JPH0775526A - Calcium-containing composition excellent in absorbability, production of the same composition, healthy food containing the same composition and medicine containing the same composition - Google Patents
Calcium-containing composition excellent in absorbability, production of the same composition, healthy food containing the same composition and medicine containing the same compositionInfo
- Publication number
- JPH0775526A JPH0775526A JP6091694A JP9169494A JPH0775526A JP H0775526 A JPH0775526 A JP H0775526A JP 6091694 A JP6091694 A JP 6091694A JP 9169494 A JP9169494 A JP 9169494A JP H0775526 A JPH0775526 A JP H0775526A
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- Japan
- Prior art keywords
- calcium
- composition
- sea urchin
- same composition
- containing composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、ウニ殻から得られる経
口吸収性の良好なカルシウム含有組成物、該組成物の製
造方法、該組成物を含有する食品、該組成物を含有する
飼料、該組成物を含有する医薬組成物に関する。TECHNICAL FIELD The present invention relates to a calcium-containing composition having good oral absorbability obtained from sea urchin shells, a method for producing the composition, a food containing the composition, a feed containing the composition, It relates to a pharmaceutical composition containing the composition.
【０００２】[0002]
【従来の技術及び課題】従来から、カルシウムの摂取不
足を補うため、種々のカルシウム製剤やカルシウムを有
効成分とする健康食品が提案されている。これらに用い
られるカルシウムは、一般に、石灰石や石灰乳などの鉱
物起源の炭酸カルシウム、リン酸カルシウム、水酸化カ
ルシウム、乳酸カルシウム、グルコン酸カルシウム等、
カキ殻、貝類、サンゴ等由来の貝カルシウム、カニ、エ
ビなどの甲殻類、コンブ、ヒジキ、ワカメなどの藻類、
哺乳動物などの骨、あるいは卵の殻などを原料としたも
のである。2. Description of the Related Art Conventionally, various calcium preparations and health foods containing calcium as an active ingredient have been proposed in order to supplement insufficient intake of calcium. Calcium used for these is generally calcium carbonate of mineral origin such as limestone and lime milk, calcium phosphate, calcium hydroxide, calcium lactate, calcium gluconate, etc.,
Oyster shells, shellfish, shellfish calcium derived from corals, crustaceans such as crabs and shrimps, algae such as kelp, hijiki and wakame,
It is made from bones of mammals or eggshells.
【０００３】しかしながら、これらの原料を用いたカル
シウムは一般に吸収性が十分でない。しかも、カルシウ
ムは、ビタミンＤや蛋白質等と同時に摂取しないと、人
体への吸収率が極めて低く、それ単独での服用によって
は、人体における所要量のカルシウムを摂取することは
困難な状況にある。また、厚生省国民栄養調査によれ
ば、我国国民は平均して１日に５３１ｍｇしか摂取して
いない。この量は実に欧米諸国の半分以下のレベルであ
る。However, calcium using these raw materials generally has insufficient absorbability. Moreover, unless calcium is taken at the same time as vitamin D, protein, etc., the absorption rate into the human body is extremely low, and it is difficult to take the required amount of calcium in the human body by taking it alone. In addition, according to the Ministry of Health and Welfare National Nutrition Survey, Japanese citizens take on average 531 mg per day. This amount is actually less than half that of Western countries.
【０００４】かかる事情に鑑み、本発明者らは、吸収性
の良好なカルシウム含有組成物を得るべく鋭意研究を重
ねた結果、原料として従来全く試みられていなかった、
しかも、全く利用されずに単に廃棄処分されていたウニ
殻を用い、これを焼成することによって、意外にも経口
吸収性に優れたカルシウム含有組成物が得られることを
見い出し、本発明を完成するに至った。In view of such circumstances, the inventors of the present invention have conducted extensive studies to obtain a calcium-containing composition having good absorbability, and as a result, have never been tried as a raw material.
