JPH0776222B2 - 6’−アルキルスペクチノマイシン用中間体の製法 - Google Patents
6’−アルキルスペクチノマイシン用中間体の製法Info
- Publication number
- JPH0776222B2 JPH0776222B2 JP5051986A JP5198693A JPH0776222B2 JP H0776222 B2 JPH0776222 B2 JP H0776222B2 JP 5051986 A JP5051986 A JP 5051986A JP 5198693 A JP5198693 A JP 5198693A JP H0776222 B2 JPH0776222 B2 JP H0776222B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- dicarbobenzyloxy
- formula
- spectinomycin
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35972382A | 1982-03-19 | 1982-03-19 | |
US359723 | 1982-12-13 | ||
US06/449,304 US4532336A (en) | 1982-03-19 | 1982-12-13 | 6'-Alkylspectinomycins |
US449304 | 1995-05-24 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP58045274A Division JPH0720967B2 (ja) | 1982-03-19 | 1983-03-17 | スペクチノマイシンの6′−アルキル類似体およびその製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0649072A JPH0649072A (ja) | 1994-02-22 |
JPH0776222B2 true JPH0776222B2 (ja) | 1995-08-16 |
Family
ID=27000602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5051986A Expired - Lifetime JPH0776222B2 (ja) | 1982-03-19 | 1993-03-12 | 6’−アルキルスペクチノマイシン用中間体の製法 |
Country Status (10)
Country | Link |
---|---|
US (1) | US4532336A (it) |
JP (1) | JPH0776222B2 (it) |
BE (1) | BE896215A (it) |
DE (1) | DE3308196A1 (it) |
FR (1) | FR2523583B1 (it) |
GB (1) | GB2117757B (it) |
HK (1) | HK61788A (it) |
IT (1) | IT1164157B (it) |
MX (1) | MX9203211A (it) |
NL (1) | NL8300893A (it) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4532336A (en) * | 1982-03-19 | 1985-07-30 | The Upjohn Company | 6'-Alkylspectinomycins |
US4578485A (en) * | 1984-02-08 | 1986-03-25 | The Upjohn Company | Synthesis of spectinomycin analogs by an improved Grignard process |
JPH07554B2 (ja) * | 1985-03-29 | 1995-01-11 | ジ・アップジョン・カンパニ− | スペクチノマイシン同族体を用いるクラミジア感染の治療 |
US4730059A (en) * | 1986-03-10 | 1988-03-08 | The Upjohn Company | 6'-thiomethylsubstituted spectinomycins |
AU6505590A (en) * | 1989-09-13 | 1991-04-18 | Upjohn Company, The | Gamma alkylation of a protected derivative of the enone of spectinomycin |
US5048126A (en) * | 1989-10-02 | 1991-09-17 | Mclaughlin James G | Protective apparel |
CN104725392B (zh) * | 2013-12-24 | 2017-01-11 | 中国农业大学 | 半抗原spe-ede及其相应的人工抗原与应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3234092A (en) * | 1959-10-20 | 1966-02-08 | Upjohn Co | Actinospectacin and process for producing same |
DE2756914A1 (de) * | 1977-12-21 | 1979-07-05 | Thomae Gmbh Dr K | 4-spectinomycylamin und seine physiologisch vertraegliche salze, verfahren zur herstellung und diese stoffe enthaltende arzneimittel |
US4351771A (en) * | 1979-03-13 | 1982-09-28 | The Upjohn Company | Spectinomycin analogs and methods for the preparation thereof |
GB2050348B (en) * | 1979-03-13 | 1983-08-03 | Upjohn Co | Spectinomycin analogues |
US4282152A (en) * | 1979-08-23 | 1981-08-04 | The Upjohn Company | Intermediates for preparing spectinomycin and analogs thereof |
BE887456R (fr) * | 1981-02-10 | 1981-08-10 | Upjohn Co | Procede de production de composes intermediaires pour l'obtention de la spectinomycine et de ses analogues et produits de ce procede |
US4420623A (en) * | 1981-07-20 | 1983-12-13 | The Upjohn Company | Process and intermediates for preparing 6'-methylspectinomycin and analogs thereof |
US4380651A (en) * | 1981-07-20 | 1983-04-19 | The Upjohn Company | Process for preparing 6'-methylspectinomycin and analogs thereof |
US4405797A (en) * | 1981-10-16 | 1983-09-20 | The Upjohn Company | Process for preparing spectinomycin analogs: N-demethylation of spectinomycin or its analogs and realkylation of the intermediates |
US4465848A (en) * | 1981-10-23 | 1984-08-14 | The Upjohn Company | Spectinomycin compounds |
US4532336A (en) * | 1982-03-19 | 1985-07-30 | The Upjohn Company | 6'-Alkylspectinomycins |
-
1982
- 1982-12-13 US US06/449,304 patent/US4532336A/en not_active Expired - Fee Related
-
1983
- 1983-02-14 GB GB08304026A patent/GB2117757B/en not_active Expired
- 1983-03-08 DE DE19833308196 patent/DE3308196A1/de active Granted
- 1983-03-11 NL NL8300893A patent/NL8300893A/nl not_active Application Discontinuation
- 1983-03-14 IT IT20066/83A patent/IT1164157B/it active
- 1983-03-18 BE BE0/210360A patent/BE896215A/fr not_active IP Right Cessation
- 1983-03-18 FR FR8304499A patent/FR2523583B1/fr not_active Expired
-
1988
- 1988-08-11 HK HK617/88A patent/HK61788A/xx not_active IP Right Cessation
-
1992
- 1992-06-24 MX MX9203211A patent/MX9203211A/es unknown
-
1993
- 1993-03-12 JP JP5051986A patent/JPH0776222B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FR2523583B1 (fr) | 1987-06-12 |
MX9203211A (es) | 1992-09-01 |
DE3308196C2 (it) | 1993-06-09 |
FR2523583A1 (fr) | 1983-09-23 |
IT8320066A0 (it) | 1983-03-14 |
GB8304026D0 (en) | 1983-03-16 |
GB2117757B (en) | 1985-08-29 |
GB2117757A (en) | 1983-10-19 |
NL8300893A (nl) | 1983-10-17 |
BE896215A (fr) | 1983-09-19 |
JPH0649072A (ja) | 1994-02-22 |
IT1164157B (it) | 1987-04-08 |
DE3308196A1 (de) | 1983-09-29 |
HK61788A (en) | 1988-08-19 |
US4532336A (en) | 1985-07-30 |
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