JP3203534B2 - Detergent composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a detergent composition, and more particularly, to a detergent composition having a low irritating property to the skin, an excellent bactericidal effect and a good feeling upon use.

[0002]

BACKGROUND OF THE INVENTION Generally, cationic fungicides are widely used in the field of hygiene because of their wide antibacterial spectrum and rapid action. Attempts have been made to develop a cleaning agent having both a cleaning effect and a bactericidal effect by combining the agent with a cleaning agent.

[0003] However, when an anionic surfactant is used or in the presence of a substance having an anionic charge such as a protein, the activity of the cationic bactericide is significantly reduced. As a method of preventing such a decrease in activity, a method of coating the cationic fungicide with a high-molecular nonionic surfactant or a pH-sensitive polymer, a method of adding a large excess of a cationic fungicide, and the like are known. The former does not substantially prevent the activity from decreasing, while the latter is not preferable from an economic viewpoint.

[0004] Therefore, there has been a demand for the development of a detergent composition which has low irritation to the skin, has a sufficient bactericidal action, and has a good feeling in use.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies in view of the above circumstances, and as a result, as will be described later, have specified a specific secondary amide type N-acylamino acid salt, a cationic fungicide and a metal chelating agent. Each composition containing a specific ratio has excellent bactericidal action while being hypoallergenic to the skin, and furthermore, has been found to give a good feeling of use during washing, and to complete the present invention. Reached.

That is, the present invention provides the following component (A):
(B) and (C); (A) the following general formula (1)

[0007]

Embedded image R ¹ CONH (CH ₂ ) _m COOM ¹ (1)

(Wherein, R ¹ CO— represents an acyl group having 10 to 16 carbon atoms, m represents a number of 1 or 2, and M ¹ represents m
Is 1 to represent a sodium atom, a potassium atom or an alkanol ammonium group, and m is 2 to represent a potassium atom or an alkanol ammonium group) 2 to 60% by weight of a secondary amide type N-acyl amino acid salt represented by the following formula: ) A cationic disinfectant: 0.05 to 3.0% by weight; (C) a metal chelating agent: 0.5 to 3 times mol of the component (B). It is.

The secondary amide-type N-acylamino acid salt of the component (A) used in the present invention has a property of reacting with calcium contained in tap water to form plate-like crystals having high lubricity. Is an effect of imparting a good feeling of use such as slippage after washing to a detergent composition containing the same. Here, the lubricating properties of the plate-like crystals generated by the reaction between the secondary amide type N-acyl amino acid salt and calcium can be determined by, for example, regenerating dried pork skin (Alloask, manufactured by Antibody Chemicals, Inc.) with physiological saline. It is determined by measuring the coefficient of static friction of the plate-like crystal on the object, and the coefficient value is always lower than that of the blank from wet to dry, and is evaluated as good.

In the general formula (1), the acyl group represented by R ¹ CO— has 10 to 16 carbon atoms, and particularly preferably has 12 to ¹ carbon atoms.
4, and specific examples include a caprinoyl group, a lauroyl group, and a myristoyl group. These have particularly good lubricity of the plate-like crystals formed and foaming during washing.

It is particularly preferable that the above secondary amide type N-acyl amino acid salt has a secondary amide type structure in which the N-acyl group is composed of a linear acyl group. In other words, when such a structure is employed, the generation of plate-like crystals is promoted, and thus the generated crystals are excellent in lubricity and less sticky, and a particularly favorable feel is obtained. Alkanol ammonium includes monoethanol ammonium, diethanol ammonium and triethanol ammonium. In the general formula (1), those in which m is 2 and M ¹ is sodium have a high Krafft point and poor water solubility,
It is not preferable when used for a liquid detergent.

The amount of the component (A) to be added to the cleaning composition of the present invention is 2 to 60% by weight (hereinafter simply referred to as "%"). Is preferred.

The cationic fungicide of the component (B) used in the present invention includes a benzethonium salt, a benzalkonium salt, a pyridinium salt, a dialkyldimethylammonium halide, a monoalkyltrimethylammonium halide or a counter ion of these fungicides. Other examples include cationic surfactant-based germicides converted into other anions; biguanide-based germicides such as chlorhexidine and chlorhexidine gluconate. Among them, the following general formula (2)

[0014]

Embedded image

(Wherein R ² represents a hydrocarbon group having 8 to 24 carbon atoms, and Z has a halogen atom, an amino acid, a fatty acid, a linear or branched alkyl group or alkenyl group having 1 to 30 carbon atoms) Sulfones of polycyclic aromatic compounds having phosphoric acid ester, phosphonic acid ester, sulfonic acid ester or sulfuric acid ester anionic residue or styrene sulfonic acid having a degree of polymerization of 3 or more or having a hydrocarbon group as a substituent Azalkonium salt represented by an anionic oligomer or polymer containing a formalin condensate of a compound) is particularly preferred because of its high bactericidal property. In the above formula (2), preferred examples of R ² include a hydrocarbon group having 12 to 18 carbon atoms, and preferred examples of Z include a chlorine atom and an anionic residue of an alkyl phosphate ester. .