Moreover, it was discovered that a calcium-containing composition having excellent oral absorbability can be obtained unexpectedly by firing sea urchin shells that have simply been discarded without being used at all, thus completing the present invention. Came to.
【０００５】[0005]
【課題を解決するための手段】すなわち、本発明はウニ
殻より得られるカルシウム含有組成物を提供するもので
ある。また、本発明は該組成物の製造方法、該組成物を
含有する食品、該組成物を含有する飼料、該組成物を含
有する医薬組成物を提供するものである。That is, the present invention provides a calcium-containing composition obtained from sea urchin shells. The present invention also provides a method for producing the composition, a food containing the composition, a feed containing the composition, and a pharmaceutical composition containing the composition.
【０００６】本発明のカルシウムの原料とするウニの種
類は特に限定されるものではなく、例えば、バフンウ
ニ、ムラサキウニ、エゾバフンウニ、アカウニ等を挙げ
ることができる。The type of sea urchin used as the raw material for calcium of the present invention is not particularly limited, and examples thereof include bafun sea urchin, purple sea urchin, zoabafun sea urchin, and red sea urchin.
【０００７】本発明のカルシウム含有組成物を製造する
には、まず、ウニ殻の肉部分を取り除く。これは、例え
ば、ウニを分割し、卵巣または肉部分を取り除くことに
よって行うことができる。肉部分を取り除いた後、洗浄
する。洗浄は、通常水洗によって行うことができる。To produce the calcium-containing composition of the present invention, first, the meat portion of the sea urchin shell is removed. This can be done, for example, by splitting the sea urchin and removing the ovaries or meat parts. Wash after removing the meat. The washing can be usually performed by washing with water.
【０００８】次いで、高温で焼成する。焼成温度は、好
ましくは５００〜１５００℃とする。焼成時間は、好ま
しくは０．５〜１．５時間とする。焼成の例としては、
例えば、焼成炉を用いる場合、好ましくは約１０００℃
で約１時間、真空炉を用いる場合、好ましくは約８００
℃で約１時間焼成する。Then, it is fired at a high temperature. The firing temperature is preferably 500 to 1500 ° C. The firing time is preferably 0.5 to 1.5 hours. As an example of firing,
For example, when using a firing furnace, it is preferably about 1000 ° C.
When using a vacuum furnace for about 1 hour, preferably about 800
Bake at about 1 hour.
【０００９】かかる焼成により、ウニ殻に炭酸カルシウ
ムの形態で含まれていたカルシウムが酸化カルシウムの
形態に変換される。By such calcination, calcium contained in the sea urchin shell in the form of calcium carbonate is converted into the form of calcium oxide.
【００１０】焼成後、適宜、酸化カルシウムを炭酸カル
シウム、水酸化カルシウム、クエン酸カルシウム、アル
ギン酸カルシウム等の利用しやすい形態に変換すること
ができる。例えば、炭酸カルシウムへの変換は、酸化カ
ルシウムに炭酸ガスを与えることによって行われる。After firing, the calcium oxide can be appropriately converted into a readily available form such as calcium carbonate, calcium hydroxide, calcium citrate or calcium alginate. For example, conversion to calcium carbonate is performed by supplying carbon dioxide to calcium oxide.
【００１１】なお、本発明のウニ殻由来カルシウムは、
食用物質から得られるもので、毒性は問題とならない。The sea urchin shell-derived calcium of the present invention is
It is obtained from edible substances and toxicity is not a problem.
