性合成樹脂体５の位置を容易に確認できるよう
に、多孔性合成樹脂体５になされたものである。The porous synthetic resin body 5 has a property of allowing a gas to pass but not a liquid. The porous synthetic resin body 5 is colored. For this coloring, dyes of three primary colors are usually used. This coloring is applied to the porous synthetic resin body 5 so that the position of the porous synthetic resin body 5 inserted into the synthetic resin tube 2 can be easily confirmed.
この多孔性合成樹脂体５は、円柱状をなし、その長さは
3mmであり、液体流入口３側から1mmきざみで目盛を付け
た合成樹脂管２の20cmのところ、すなわち、０点（基
点）にその一端面5aが位置するように、合成樹脂管２内
に挿着されている。そして、この多孔性合成樹脂体５
は、その長さが3mmあるため、2Kg/cm2の差圧があって
も、合成樹脂管２内を移動しない。なお、この多孔性合
成樹脂体５の形状は円柱状に限定されず、球状その他の
形状であっても良い。The porous synthetic resin body 5 has a columnar shape and its length is
It is 3 mm, and is located within 20 cm of the synthetic resin pipe 2 graduated in 1 mm increments from the liquid inlet 3 side, that is, so that one end surface 5a thereof is located at the 0 point (base point). It has been inserted. And this porous synthetic resin body 5
Since it has a length of 3 mm, it does not move in the synthetic resin tube 2 even if there is a differential pressure of 2 kg / cm 2 . The shape of the porous synthetic resin body 5 is not limited to the cylindrical shape, and may be a spherical shape or another shape.
この多孔性合成樹脂体５は、ポリエチレン、ポリプロピ
レン、エチレン・酢酸ビニル共重合体、ポリスチレン等
の樹脂自体が揆水性を有する熱可塑性樹脂の粉粒体を半
融成形をして得られた多孔体を、更にのちに詳述するよ
うに、例えば揆水処理をし、この揆水性多孔体内に、こ
れの総重量に対して高吸水性高分子（キセロゲル）を0.
5〜10.0重量％含有させることにより得られるものであ
る。この高吸水性高分子が0.5重量％に満たないと、血
液等の液体が接触しても水封止としての働きが不十分と
なり、10.0重量％より多いと水封止としての働きは充分
であるが、ゲルが液体中に多く流れ出てしまい赤血球の
沈降状態に影響を与えることになる。The porous synthetic resin body 5 is a porous body obtained by semi-melt molding a powder or granular material of a thermoplastic resin such as polyethylene, polypropylene, an ethylene / vinyl acetate copolymer, polystyrene, etc., which itself has water repellent property. As described in more detail later, for example, water treatment is performed, and a superabsorbent polymer (xerogel) is added to the water-absorbing porous body in an amount of 0.
It is obtained by containing 5 to 10.0% by weight. If this superabsorbent polymer is less than 0.5% by weight, the function as a water seal becomes insufficient even if a liquid such as blood comes into contact, and if it is more than 10.0% by weight, the function as a water seal is sufficient. However, a large amount of gel flows out into the liquid, which affects the sedimentation state of red blood cells.
なお、多孔性合成樹脂体５は、樹脂自体揆水性を有する
から、半融成形しても揆水性を保持しているが、多孔質
であるため毛細管現象により液を良く吸うことになり、
結果的に浸水性を示すことになる。In addition, since the porous synthetic resin body 5 itself has water repellent property, it retains water repellent property even if it is semi-melt molded, but since it is porous, it absorbs liquid well by capillary action.
As a result, it shows water infiltration.
ここで、半融形成とは、上述のような熱可塑性樹脂の粉
粒体を一定形状の金型に充填し、気孔率を調整する目的
で充填層を加圧し、更に、この粉粒体充填層を均一に加
熱して、粒子の接触表面が半融状態で融着した時点で冷
却して、各粒子間空隙が完全に連続した３次元的空間
（気孔）を形成させる形成法をいう。また、高吸水性高
分子とは、コーンスターチ、小麦テンプン、米デンプ
ン、イモデンプン、ゼラチン、寒天、アラビアガム等の
吸水性及び封止能力のある高分子化合物をいい、キセロ
ゲルとは、この高吸水性高分子が乾いた状態のことをい
う。Here, the semi-melt formation means that the powder particles of the thermoplastic resin as described above are filled in a mold of a constant shape, the filling layer is pressed for the purpose of adjusting the porosity, and further, the powder particles are filled. It is a method of forming a three-dimensional space (pores) in which the interparticle voids are completely continuous by uniformly heating the layer and cooling when the contact surfaces of the particles are fused in a semi-melted state. Further, the super absorbent polymer means a polymer compound having a water absorbing and sealing ability such as corn starch, wheat tempun, rice starch, potato starch, gelatin, agar and gum arabic, and xerogel means the super absorbent polymer. The polymer is in a dry state.