The compounding amount of the component (B) in the detergent composition of the present invention is 0.05 to 3.0%, particularly 0.1 to 1.5%.
% Is preferable because of its good bactericidal action and no irritation by the bactericide.

The metal chelating agent of component (C) used in the present invention is not particularly limited as long as it has the ability to chelate metal ions. Examples thereof include ethylenediaminetetraacetic acid, hydroxyethylethylenediaminetriacetic acid, diethylenetriaminepentaacetic acid, Nitrilotriacetic acid, triethylenetetramine hexaacetic acid, phosphonic acids, tripolyphosphoric acid, ethylene glycol bis (2-aminoethyl ether) tetraacetic acid, citric acid, maleic acid, polyacrylic acid, isoamylene-maleic acid copolymer, silicic acid, glucone Acids, hydroxybenzyliminodiacetic acid, iminodiacetic acid and salts thereof. Among them, ethylenediaminetetraacetic acid, hydroxyethylethylenediaminetriacetic acid, citric acid, tripolyphosphoric acid and salts thereof are particularly preferred.

The amount of the component (C) to be added to the detergent composition of the present invention is 0.5 to 3 times the mole of the component (B), and particularly 0.7 to 2 times the mole of the cationic fungicide. It is preferable because the bactericidal activity is not reduced.

Incidentally, in addition to an anionic surfactant and a cationic surfactant, a metal chelating agent may be added to a shampoo, a rinse or the like for the purpose of foaming and improvement of detergency at a low temperature. In this case, the amount of the metal chelating agent is very small unlike the present invention, and it is needless to say that the effect thereof is completely different from that of the present invention.

The cleaning composition of the present invention may optionally contain
Other activators such as higher fatty acid salts, alkyl sulfates, alkyl sulfonates, polyoxyethylene alkyl sulfates, alkyl benzene sulfonates, N-acyl sarcosine salts, N-acyl-N-methyltaurine salts, alpha olefin sulfones Anionic surfactants such as acid salts, alkyl ether acetates, polyoxyethylene alkyl ether acetates, nonionic surfactants such as polyoxyethylene alkyl ethers, sugar esters, sugar ethers, sugar amides, and imidazolines And betaine-based amphoteric surfactants can be optionally used in combination within a range not to impair the effects of the present invention.

Further, in the cleaning composition of the present invention, as a further additive, a component usually used for a cleaning agent can be optionally used in a range not to impair the effect of the present invention. For example, propylene glycol, sorbitol,
Moisturizers such as glycerin, viscosity modifiers such as carboxyvinyl polymer, methylcellulose, ethanol, and polyoxyethylene glycol distearate, pearling agents, fragrances, dyes, ultraviolet absorbers, antioxidants, anti-inflammatory agents, preservatives, etc. Can be blended.

The detergent composition of the present invention can be manufactured into a desired dosage form such as a solid, gel, paste, or liquid by mixing, heating, stirring, etc. the above components in a conventional manner. The cleaning composition of the present invention is suitable for cleaning the body such as skin and hair, and is particularly preferable for cleaning the skin.

[0023]

The cleaning composition of the present invention has excellent bactericidal action while being less irritating to the skin, and has a good feeling of use during washing.

[0024]

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.

Example 1 A cleaning composition having the composition shown in Tables 1 and 2 was produced by the following method. (Production method) A liquid detergent was obtained by sequentially dissolving other components in purified water.

The bactericidal effect of each of the obtained liquid detergent compositions was measured by the following method, and the feeling of use was evaluated by the following method and criteria. Table 1 shows the results.
And Table 2. In addition, No. The cleaning compositions 14 to 18 are comparative products.

(Measurement of bactericidal effect) A bactericidal test method, diluents were prepared for each of the obtained detergents, and each of them was subjected to a test microorganism (Escherichia coli IFO 397).
2. Pseudomonas aeruginosa
IFO 12689) and the concentration and time for 100% sterilization were determined. That is, bacteria (about 10 ⁹ to 10 ¹⁰ cells) pre-cultured on an SCD medium (manufactured by Nippon Pharmaceutical Co., Ltd.)
/ Ml) and sterilized distilled water to a predetermined concentration (disinfectant concentration: 1, 5, 10, 25, 50, 75, 100, 20).
(0,300,500 ppm) and inoculated into 10 ml of the test solution, and allowed to act at room temperature. Fixed time (5,10,1
Every 5 and 30 minutes), collect one loopful of the bacterial contact solution and use a micro Petri dish (COR) containing 0.3 ml of SCD medium for post-culture.
NING, 96-Cell Wells). After culturing at 30 ° C. for 3 days, the growth of the bacteria was visually observed, and the strength of the effect was determined by the number of sterilized areas. That is,
Judgment was made by measuring the area where no bacteria grew on the microplanter (maximum 40). The larger the value, the stronger the sterilizing power.

