JPH0753995A - Sterilizing and desinfecting detergent composition - Google Patents

Abstract

PURPOSE:To obtain the composition not suffering from a decrease in the activity of the constituent cationic sterilizer even in the presence of a negatively charged substance and excelling in detergency by mixing a cationic sterilizer with a metal chelating agent and a nonionic surfactant and/or an amphoteric surfactant. CONSTITUTION:The composition comprises a cationic sterilizer (a), a metal chelating agent (b) in an amount 0.5 time by moles that of component (a) and a nonionic surfactant and/or an amphoteric surfactant (c). Component (a) is used in an amount of desirably 0.5-5wt.% based on the total composition, and component (c) is used in an amount of desirably 5-50wt.% based on the total composition. Desirable examples of component (b) used include ethylenediaminetetraacetic acid, hydroxyethyethylenediaminetriacetic acid and citric acid. Desirable examples of component (c) used include alkylpolyglycoside and alkyldimethylamino fatty acid betaine.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sterilizing / disinfecting detergent composition which does not reduce the activity of a cationic bactericide.

[0002]

2. Description of the Related Art Cationic fungicides are widely used in the field of hygiene and the like because they have a broad antibacterial spectrum and a fast-acting effect. A sterilizing / disinfecting detergent having a bactericidal effect and a cleaning effect by combining such a cationic bactericidal agent and a surfactant is also known.

However, when an anionic surfactant is used as the surfactant or in the presence of a substance having an anionic charge such as protein, the activity of the cationic bactericidal agent is significantly reduced. was there.
As a method of preventing such a decrease in activity, a method of coating a cationic bactericidal agent with a polymeric nonionic activator or a pH-sensitive polymer, a method of adding a large amount of a cationic bactericidal agent, and the like are adopted. However, the former polymer coating method reduces the activity of the cationic bactericide,
On the other hand, the method of using an excessive amount is not economically preferable.

Therefore, an object of the present invention is to provide a sterilizing / disinfecting detergent which is excellent in detergency and which does not reduce the activity of the cationic sterilizing agent even in the presence of a substance having an anionic charge.

[0005]

Therefore, as a result of intensive studies to solve the above problems, the present inventors have found that a cationic bactericidal agent, a metal chelating agent, a nonionic surfactant and / or an amphoteric interface are used. The present invention was completed by finding that a bactericidal / disinfecting detergent composition having an ability to exert its original function without deteriorating the activity of the cationic bactericidal agent and having excellent detergency can be obtained by using a combination of the active agents, and completed the present invention. did.

That is, the present invention provides (a) a cationic bactericidal agent, (b) a metal chelating agent in an amount of 0.5 times or more the molar amount of the bactericidal agent, and (c) a nonionic surfactant and / or an amphoteric interface. Disclosed is a sterilizing and disinfecting detergent composition containing an active agent.

As the cationic bactericide of the component (a) used in the present invention, benzethonium chloride, benzalkonium chloride, dialkyldimethylammonium halide,
Monoalkyl trimethyl ammonium halide or a cationic surfactant-based bactericide in which the counter ion of these bactericides is converted to other anions; biguanide bactericides such as chlorhexidine, chlorohexidine gluconate; alkyldiaminoethylglycine, alkylpolyaminoethyl Examples thereof include amino acid surfactants such as glycine.

These cationic bactericides are contained in the total composition in an amount of 0.1 to 10% by weight (hereinafter simply referred to as%), particularly 0.1.
It is preferable to add 5 to 5%.

The metal chelating agent as the component (b) is not particularly limited as long as it has the ability to chelate metal ions. For example, ethylenediaminetetraacetic acid, hydroxyethylethylenediaminetriacetic acid, diethylenetriaminepentaacetic acid, nitrilotriacetic acid. , Triethylenetetramine hexaacetic acid, phosphonic acids, tripolyphosphoric acid, ethylene glycol bis (2-aminoethyl ether) tetraacetic acid, citric acid, maleic acid, polyacrylic acid, isoamylene-maleic acid copolymer, silicic acid, gluconic acid, Examples include hydroxybenzylimidinoacetic acid, imidinoacetic acid and salts thereof. Of these, ethylenediaminetetraacetic acid, hydroxyethylethylenediaminetriacetic acid, citric acid, tripolyphosphoric acid or salts thereof are particularly preferable.

It is necessary to add such a metal chelating agent to the cationic bactericidal agent in an amount of 0.5 times by mole or more, but 0.5 to 5 times by mole, further 0.5 to 2 times by mole, and particularly 1 mole. ~ 2 times the molar amount is preferred. If it is less than 0.5 times by mole, a sufficient activity reduction preventing effect cannot be obtained. In addition, it is preferable to add 0.05 to 5%, particularly 0.2 to 3% in the total composition.

A chelating agent may be added to shampoos, rinses and the like in addition to the anionic and cationic surfactants for the purpose of improving foaming properties and detergency at low temperatures. The compounding amount is usually a very small amount, and the effect of not lowering the activity of the cationic bactericidal agent as in the present invention cannot be exerted at all.

Among the components (c), examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkylene ether, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, alkyl polyglycoside, Examples thereof include sucrose fatty acid ester and alkyl polyglycerin ether. As the amphoteric surfactant,
Examples thereof include alkyldimethylamino fatty acid betaine, alkyldimethylamine oxide, alkylcarboxymethyl hydroxyethyl imidazolium betaine and the like. Of these, alkyl polyglycoside, alkyl dimethyl amino fatty acid betaine, and alkyl dimethyl amine oxide are particularly preferable.

As the component (c), one kind or a combination of two or more kinds of these nonionic surfactants and amphoteric surfactants can be used. In order to obtain a sufficient cleaning effect, It is preferable to add 1 to 80%, especially 5 to 50% in the composition.

In the sterilizing / disinfecting detergent composition of the present invention, the cationic bactericidal agent and the metal chelating agent are blended so that even in the presence of a substance having an anionic charge,
The activity of the cationic bactericide does not decrease. Therefore, the sterilizing / disinfecting detergent composition of the present invention may further contain a substance having an anionic charge. Examples of the substance having such an anionic charge include compounds having an acid residue such as a carboxyl group, a sulfuric acid residue, a sulfonyl group and a phosphoric acid residue. Specific examples include various anionic surfactants, proteins, amino acids, phospholipids, anionic polymers and the like. Examples of the anionic surfactant include higher fatty acid salts, higher alcohol sulfate ester salts, higher alcohol sulfonate salts, sulfated fatty acid salts, sulfonated fatty acid salts, phosphate ester salts, fatty acid ester sulfate ester salts, and fatty acid ester salts. Sulfonic acid ester salts, sulfuric acid ester salts of higher alcohol ethers, sulfonic acid ester salts of higher alcohol ethers,
Higher alcohol ether substituted acetate, fatty acid and amino acid condensate, fatty acid amide alkylated sulfuric acid ester salt, fatty acid amide alkylated sulfonate, sulfosuccinic acid ester salt, alkylbenzene sulfonate,
Examples thereof include alkylphenol sulfonate, alkylnaphthalene sulfonate, alkylbenzimidazole sulfonate and the like. As the anionic polymer, a polymer having a carboxyl group, a sulfonyl group, a sulfuric acid residue or the like, for example, poly (meth) acrylic acid salt, polyvinyl alcohol sulfate ester salt, naphthalenesulfonic acid formalin condensate or an alkylene oxide adduct thereof, etc. Can be mentioned.

Further, other additives such as salts, thickeners, other bactericides, thinning agents, solvents such as ethanol and propylene glycol may be added to the sterilizing / disinfecting detergent composition of the present invention, if necessary. Fragrances, colorants and the like can be appropriately added within a range that does not impair the effects of the present invention.

The sterilizing / disinfecting detergent composition of the present invention can be produced by a conventional method, for example, by mixing and stirring each component, and various dosage forms such as a water solvent, a solid agent, an aqueous dispersion and the like. Can be

[0017]

ACTION AND EFFECT Although the mechanism of action for preventing the activity reduction in the sterilizing / disinfecting detergent composition of the present invention is not clear, it is presumed as follows. That is, ¹³ C-NMR of α-carbon of a fatty acid salt, which is an example of a substance having an anionic charge, shifts to a high magnetic field side in the presence of a cationic bactericide, and some interaction occurs between these substances. I understand. When EDTA on the metal chelate side is allowed to coexist with this, ¹³ C-NMR of the α carbon returns to the low magnetic field side. Therefore,
The addition of the metal chelating agent reduces the activity of the cationic bactericide due to the interaction with the substance having an anionic charge. It is presumed that it will return to a state in which it can exert its effects. The sterilizing / disinfecting detergent composition of the present invention can exhibit the original action of the cationic bactericide because the activity of the cationic bactericide does not decrease even in the presence of a substance having an anionic charge. ,
Moreover, it has excellent cleaning power. Therefore, when the sterilizing / disinfecting detergent composition of the present invention is applied to an object to be washed such as skin in which a substance having an anionic charge such as protein or phospholipid is present, the bactericidal effect is significantly higher than that of conventional sterilizing agents. Increase.

[0018]

EXAMPLES The present invention will now be described in detail with reference to examples, but the present invention is not limited thereto.

Example 1 Various fungicides (benzalkonium hexadecylphosphate, benzalkonium chloride, didecyldimethylammonium chloride or chlorohexidine gluconate) are mixed with a nonionic surfactant and / or an amphoteric surfactant. The bactericidal effect in the presence of a substance having an anionic charge and the bactericidal effect when a metal chelating agent was added to the system were examined. (Method) 10 parts by weight of the following alkyl polyglycoside, which is a nonionic surfactant, was mixed with 1 part by weight of each bactericide.