従って、前記多孔性合成樹脂体５は、前述の揆水性を有
する熱可塑性樹脂の粉粒体を半融成形し、更に揆水処理
して得られた揆水性多孔体内にキセロゲル状態の高吸水
性高分子を密着させたものであるから、空気等の気体を
通すが、血液等の液体が多孔性合成樹脂体５に接触する
と、キセロゲル状態の高吸水性高分子が液体を瞬時に吸
収して、高吸水性高分子が膨潤し、液体を通さなくな
る。Therefore, the porous synthetic resin body 5 is a xerogel-state highly water-absorbing material in the water-repellent porous body obtained by semi-melt-molding the powdery particles of the thermoplastic resin having the above-mentioned water-repellent property and further water-treating. Since the polymer is closely attached, a gas such as air is passed through, but when a liquid such as blood comes into contact with the porous synthetic resin body 5, the super absorbent polymer in a xerogel state instantly absorbs the liquid. , The super absorbent polymer swells and becomes impermeable to liquids.
この多孔性合成樹脂体５は、熱可塑性樹脂（樹脂自体が
揆水性を有しなくても良い）の粉粒体を半融成形して得
られた多孔体に揆水処理をすることで得られる。すなわ
ち、この揆水多孔性合成樹脂体は、まず、前述の多孔体
をシリコン等の揆水性を有する液体中に所定時間浸漬
し、そのあと温度60℃にて10〜20分間乾燥させ、揆水性
を有した多孔体内にキセロゲル状態の高吸水性高分子を
密着させることにより作られる。The porous synthetic resin body 5 is obtained by subjecting a porous body obtained by semi-melt molding a powdered or granular material of a thermoplastic resin (resin itself may not have water repellent property) to water treatment. To be That is, the water-repellent porous synthetic resin body, first, the porous body described above is immersed in a liquid having a water repellent property such as silicon for a predetermined time, and then dried at a temperature of 60 ° C. for 10 to 20 minutes to repel water. It is made by bringing a super absorbent polymer in a xerogel state into close contact with a porous body having a.
次に、上記構成になる血沈管の使用方法を説明する。Next, a method of using the blood tube having the above structure will be described.
まず、本発明の血沈管１を用意し、クエン酸ナトリウム
により凝固防止された血液の入った試験管等の中に、血
沈管１の液体流入口３を入れる。この際、不注意に水
滴、血液を血沈管１にたらしても、合成樹脂管２、多孔
性合成樹脂体５は、いずれも揆水性があるから、水滴、
血液はキセロゲル状の高給水性高分子に到達しない。従
って、若干量の水滴、血液をたらしたものであれば、血
沈管１は使用すること可能である。次に、真空ポンプ等
でテーパ状開口４側から合成樹脂管２内を減圧すると、
多孔性合成樹脂体５は2kg/cm2の差圧に耐えることがで
きるから、合成樹脂管２内を移動することなく、液体流
入口３から合成樹脂管２内に血液が入り、この血液が目
盛の０点、すなわち、多孔性合成樹脂体５の一端面5aに
達すると、多孔性合成樹脂体５内に密着したキセロゲル
状態の高吸水性高分子が瞬時に血液中の水分を吸収し膨
潤して封止状態になり、血液は０点にて止まる。この
際、多孔性合成樹脂体５が揆水性を有しているから、多
孔体の孔径が大きくても、例えば、30μｍであっても血
液を通しにくいが、通気は通しやすいので、低い吸引圧
力で血液を吸引することができる。このあと、血液が多
孔性合成樹脂体５に到達すると、上述のように高吸水性
高分子が直ちに膨潤し封止状態となるが、揆水性のため
血液を通しにくくなり、血液とキセロゲル状態の高吸水
性高分子との接触の機会が相対的に少なくなっており、
通常のゲルの発生が相対的に少なく血液側にほとんど流
出しない。従って、ゲルが赤血球の沈降状態に影響を与
えることがない。First, the blood tube 1 of the present invention is prepared, and the liquid inlet 3 of the blood tube 1 is placed in a test tube or the like containing blood coagulated with sodium citrate. At this time, even if water droplets or blood is inadvertently poured into the blood settling tube 1, since the synthetic resin tube 2 and the porous synthetic resin body 5 are both water-repellent,
Blood does not reach xerogel-like highly water-soluble polymers. Therefore, the blood sink tube 1 can be used as long as a slight amount of water droplets or blood is deposited. Next, when the pressure inside the synthetic resin pipe 2 is reduced from the tapered opening 4 side with a vacuum pump or the like,