(Evaluation of Feeling of Use) For each of the detergent compositions, panelists of 10 men and women were allowed to clean their bodies, and a sensory evaluation was performed. In the evaluation, an average value was calculated according to the following criteria. When the average value was 4.5 or more, it was very good (（), and when it was 3.5 to 4.4, it was good (○), and 2.5 to
The case of 3.4 was judged as normal (△), and the case of 2.4 or less was judged as bad (×). [(1) Out of bubbles at the time of rinsing] 5; 4: Slightly defoamed. 3: Normal. 2: Bubble is somewhat poor. 1; foaming is poor. [(2) Slip during rinsing, (3) Slip after rinsing, and (4) Slip after drying] 5; Slip is good. 4: Slightly good slippage. 3: Normal. 2: Sliding is somewhat poor. 1: Sliding is poor.

[0029]

[Table 1]

[0030]

[Table 2]

As is clear from the results shown in Tables 1 and 2, the products of the present invention (Nos. 1 to 13) are comparative products (No. 14).
-18), all were excellent in the bactericidal effect and the feeling of use during skin washing. In addition, these cleaning agents had low irritation to the skin.

Example 2 A liquid detergent composition having the following composition was produced by the following method.

[0033]

(Table 3) (Blending composition) (%) (1) Lauroyl-β-alanine triethanol ammonium 20.0 (2) Triethanol ammonium laurate 4.0 (3) Lauroyl amide propyl dimethyl carboxy betaine 2.0 (4) ) Benzalkonium chloride 1.0 (5) 1-hydroxyethylidene-1,1-diphosphonic acid 1.0 ^* (*: indicates the molar ratio to (4)) (6) Fragrance 0.5 (7) Dibutylhydroxyl Toluene 0.2 (8) Ethanol 4.0 (9) Purified water balance

(Manufacturing method)
After dissolving (3) and cooling, (4) to (8) were added to obtain a liquid detergent composition.

Example 3 A liquid detergent composition having the following composition was produced by the following method.

[0036]

(Table 4) (Blending composition) (%) (1) Lauroyl-β-alanine triethanolammonium 20.0 (2) Triethanolammonium laurate 3.0 (3) Triethanolammonium myristate 3.0 (4) Lauroyl amide propyl dimethyl carboxy betaine 3.0 (5) Cationized cellulose 0.2 (6) Benzalkonium hexadecyl phosphate 1.0 (7) Disodium ethylenediaminetetraacetate 1.0 ^* (*: to (6) (Shows molar ratio) (8) Perfume 0.5 (9) Dibutylhydroxytoluene 0.2 (10) Ethanol 4.0 (11) Purified water Balance

(Manufacturing method) (1) to (11)
After dissolving (5) and cooling, (6) to (10) are added,
A liquid detergent composition was obtained.

When the body was washed with the detergent compositions obtained in the above Examples 2 and 3, both of them had high bactericidal activity and thus had an excellent deodorant effect, and had good foaming and defoaming, and were dried after rinsing. The sliding was good until later, and the usability was excellent. In addition, both of the cleaning compositions had low irritation to the skin.

Claims (2)

(57) [Claims] (1) The following components (A), (B) and (C); (A) the following general formula (1): R ¹ CONH (CH ₂ ) _m COOM ¹ (1) R ¹ CO— represents an acyl group having 10 to 16 carbon atoms, m represents a number of 1 or 2, and M ¹ represents a sodium atom, a potassium atom or an alkanol ammonium group when m is 1, A potassium atom or an alkanol ammonium group, respectively) 2 to 60% by weight of a secondary amide type N-acyl amino acid salt represented by the following formula: (B) 0.05 to 3.0% by weight of a cationic fungicide; A chelating agent comprising: 0.5 to 3 moles of the component (B). 2. Component (B) is represented by the following general formula (2): (Wherein, R ² represents a hydrocarbon group having 8 to 24 carbon atoms;
Is a halogen atom, an amino acid, a fatty acid, an anionic residue of a phosphate ester, a phosphonate ester, a sulfonate ester or a sulfate ester having a linear or branched alkyl or alkenyl group having 1 to 30 carbon atoms, or a degree of polymerization of 3 or more. Anionic oligomer or polymer containing a formalin condensate of a sulfonated polycyclic aromatic compound which may have styrenesulfonic acid or may have a hydrocarbon group as a substituent) The cleaning composition according to claim 1, which is: