JP2579788Y2 - Blood sediment measurement instrument - Google Patents

Description

[Detailed description of the invention]

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a blood sedimentation measuring instrument for measuring a blood cell sedimentation velocity.

[0002]

2. Description of the Related Art In the past, in hospitals and inspection institutions, the measurement of erythrocyte sedimentation velocity (blood sedimentation) has been performed for diagnosis of various disease states. In this blood sedimentation measurement, for example, a predetermined amount of blood mixed with an anticoagulant at a predetermined amount is sucked into a transparent elongated straight tube with a scale called a sedimentation tube, and the blood sediment tube is held vertically. Done in

[0003] By the way, the suction of blood into the blood sedimentation tube is conventionally performed as follows. That is, using a blood collection needle having sharp blades at both ends, blood is collected and mixed into a reduced-pressure blood collection tube (vacuum blood collection tube) containing an anticoagulant, and thereafter, a rubber stopper sealing the opening of the reduced-pressure blood collection tube. Or remove the sealing member such as a film and open it, then insert the lower end of the blood collection tube from the opening of the vacuum blood collection tube to reach near the bottom of the blood collection tube, and from the upper end side of the blood collection tube, the tip of the mouth or syringe. The blood is introduced into the sedimentation tube by the negative pressure of the adapter (JP-A-63-252249).

In this case, the blood collection tube is opened in order to insert the blood collection tube into the blood collection tube. However, when the blood collection tube is opened, blood is scattered and the operator is infected, and the outer wall of the blood collection tube is exposed to the blood. There is a problem of getting wet and contaminating the surroundings. In addition, when sucking by mouth, blood may accidentally enter the mouth and become infected.

[0005] Furthermore, since outside air enters the reduced-pressure blood collection tube by opening, there is a problem that the collected blood is contaminated. In addition, during the blood sedimentation measurement and the processing after the measurement, since the reduced-pressure blood collection tube is in an opened state, when the reduced-pressure blood collection tube is collapsed, blood may spill out and may come into contact with the blood vessel and become infected.

[0006]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a blood sedimentation measuring instrument capable of performing measurement without opening a reduced-pressure blood collection tube and preventing blood contamination and infection.

[0007]

This and other objects are achieved by the present invention described in (1) below.

(1) The inner diameter is 2.55 ± 0.15 mm, the length is 200 to 350 mm, and at least one end has flexibility, and the measuring section at the other end is substantially capable of confirming the inside. A blood sedimentation measuring instrument comprising: a transparent tube; and a needle tube attached to one end of the tube and penetrating a member for sealing an opening of a blood collection tube.

[0009]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of a blood sedimentation measuring instrument according to the present invention.

FIG. 1 is a front view showing a first configuration example of the blood sedimentation measuring instrument of the present invention. As shown in the figure, the blood sedimentation measuring instrument 1A includes an elongated tube 2, a needle tube 3 attached to the lower end of the tube 2 in the figure, and a connector 4 attached to the upper end of the tube 2 in the figure. It is configured.

The tube 2 has a measuring section 21 as shown in FIG. 1, and the measuring section 21 is substantially in such a position that the liquid level of blood in the pipe and the upper end position of sedimented red blood cells can be confirmed. It is transparent.

A scale 23 is provided on the outer peripheral surface of the measuring section 21 along the longitudinal direction of the tube 2. Note that the tube 2 may not be directly provided with the graduations 23, but may be fixed to a graduated plate-like body (not shown).

Such a tubular body 2 is made of a material having flexibility over substantially the entire length thereof (hereinafter, referred to as a flexible material), and a case where the upper part of the measuring section 21 is made of a hard material. The lower needle tube side portion 22 may be made of a flexible material. Hereinafter, the features of each case will be described.

When the upper portion of the measuring section 21 of the tube 2 is made of a hard material and the needle tube side portion 22 is made of a flexible material, the state shown in FIG. When the is introduced into the tube 2, the needle tube side portion 22 is curved as shown in FIG. As a result, as described above,
Blood can be introduced into the tubular body 2 while the upper part of the measuring unit 21 is kept substantially vertical, the operation is easy, and the degree of freedom of the installation angle of the decompression blood collection tube 10 is increased, and the decompression blood collection is performed. Even when the blood collection volume in the blood vessel 10 is small,
Blood can be more reliably introduced.