Since the porous synthetic resin body 5 can withstand a differential pressure of 2 kg / cm 2 , blood does not move in the synthetic resin tube 2 but enters the synthetic resin tube 2 through the liquid inlet 3, and this blood When reaching the 0 point on the scale, that is, the one end surface 5a of the porous synthetic resin body 5, the superabsorbent polymer in the xerogel state, which is in close contact with the porous synthetic resin body 5, instantly absorbs water in the blood and swells. Then, it becomes a sealed state, and blood stops at 0 point. At this time, since the porous synthetic resin body 5 has water repellent property, even if the pore size of the porous body is large, for example, even if it is 30 μm, it is difficult for blood to pass through, but ventilation is easy to pass, so a low suction pressure is required. Blood can be sucked in. After that, when the blood reaches the porous synthetic resin body 5, the superabsorbent polymer immediately swells to be in a sealed state as described above, but it becomes difficult to pass the blood due to the water repellent property, and the blood and the xerogel state are changed. Opportunities for contact with super absorbent polymers are relatively low,
The generation of normal gel is relatively small and hardly flows out to the blood side. Therefore, the gel does not affect the sedimentation state of red blood cells.
そして、血沈管１内に血液を０点まで入れる操作は、容
易且つ瞬時に行なうことができる。このあと、血沈管１
を垂直にして、赤血球の沈降状態を所定時間ごとに測定
すれば良い。測定後、使用した血沈管１は廃棄する。Then, the operation of filling the blood into the blood tube 1 to the zero point can be performed easily and instantly. After this, blood tube 1
Is set vertically and the sedimentation state of erythrocytes may be measured every predetermined time. After the measurement, the used blood tube 1 is discarded.
次に、本発明の血沈管と従来の血沈管との対比実験のデ
ータを示す。Next, the data of the comparison experiment of the blood tube of the present invention and the conventional blood tube will be shown.
（実施例１） 合成樹脂管２内に揆水性多孔体の多孔性合成樹脂体を挿
着した血沈管に、第２図に示すように、スポイトにて水
を２滴（１滴約0.05ml）たらして、５分後に真空ポンプ
にて負圧500mmHgにて吸引して差圧を測定する。(Example 1) As shown in FIG. 2, 2 drops of water (1 drop of about 0.05 ml) was put into a blood sedimentation tube in which a porous synthetic resin body of a water repellent porous body was inserted in the synthetic resin tube 2. ) Then, after 5 minutes, a vacuum pump sucks at a negative pressure of 500 mmHg to measure the differential pressure.
更に比較のために水をたらさない場合の差圧を上述と同
様の方法にて測定する。Further, for comparison, the pressure difference when water is not dropped is measured by the same method as described above.
（実施例２） 合成樹脂管２内に揆水処理（シリコン処理）した多孔性
合成樹脂体を挿着した血沈管により、実施例１と同様な
測定を行なう。(Example 2) The same measurement as in Example 1 is performed using a blood sedimentation tube having a synthetic resin tube 2 in which a porous synthetic resin body treated with water (silicon treatment) is inserted.
（比較例１） 合成樹脂管２内に浸水性の多孔性合成樹脂体を挿着した
血沈管により、実施例１と同様な測定を行なう。(Comparative Example 1) The same measurement as in Example 1 is performed using a blood sedimentation tube in which a water-permeable porous synthetic resin body is inserted in the synthetic resin tube 2.
以下に測定結果を表−１に示す。The measurement results are shown in Table 1 below.
表−１から実施例１、２は水をたらした場合の差圧と水
をたらさない場合の差圧は全くないが、比較例１ではミ
ストが多孔性合成樹脂体内に入りゲル化して目をつぶし
ていると予測できる。また、水をたらさない状態の差圧
が実施例１、２と比較例１とでは大きく異なっている
が、比較例１は浸水性であるため血液が止まりにくいた
め、孔径の小さな多孔体を多孔性合成樹脂体に使用して
いるためである。 From Table 1, Examples 1 and 2 have no differential pressure when water is poured and no differential pressure when water is not poured, but in Comparative Example 1, mist enters the porous synthetic resin body and gels to form a visible image. You can predict that you are crushing. Further, the pressure difference in the state where water is not poured is greatly different between Examples 1 and 2 and Comparative Example 1, but since Comparative Example 1 is submerged, it is difficult for blood to stop. This is because it is used for the porous synthetic resin body.
（実施例３） 実施例１の多孔性合成樹脂体の長さを1mmにした血沈管
の液体流入口を、第３図に示すように血液中に入れ、真
空ポンプにて500mmHgにて５分間吸引して血液の流れ状
態を目視観察する。(Example 3) As shown in Fig. 3, the liquid inflow port of a blood sedimentation tube in which the length of the porous synthetic resin body of Example 1 was set to 1 mm was put into blood, and a vacuum pump was used at 500 mmHg for 5 minutes. Aspirate and visually observe the blood flow condition.
（実施例４） 実施例１の多孔性合成樹脂体の長さを1.5mmにした血沈
管につき、実施例３と同様な測定を行なう。(Example 4) The same measurement as in Example 3 is carried out on the blood sedimentation tube in which the length of the porous synthetic resin body of Example 1 is 1.5 mm.
（実施例５） 実施例１の多孔性合成樹脂体の長さを2.0mmにした血沈
管につき、実施例３と同様な測定を行なう。(Example 5) The same measurement as in Example 3 is carried out on the blood sedimentation tube in which the length of the porous synthetic resin body of Example 1 is 2.0 mm.
（実施例６） 実施例１の多孔性合成樹脂体の長さを2.5mmにした血沈
管につき、実施例３と同様な測定を行なう。(Example 6) The same measurement as in Example 3 is performed on the blood-condensing tube in which the length of the porous synthetic resin body of Example 1 is 2.5 mm.
（実施例７） 実施例１の多孔性合成樹脂体の長さを3.0mmにした血沈
管につき、実施例３と同様な測定を行なう。(Example 7) The same measurement as in Example 3 is carried out on the blood sedimentation tube in which the length of the porous synthetic resin body of Example 1 is 3.0 mm.
（比較例２） 比較例１の多孔性合成樹脂体の長さを1mmにした血沈管
につき、実施例３と同様な測定を行なう。(Comparative Example 2) The same measurement as in Example 3 is carried out on the blood sedimentation tube in which the length of the porous synthetic resin body of Comparative Example 1 is 1 mm.
（比較例３） 比較例１の多孔性合成樹脂体の長さを1.5mmにした血沈
管につき、実施例３と同様な測定を行なう。(Comparative Example 3) The same measurement as in Example 3 is carried out on the blood sedimentation tube in which the length of the porous synthetic resin body of Comparative Example 1 is 1.5 mm.
（比較例４） 比較例１の多孔性合成樹脂体の長さを2.0mmにした血沈
管につき、実施例３と同様な測定を行なう。(Comparative Example 4) The same measurement as in Example 3 is performed on the blood sedimentation tube in which the length of the porous synthetic resin body of Comparative Example 1 is 2.0 mm.
（比較例５） 比較例１の多孔性合成樹脂体の長さを2.5mmにした血沈
管につき、実施例３と同様な測定を行なう。(Comparative Example 5) The same measurement as in Example 3 is carried out on the blood sedimentation tube in which the length of the porous synthetic resin body of Comparative Example 1 is 2.5 mm.
（比較例６） 比較例１の多孔性合成樹脂体の長さを3.0mmにした血沈
管につき、実施例３と同様な測定を行なう。(Comparative Example 6) The same measurement as in Example 3 is carried out on the blood sedimentation tube in which the length of the porous synthetic resin body of Comparative Example 1 is 3.0 mm.
以下に測定結果を表−２に示す。The measurement results are shown in Table 2 below.
表−２から実施例３、４、５に比較して比較例２、３、
４は血液が明らかに通過しており、血液が止まりにくい
ことを示し、これを揆水にすることにより血液が止まり
やすくなっている。また、このことは、実施例３、４、
５が浸水性でないから、血液中の水分によるゲル状化し
た高吸水性高分子が血液中に流れにくいことを示すもの
である。 From Table-2, Comparative Examples 2 and 3 are compared with Examples 3, 4 and 5.