【００１２】次に、本発明のウニ殻を焼成して得られる
カルシウム含有組成物を含有してなる食品、飼料または
医薬組成物は、例えば、本発明のウニ殻を焼成して得ら
れるカルシウム含有組成物を、常法により、クエン酸、
その他の賦形剤などと共に配合し、錠剤または顆粒剤等
を製すること、あるいは溶解し、その他の調味剤等と共
に飲用水のような形態とすることができる。該カルシウ
ム含有組成物の配合量は適宜選択することができるが、
通常、食品等の全量に対して１０〜５０重量％程度であ
る。かくして、本発明のウニ殻由来カルシウムを配合し
た食品等を摂取させることによりカルシウムの良好な経
口吸収が得られる。Next, the food, feed or pharmaceutical composition containing the calcium-containing composition obtained by baking the sea urchin shell of the present invention includes, for example, the calcium-containing composition obtained by baking the sea urchin shell of the present invention. The composition, citric acid, by a conventional method,
It can be blended with other excipients to produce tablets or granules or the like, or can be dissolved and made into a form like drinking water together with other seasonings and the like. The blending amount of the calcium-containing composition can be appropriately selected,
Usually, it is about 10 to 50% by weight with respect to the total amount of food and the like. Thus, good oral absorption of calcium can be obtained by ingesting a food or the like containing the sea urchin shell-derived calcium of the present invention.
【００１３】[0013]
【実施例】次に、実施例を挙げて本発明をさらに具体的
に説明するが、本発明はこれに限定されるものではな
い。EXAMPLES Next, the present invention will be described more specifically by way of examples, but the present invention is not limited thereto.
【００１４】［実施例１］バフンウニ及びムラサキウニ
の肉部分をヘラで取り除いた後、水洗した。このウニ殻
を焼成炉にて１０００℃で１時間焼成した。かかる焼成
によりウニ殻に炭酸カルシウムの形態で含まれていたカ
ルシウムが酸化カルシウムの形態に変換される。焼成
後、所定量の水を与え、撹拌反応させて水酸化カルシウ
ムの形態とした。この成分分析値を表１に掲げる。[Example 1] After removing the meat portion of sea urchin and purple sea urchin with a spatula, it was washed with water. The sea urchin shell was baked in a baking furnace at 1000 ° C. for 1 hour. By such firing, the calcium contained in the sea urchin shell in the form of calcium carbonate is converted into the form of calcium oxide. After the calcination, a predetermined amount of water was added, and the mixture was stirred and reacted to form calcium hydroxide. The component analysis values are listed in Table 1.
【００１５】[0015]
【表１】 次に、本発明のウニ殻由来カルシウム含有組成物の特性
を、他の原料由来のカルシウム含有組成物と比較した。
比較した試料は、各原料を１０００℃で１時間焼成する
ことによって、各原料に炭酸カルシウム等の形態で含ま
れていたカルシウムを一度酸化カルシウムの形態とし、
更にこれらに炭酸ガスを与えて食餌として摂取可能な炭
酸カルシウムの形態に再度変換した上で比較した。結果
を表２に掲げる。[Table 1] Next, the characteristics of the sea urchin shell-derived calcium-containing composition of the present invention were compared with those of other raw material-derived calcium-containing compositions.
In the samples for comparison, by calcining each raw material at 1000 ° C. for 1 hour, the calcium contained in each raw material in the form of calcium carbonate or the like was once converted into the form of calcium oxide,
Furthermore, carbon dioxide was given to these to convert them again into a form of calcium carbonate that can be taken as a diet, and then compared. The results are listed in Table 2.
【００１６】[0016]
【表２】 表２から明らかなごとく、ウニ殻由来のカルシウム含有
組成物は外観・味が良好で、不純物も無く、さらには、
歩留りも良い。[Table 2] As is clear from Table 2, the sea urchin shell-derived calcium-containing composition has a good appearance and taste, is free of impurities, and
The yield is also good.
【００１７】次に、本発明のウニ殻由来カルシウム含有
組成物を他の原料由来の他の形態のカルシウム含有物と
吸収性の比較を行った。Next, the sea urchin shell-derived calcium-containing composition of the present invention was compared with other forms of calcium-containing substances derived from other raw materials for absorption comparison.
【００１８】比較試料としては、医薬品として使用され
る（６局）収載の炭酸カルシウム９８．５％以上の沈降
炭酸カルシウム、乳酸カルシウム（第１２改訂）、塩化
カルシウム（第１２改訂）を用いた。As comparative samples, precipitated calcium carbonate containing 98.5% or more of calcium carbonate, calcium lactate (12th revision) and calcium chloride (12th revision), which are used as pharmaceuticals (6 stations), were used.
【００１９】吸収性については、ラットの腸管を使用し
てテストした。The absorbability was tested using the rat intestine.
【００２０】すなわち、ラット５匹を１グループとし、
麻酔した後、開腸し、小腸を結紮して腸大静脈を事前に
採血した後、２％沈降炭酸カルシウム、２％乳酸カルシ
ウム、２％塩化カルシウム、本発明の２％ウニ殻由来カ
ルシウムの、各々、ｐＨ２．０水溶液５ｍｌを腸内に注
入した。注入後、１０分間隔で、腸大静脈から採血し、
血清分離後総カルシウムイオン濃度を測定した。That is, one group consisting of 5 rats,
After anesthesia, the intestine was opened, the small intestine was ligated, and the intestinal vena cava was collected in advance. 5 ml of a pH 2.0 aqueous solution was injected into each intestine. Blood is collected from the intestinal vena cava at 10-minute intervals after injection,
After separation of serum, total calcium ion concentration was measured.
【００２１】本発明２％ウニ殻由来カルシウム含有組成
物のｐＨ２．０水溶液５ｍｌを腸に注入すると、１０分
後には上昇を始め、３０分後には著しい増加が認められ
た。驚くべきことに、最も多用されている沈降炭酸カル
シウムの８．５倍、塩化カルシウムの４倍、乳酸カルシ
ウムの３倍というイオン濃度が血液中から測定された。When 5 ml of a pH 2.0 aqueous solution of the 2% sea urchin shell-derived calcium-containing composition of the present invention was injected into the intestine, an increase started after 10 minutes and a remarkable increase after 30 minutes. Surprisingly, the ion concentrations of 8.5 times that of the most frequently used precipitated calcium carbonate, 4 times that of calcium chloride and 3 times that of calcium lactate were measured in blood.
【００２２】［実施例２］本発明のウニ殻由来カルシウ
ム含有組成物を、副甲状腺摘出ラットに投与し、ウニ殻
由来カルシウム含有組成物の経口吸収性を、他の形態の
カルシウム含有物と比較した。なお、以下の「ウニ殻由
来カルシウム含有組成物」「カキ殻由来カルシウム含有
組成物」は実施例１のものと同一である。複数のラット
に副甲状腺摘出手術を行い、その後１５６時間にわたっ
て該ラットに低カルシウム食（通常のラット用の食餌に
カルシウムが０．１％しか含まれていないもの）を与え
て血中カルシウム濃度を低下させた。健康状態が正常で
あり、かつ十分血中カルシウム濃度が低下しているラッ
トを２４頭（雌雄同数）選別し、１群６頭ずつ（各雌雄
同数）４群にグループ分けした。その後いずれの群も絶
食を開始し、絶食開始から１２時間後にそれぞれ第１回
目の試料投与を行った。Example 2 The sea urchin shell-derived calcium-containing composition of the present invention was administered to parathyroidectomized rats, and the oral absorbability of the sea urchin shell-derived calcium-containing composition was compared with other forms of calcium-containing material. did. The following "sea urchin shell-derived calcium-containing composition" and "oyster shell-derived calcium-containing composition" are the same as those in Example 1. Parathyroidectomy was performed on multiple rats, and then the rats were given a low-calcium diet (normal rat diet containing only 0.1% calcium) for 156 hours to increase blood calcium levels. Lowered. Twenty-four rats (having the same number of males and females) having a normal health condition and having a sufficiently lowered blood calcium concentration were selected, and each group was divided into four groups of 6 animals (the same number of males and females). After that, all the groups started fasting, and 12 hours after the start of fasting, the first sample administration was performed.
【００２３】その後、各群に以下の操作を行った。Thereafter, the following operations were performed on each group.
【００２４】 ネガティブ対照群：第１回目の試料投
与として生理食塩水２ｍｌを胃の中に注入した。その後
２４〜９６時間の間、前記低カルシウム食を摂取させ
た。Negative control group: 2 ml of physiological saline was infused into the stomach as the first sample administration. Then, the low calcium diet was ingested for 24 to 96 hours.
【００２５】 ポジティブ対照群：第１回目の試料投
与として炭酸カルシウムを生理食塩水に溶解したもの
（カルシウム換算で６８．４ｍｇ／（１ｋｇラット体
重）を溶解したもの）２ｍｌを胃の中に注入した。その
後２４〜９６時間の間、前記低カルシウム食に炭酸カル
シウムを混合したもの（１日当りカルシウム換算で６
８．４ｍｇ／１ｋｇラット体重）を摂取させた。Positive control group: As the first sample administration, 2 ml of calcium carbonate dissolved in physiological saline (68.4 mg / (1 kg rat body weight in terms of calcium) dissolved) was injected into the stomach. . After that, for 24 to 96 hours, a mixture of the low calcium diet and calcium carbonate (calculated as 6
8.4 mg / 1 kg rat body weight) was ingested.
【００２６】 ウニ殻由来カルシウム群：第１回目の
試料投与としてウニ殻由来カルシウム含有組成物を生理
食塩水に溶解したもの（カルシウム換算で６８．４ｍｇ
／１ｋｇラット体重）を溶解したもの）２ｍｌを胃の中
に注入した。その後２４〜９６時間の間、前記低カルシ
ウム食にウニ殻由来カルシウム含有組成物を混合したも
の（１日当たりカルシウム換算で６８．４ｍｇ／１ｋｇ
ラット体重）を摂取させた。Sea urchin shell-derived calcium group: A sea urchin shell-derived calcium-containing composition dissolved in physiological saline as the first sample administration (68.4 mg in terms of calcium)
(1 kg rat body weight)) 2 ml) was infused into the stomach. Then, for 24 to 96 hours, the low calcium diet was mixed with a sea urchin shell-derived calcium-containing composition (68.4 mg / 1 kg in terms of calcium per day).
Rat weight) was ingested.
【００２７】 カキ殻由来カルシウム群：第１回目の
試料投与としてカキ殻由来カルシウム含有組成物を生理
食塩水に溶解したもの（カルシウム換算で６８．４ｍｇ
／（１ｋｇラット体重）を溶解したもの）２ｍｌを胃の
中に注入した。その後２４〜９６時間の間、前記低カル
シウム食にカキ殻由来カルシウム含有組成物を混合した
もの（１日当たりカルシウム換算で６８．４ｍｇ／１ｋ
ｇラット体重）を摂取させた。Oyster shell-derived calcium group: A solution containing the oyster shell-derived calcium-containing composition in physiological saline as the first sample administration (68.4 mg in terms of calcium)
2 ml of (1 / kg rat body weight dissolved) was injected into the stomach. Then, during the period of 24 to 96 hours, the low calcium diet was mixed with the oyster shell-derived calcium-containing composition (68.4 mg / 1 k / day in terms of calcium).
g rat body weight).
【００２８】なお、上記４群とも、第１回目の試料投与
後６〜２４時間の間は、低カルシウム食を摂取させた。In each of the four groups, a low calcium diet was ingested for 6 to 24 hours after the first sample administration.
【００２９】上記４群とも、第１回目の試料投与直前、
その２４時間後、４８時間後、７２時間後、９６時間後
にそれぞれ採血を行い、血中カルシウム濃度を測定し
た。結果を図１に示す（図１では、第１回目の試料投与
の２４時間後を０時間として表示してある。ただし、２
４時間後の血中カルシウム濃度は、各群とも第１回目の
試料投与直前の血中カルシウム濃度と同じレベルまで下
がっていたことが確認されている）。この図から明らか
なように、血中カルシウム濃度の上昇は、ウニ殻由来カ
ルシウム群＞カキ殻由来カルシウム群＞ポジティブ対照
群＞ネガティブ対照群の順に高く、ウニ殻由来カルシウ
ム含有組成物を経口投与した場合、他の形態のカルシウ
ム含有物に比して、吸収が優れていることが判明した。In all of the above four groups, immediately before the first sample administration,
24 hours, 48 hours, 72 hours, and 96 hours later, blood was collected to measure the blood calcium concentration. The results are shown in FIG. 1 (in FIG. 1, 24 hours after the first sample administration is indicated as 0 hour.
It was confirmed that the blood calcium concentration after 4 hours had decreased to the same level as the blood calcium concentration immediately before the first sample administration in each group). As is clear from this figure, the increase in blood calcium concentration was higher in the order of sea urchin shell-derived calcium group> oyster shell-derived calcium group> positive control group> negative control group, and the sea urchin shell-derived calcium-containing composition was orally administered. In this case, absorption was found to be superior to other forms of calcium-containing material.
【００３０】また、上記４群とも、第１回目の試料投与
後２４時間にわたって各ラットの糞便を全量回収し、糞
便中に含まれているカルシウム量を測定した。結果を表
３に示す。In each of the above 4 groups, the total amount of feces of each rat was collected for 24 hours after the first administration of the sample, and the amount of calcium contained in the feces was measured. The results are shown in Table 3.
【００３１】[0031]
【表３】 この表から明らかなように、糞便中へのカルシウムの排
出は、ポジティブ対照群＞カキ殻由来カルシウム群＞ネ
ガティブ対照群＞ウニ殻由来カルシウム群の順で多かっ
た。ウニ殻由来カルシウム群の糞便中へのカルシウムの
排出が少ないことは、ウニ殻由来カルシウム含有組成物
を経口投与した場合、腸管から良好に吸収され、糞便中
には少量しか排出されないことを意味する。すなわち、
このことにより、ウニ殻由来カルシウム含有組成物を経
口投与した場合、他の形態のカルシウム含有物に比し
て、吸収が優れていることが確認された。一般に、ラッ
トが食餌を摂取してから糞便として排泄されるまでの時
間は約６時間程度と言われており、第１回目の試料投与
の際に生理食塩水とともに胃の中に注入された各試料は
腸で吸収されなければ、２４時間後までにはすべて糞便
中に排泄されると考えられる。[Table 3] As is clear from this table, the excretion of calcium into feces was higher in the order of positive control group> oyster shell-derived calcium group> negative control group> sea urchin shell-derived calcium group. The low excretion of calcium in the sea urchin shell-derived calcium group means that when the sea urchin shell-derived calcium-containing composition is orally administered, it is well absorbed from the intestine and is excreted in the feces only in a small amount. . That is,
From this, it was confirmed that when the sea urchin shell-derived calcium-containing composition was orally administered, the absorption was superior to that of other forms of the calcium-containing composition. Generally, it is said that the time from when a rat ingests food to excretion as feces is about 6 hours, and that each rat was injected into the stomach together with physiological saline at the time of the first sample administration. If the sample is not absorbed in the intestine, it is believed that it will be excreted entirely in the feces by 24 hours.
【００３２】実施例１では正常なラットを、実施例２で
は血中カルシウム濃度の低い副甲状腺摘出ラットを用い
ているが、両実施例とも、本発明のウニ殻由来のカルシ
ウム含有組成物を経口投与した場合の優れたカルシウム
吸収性を定量的に示している。このことから、本発明の
ウニ殻由来カルシウム含有組成物は、低カルシウム血症
（hypocalcemia）、骨粗鬆症（osteoporosis）、腎性骨
形成異常症（renal osteodystrophy）等の、カルシウム
の供給を必要とする多くの疾病の治療または予防に有効
であることは明白である。また、実施例１で示したよう
に、本発明のウニ殻由来カルシウム含有組成物は、外
観、味が良好で、不純物が少ないことを考え合わせる
と、カルシウム供給を目的とする健康食品や飼料への配
合にも極めて適していることは明らかである。In Example 1, a normal rat was used, and in Example 2, a parathyroidectomized rat having a low blood calcium concentration was used. In both Examples, the sea urchin shell-derived calcium-containing composition of the present invention was orally administered. It shows quantitatively the excellent calcium absorption when administered. From this fact, the sea urchin shell-derived calcium-containing composition of the present invention often requires calcium supply such as hypocalcemia, osteoporosis, and renal osteodystrophy. It is clearly effective in treating or preventing the diseases of Further, as shown in Example 1, considering that the sea urchin shell-derived calcium-containing composition of the present invention has a good appearance and taste, and has few impurities, it can be used as a health food or a feed for the purpose of supplying calcium. It is obvious that it is also very suitable for blending.