The hard material and the flexible material are joined by a method of inserting one into the other, a method of bonding both materials with an adhesive (solvent), and a method of fusing both materials (for example, heat fusion, high frequency (Fusion, ultrasonic fusion), a method of integrally molding both materials by two-color molding, and the like.

When the tube 2 is made of a flexible material over substantially the entire length, there is an advantage that the manufacturing cost is low because it can be made of one kind of material. Examples of the hard material used for the tube body 2 include various kinds of glass, hard polyvinyl chloride, polyethylene, polypropylene, polystyrene, polycarbonate, acrylic resin such as polymethyl methacrylate (PMMA), and polyethylene terephthalate (PET). Hard resin is mentioned.

The flexible material used for the tube 2 includes
For example, various soft resins such as soft polyvinyl chloride, low-density polyethylene, polyamide, ethylene-vinyl acetate copolymer, and 1,2-polybutadiene, and various elastomers such as polyurethane and silicone rubber are exemplified.

The total length of the tube 2 is about 200 to 350 mm, and preferably about 200 to 300 mm. The inner diameter of the tube 2 is 2.55 ± 0.15 mm, and the outer diameter of the tube 2 is about 3 to 6 mm, particularly 3.5 to 4.5 mm.
It is preferable to set the degree.

FIG. 3 is a longitudinal sectional view showing a configuration example of the needle tube 3. As shown in the figure, the needle tube 3 includes a needle tube base 31 and a puncture portion 34. The needle tube base 31 includes the outer tube 3
2 and an inner tube 33, and an outer tube 32 and an inner tube 3
3, the lower end of the tube 2 is fitted, and the tube 2 and the needle tube 3 are connected. A sharp needle tip 35 is formed at the distal end of the puncture portion 34, and a side hole 36 communicating with the lumen 37 of the needle tube 3 is formed at a side of the needle tip 35.

As shown in FIG. 2, the decompressed blood collection tube 10 is composed of a transparent tubular blood collection tube main body 11 having a bottom and a cylindrical shape.
When the blood (including an anticoagulant) collected in the reduced-pressure blood collection tube 10 is introduced and filled into the tubular body 2, , Sealing member 1
The puncture part 34 of the needle tube 3 is pierced into 2 to position the needle tip 35 inside the reduced-pressure blood collection tube 10. In this state, when the plunger 82 of the syringe 8 described later is operated and sucked, the blood in the reduced-pressure blood collection tube 10 is removed from the side hole 36 and the lumen 37 of the needle tube 3.
Is introduced into the tube 2. The sealing member 12
Is not limited to a film-like film as shown, but may be a rubber stopper.

The length of the puncture portion 34 is about 3 to 30 mm, particularly about 5 to 20 mm, in consideration of the position of the needle tip 35 in the reduced-pressure blood collection tube 10 when the puncture portion 34 is pierced. Is preferred.

The constituent material of the needle tube 3 is hard polyvinyl chloride, polyethylene, polypropylene, polystyrene, polycarbonate, polymethyl methacrylate (P
Acrylic resins such as MMA), polyesters such as polyethylene terephthalate and polybutylene terephthalate, various hard resins such as butadiene-styrene copolymer, acrylonitrile-butadiene-styrene copolymer, and metals such as stainless steel, titanium and aluminum; Ceramics such as alumina may be mentioned, but are preferably made of resin from the viewpoint of disposal and the like.

The structure of the connecting portion between the lower end of the tube 2 and the needle tube 3 is not limited to the one shown in the figure. For example, a structure in which the lower end of the tube 2 and the needle tube base 31 are screwed together, or a tube The lower end of the body 2 and the needle tube base 31 may be bonded or fused together, or the tube 2 and the needle tube 3 may be integrally formed. Although not shown, a cap for enclosing the puncture unit 34 may be provided to prevent contamination and danger of the puncture unit 34 when not in use.

The connector 4 mounted on the upper end of the tube 2
This is for connecting a syringe 8, which is a suction device for sucking blood in the reduced-pressure blood collection tube 10 and introducing it into the tube 2, directly or indirectly via a member such as a stopcock 5 described later. In this case, the connection surface of the connector 4 may be formed with a taper in order to easily and surely connect with the second port 52 of the cock 5 and the distal end projection 81 of the syringe 8.

The structure of the connecting portion between the upper end of the tube 2 and the connector 4 may be any structure as long as the insides thereof can communicate with each other. For example, the structure of the tube 2 as shown in FIG. The same structure as the joint portion with the needle tube 3, the structure in which the upper end of the tube 2 fits inside the connector 4, the structure in which the connector 4 and the upper end of the tube 2 are screwed, the connector 4 and the tube A structure in which the upper end of the tube 2 is bonded or fused, or a structure in which the tube 2 and the connector 4 are integrally molded are possible.

In the illustrated example, a three-way cock (two-way stopcock) is provided between the connector 4 and the syringe 8 as means for opening and closing the internal flow path to the tube 2 as required (hereinafter referred to as flow path opening / closing means). A stopcock 5 such as a stopcock is also provided. The stopcock (three-way stopcock) 5 has a first port 51, a two-port
2, a third port 53 and a lever 54, and the three ports 51, 5
Any two of 2, 53 can be communicated.

The connection end 41 of the connector 4 on the upper end side in FIG.
Has a taper (Luer taper) formed therein, and is airtightly fitted to the second port 52 of the cock 5. A similar taper is formed inside the first port 51 of the stopcock 5, and the distal end protruding portion 81 of the syringe 8 is airtightly fitted therein.

Further, the third port 53 of the cock 5 is opened to the outside air so that intake and exhaust can be performed.
Instead of the stopcock 5 as the channel opening / closing means,
The blood collection aid for blood sedimentation rods described in JP-A-148869 can also be used.

The channel opening / closing means typified by the stopcock 5 is not necessarily required to be installed, and the tip projecting portion 81 of the syringe 8 may be directly connected (fitted) to the connection end 41 of the connector 4. . Further, the channel opening / closing means may be installed at another position, for example, between the connector 4 and the measuring section 21 of the tube 2 or between the needle tube side portion 22 of the measuring section 21 and the needle tube 3.

Further, the suction device is not limited to the syringe 8, and for example, various pumps such as a vacuum pump and a bellows pump,
It may be a pipettor. In the present invention, the needle tube 3 is preferably detachable from the tube 2. One of the reasons is that the type of the needle tube, the length of the puncture portion 34, and the like are more appropriate according to various conditions such as the type of the sealing member 12 of the reduced-pressure blood collection tube 10 and the amount of blood collected in the reduced-pressure blood collection tube 10. It is possible to select and mount a suitable needle tube.

Next, the operation (use method) of the blood sedimentation measuring instrument 1A of the present invention will be described with reference to FIG. First, the sealing member 12 side of the reduced-pressure blood collection tube 10 is directed downward or obliquely downward, and the puncture portion 34 of the needle tube 3 is pierced into the sealing member 12 so that the needle tip 3
5 is positioned inside the vacuum blood collection tube 10. The needle tube side portion 22 of the measurement unit 21 is made of a flexible material, and the puncture unit 34 is punctured by appropriately bending the needle tube side portion 22.
This makes it possible to easily perform the puncturing operation and the subsequent operations, and also to reliably remove blood by aspiration. In particular, even when the blood collection blood volume in the reduced-pressure blood collection tube 10 is small, the angle of the reduced-pressure blood collection tube 10 can be made substantially vertical, so that blood can be easily and reliably taken out.

Next, the distal end protruding portion 81 of the syringe 8 is fitted into the first port 51 of the stopcock 5 (it may be fitted in advance), and the lever 54 is operated to operate the first port 51 and the second port 51. 52, and the plunger 82 of the syringe 8 is pulled upward in FIG. Thereby, a negative pressure is generated in the tube 2, and the blood in the reduced-pressure blood collection tube 10 is introduced into the tube 2 through the side hole 36 and the lumen 37 of the needle tube 3.

When the blood is introduced to the vicinity of the upper part of the measuring section 21 of the tube 2, the needle tube 3 is withdrawn, and then the measuring section 21
While maintaining the needle tube 3 vertically, the plunger 82 is operated to adjust the blood level of the blood in the tube body 2 to zero. Next, the lever 54 is operated so that the first port 51 and the second port 52 do not communicate with each other, that is, the internal flow path between the syringe 8 and the tube 2 is sealed, and the blood in the tube 2 is Is fixed at the position of 0 scale. Thereafter, the syringe 8 is removed from the stopcock 5 as necessary.

It should be noted that there is no channel opening / closing means such as the stopcock 5, etc.
The distal end projection 81 of the syringe 8 is connected to the connection end 4 of the connector 4.
In the case where the plunger 82 is directly connected to the tube 1, the position of the plunger 82 is fixed while the syringe 8 is connected, so that the level of the blood in the tube 2 is fixed.

After a certain period of time with the blood sedimentation measuring instrument 1A standing still, the length (fluid volume) of the supernatant plasma portion is read by the scale 23, and the blood cell sedimentation speed is measured. Although the configuration example of the blood sedimentation measuring device has been described above, the blood sedimentation measuring device of the present invention is not limited to the illustrated one. In particular, the configuration between the connector 4 and the syringe 8 is not limited to the illustrated one, and for example, a connecting member such as a flexible tube may be interposed.

Further, the connector 4 may be omitted, and the stopcock 5 may be directly connected to the upper end of the tubular body 2, or neither the connector 4 nor the stopcock 5 may be provided. In the latter case, if the upper end of the tube 2 has flexibility, the distal end protruding portion 81 of the syringe 8 can be directly connected.

Next, a second configuration example of the present invention will be described in detail. The same parts as those in the first configuration example are denoted by the same reference numerals, and description thereof will be omitted. FIG. 4 is a front view showing a second configuration example of the blood sedimentation measuring instrument of the present invention. As shown in the figure, the blood sedimentation measuring instrument 1B does not have a connector for connecting a suction instrument and a stopcock as a flow path opening / closing means, and the upper end of the tube 2 in the drawing is an opening 6. In place of the connector and the stopcock, a stopper 9 having air permeability and exhibiting liquid tightness and airtightness when it comes into contact with blood is provided at a position of 0 scale in the tube 2.
This is different from the blood sedimentation measuring instrument 1A of the configuration example.

The stopper 9 is provided such that its central portion coincides with the position of the 0 scale of the tube 2. The stopper 9 is formed so as to have an outer diameter slightly larger than the inner diameter of the tube 2 so as not to move from the above position due to suction by a syringe or the like, and is pressed into the tube 2 through the opening 6. Note that the stopper 9 may be fixed in the tube 2 by bonding or the like.

As the stopper 9, a stopper that has air permeability until it comes into contact with blood and has liquid tightness and air tightness after it comes into contact with blood is used. Such a material includes, for example, a porous sintered body containing a water-swellable polymer material. As the porous sintered body, various known materials can be used, but a sintered body of a thermoplastic polymer such as polypropylene, polyethylene, or polyacrylonitrile is preferable in that the molding process can be easily performed. . Also, the stopper 9 may have a communication vent, and may be any as long as it allows air to communicate. And, in a state containing the water-swellable polymer material in a dry state,
Generally, the porosity is 15-60%, preferably 20-40.
%. The pore size is preferably 1 to 20 μm, more preferably about 5 to 10 μm. On the other hand, the degree of swelling of the water-swellable polymer material contained in the stopper 9 should be such that it swells 100 to 1000 times its own weight within 10 minutes upon contact with water at room temperature or about body temperature. Is preferred.

As such a water-swellable polymer material,
Various things known as superabsorbent resin, corn starch, wheat starch, rice starch, potato starch,
High molecular compounds such as gelatin, agar, gum arabic, and the like that can absorb water and swell and seal the inside of the tube 2 can be used. However, in order not to affect the measurement of blood sedimentation rate, starch-acrylonitrile is used. , Starch-acrylic acid, starch-acrylamide, starch-grafted acrylates containing hydrolysates such as sodium acrylate, partially hydrolyzed polyvinyl alcohol, polyacrylic acid-based and acrylic-based heavyweights such as acrylic acid-vinyl alcohol Coalescence, furthermore, polyethylene oxide, cellulosic polymer and the like can be mentioned. Such a water-swellable polymer material is usually contained in a porous sintered body in a dry state in a granular form. In this case, the content of the water-swellable polymer material in the porous sintered body is 10 to 6
It is preferably 0% by weight, more preferably 10 to 40% by weight.

In order to incorporate the water-swellable polymer material into the porous sintered body, generally, it may be mixed with a constituent material of the sintered body and molded. For example, before molding, a water-swellable polymer material may be uniformly dispersed and mixed in the above-described thermoplastic resin, and the resulting mixture may be placed in a molding die and subjected to heating and pressurization or the like, followed by molding. The stopper 9 is not limited to a porous sintered body containing the water-swellable polymer material described above. The stopper 9 has air permeability until it comes into contact with blood, and after coming into contact with blood, Various liquid-tight and air-tight materials can be used.

The length of the stopper 9 with respect to the longitudinal direction of the tube 2 varies depending on the material of the stopper 9, but in order to sufficiently exhibit the above liquid tightness and air tightness, the length is 2 mm to 2 mm.
It is preferably about 5 mm.

Next, the operation (usage method) of the blood sedimentation measuring instrument 1B according to the second embodiment of the present invention will be described with reference to FIG.
The description of the same parts as those of the blood sedimentation measuring instrument 1A is omitted. First, the puncture part 34 of the needle tube 3 is pierced into the sealing member 12 of the reduced-pressure blood collection tube 10. Subsequently, the syringe 8 having the connector 13 for blood sedimentation measuring instrument, the connecting tube 14 and the connector 15 for the syringe is airtightly connected to the tube 2 via the connector 13, and the needle tube side portion 22 of the measuring section 21 is bent. With the sealing member 12 side of the reduced-pressure blood collection tube 10 positioned downward or obliquely downward, the plunger 82 is operated to introduce the blood in the reduced-pressure blood collection tube 10 into the tube 2. At this time, since the stopper 9 is press-fitted into the tube 2, the stopper 9 does not move in the tube 2 due to suction by the syringe 8.

In the present configuration example, the connector 13 for a blood sedimentation measuring instrument has a cylindrical portion (not shown) having a taper (not shown) whose outer diameter decreases toward the distal end for connection with the opening 6 of the tube 2. By inserting the distal end of the tubular portion into the opening 6, the tubular portion is fitted airtightly to the tubular body 2. The connection tube 14 is provided to facilitate connection between the tube 2 and the connector 13 for blood sedimentation measurement instruments. The connecting tube 14 is made of a flexible material.
One end is connected to the syringe connector 15 connected to the distal end protruding portion 81 of the syringe 8, and the other end is connected to the blood sedimentation measuring instrument connector 1.
3 are hermetically connected.

The syringe connector 15 has a taper (Luer taper) (not shown) formed at one end thereof, and is configured so that the distal end protruding portion 81 of the syringe 8 is fitted in an airtight manner. The connection between the syringe connector 15 and the syringe 8 is not limited to this, and may be airtightly connected by, for example, screwing. Alternatively, the connecting tube 14 may be directly connected to the distal end projection 81 without providing the syringe connector 15.
Furthermore, the connecting tube 1 of the connector 13 for blood sedimentation measuring instrument
4 and the connector for syringe 1
The structure on the side connected to the connecting tube 14 may be any structure as long as it can be air-tightly connected to the tube 2 and the connecting tube 14. For example, the structure of the tube 2 and the needle tube 3 as shown in FIG. What is necessary is just to make it the structure similar to a joining part.

When the blood introduced into the tube 2 reaches the stopper 9 at the 0-scale position, the water-swellable polymer material contained in the porous sintered body instantly absorbs the water in the blood. Since the stopper 9 swells, the stopper 9 exhibits airtightness and liquid tightness to be in a sealed state, and blood stops at the position of the stopper 9. Thereafter, if necessary, the blood sedimentation measuring instrument connector 13 of the syringe 8 is detached from the tube 2, the blood sedimentation measuring instrument 1B is allowed to stand in a vertical state, and the blood cell sedimentation velocity is measured. At this time, it is preferable that the needle tube 3 be held while puncturing the reduced-pressure blood collection tube 10 in order to prevent infection or the like due to blood adhering to the needle tube 3.

As described above, according to the blood sedimentation measuring instrument of the present configuration example, blood can be easily and instantaneously introduced to the zero scale by sucking the blood until it reaches the stopper, and the blood level can be reduced. There is no need to perform a complicated operation of adjusting to zero scale, and the operation of blood sediment measurement becomes easy. Also, since there is no need to provide a member such as a multi-way cock, it is only necessary to insert and fix the porous sintered body or the like into the tube,
Manufacturing becomes easier.

The structure of the part relating to the connection between the blood sedimentation measuring instrument 1B and the syringe 8 is not limited to the one shown in the figure. The connector 13 for the blood sedimentation measuring instrument or the connector having neither the connector 13 nor the connecting tube 14 may be used.
In the latter case, if the upper end of the tube 2 has flexibility,
The distal end projection 81 of the syringe 8 can be directly connected. Further, the connector 13 may be attached to the opening 6.

As described above, the blood sedimentation measuring instrument of the present invention has been described with reference to the second configuration example shown in the attached drawings, but the present invention is not limited to these. In particular, the stopper 9 is not limited to the above-described configuration. For example, the stopper 9 does not contain the water-swellable polymer material and the like, and is made of a material that allows gas to pass therethrough but has liquid tightness. The blood may be stopped so that it does not reach above the position, a predetermined amount of suction is performed, and after the blood reaches the position, the plunger of the syringe is fixed. As such a stopper, a known stopper such as a porous body having pores that allow gas to pass but not blood can be used.

[0050]

As described above, according to the blood sedimentation measuring instrument of the present invention, a series of operations from blood suction to measurement can be performed without opening the decompressed blood collection tube. Blood contamination and blood leakage can be prevented.

Further, the blood sedimentation measuring instrument of the present invention can easily perform operations such as blood suction, and can reliably perform blood suction.

[Brief description of the drawings]

FIG. 1 is a front view showing a first configuration example of a blood sedimentation measuring instrument of the present invention.

FIG. 2 is a front view of the first embodiment of the blood sedimentation measuring device according to the present invention in a used state.

FIG. 3 is a longitudinal sectional view showing a configuration example of a needle tube according to the present invention.

FIG. 4 is a front view showing a second configuration example of the blood sedimentation measuring instrument of the present invention.

FIG. 5 is a front view of the second embodiment of the blood sedimentation measuring device according to the present invention in a used state.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Blood sedimentation measuring instrument 2 Tube 21 Measurement part 22 Needle tube side part 23 Scale 3 Needle tube 31 Needle tube base 32 Outer tube 33 Inner tube 34 Puncturing part 35 Needle tip 36 Side hole 37 Inner cavity 4 Connector 41 Connection end 5 Stopcock 51 First Port 52 Second port 53 Third port 54 Lever 54 Lever 6 Opening 8 Syringe 81 Tip protruding part 82 Plunger 9 Stopper 10 Decompression blood collection tube 11 Blood collection tube body 12 Sealing member 13 Connector for blood sedimentation measurement instrument 14 Connecting tube 15 Syringe connector

Claims (1)

(57) [Scope of request for utility model registration] 1. An inner diameter of 2.55 ± 0.15 mm and a length of 200 to
A tube having a length of 350 mm, at least one end having flexibility, and a measuring part at the other end being substantially transparent so that the inside thereof can be checked; A needle tube that can penetrate the member that seals the opening
Ri, blood sedimentation measuring instrument, characterized in Rukoto suction apparatus is connected to the other end.