[0020]

[Chemical 1]

To this, 0.5 to 10.0 times the molar amount of EDTA sodium salt as a metal chelating agent of the bactericide was added, and the total amount was adjusted to 100 parts by weight with sterile distilled water, and the bactericidal activity was measured. As a comparative control group, a metal chelating agent, 3 parts by weight of triethanolamine laurate which is an anionic surfactant, or a system without addition of various fungicides, and a single system thereof were set. The bactericidal test method is to prepare a diluted system of various compounding agents, and use the test bacteria (Escherichia coli I
FO 3972, Pseudomonas aerug
inosa IFO 12689), 100%
The concentration and time for sterilization were calculated. That is, the bacteria (about 10 ⁹ to 10 ¹⁰ ce) pre-cultured in the SCD medium (manufactured by Nippon Pharmaceutical Co., Ltd.)
ll / ml) 0.1 ml, and use sterile distilled water to obtain the desired concentration (bactericide concentration 1, 5, 10, 25, 50, 75, 100, 2
It was inoculated into 10 ml of a solution diluted to 00,300,500 ppm) and allowed to act at room temperature. Fixed time (5, 10, 15,
Every 30 minutes), one platinum loop amount of the bacterial contact liquid is sampled, and post-cultivation S
Micro Petri dish (CORNI) containing 0.3 ml of CD medium
NG, 96-Cell Wells) was inoculated.
The cells were cultured at 30 ° C. for 3 days, the growth of the bacteria was visually observed, and the intensity of the effect was judged by the number of sterilized areas. That is, the determination was made by measuring the places where the bacteria did not grow on the micro planter (maximum 40). The obtained results are shown in Tables 1 and 2.

[0022]

[Table 1]

[0023]

[Table 2]

Example 2 Various bactericides (benzalkonium hexadecylphosphate, benzalkonium chloride, didecyldimethylammonium chloride or chlorohexidine gluconate) are mixed with a nonionic surfactant and / or an amphoteric surfactant. The bactericidal effect in the presence of a substance having an anionic charge and the bactericidal effect when a metal chelating agent was added to the system were examined. The sterilization test was performed in the same manner as in Example 1 except that polyoxyethylene (3.0) lauryl ether was used instead of the nonionic surfactant alkyl polyglycoside. The results are shown in Tables 3 and 4.

[0025]

[Table 3]

[0026]

[Table 4]

Example 3 A system in which various fungicides (benzalkonium chloride, chlorohexidine gluconate) and a nonionic surfactant and / or amphoteric surfactant were mixed in the presence of a substance having an anionic charge. The bactericidal effect and the bactericidal effect when a metal chelating agent was added thereto were examined. The bactericidal effect was obtained in the same manner as in Example 1 except that the following alkyldimethylamine oxide, which is an amphoteric surfactant, was used in place of the nonionic surfactant, alkyl polyglycoside. The results are shown in Table 5.

[0028]

[Chemical 2]

[0029]

[Table 5]

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Chikako Ikeda 5-3, Tsuzuma, Wakayama, Wakayama Prefecture (72) Inventor Shuri Okamoto 1-9, Sunayama South, Wakayama City, Wakayama Prefecture

Claims (5)

[Claims] 1. A cationic bactericidal agent, (b) a metal chelating agent which is 0.5 times or more moles of the bactericidal agent, and (c).
A sterilizing and disinfecting detergent composition containing a nonionic surfactant and / or an amphoteric surfactant. 2. The sterilizing / disinfecting detergent composition according to claim 1, wherein the cationic bactericide is selected from a cationic surfactant bactericide, a biguanide bactericide and an amino acid surfactant. 3. The metal chelating agent is ethylenediaminetetraacetic acid, hydroxyethylethylenediaminetriacetic acid, diethylenetriaminepentaacetic acid, nitrilotriacetic acid, triethylenetetraminehexaacetic acid, phosphonate, ethyleneglycolbis (2-aminoethylether) tetraacetic acid, The sterilizing and disinfecting cleaning according to claim 1, which is selected from citric acid, maleic acid, polyacrylic acid, isoamylene-maleic acid copolymer, silicic acid, gluconic acid, hydroxybenzylimidinoacetic acid, imidinoacetic acid and salts thereof. Agent composition. 4. The nonionic surfactant is polyoxyethylene alkyl ether, polyoxyethylene alkylene ether, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, alkyl polyglycoside, sucrose fatty acid ester and alkyl polyglycerin. Selected from ether,
The sterilizing / disinfecting detergent composition according to claim 1, wherein the amphoteric surfactant is selected from alkyldimethylamino fatty acid betaine alkyldimethylamine oxide and alkylcarboxymethyl hydroxyethyl imidazolium betaine. 5. A cationic bactericidal agent, (b) a metal chelating agent in an amount of 0.5 times or more the molar amount of the bactericidal agent, (c) a nonionic surfactant and / or an amphoteric surfactant, and ( d) A sterilizing / disinfecting detergent composition containing a substance having an anionic charge.