4 clearly shows that the blood has passed, and it is difficult for the blood to stop, and by making it into water, the blood easily stops. In addition, this means that
Since 5 is not submerged, it shows that the superabsorbent polymer gelled by water in the blood does not easily flow into the blood.
以上詳述したように、本発明の血沈管によれば、不注意
で血沈管に若干量の水や血液がたれても、血沈管におけ
る合成樹脂管及び多孔性合成樹脂体がいずれも揆水性で
あるから、水や血液をはじき、水や血液が高吸水性高分
子に到達しにくく、高吸水性高分子は作用しない。ま
た、多孔性合成樹脂体は揆水性多孔体であるから、浸水
性のものに比して孔径が大きく且つ長手方向に短くして
も血液も止めることができ、吸引圧力が低くても血液を
吸引することができ、水や血液が高吸水性高分子に接触
した後、水や血液は直ちに封止される。更に浸水性でな
いから高吸水性高分子が血液側に流れにくい。As described above in detail, according to the blood sedimentation tube of the present invention, even if some amount of water or blood is inadvertently dropped into the blood sedimentation tube, both the synthetic resin tube and the porous synthetic resin body in the blood sedimentation tube are water repellent. Therefore, it repels water and blood, water and blood hardly reach the superabsorbent polymer, and the superabsorbent polymer does not act. In addition, since the porous synthetic resin body is a water repellent porous body, it can stop blood even if it has a large pore size and is shortened in the longitudinal direction as compared with a water-immersed one, and blood is retained even if the suction pressure is low. It can be aspirated and water or blood is immediately sealed after contact with the superabsorbent polymer. Furthermore, since it is not submerged, the super absorbent polymer does not easily flow to the blood side.
従って、血沈管に不注意で水、血液等の液体をたらして
も、多量でなければ血沈管をそのまま使用することがで
きるから、取扱いが容易である。また、孔径の大きい揆
水性多孔体を用いることができるから、吸引圧力が低く
ても血液を吸引することができ、且つゲル状態の高吸収
性高分子も血液中に流れにくく赤血球の沈降状態に影響
を及ぼさない等の効果がある。Therefore, even if a liquid such as water or blood is inadvertently poured into the blood sedimentation tube, the blood sedimentation tube can be used as it is if it is not large in volume, so that it is easy to handle. In addition, since a water repellent porous body having a large pore size can be used, blood can be sucked even when the suction pressure is low, and a gel-state superabsorbent polymer hardly flows into the blood, causing erythrocyte sedimentation. It has the effect of not affecting.
また、多孔性合成樹脂体が着色されていると、上述の効
果に加えて目盛の基点が一見してわかるから、血沈管の
取扱いが一層容易になる。Further, when the porous synthetic resin body is colored, in addition to the above-mentioned effects, since the base point of the scale can be seen at a glance, it becomes easier to handle the blood sedimentation tube.
更に、流体流入口側から目盛を付け、この目盛の基点と
なる位置に多孔性合成樹脂体の一端面が位置するように
したので、開口側から吸引すれば血液等の液体は目盛の
基点まで直ちに流入し、多孔性合成樹脂体によりそれ以
上流入しない。従って、目盛の基点まで血液等の液体を
入れるのに調節する必要がないから、血沈検査の基準作
業が容易である。Furthermore, since a scale is attached from the fluid inlet side and one end surface of the porous synthetic resin body is positioned at the position that is the base point of this scale, liquid such as blood will reach the base point of the scale by suction from the opening side. Immediate inflow and no further inflow due to the porous synthetic resin body. Therefore, it is not necessary to make adjustments to fill a liquid such as blood up to the base point of the scale, and the reference work of the blood sedimentation test is easy.
そして、揆水多孔性合成樹脂体は、熱可塑性樹脂の粉粒
体を半融成形して多孔体として、該多孔体を所定形状に
形成してシリコン油に浸漬し、温度60℃、10〜20分間乾
燥させて、この多孔体に高吸水性高分子を含有させれば
良いから、樹脂自体に揆水性がなくても、容易に揆水多
孔性合成樹脂体を作ることが可能である。Then, the water-refined porous synthetic resin body is a porous body obtained by semi-melt molding the thermoplastic resin powder, and the porous body is formed into a predetermined shape and immersed in silicon oil, and the temperature is 60 ° C., 10 to 10. Since it suffices that the superabsorbent polymer is contained in this porous body by drying for 20 minutes, it is possible to easily prepare a water-repellent porous synthetic resin body even if the resin itself has no water repellent property.
図面は本発明の実施例を示し、第１図は血沈管の斜視
図、第２図、第３図は実験例を示す模式図である。 １……血沈管、２……合成樹脂管 ３……液体流入口、４……テーパ状開口（一方の開口） ５……多孔性合成樹脂体、5a……一端面The drawings show an embodiment of the present invention, FIG. 1 is a perspective view of a blood tube, and FIGS. 2 and 3 are schematic views showing experimental examples. 1 ... Blood sedimentation tube, 2 ... Synthetic resin tube 3 ... Liquid inlet, 4 ... Tapered opening (one opening) 5 ... Porous synthetic resin body, 5a ... One end surface
Claims (4)
合成樹脂管のいずれか一方の開口から所定位置に、気体
は通過するが液体は通過させない特性を有する多孔性合
成樹脂体を挿着し、いずれか他方の開口を液体流入口と
する血沈管において、前記合成樹脂管を揆水性とし、か
つ前記多孔性合成樹脂体を揆水性多孔体にて構成すると
共に該揆水性多孔体内にこれの総重量に対してキセロゲ
ル状の高吸水性高分子を0.5〜10.0重量％含有させてな
ることを特徴とする血沈管。1. A porous synthetic resin body having a property of passing a gas but not a liquid at a predetermined position from one of openings of a synthetic resin tube having a uniform inner diameter and having both ends opened. In a blood sedimentation tube that is inserted and attached and has one of the other openings as a liquid inlet, the synthetic resin tube is made water repellent, and the porous synthetic resin body is made of a water repellent porous body, and the water repellent porous body is also formed. And a blood-absorbing polymer in the form of a xerogel-like superabsorbent polymer in an amount of 0.5 to 10.0% by weight based on the total weight of the blood.
（１）記載の血沈管。2. The blood sedimentation tube according to claim 1, wherein the porous synthetic resin body is colored.
け、多孔性合成樹脂体の一端面が前記目盛の基点となる
ように、前記合成樹脂管内に前記多孔性合成樹脂体を挿
着する請求項（１）又は（２）記載の血沈管。3. A scale is attached to the synthetic resin pipe from the liquid inlet side, and the porous synthetic resin body is inserted into the synthetic resin pipe so that one end face of the porous synthetic resin body becomes the base point of the scale. The blood-condensing tube according to claim 1 or 2.
体とし、該多孔体を所定形状に形成してシリコン油に浸
漬し、温度60℃、10〜20分間乾燥させてなることを特徴
とする揆水多孔性合成樹脂体の製造方法。4. A thermoplastic resin powder granule is semi-melted into a porous body, the porous body is formed into a predetermined shape, immersed in silicone oil, and dried at a temperature of 60 ° C. for 10 to 20 minutes. A method for producing a water-refined porous synthetic resin body, comprising:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1284230A JPH0782012B2 (en) | 1989-10-31 | 1989-10-31 | Blood-sink tube and method for producing water-filled porous synthetic resin body used therein |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1284230A JPH0782012B2 (en) | 1989-10-31 | 1989-10-31 | Blood-sink tube and method for producing water-filled porous synthetic resin body used therein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03144365A JPH03144365A (en) | 1991-06-19 |
| JPH0782012B2 true JPH0782012B2 (en) | 1995-09-06 |
Family
ID=17675859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1284230A Expired - Fee Related JPH0782012B2 (en) | 1989-10-31 | 1989-10-31 | Blood-sink tube and method for producing water-filled porous synthetic resin body used therein |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0782012B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08145990A (en) * | 1994-11-24 | 1996-06-07 | Shigeru Obata | Precipitation tube |
| JPH08254531A (en) * | 1995-03-16 | 1996-10-01 | Shigeru Obata | Blood sedimentation tube |
| JP2003171496A (en) * | 2001-12-04 | 2003-06-20 | Naisemu:Kk | Hybrid resin material and method for producing the same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0533966Y2 (en) * | 1987-09-25 | 1993-08-27 |
-
1989
- 1989-10-31 JP JP1284230A patent/JPH0782012B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03144365A (en) | 1991-06-19 |
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