【００３３】[0033]
【発明の効果】本発明により従来は廃棄されていたウニ
殻から、経口吸収性が優れるほか、味が良好で、不純物
が少なく、歩留りが良いカルシウム含有組成物が提供さ
れた。EFFECTS OF THE INVENTION The present invention provides a calcium-containing composition which is excellent in oral absorption from sea urchin shells that have been conventionally discarded, has a good taste, has few impurities, and has a good yield.
【００３４】該ウニ殻由来カルシウム含有組成物は、低
カルシウム血症、骨粗鬆症、腎性骨形成異常症等の、カ
ルシウムの供給を必要とする多くの疾病の治療または予
防に有効である。また、カルシウム供給を目的とする健
康食品や飼料への配合にも適している。The sea urchin shell-derived calcium-containing composition is effective for treating or preventing many diseases requiring calcium supply, such as hypocalcemia, osteoporosis, renal osteodystrophy. It is also suitable for incorporation into health foods and feeds for the purpose of supplying calcium.
【図１】副甲状腺摘出ラットに各種カルシウム含有物を
経口投与したときの血中カルシウム濃度を示す図である
（第１回目の試料投与から２４時間後の血中カルシウム
濃度を基準（１００）とし、その後２４時間毎の各群の
血中カルシウム濃度を相対値で示した。なお、ここで基
準とした第１回目の試料投与から２４時間後の血中カル
シウム濃度は、各群とも第１回目の試料投与直前の血中
カルシウム濃度と同じレベルまで下がっていたことが確
認されている）。FIG. 1 is a graph showing the blood calcium concentration when various calcium-containing substances were orally administered to parathyroidectomized rats (using the blood calcium concentration 24 hours after the first sample administration as a reference (100)). The blood calcium concentration in each group was shown as a relative value every 24 hours thereafter, and the blood calcium concentration 24 hours after the first sample administration was used as the reference, and the blood calcium concentration in each group was the first time. It has been confirmed that the blood calcium level was decreased to the same level immediately before the administration of the sample).
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ｃ０１Ｆ 11/06 9040−4Ｇ 11/18 Ｃ 9040−4Ｇ ─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 6 Identification code Internal reference number FI Technical indication C01F 11/06 9040-4G 11/18 C 9040-4G
Claims (5)
有組成物。1. A calcium-containing composition obtained by firing sea urchin shells.
ム含有組成物の製造方法。2. A method for producing a calcium-containing composition, which comprises firing sea urchin shells.
含むことを特徴とするカルシウムを生体内に供給する食
品。3. A food for supplying calcium into a living body, which comprises the calcium-containing composition according to claim 1.
含むことを特徴とするカルシウムを生体内に供給する飼
料。4. A feed for supplying calcium into a living body, which comprises the calcium-containing composition according to claim 1.
含むことを特徴とする経口投与によってカルシウムを生
体内に供給する医薬組成物。5. A pharmaceutical composition comprising the calcium-containing composition according to claim 1 for supplying calcium into a living body by oral administration.
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6091694A JP2579593B2 (en) | 1993-07-16 | 1994-04-28 | Health food containing calcium-containing composition excellent in absorbability, drug containing the composition |
| CA002128042A CA2128042C (en) | 1993-07-16 | 1994-07-14 | Calcium containing compositions with high oral bioavailability, manufacturing method of such a composition, health food containing such a composition, and pharmaceutical composition containing such a composition |
| US08/274,867 US5620709A (en) | 1993-07-16 | 1994-07-14 | Calcium containing composition from sea urchin with high oral bioavailability |
| ES94305216T ES2132344T3 (en) | 1993-07-16 | 1994-07-15 | COMPOSITION CONTAINING CALCIUM. |
| EP94305216A EP0634105B1 (en) | 1993-07-16 | 1994-07-15 | Calcium containing composition |
| CN94107988A CN1103785A (en) | 1993-07-16 | 1994-07-15 | A calcium containing composition with high oral bioavailability, manufacturing method of such a composition, health food containing such a composition, and pharmaceutical composition containing such.. |
| DK94305216T DK0634105T3 (en) | 1993-07-16 | 1994-07-15 | Calcium-containing preparation |
| DE69418254T DE69418254T2 (en) | 1993-07-16 | 1994-07-15 | Calcium containing composition |
| TW083106512A TW460285B (en) | 1993-07-16 | 1994-07-16 | A process for preparing calcium containing composition with high oral bioavailability |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17650393 | 1993-07-16 | ||
| JP5-176503 | 1993-07-16 | ||
| JP6091694A JP2579593B2 (en) | 1993-07-16 | 1994-04-28 | Health food containing calcium-containing composition excellent in absorbability, drug containing the composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8007437A Division JPH0984552A (en) | 1993-07-16 | 1996-01-19 | Calcium-containing composition excellent in absorbing property |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0775526A true JPH0775526A (en) | 1995-03-20 |
| JP2579593B2 JP2579593B2 (en) | 1997-02-05 |
Family
ID=26433136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6091694A Expired - Fee Related JP2579593B2 (en) | 1993-07-16 | 1994-04-28 | Health food containing calcium-containing composition excellent in absorbability, drug containing the composition |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2579593B2 (en) |
| CN (1) | CN1103785A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996038058A1 (en) * | 1995-05-28 | 1996-12-05 | Nishimura, Masahiko | Composition containing readily absorbable calcium and process for producing the same |
| WO1998017128A1 (en) * | 1996-10-24 | 1998-04-30 | California Calcium Corporation | Calcium-containing food |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5581552A (en) * | 1978-12-15 | 1980-06-19 | Kazunori Nishimura | Feed for cattle and fish |
| JPS5697231A (en) * | 1979-12-31 | 1981-08-05 | Koji Mitsuo | Preparation of solid or liquid substance usable as drug, food, cosmetic, feed, fertilizer, etc. |
| JPH03291230A (en) * | 1990-04-09 | 1991-12-20 | Kiyoshi Shinohara | Natural calcium formulation |
-
1994
- 1994-04-28 JP JP6091694A patent/JP2579593B2/en not_active Expired - Fee Related
- 1994-07-15 CN CN94107988A patent/CN1103785A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5581552A (en) * | 1978-12-15 | 1980-06-19 | Kazunori Nishimura | Feed for cattle and fish |
| JPS5697231A (en) * | 1979-12-31 | 1981-08-05 | Koji Mitsuo | Preparation of solid or liquid substance usable as drug, food, cosmetic, feed, fertilizer, etc. |
| JPH03291230A (en) * | 1990-04-09 | 1991-12-20 | Kiyoshi Shinohara | Natural calcium formulation |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996038058A1 (en) * | 1995-05-28 | 1996-12-05 | Nishimura, Masahiko | Composition containing readily absorbable calcium and process for producing the same |
| WO1998017128A1 (en) * | 1996-10-24 | 1998-04-30 | California Calcium Corporation | Calcium-containing food |
| AU713772B2 (en) * | 1996-10-24 | 1999-12-09 | California Calcium Corporation | Calcium-containing foods |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1103785A (en) | 1995-06-21 |
| JP2579593B2 (en) | 1997-02-05 |
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